Mitochondrial Gene Expression of Three Different Dragonflies Under the Stress of Chlorpyrifos by Yuxin Chen, Ziwen Yang, Zhiqiang Guo, Lemei Zhan, Kenneth B. Storey, Danna Yu, Jiayong Zhang

“…CPF exhibits its toxicity primarily through the inhibition of the acetylcholinesterase (AChE) enzyme, while mitochondrial damage and dysfunction have also been observed. …”
Get full text

Aseptic inflammation as the essential link in the pathogenesis of endometrioid disease by Yu.A. Orlova, A.M. Hromova, O.M. Ketova, T.Yu. Liakhovska, V.B. Martynenko, E.I. Krutikova

“…When comparing the stages of endometrioid disease to the rates of quantitative activity of macrophage enzyme markers (in peritoneal fluid), it was found that the increase in the stage of the disease (from stage 3 to stage 4) caused an increase in the quantitative activity of Arg1 by 1.9 times and a decrease in the quantitative activity of iNOS by 2.9 times. …”
Get full text

Systemic delivery of AAV5, AAV8, and AAV9 packaging a C5-12-microdystrophin-FLAG expression cassette in non-human primates by Mengping Liu, Erica Cook, Yanshan Dai, Erich Ehlert, Francois du Plessis, Jacek Lubelski, Bogdan G. Sleczka, Petia Shipkova, Zhuyin Li, Joshua Gamse, David Gordon, Leonard P. Adam, Paul C. Levesque, Glen B. Banks

“…At 1 month post-dose, we compared tissue vector genomes, mRNA, and microdystrophin-FLAG protein levels by meso-scale discovery-enzyme-linked immunosorbent assay, liquid chromatography-mass spectrometry, and immunofluorescence. …”
Get full text

A novel nomogram to predict all‐cause readmission or death risk in Chinese elderly patients with heart failure by Mengxi Yang, Liyuan Tao, Hui An, Gang Liu, Qiang Tu, Hu Zhang, Li Qin, Zhu Xiao, Yu Wang, Jiaxai Fan, Dongping Feng, Yan Liang, Jingyi Ren

“…Anaemia, abnormal neutrophils, and admission without angiotensin‐converting enzyme inhibitors/angiotensin receptor blockers were the specific independent risk factors of 30 day all‐cause readmission or death (all P < 0.05), whereas serum sodium ≤ 140 mmol/L and admission without beta‐blockers were the specific independent risk factors of 1 year all‐cause readmission or death (all P < 0.05). …”
Get full text

Multigenerational effects of cultivating transgenic maize straw on earthworms: A combined laboratory and field experiment by Li Zhang, Wenjing Shen, Zhixiang Fang, Laipan Liu, Ruizong Jia, Jingang Liang, Biao Liu

“…The enzymatic activity assay results revealed no significant differences in superoxide dismutase (SOD) or catalase (CAT) enzyme activity between the GM and non-GM maize varieties. …”
Get full text

Nutritional Innovation Using Green Seaweed (Ulva sp.) and Garlic Powder Extracts for White‐Leg Shrimp (Litopenaeus vannamei) Challenged by Vibrio harveyi by Nashwa Abdel‐Razek, Riad H. Khalil, Abeer A. M. Afifi, Afrah F. Alkhuriji, Dina M. Metwally

“…There were significant increases in serum total protein, acid phosphatase activity, alkaline phosphatase, lysosomal enzyme activity, phenoloxidase activity and superoxide dismutase activity with offered diets with increasing the levels of ethanolic extracts of Ulva sp. and garlic powder up to 2.0 g UE/kg diet and 6 g GPE/kg diet, respectively. …”
Get full text

Tryptanthrin exerts anti-breast cancer effects both in vitro and in vivo through modulating the inflammatory tumor microenvironment by Zeng Qingfang, Luo Cairong, Cho Junlae, Lai Donna, Shen Xiangchun, Zhang Xiaoyan, Zhou Wei

“…After two weeks of tryptanthrin treatment, samples from serum, tumor tissue and different organs from tumor-bearing mice were collected, and the enzyme-linked immunosorbent assay (ELISA) was performed to assess the regulation of inflammatory molecules in mouse serum. …”
Get full text

Screening of West Siberian patients with primary congenital glaucoma for CYP1B1 gene mutations by D. E. Ivanoshchuk, S. V. Mikhailova, O. G. Fenkova, E. V. Shakhtshneider, A. Z. Fursova, I. V. Bychkov, M. I. Voevoda

“…Mutations in the CYP1B1 gene, which encodes cytochrome P450 1B1, are the most common cause of autosomal recessive primary congenital glaucoma. This enzyme is known to be involved in retinoic acid metabolism and is necessary for normal eye development. …”
Get full text

Dihydroporphyrin iron (III) enhances low temperature tolerance by increasing carbon and nitrogen metabolism in Andrographis paniculata by Shao-Fen Jian, Shao-Fen Jian, Shao-Fen Jian, Yan-Fen Huang, Yan-Fen Huang, Yan-Fen Huang, Dong-Liang Chen, Chu Zhong, Chu Zhong, Chu Zhong

“…DH-Fe reduced the contents of sucrose, soluble sugar and starch and the activities of sucrose synthase (SS) and hexokinase (HXK), but stimulated the activities of sucrose phosphate synthase (SPS), glucose-6-phosphate dehydrogenase (G6PDH), glyceraldehyde 3-phosphate dehydrogenase (GAPDH), phosphoenolpyruvate carboxylase (PEPC), isocitrate dehydrogenase (ICDH), and malic enzyme (ME). Soluble protein and proline contents were decreased by DH-Fe, while total N and free amino acids contents were increased, accompanying by the enhancement of the activities of glutamine synthase (GS), glutamic-oxaloacetic transaminase (GOT) and glutamic-pyruvic transaminase (GTP). …”
Get full text

Multi-omics reveals that ST6GAL1 promotes colorectal cancer progression through LGALS3BP sialylation by Yuanchao Shi, Zhenzhong Pan, Jingwei Duan, Zexing Wang, Yiliang Fang, Bo Tang, Quanlin Guan

“… ST6 β-galactoside α2,6-sialyltransferase 1 (ST6GAL1), a crucial enzyme for tumor-associated sialic acid modification, has been reported to positively correlate with colorectal cancer (CRC) tumorigenesis; however, the underlying mechanism remains unclear. …”
Get full text

Development of a Wine Yeast Strain Capable of Malolactic Fermentation and Reducing the Ethyl Carbamate Content in Wine by Egor A. Vasyagin, Valery N. Urakov, Maksim Yu. Shalamitskiy, Sofia N. Cherviak, Elena V. Ivanova, Valentina I. Zagoruyko, Alexey V. Beletsky, Andrey L. Rakitin, Eugenia S. Mardanova, Vitaly V. Kushnirov, Nikolai V. Ravin, Andrey V. Mardanov

“…Using genome editing, we engineered a modified variant of the triploid wine yeast strain <i>Saccharomyces cerevisiae</i> I-328, in which the <i>CAR1</i> arginase gene was replaced by the malate permease gene from <i>Schizosaccharomyces pombe</i> and the malolactic enzyme gene from <i>Oenococcus oeni</i>. Genome-wide transcriptional profiling confirmed the expression of the introduced genes and revealed a limited effect of the modification on global gene expression. …”
Get full text

Is Amanita phalloides Nephrotoxicity due to Mitochondrial Toxicity? by Jules Weinhard, Justine Serre, Perrine Frère, Clovis Adam, Marie Camille Lafargue, David Buob, Cédric Rafat

“…However, one key mitochondrial function, involving an enzyme called complex IV, appeared to be unaffected.This case suggests that the death cap mushroom may harm kidneys by damaging mitochondria in a way that leaves certain functions intact.…”
Get full text

5,10-methylenetetrahydrofolate reductase C677T gene polymorphism as a risk factor for premature coronary artery disease in patients with type 2 diabetes mellitus by Nisreen O. Mohammed, Ibtisam A. Ali, Bahaelddin K. Elamin, Bakri Osman Saeed

“…Polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP), using Hinf1 restriction enzyme, were used to determine MTHFR genotypes. Plasma homocysteine levels were determined by enzymatic assay on the Hitachi Cobas Integra® 400 plus. …”
Get full text

Micro-/nanobubble oxygenation irrigation enhances soil phosphorus availability and yield by altering soil bacterial community abundance and core microbial populations by Qingyong Bian, Qingyong Bian, Zhiduo Dong, Yupeng Zhao, Yaozu Feng, Yaozu Feng, Yaozu Feng, Yanbo Fu, Yanbo Fu, Zhiguo Wang, Jingquan Zhu, Liang Ma

“…Therefore, we established two irrigation methods, conventional irrigation (CF) and micro-/nanobubble oxygenation irrigation (MB), to investigate the combined effects on enzyme activity, microbial communities, and soil phosphorus availability in the rhizosphere soil of maize.The results showed that compared to the CF treatment, the MB treatment significantly increased available phosphorus content and alkaline phosphatase activity in maize rhizosphere soil by 21.3% and 15.4%, respectively. …”
Get full text

Epidemiology and outcomes of carbapenem-resistant Klebsiella pneumoniae infections in patients with hematological malignancies from 2014 to 2022 by Meng Li, Liyan Ye, Zhenghao Yu, Hongwu Yao, Yunxi Liu, Guanglei Wang, Mingmei Du

“…The predominant clone in the HM department was ST11 CRKP producing the KPC-2 enzyme (21, 70.0%). A total of 23 cases of HM department-acquired CRKP infections were identified, and five hospital cross-transmission events were observed. …”
Get full text

Molecular characterization of siderophore biosynthesis in Paracoccidioides brasiliensis by Marielle Garcia Silva, Juliana Santana de Curcio, Mirelle Garcia Silva-Bailão, Raisa Melo Lima, Mariana Vieira Tomazett, Aparecido Ferreira de Souza, Vanessa Rafaela Milhomem Cruz-Leite, Nicolau Sbaraini, Alexandre Melo Bailão, Fernando Rodrigues, Maristela Pereira, Relber Aguiar Gonçales, Célia Maria de Almeida Soares

“…Paracoccidioides spp. present orthologous genes encoding the enzymes necessary for the biosynthesis of hydroxamates, and plasma membrane proteins related to the transport of these molecules. …”
Get full text

Targeting HVEM-GPT2 axis: a novel approach to T cell activation and metabolic reprogramming in non-small cell lung cancer therapy by Yuanshan Yao, Chunji Chen, Bin Li, Wen Gao

“…RNA sequencing illuminated a potential relationship between HVEM and GPT2, an enzyme tied to amino acid metabolism and cellular energetics. …”
Get full text

Effect of acid whey protein concentrate on the rheological properties, antioxidant capacities, and biological activities of bioaccessible fractions in fermented camel milk by Mutamed Ayyash, Abdelmoneim H. Ali, Anas Al-Nabulsi, Tareq Osaili, Gafar Bamigbade, Athira Subash, Basim Abu-Jdayil, Afaf Kamal-Eldin

“…The biological activities, including α-amylase, α-glucosidase, and angiotensin-converting enzyme inhibition, increased after in vitro digestion of yogurt samples. …”
Get full text

Effective control of southern blight and root rot of Aconitum carmichaelii Debeaux by endophytic Bacillus velezensis YN-2-6S by Qian Wang, Yujie Qiu, Siyu Wang, Yumei Gou, Hongji Hou, Tianwei Su, Lan Zou, Jing Huang

“…Increase of peroxidase (POD) and catalase (CAT) enzyme activity of A. carmichaelii leaves was detected upon inoculation of YN-2-6S, which indicated that YN-2-6S may induce systemic resistance on A. carmichaelii. …”
Get full text

Preventive treatment with guarana powder (Paullinia cupana) mitigates acute paracetamol-induced hepatotoxicity by modulating oxidative stress by Clécia Dias Teixeira, Priscila Oliveira Barbosa, Wanderson Geraldo Lima, Gustavo Silveira Breguez, Miliane Martins de Andrade Fagundes, Daniela Caldeira Costa, Cintia Lopes de Brito Magalhães, Joana Ferreira Amaral, Melina Oliveira de Souza

“…Guarana treatment, which prevented reductions in glutathione levels, modulated antioxidant enzyme (SOD and CAT) expression and activity, and protein carbonylation, while enhancing the total antioxidant capacity. …”
Get full text