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  1. 3301

    METTL3-Mediated m6A Modification Regulates the Osteogenic Differentiation through LncRNA CUTALP in Periodontal Mesenchymal Stem Cells of Periodontitis Patients by Xin Chen, Yuan Qin, Xian Wang, Hao Lei, Xiaochen Zhang, Houzhuo Luo, Changgang Guo, Weifu Sun, Shishu Fang, Wen Qin, Zuolin Jin

    Published 2024-01-01
    “…We found that METTL3 was the most significantly differentially expressed methylation-related enzyme in pPDLSCs and promoted osteogenic differentiation of pPDLSCs. …”
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  2. 3302

    Controlled Resistant Hypertension Following A Successful Renal Artery Stenting: A Rare Case Report in A Developing Country by Fatihatul Firdaus Munita, Badai Bhatara Tiksnadi, Januar Wibawa Martha, Margareta Ginanti Ratna

    Published 2025-01-01
    “…At the beginning of her treatment, she has prescribed an angiotensin-converting-enzyme inhibitor, yet her pressure was uncontrolled and worsened. …”
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  3. 3303

    Evolution of SARS-CoV-2 spike trimers towards optimized heparan sulfate cross-linking and inter-chain mobility by Jurij Froese, Marco Mandalari, Monica Civera, Stefano Elli, Isabel Pagani, Elisa Vicenzi, Itzel Garcia-Monge, Daniele Di Iorio, Saskia Frank, Antonella Bisio, Dominik Lenhart, Rudolf Gruber, Edwin A. Yates, Ralf P. Richter, Marco Guerrini, Seraphine V. Wegner, Kay Grobe

    Published 2024-12-01
    “…Abstract The heparan sulfate (HS)-rich extracellular matrix (ECM) serves as an initial interaction site for the homotrimeric spike (S) protein of SARS-CoV-2 to facilitate subsequent docking to angiotensin-converting enzyme 2 (ACE2) receptors and cellular infection. …”
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  4. 3304

    Myristoylated Eepd1 Enhances Lipolysis and Thermogenesis through PKA Activation to Combat Obesity by Suzhen Chen, Yanping Wang, Qian Zhou, Qiqi Qian, Quanxin Jiang, Chuchu Liu, Yan Liu, Peihui Zhou, Jie Xiong, Yao Zhang, Ning Wang, Yang Emma Li, Limin Yin, Hongyuan Yang, Junli Liu

    Published 2025-01-01
    “…Here, we explore the role of Eepd1, a DNA repair enzyme, in regulating adipose tissue function and obesity onset. …”
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  5. 3305

    Seroprevalence characteristics of hepatitis E virus among blood donors infected with hepatitis B virus by YU Qin, XU Tingting, YANG Hao, ZHAO Lei

    Published 2025-01-01
    “…Commercially available enzyme-linked immunosorbent assays (ELISA) were used for the detection of anti-HEV IgG, anti-HEV IgM and HEV antigen (Ag). …”
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  6. 3306

    Functional Characteristics and Lipid Lowering Activity of Auricularia heimuer Soluble Dietary Fiber by Xueyu SHANG, Heriban MEI, Ling SU, Qi WANG

    Published 2025-01-01
    “…In this study, the residue of Auricularia heimuer polysaccharide after hot water extraction was used as raw material, and the soluble dietary fiber (HSDF) of A. heimuer was extracted by compound enzyme method. Its molecular weight, monosaccharide composition and sugar chain composition were analyzed, its water holding capacity, oil holding capacity, swelling power and other physical and chemical properties were detected, and its lipid-lowering activity in vitro was evaluated by measuring cholesterol adsorption capacity, lipase inhibition rate and cholate binding rate. …”
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  7. 3307
  8. 3308

    Differences in carbon and nitrogen metabolism of soft japonica rice in southern China during grain filling stage under different light and nitrogen fertilizer conditions and their... by Zhongtao Ma, Zhongtao Ma, Zhongtao Ma, Zhongtao Ma, Jiale Cao, Jiale Cao, Jiale Cao, Jiale Cao, Xi Chen, Xi Chen, Xi Chen, Xi Chen, Jianghui Yu, Jianghui Yu, Jianghui Yu, Jianghui Yu, Liu Guodong, Liu Guodong, Liu Guodong, Liu Guodong, Fangfu Xu, Fangfu Xu, Fangfu Xu, Fangfu Xu, Qun Hu, Qun Hu, Qun Hu, Qun Hu, Guangyan Li, Guangyan Li, Guangyan Li, Guangyan Li, Ying Zhu, Ying Zhu, Ying Zhu, Ying Zhu, Hongcheng Zhang, Hongcheng Zhang, Hongcheng Zhang, Hongcheng Zhang, Haiyan Wei, Haiyan Wei, Haiyan Wei, Haiyan Wei

    Published 2025-01-01
    “…Correlation analysis revealed a significant positive correlation between the C/N ratio and carbon metabolism-related enzyme activities and products, along with a significant negative correlation with nitrogen metabolism-related enzyme activities and products, suggesting that the C/N ratio can serve as an indicator of carbon and nitrogen metabolism levels. …”
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  9. 3309

    Principles of Medical Biochemistry / by Meisenberg, Gerhard

    Published 2017
    Table of Contents: “…Introduction to biomolecules -- Introduction to protein structure -- Oxygen-binding proteins : hemoglobin and myoglobin -- Enzymatic reactions -- Coenzymes -- DNA, RNA, and protein synthesis -- The human genome -- Protein targeting and proteostasis -- Introduction to genetic diseases -- Viruses -- DNA technology -- Biological membranes -- The cytoskeleton -- The extracellular matrix -- Extracellular messengers -- Intracellular messengers -- Plasma proteins -- Defense mechanisms -- Cellular growth control and cancer -- Digestive enzymes -- Introduction to metabolic pathways -- Glycolysis, tricarboxylic acid cycle, and oxidative phosphorylation -- Oxygen deficiency and oxygen toxicity -- Carbohydrate metabolism -- The metabolism of fatty acids and triglycerides -- The metabolism of membrane lipids -- Lipid transport -- Amino acid metabolism -- Metabolism of iron and heme -- The metabolism of purines and pyrimidines -- Micronutrients -- Integration of metabolism.…”
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  10. 3310
  11. 3311

    Cognitive Status Correlates with CXCL10/IP-10 Levels in Parkinson’s Disease by Natália Pessoa Rocha, Paula Luciana Scalzo, Izabela Guimarães Barbosa, Mariana Soares Souza, Isabela Boechat Morato, Érica Leandro Marciano Vieira, Paulo Pereira Christo, Antônio Lúcio Teixeira, Helton José Reis

    Published 2014-01-01
    “…Peripheral blood was drawn and plasma levels of CCL2/MCP-1, CCL11/eotaxin, CCL24/eotaxin-2, and CXCL10/IP-10 were measured by enzyme-linked immunosorbent assay. PD patients and control individuals presented comparable plasma concentrations of all the evaluated chemokines. …”
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  12. 3312

    Effect of Planting Systems on the Physicochemical Properties and Bioactivities of Strawberry Polysaccharides by Qiuqiu Zhang, Renshuai Huang, Guangjing Chen, Fen Guo, Yan Hu

    Published 2025-01-01
    “…Additionally, GP-SP exerted superior α-glucosidase inhibition (IC<sub>50</sub> = 2.4583 mg/mL), in line with kinetic and fluorescence quenching analyses showing a higher enzyme–substrate complex binding affinity (<i>Kis</i> = 1.6682 mg/mL; <i>Ka</i> = 5.1352 × 10<sup>5</sup> M<sup>−1</sup>). …”
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  13. 3313

    Nucleic Acid Aptamers for Human Norovirus GII.4 and GII.17 Virus-Like Particles (VLPs) Exhibit Specific Binding and Inhibit VLPs from Entering Cells by Cheng C, Sun M, Li J, Xue Y, Cai X, Liu J, Wang X, Xu S, Xie Y, Zhang J

    Published 2025-02-01
    “…Two aptamers (AP4-2 and AP17-4) were selected for enzyme-linked aptamer sorbent assay (ELASA) and further analysis. …”
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  14. 3314

    Hubungan Kadar Trigliserida dan Kolesterol-HDL Terhadap Kadar Alanine Aminotransferase pada Pasien Non Alcoholic Fatty Liver Disease by Bayu Gemilang, Yanwirasti ., Saptino Miro

    Published 2016-01-01
    “…NAFLD does not show a typical clinical appearance, so it is important to do workups such as liver enzyme test to make the diagnosis. Alanine Aminotransferase (ALT) is considered as the marker of NAFLD.…”
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  15. 3315

    Experimental Validation of Antiobesogenic and Osteoprotective Efficacy of Ginsenoside CK via Targeting Lipid and Atherosclerosis Pathways by Md. Niaj Morshed, Reshmi Akter, Imran Mahmud, Ah-Yeong Gwon, Jin Woo Jeang, Yeong-Geun Lee, Dae Won Park, Deok Chun Yang, Yeon Ju Kim, Se-Chan Kang

    Published 2024-12-01
    “…Using 3T3-L1 adipocytes in vitro assessments, CK could effectively decrease intracellular lipid accumulation, inhibit α-glucosidase enzyme, increase 2-NBDG glucose uptake, reduce inflammation-associated cytokines (<i>TNFα</i>, and <i>IL-6</i>), adipogenic regulatory genes (<i>PPARγ</i>, <i>FAS</i>, <i>C/EBPα</i>), lipogenic gene <i>LPL</i>, and increase the expression of thermogenic gene <i>UCP1</i>. …”
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  16. 3316

    Anti-inflammatory and antioxidant properties of Camellia sinensis L. extract as a potential therapeutic for atopic dermatitis through NF-κB pathway inhibition by Min Jung Kim, Ye Jin Yang, Ga-Yul Min, Ji Woong Heo, Jae Dong Son, Young Zoo You, Hun Hwan Kim, Gon Sup Kim, Hu-Jang Lee, Ju-Hye Yang, Kwang Il Park

    Published 2025-01-01
    “…Cell viability was assessed with 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT), polyphenol and flavonoid content were determined. 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay measured antioxidant activity. Enzyme-Linked Immunosorbent Assay (ELISA), western blotting, and Immunofluorescence (IF) assays examined cytokines, pathways, and protein localization, respectively. …”
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  17. 3317

    Genetic predisposition to Behcet's disease mediated by a IL10RA enhancer polymorphism by Handan Tan, Zhenyu Zhong, Xiaojie Feng, Xiang Luo, Qingfeng Cao, Peizeng Yang

    Published 2025-01-01
    “…Methods: To analyse the genetic susceptibility to BD mediated by IL10RA causal polymorphisms, we performed a study on data from our previous genome-wide association studies (GWAS), the bioinformatic analysis of post-annotation of GWAS and relevant mechanism verification experiments, including chromatin immunoprecipitation, luciferase gene-reporter assay, electrophoretic mobility shift assays, and enzyme-linked immunosorbent assay. Results: Among 125 single nucleotide polymorphisms (SNPs) with P < 1 × 10-5 identified in our previous GWAS study on BD, rs4936415 (G/C) was predicted with the highest conserved score as an expression quantitative-trait-locus SNP for IL10RA in whole blood. …”
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  18. 3318
  19. 3319

    Pengaruh Paparan Medan Magnet Extremely Low Frequency (ELF) terhadap Perubahan pH Pada Proses Fermentasi Biji Kopi Lanang (Peaberry) Kering by Mamik Purbawati, Sudarti Sudarti, Firdha Kusuma A A

    Published 2021-09-01
    “…The study aims to examine the effect of exposure to the ELF (Extremely Low Frequency) magnetic field on changes of pH in the fermentation process of robusta peaberry dray coffee beans with the addition of -amylase enzyme. The type of research that use in the experimental reseacrh with a randomized subject post test only control grup design, it aiming to examine the effect of treatment by repeating the experiment. …”
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  20. 3320

    Meta Analysis of Methylenetetrahydrofolate Reductase (MTHFR) C677T polymorphism and its association with folate and colorectal cancer by Meng Ye, Guojie Xu, Liming Zhang, Zhihui Kong, Zhenhua Qiu

    Published 2025-01-01
    “…Folate plays a crucial role in DNA synthesis, acting as a coenzyme in one-carbon metabolism, which involves the synthesis of purines, pyrimidines, and methyl groups. MTHFR, a key enzyme in folate metabolism, has been widely studied in relation to neural tube defects and hypertension, but its role in colorectal cancer remains underexplored. …”
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