Hypoglycemic polysaccharides from Auricularia auricula and Auricularia polytricha inhibit oxidative stress, NF-κB signaling and proinflammatory cytokine production in streptozotoci... by Huan Xiang, Dongxiao Sun-Waterhouse, Chun Cui

“…This is the first report to compare the effectiveness of AAP and APP in combating streptozotocin-induced oxidative stress and diabetes-related changes in mice (body weight, fasting blood glucose, serum insulin, proinflammatory mediator and cytokines, oxidative stress-related products, antioxidant enzymes). APP and AAP with different molecular weights and monosaccharide molar ratios could be therapeutic options for diabetes with a low dose (100 mg/kg/day) likely working better. …”
Get full text

Design, Synthesis, Molecular Docking, and Antibacterial Evaluation of Some Novel Flouroquinolone Derivatives as Potent Antibacterial Agent by Mehul M. Patel, Laxman J. Patel

“…To understand the interaction of binding sites with bacterial protein receptor, the docking study was performed using topoisomerase II DNA gyrase enzymes (PDB ID: 2XCT) by Schrodinger’s Maestro program. …”
Get full text

Functional Development of the Human Gastrointestinal Tract: Hormone- and Growth Factor-Mediated Regulatory Mechanisms by Daniel Ménard

“…In the third section, emphasis is placed on the functional development of human fetal stomach and its various epithelial cell types; in particular, the glandular chief cells responsible for the synthesis and secretion of gastric enzymes such as pepsinogen-5 and gastric lipase. Bearing in mind that limitations of available cell models have, until now, greatly impeded the comprehension of molecular mechanisms regulating human gastric epithelial cell functions, the last section focuses on new human gastric epithelial cell models recently developed in the author's laboratory. …”
Get full text

Pyogenic Liver Abscess Caused by Methicillin-Susceptible Staphylococcus aureus in a 21-Year-Old Male by Samuel Igbinedion, Meher S. Mavuram, Moheb Boktor, John Bienvenu

“…Labs were significant for leukocytosis with predominant neutrophilia and elevated liver enzymes. CT abdomen with contrast revealed an 8.4 cm multiloculated right hepatic mass extending to the kidney. …”
Get full text

Case Report: Necrotizing pneumonia in pediatric patients: a rare case of unilateral necrosis in two entire lobe tissues by Jingli Zhang, Yingqian Zhang, Longfei Gao, Huifang Wu, Xiaojuan Liu, Fan Yang, Yingxue Wang

“…Laboratory investigations revealed elevated white blood cell count, increased inflammatory markers, elevated liver enzymes, coagulation dysfunction, and hypoalbuminemia. …”
Get full text

Recapitulation of previously reported associations for type 2 diabetes and metabolic traits in the 126K East Asians by Ji-Young Choi, Hye-Mi Jang, Sohee Han, Mi Yeong Hwang, Bong-Jo Kim, Young Jin Kim

“…In this study, we validated 422 variants independently associated with glycemic indexes, liver enzymes, and type 2 diabetes in 125,872 samples from a Korean population, and further validated the results by assessing publicly available summary statistics from European GWAS (n = 898,130). …”
Get full text

Unraveling cerebroprotective potential of fenchone: A combined in vivo and in silico exploration of nitric oxide synthase modulation by Bangaru Mamatha, Anka Rao Areti, DSNBK Prasanth, Narender Malothu

“…Additionally, FEN restored the activity of antioxidant enzymes (catalase and superoxide dismutase) and decreased malondialdehyde (MDA) and nitric oxide (NO) levels and infarct size compared to those in untreated ischemic rats. …”
Get full text

DAMPs Synergize with Cytokines or Fibronectin Fragment on Inducing Chondrolysis but Lose Effect When Acting Alone by Lei Ding, Joseph A. Buckwalter, James A. Martin

“…However, when acting alone, MTDs or HMGB1 did not upregulate cartilage degrading enzymes or iNOS. Conclusion. MTDs or HMGB1 could only stimulate inflammatory response in chondrocytes with the presence of cytokines or Fn-f.…”
Get full text

Histopathological, Immunohistochemical and Biochemical Studies of Murine Hepatosplenic Tissues Affected by Chronic Toxoplasmosis by Samah Hassan Yahia, Samia Elsayed Etewa, Nesreen Saeed Saleh, Samira Metwally Mohammad, Nora Ibrahim Aboulfotouh, Ahmad Mansour Kandil, Mohamed Hassan Sarhan

“…The biochemical profile of the liver has been changed in the form of increased liver enzymes, and oxidative stress has been evidenced by elevated nitric oxide (NO) concentration in liver homogenate. …”
Get full text

Effects of Fungi-Mediated Solid-State Fermentation on Phenolic Contents and Antioxidant Activity of Brown and White Teff (Eragrostis tef (Zucc.) Trotter) Grains by Yoseph Asmelash Gebru, Desta Berhe Sbhatu

“…Such changes are suggested to be attributed to activities of fungal enzymes such as amylases, xylanases, and proteases that induce structural breakdown of grain components including cell walls leading to the liberation or synthesis of a variety of phenolic compounds. …”
Get full text

Microwave-Assisted Synthesis of Cross-Linked Co-poly(itaconic anhydride-methyl methacrylate): The Effects of the Molar Ratio and Cross-Linking Agent on the Thermal Stability by Ali Aldalbahi, Mostafizur Rahaman, Ayman El-Faham

“…The copolymers containing itaconic anhydride (ITA) and methyl methacrylate (MMA) were chosen due to the formation of long-term stable anhydride moieties, which might be useful to attach enzymes covalently with numerous applications in water treatment. …”
Get full text

Warfarin Dosing in a Patient with CYP2C9*3*3 and VKORC1-1639 AA Genotypes by Mark Johnson, Craig Richard, Renee Bogdan, Robert Kidd

“…Genetic factors most correlated with warfarin dose requirements are variations in the genes encoding the enzymes cytochrome P450 2C9 (CYP2C9) and vitamin K epoxide reductase (VKOR). …”
Get full text

Sulbactam–Durlobactam: A Novel Antibiotic Combination for the Treatment of Acinetobacter baumannii–Calcoaceticus Complex (ABC) Hospital-Acquired Bacterial Pneumonia and Ventilator-... by Wissam K. Kabbara, Elina Sadek, Hanine Mansour

“…Reported adverse events include anemia, elevated liver enzymes, hyperkalemia, headache, diarrhea, nausea, urticaria, and vascular pain. …”
Get full text

In Vivo and Ex Vivo Evaluation of 1,3-Thiazolidine-2,4-Dione Derivatives as Euglycemic Agents by Diana Alemán-González-Duhart, Samuel Álvarez-Almazán, Miguel Valdes, Feliciano Tamay-Cach, Jessica Elena Mendieta-Wejebe

“…At the end of the experiment, tissue samples were collected to quantify the level of glucose, insulin, triglycerides, total cholesterol, and liver enzymes, as well as enzymatic and nonenzymatic antioxidant activity. …”
Get full text

Duodenal Obstruction during Pregnancy by Mansooreh Haghiri, Sedigheh Borna, Kamran Hessami, Ali Sharifi, Seyed Mohsen Ahmadi Tafti, Mahrooz Malek, Nasim Pourdamghan, Sedigheh Hantoushzadeh, Abolfazl Shirdel Abdolmaleki, Maasoumeh Saleh

“…Intractable vomiting and elevated liver enzymes during pregnancy seem to be associated to the obstetric etiologies; however, other causes such as acute surgical emergencies should be considered. …”
Get full text

Comparative Neuroprotective Effects of Dexamethasone and Minocycline during Hepatic Encephalopathy by Maha Gamal, Zainab Abdel Wahab, Mohamed Eshra, Laila Rashed, Nivin Sharawy

“…Methods. 48 male albino rats were divided into 4 groups: control group, acute liver injury (ALI) group, minocycline pretreated ALI group, and dexamethasone pretreated ALI group. 24 hours after acute liver injury serum ammonia, liver enzymes, brain levels of heme oxygenase-1 gene, iNOS gene expression, nitrite/nitrate, and cytokines were measured. …”
Get full text

Comparative analysis of selected methods of carbapenemase determination among clinical Klebsiella pneumoniae. by Agata Pruss, Alicja Skierska, Paweł Kwiatkowski, Helena Masiuk, Joanna Jursa-Kulesza, Stefania Giedrys-Kalemba, Iwona Bilska, Monika Sienkiewicz, Maria V Melnyk, Barbara Dołęgowska

“…Klebsiella pneumoniae is a typical opportunistic pathogen that exhibits multiple virulence factors and antibiotic resistance conditioning mechanisms. Carbapenemases are enzymes that help bacteria to exhibit the strongest resistance against antibiotics. …”
Get full text

Search for new antimicrobials against extended spectrum β-lactamase-positive Escherichia coli: Potential of fungi from the phylum Ascomycota by Walter Oliva Pinto Filho Segundo, Luciana Aires de Oliveira, Ana Cláudia Alves Cortez, Érica Simplício de Souza, Hagen Frickmann, João Vicente Braga de Souza

“…Some isolates of this species are capable of producing extended-spectrum β-lactamase (ESBL) enzymes, which mediate resistance against penicillin derivates and cephalosporins. …”
Get full text

Regulated Spatial Distribution of Cyclooxygenases and Lipoxygenases in Crohn's Ulcer by Yao Mao, Jian'an Ren, Jieshou Li

“…Results. (1) The spatial distribution of the three leading enzymes in arachidonic acid pathway—cyclooxygenase 2, 5-lipoxygenase, and 15-lipoxygenase-1—followed sequential arrangement in Crohn's ulcer: neutrophils highly expressing 5-lipoxygenase were in the utmost surface which bordered the band of cyclooxygenase-2 expression that is located just beneath it, and in the lower layers and below the granulation region were eosinophils carrying 15-lipoxygeanse-1. (2) Cyclooxygenase-2 and 15-Lipoxygenase-1-positive cells formed two barrier-like structures that possibly inhibited neutrophil infiltration. …”
Get full text

Effect of Addition of Taurine on the Liquid Storage (5°C) of Mithun (Bos frontalis) Semen by P. Perumal, Kezhavituo Vupru, C. Rajkhowa

“…It was concluded that the possible protective effects of taurine on sperm parameters are from enhancing the function of antioxidant enzymes, preventing efflux of cholesterol from cell membranes and decreased MDA production.…”
Get full text