Two Patients with Extremely Elevated Tumor Markers: Where Is the Malignancy? by Patrick P. J. van der Veek, Wouter H. de Vos tot Nederveen Cappel, Alexandra M. J. Langers, Bart van Hoek

“…Extensive imaging showed no signs of hepatocellular carcinoma or other cancer, and treatment with Prednisone led to rapid normalization of both liver enzymes and aFP. The second patient, a 60-year-old female with painless jaundice due to biliary stone disease, had very high serum levels of CA19-9 (18,000 kU/L, normal <27 kU/L). …”
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In vitro inhibition mechanisms of Trichoderma yunnanense TM10 against Pyricularia oryzae and Rhizoctonia solani causing blast and sheath blight diseases in rice (Oryza sativa L.) by Dedat Prismantoro, Thomas Argyarich Jefferson, Sulistya Ika Akbari, Mia Miranti, Muhamad Shakirin Mispan, Febri Doni

“…Additionally, T. yunnanense TM10 was capable of producing cell wall-degrading enzymes (CWDEs) such as chitinase and cellulase, as well as volatile organic compounds (VOCs) such as hydrogen cyanide (HCN). …”
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Specific immunohistochemical expression of Mmp-26 in prostatic adenocarcinoma by ROMILDO LUCIANO DA SILVA, FRANCISCO LUÍS A. PAES, SANDRA MARIA S. DA SILVA, FABIANO SANTOS, EDUARDA S. DE SANTANA, JACINTO DA C. SILVA NETO

“…The increase in the expression of these enzymes has been related to greater tumor aggressiveness. …”
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Research Progress on Nutritional Characteristics, Taste Quality Improvement and Functional Evaluation of Germinated Brown Rice by REN Chuanying, HONG Bin, ZHANG Shan, YUAN Di, FENG Junran, SHAN Shan, ZHANG Jingyi, GUAN Lijun, LI Bo, HUANG Wengong, LU Shuwen

“…It also summarizes and analyzes the current status of research on stress enrichment of γ-aminobutyric acid (GABA) and functional characteristics of GBR. During germination, enzymes promote the enrichment of various bioactive substances, especially GABA, a characteristic component. …”
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Metabolic reprogramming in cancer: Mechanisms and therapeutics by Shiqi Nong, Xiaoyue Han, Yu Xiang, Yuran Qian, Yuhao Wei, Tingyue Zhang, Keyue Tian, Kai Shen, Jing Yang, Xuelei Ma

“…These metabolic pathways have complex mechanisms and involve the coordination of various signaling molecules, proteins, and enzymes, which increases the resistance of tumor cells to traditional antitumor therapies. …”
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First Description of KPC-2-Producing Klebsiella oxytoca Isolated from a Pediatric Patient with Nosocomial Pneumonia in Venezuela by Indira Labrador, María Araque

“…This has been increasingly attributed to the production of β-lactamases capable of hydrolyzing carbapenems. Among these enzymes, Klebsiella pneumoniae carbapenemases (KPCs) are the most frequently and clinically significant class-A carbapenemases. …”
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Protective Action of Antioxidants on Hepatic Damage Induced by Griseofulvin by M. del C. Martinez, S. G. Afonso, A. M. Buzaleh, A. Batlle

“…Coadministration of Gris with Tx, Asc, and its combination, or Mel mainly affected heme biosynthetic pathway, resulting in a decrease in ALA-S activity which was increased by Gris, while the tested polyphenols exerted a protective effect on oxidative stress, decreasing lipid peroxidation and the activity of some antioxidant enzymes. In conclusion, antioxidant compounds can only protect partially against the liver damage induced by Gris, reducing oxidative stress or acting on heme regulation.…”
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Functional Conducting Polymers in the Application of SPR Biosensors by Rapiphun Janmanee, Sopis Chuekachang, Saengrawee Sriwichai, Akira Baba, Sukon Phanichphant

“…The functional conducting polymers have been successfully utilized to immobilize enzymes for construction of biosensors. Recently, the combination of SPR and electrochemical, known as electrochemical-surface plasmon resonance (EC-SPR), spectroscopy, has been used for in situ investigation of optical and electrical properties of conducting polymer films. …”
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More than PHB – the PHAmily of Copolymers: Justifications for Broader Use and Summary of Biodegradation Facts on Polyhydroxyalkanoates (PHA) – A Review by M. Lackner, P. Costa, M. Koller, M. Zinn

“…This review summarizes the current state of knowledge on PHA copolymers, their cur rent end-of-life pathways, the most relevant biodegradability standards, and their degradability by depolymerase enzymes.…”
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DFCP1 is a regulator of starvation-driven ATGL-mediated lipid droplet lipolysis by Victoria A. Ismail, Meg Schuetz, Zak N. Baker, Jean A. Castillo-Badillo, Teri V. Naismith, David J. Pagliarini, David J. Kast

“…We show through pharmacological inhibition of key enzymes associated with LD metabolism that DFCP1 specifically regulates lipolysis and, to a lesser extent, lipophagy. …”
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A comprehensive numerical study exploring the significance of thermally reactive bioconvection in Falkner-Skan flow of Williamson nanomaterials influenced by activation energy and... by M. Israr Ur Rehman, Haibo Chen, Aamir Hamid, Wu Qian, Refka Ghodhbani, Mohamed Hussien

“…The analysis is further improved by adding thermophoretic diffusion and Brownian motion to the energy and concentration equations Bio-fuels, enzymes, industry, bio-sensors, petroleum, and a number of other novel biotechnological features are also influenced by the bioconvective mechanisms in nanomaterials. …”
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Ganoderma lucidum spore oil (GLSO), a novel antioxidant, extends the average life span in Drosophila melanogaster by Yi Zhang, Hongfei Cai, Zhu Tao, Cheng Yuan, Zhaojian Jiang, Juyan Liu, Hiroshi Kurihara, Wendong Xu

“…The activities of various antioxidant enzymes were measured to determine the antioxidant effect of GLSO. …”
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Therapeutic Potential of HGF-Expressing Human Umbilical Cord Mesenchymal Stem Cells in Mice with Acute Liver Failure by Yunxia Tang, Qiongshu Li, Fanwei Meng, Xingyu Huang, Chan Li, Xin Zhou, Xiaoping Zeng, Yixin He, Jia Liu, Xiang Hu, Ji-Fan Hu, Tao Li

“…The therapeutic effect of HGF-UCMSCs was associated with the increment in serum glutathione (GSH) and hepatic enzymes that maintain redox homeostasis, including γ-glutamylcysteine synthetase (γ-GCS), superoxide dismutase (SOD), and catalase (CAT). …”
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LPS Counter Regulates RNA Expression of Extracellular Proteases and Their Inhibitors in Murine Macrophages by Andreas Hald, Birgitte Rønø, Leif R. Lund, Kristoffer L. Egerod

“…This process is accomplished by multiple proteolytic enzymes, including serine proteases and members of the matrix metalloproteinase family. …”
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A Hepatitis C Educational Needs Assessment of Canadian Healthcare Providers by Reza Naghdi, Karen Seto, Carolyn Klassen, Didi Emokpare, Brian Conway, Melissa Kelley, Eric Yoshida, Hemant A. Shah

“…Physicians most frequently screened patients who had abnormal liver enzymes, while nurses tended to screen based on lifestyle factors. …”
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Recent approaches in the drug research and development of novel antimalarial drugs with new targets by Chinnappanna Naveen Kumar Reddy, Yennam Gopi, Chaitanya Chaitanya Budagam Haima Naga Venkata, Pottathil Shinu, Borah Pobitra, Venugopala Katharigatta N., Deb Pran Kishore, Mailavaram Raghu Prasad

“…The protein kinases, choline transport inhibitors, dihydroorotate dehydrogenase inhibitors, isoprenoid biosynthesis inhibitors, and enzymes involved in the metabolism of lipids and replication of deoxyribonucleic acid, are among the most fascinating antimalarial target proteins presently being investigated. …”
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Phospholipase A2 Mediates Apolipoprotein-Independent Uptake of Chylomicron Remnant-Like Particles by Human Macrophages by Mariarosaria Napolitano, Howard S. Kruth, Elena Bravo

“…These results suggest that macrophage lipolytic enzymes mediate the internalization of postprandial TG-rich lipoproteins and that sPLA2 and cytosolic PLA2, play a more important role than extracellular lipoprotein lipase-mediated TG hydrolysis.…”
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Structure Diversity and Properties of Some Bola-like Natural Products by Valentin A. Stonik, Tatyana N. Makarieva, Larisa K. Shubina, Alla G. Guzii, Natalia V. Ivanchina

“…The recent identification of new enzymes, taking part in their biosynthesis and metabolism, made it possible to understand molecular aspects of their origination and some features of evolution during geological times. …”
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Emerging Role of Histone Acetyltransferase in Stem Cells and Cancer by Daniela Trisciuoglio, Marta Di Martile, Donatella Del Bufalo

“…Here, we summarize a combination of in vitro and in vivo studies, undertaken on a set of acetyltransferases, and discuss the physiological and pathological roles of this class of enzymes. We also review the available data on the involvement of acetyltransferases in the regulation of stem cell renewal and differentiation in both normal and cancer cell population.…”
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Multiple action sites of ultrasound on Escherichia coli and Staphylococcus aureus by Xinyu Liao, Jiao Li, Yuanjie Suo, Shiguo Chen, Xingqian Ye, Donghong Liu, Tian Ding

“…The result in this study also showed that a proportion of bacteria subpopulation suffered from serious damage of intracellular components (e.g. DNA and enzymes) but with intact cell envelopes. We speculated that the inactivated effects of ultrasound on microbes might more than simply completed disruption of cell exteriors. …”
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