Evaluation of Colorimetric BCA-Based Quantification of Hydrazide Groups on Magnetic Particles by Zuzana Svobodova, Barbora Jankovicova, Zdenek Plichta, Daniel Horak, Zuzana Bilkova

“…Magnetic micro- and nanoparticles (MPs) are considered to provide excellent solid support for many immunoanalytical and bioaffinity applications, particularly when they contain hydrazide groups available for site-specific immobilization of various glycoproteins, such as immunoglobulin G and enzymes. To prepare a highly active bioaffinity carrier with sufficient binding capacity, knowledge as to the type and concentration of functional groups used for ligand binding is crucial. …”
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Insights into the relations between cell wall integrity and in vitro digestion properties of granular starches in pulse cotyledon cells after dry heat treatment by Ping Li, Bin Zhang, Rui Liu, Li Ding, Xiong Fu, Haiteng Li, Qiang Huang, Xiaowei He

“…DHT decreased the inhibitory effects of enzymes of both the soluble and insoluble components, but the digestion rate and extent of slightly and highly damaged cell samples did not exhibit significant differences compared with their native counterparts. …”
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Maintenance of Synaptic Stability Requires Calcium-Independent Phospholipase A2 Activity by Julie Allyson, Xiaoning Bi, Michel Baudry, Guy Massicotte

“…Phospholipases A2 (PLA2s) represent one of the largest groups of lipid-modifying enzymes. Over the years, significant advances have been made in understanding their potential physiological and pathological functions. …”
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Improving polyketide biosynthesis by rescuing the translation of truncated mRNAs into functional polyketide synthase subunits by Yan Liu, Chaoyi Song, Qingwen Cui, Hongluan Sun, Chanjuan Jiang, Ruofei Guo, Ruoting He, Zhen Li, Ji Luan, Hailong Wang

“…Abstract Modular polyketide synthases (mPKSs) are multidomain enzymes in bacteria that synthesize a variety of pharmaceutically important compounds. mPKS genes are usually longer than 10 kb and organized in operons. …”
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Theaflavin Ameliorates Cerebral Ischemia-Reperfusion Injury in Rats Through Its Anti-Inflammatory Effect and Modulation of STAT-1 by Fei Cai, Cai-Rong Li, Ji-Liang Wu, Jian-Guo Chen, Chao Liu, Qing Min, Wei Yu, Chang-Han Ouyang, Jin-He Chen

“…Our study demonstrated that theaflavin significantly protected neurons from cerebral ischemia-reperfusion injury by limiting leukocyte infiltration and expression of ICAM-1, and suppressing upregulation of inflammatory-related prooxidative enzymes (iNOS and COX-2) in ischemic brain via, at least in part, reducing the phosphorylation of STAT-1.…”
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Interplay between Extracellular Matrix and Neutrophils in Diseases by Yanyan Zhu, Yumeng Huang, Qian Ji, Shengqiao Fu, Jia Gu, Ningzheng Tai, Xu Wang

“…Neutrophils can also mediate ECM remodeling by providing specific matrix-remodeling enzymes (such as neutrophil elastase and metalloproteinases), generating neutrophil extracellular traps, and releasing exosomes. …”
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Bile Acids and Their Value for Central Nervous System by Yu. O. Shulpekova, P. E. Tkachenko, E. N. Shirokova, I. V. Damulin

“…The presence in CNS of various bile acid synthesis-related receptors and enzymes indicates their value in brain functioning and warrants research into their metabolism.…”
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Severe Vitamin B12 Deficiency in Pregnancy Mimicking HELLP Syndrome by Shravya Govindappagari, Michelle Nguyen, Megha Gupta, Ramy M. Hanna, Richard M. Burwick

“…Severe vitamin B12 deficiency may present with hematologic abnormalities that mimic thrombotic microangiopathy disorders such as hemolysis, elevated liver enzymes, and low platelet count (HELLP) syndrome. …”
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Characterization of eDNA from the Clinical Strain Acinetobacter baumannii AIIMS 7 and Its Role in Biofilm Formation by Praveen K. Sahu, Pavithra S. Iyer, Amrita M. Oak, Karishma R. Pardesi, Balu A. Chopade

“…An assessment of the characteristics of the eDNA with respect to size, digestion pattern by DNase I/restriction enzymes, and PCR-sequencing, indicates a high similarity with genomic DNA. …”
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Antibacterial Effect of Black Pepper Petroleum Ether Extract against Listeria monocytogenes and Salmonella typhimurium by Wenxue Chen, Hui Tang, Ningxin Jiang, Qiuping Zhong, Yueying Hu, Haiming Chen, Weijun Chen

“…The activities of key metabolic enzymes shed some light on the biochemical mechanism of aglycon cell growth inhibition, indicating that the energetic metabolism of L. monocytogenes and S. typhimurium was markedly influenced by the BPPE. …”
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Insights into microbiota community dynamics and flavor development mechanism during golden pomfret (Trachinotus ovatus) fermentation based on single-molecule real-time sequencing a... by Yueqi Wang, Qian Chen, Huan Xiang, Dongxiao Sun-Waterhouse, Shengjun Chen, Yongqiang Zhao, Laihao Li, Yanyan Wu

“…Volatile profiles resulted from the interactions among the microorganisms and derived enzymes, with the main metabolic pathways being amino acid biosynthesis/metabolism, carbon metabolism, and glycolysis/gluconeogenesis. …”
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Frequency of Drug Resistance Gene Amplification in Clinical Leishmania Strains by C. Mary, F. Faraut, M. Deniau, J. Dereure, K. Aoun, S. Ranque, R. Piarroux

“…Amplified genes code for adenosine triphosphate-dependent transporters (multidrug resistance and P-glycoproteins P), enzymes involved in trypanothione pathway, particularly gamma glutamyl cysteine synthase, and others involved in folates metabolism, such as dihydrofolate reductase and pterine reductase. …”
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Microbiota-derived β carotene is required for strobilation of Aurelia aurita by impacting host retinoic acid signaling by Nadin Jensen, Nancy Weiland-Bräuer, Cynthia Maria Chibani, Ruth Anne Schmitz

“…Transcriptional analysis revealed that beta carotene and 9-cis RA restored expression of strobilation genes in sterile polyps to native levels. Inhibition of key enzymes in the RA pathway disrupted strobilation, further confirming its importance. …”
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Targeting the kynurenine pathway: another therapeutic opportunity in the metabolic crosstalk between cancer and immune cells by Irene Kang, Irene Kang, George Theodoropoulos, Medhi Wangpaichitr, Medhi Wangpaichitr, Medhi Wangpaichitr, Medhi Wangpaichitr

“…In this review, we revisit current advances, explore future directions, and emphasize the importance of dual inhibition of the KP rate-limiting enzymes IDO1 and tryptophan 2,3-dioxygenase-2 (TDO2) in appropriate patient populations. …”
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Prolonged Serum Alanine Aminotransferase Elevation Associated with Isotretinoin Administration by Roya S. Nazarian, Elizabeth Zheng, Caroline Halverstam, Steven R. Cohen, Allan W. Wolkoff

“…When oral isotretinoin was readministered for intractable facial acne 3 years later, liver enzymes remained normal throughout the course of therapy. …”
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Sirtuin 1: A Dilemma in Transplantation by Sara Assadiasl, Nuala Mooney, Bahareh Mohebbi, Yousef Fatahi, Narjes Soleimanifar

“…Sirtuin 1, a member of sirtuin family of histone deacetylase enzymes, has been implicated in a variety of physiologic and pathologic events, including energy metabolism, cell survival, and age-related alterations. …”
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COFcap2, a recyclable tandem catalysis reactor for nitrogen fixation and conversion to chiral amines by Qianqian Zhu, Peijie Dong, Jiangyue Yu, Zhifang Wang, Ting Wang, Shan Qiao, Jinjin Liu, Shubo Geng, Yunlong Zheng, Peng Cheng, Michael J. Zaworotko, Zhenjie Zhang, Yao Chen

“…Importantly, the COFcap-2 system is recycled 15 times with retention of performance, addressing the relative instability and poor recyclability of enzymes that has hindered their broad implementation for energy-efficient, low waste production of chemicals and (bio)pharmaceuticals.…”
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α-Glucosidase inhibitor produced by an endophytic fungus, Xylariaceae sp. QGS 01 from Quercus gilva Blume by Anastasia Wheni Indrianingsih, Sanro Tachibana

“…QGS 01, an endophytic fungus isolated from the stem of Quercus gilva Blume showed high α-glucosidase inhibitory activity. α-Glucosidase inhibitor have the role as one of carbohydrate-hydrolyzing enzymes to postpone absorption of glucose in the digestive organs. …”
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A Review of Marine Bacterial Intracellular and Extracellular Bioactive Compounds as Novel Antibacterial and Anti-Inflammation Agents by Harningsih Karim, Arief Azis, Ananda Ramadani, Anita Anita, Ahyar Ahmad, Hasnah Natsir, Paulina Taba, Suriati Eka Putri, Sarlan Sarlan, Siti Halimah Larekeng, Rizal Irfandi

“…A crucial resource in the ongoing search for novel peptides, proteins, lipids, nucleosides, enzymes, alkaloids, polyketides, and terpenoids is the diversity of marine bacterium strains. …”
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Sleeve gastrectomy reveals the plasticity of the human gastric epithelium by Amit Elad, Botros Moalem, Dana Sender, Aya Bardugo, Ki-Suk Kim, Yhara Arad, Haya Benhayon, Ayelet Gal Etzyoni, Nehemia Greenstein, Aviv Halfon, Sarah Knapp, Michelle Malis, Bailey Peck, Itia Samuel, Amram Kupietzky, Saleh Daher, Esther Forkosh, David Hakimian, Tiberiu Hershcovici, Nadav Ilani, Lior Katz, Moshe Rottenstreich, Elez Vainer, Yuval Ishay, Eitan Zlotnick, Abed Nasereddin, Idid Shiff, Ariel Benson, Ronit Grinbaum, Siddhartha Mishra, Shlomi Kotler, Linda C. Samuelson, Darleen A. Sandoval, Rachel Ben-Haroush Schyr, Danny Ben-Zvi

“…Using histology, and single-cell RNA sequencing of the gastric epithelium in 12 women, we observed that SG is associated with an increase in a sub-population of acid-secreting parietal cells that overexpress respiratory enzymes and an increase in histamine-secreting enterochromaffin-like cells (ECLs). …”
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