Immune-Stimulatory and Therapeutic Activity of Tinospora cordifolia: Double-Edged Sword against Salmonellosis by Sultan Alsuhaibani, Masood A. Khan

“…The toxicity of AETC or METC was determined by measuring the levels of liver inflammation markers aspartate transaminase (AST) and alanine transaminase (ALT) and antioxidant enzymes. Macrophages treated with AETC or METC secreted greater levels of IFN-γ, TNF-α, and IL-1β. …”
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Optimization Conditions of Extracellular Proteases Production from a Newly Isolated Streptomyces Pseudogrisiolus NRC-15 by El-Sayed E. Mostafa, Moataza M. Saad, Hassan M. Awad, Mohsen H. Selim, Helmy M. Hassan

“…Microbial protease represents the most important industrial enzymes, which have an active role in biotechnological processes. …”
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Propionate metabolism in Desulfurella acetivorans by Eugenio Pettinato, Thomas M. Steiner, Eric A. Cassens, Thomas Geisberger, Christian Seitz, Simone König, Wolfgang Eisenreich, Ivan A. Berg

“…Here we show that D. acetivorans possesses a putative operon encoding enzymes of the methylcitrate cycle of propionate oxidation and demonstrate that this bacterium is capable of propionate growth. …”
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Estimation of median LC50 and toxicity of environmentally relevant concentrations of thiram in Labeo rohita by Sana Alam, Gulnaz Afzal, Riaz Hussain, Hafiz Muhammad Ali, Amtul Sami, Rabbiah Manzoor Malik, Raheela Jabeen, Farid Shokry Ataya, Kun Li

“…Oxidative stress parameters; ROS and TBARS were increased significantly (p < 0.05) while antioxidant enzymes (CAT, SOD, POD, GSH) showed a significant (p < 0.05) decrease in the treated groups compared to the control. …”
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Aluminum Poisoning with Emphasis on Its Mechanism and Treatment of Intoxication by Mehrdad Rafati Rahimzadeh, Mehravar Rafati Rahimzadeh, Sohrab Kazemi, Roghayeh Jafarian Amiri, Marzieh Pirzadeh, Ali Akbar Moghadamnia

“…Aluminum poisoning has complex and multidimensional effects, such as disruption or inhibition of enzymes activities, changing protein synthesis, nucleic acid function, and cell membrane permeability, preventing DNA repair, altering the stability of DNA organization, inhibition of the protein phosphatase 2A (PP2A) activity, increasing reactive oxygen species (ROS) production, inducing oxidative stress, decreasing activity of antioxidant enzymes, altering cellular iron homeostasis, and changing NF-kB, p53, and JNK pathway leading to apoptosis. …”
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Combination Therapy of PPAR𝛾 Ligands and Inhibitors of Arachidonic Acid in Lung Cancer by Jordi Tauler, James L. Mulshine

“…Targeting LOX/COX enzymes and inducing activation of PPAR𝛾 have resulted in significant reduction of cell growth in lung cancer cell lines. …”
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Flavonoids-rich extract of Aframomum melegueta (black pepper) improves antioxidant status and modulates aging process in lead-induced neurotoxic Drosophila melanogaster by Mohammed Sani Jaafaru

“…The expression and activities of the phase II antioxidant and age-related enzymes were determined using quantitative polymerase chain reaction (qPCR) to assess the oxidative and longevity effects of the extract. …”
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Epigenetic regulation in coronary artery disease: from mechanisms to emerging therapies by Rui Gao, Rui Gao, Rui Gao, Meilin Liu, Meilin Liu, Meilin Liu, Haoyi Yang, Haoyi Yang, Haoyi Yang, Yuhan Shen, Yuhan Shen, Yuhan Shen, Ni Xia, Ni Xia, Ni Xia

“…Focusing on the key epigenetic enzymes and their target genes will help to facilitate the diagnosis and treatment of CAD. …”
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Positive effect of ethanol-induced Lactococcus lactis on alcohol metabolism in mice by Sisi Chen, Shimin Jia, Keke Suo, Qiaozhen Kang, Limin Hao, Laizheng Lu, Xin Liu, Jinyong Huang, Jike Lu

“…It is well known that exposure to environmental stresses could enhance the adaptability of bacteria and up-regulate the expression of a variety of oxidative stress-related genes and antioxidant enzymes. It is unclear whether the adaptability of microorganisms formed naturally in special environments could transfer to other organisms. …”
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CORRELATION BETWEEN SGOT AND SGPT LEVELS WITH POSITIVE HBsAg LEVELS by Nisa'ur Rosyidah, Erlinda Widyastuti, Annisa Auliya Rahman, Nur Septia Handayani, Belgis

“…Background: Serum Glutamic Oxaloacetate Transaminase (SGOT) and Serum Glutamic Pyruvic Transaminase (SGPT) are transaminase enzymes used to determine liver damage. The increase in both enzymes can indicate the level of liver cell damage. …”
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A Novel Process for Oleacein Production from Olive Leaves Using Freeze Drying Methodology by Christina Koutra, Efi Routsi, Panagiotis Stathopoulos, Eleftherios Kalpoutzakis, Marina Humbert, Olivier Maubert, Alexios-Leandros Skaltsounis

“…The findings demonstrated that freeze drying uniquely promotes the selective activation of β-glucosidase and esterase enzymes while simultaneously inhibiting oxidative enzymes, such as polyphenol oxidase and peroxidase, resulting in significantly enriched oleacein content. …”
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The tyrosine kinase inhibitor lenvatinib is oxidized by rat cytochromes P450 and affects their expression in rat liver by Indra Radek, Jelínková Sandra, Kollárová Katarína, Zahumenská Petra, Dvořák Josef, Dušková Šárka, Dračínská Helena

“…Using the rat as an experimental animal model, this study aimed to investigate the metabolism of lenvatinib by rat microsomal enzymes and cytochrome P450 (CYPs) enzymes recombinantly expressed in SupersomesTM in vitro and to assess the effect of lenvatinib on rat CYP expression in vivo. …”
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Metabolic reprogramming of glucose: the metabolic basis for the occurrence and development of hepatocellular carcinoma by Kai Wang, Xiaodan Li, Shuwei Guo, Junsheng Chen, Yandong Lv, Zhiqiang Guo, Hongzhou Liu

“…Additionally, various enzymes and signaling molecules involved in glucose metabolism reprogramming play irreplaceable roles. …”
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A Field Trial to Demonstrate the Potential of a Vitamin B Diet Supplement in Reducing Oxidative Stress and Improving Hygienic and Grooming Behaviors in Honey Bees by Nemanja M. Jovanovic, Uros Glavinic, Jevrosima Stevanovic, Marko Ristanic, Branislav Vejnovic, Slobodan Dolasevic, Zoran Stanimirovic

“…The expression levels of genes for antioxidative enzymes were significantly lower, but the vitellogenin gene transcript level was significantly higher. …”
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Resistin Regulates Pituitary Lipid Metabolism and Inflammation In Vivo and In Vitro by F. Rodriguez-Pacheco, M. G. Novelle, M. J. Vazquez, E. Garcia-Escobar, F. Soriguer, G. Rojo-Martinez, E. García-Fuentes, M. M. Malagon, C. Dieguez

“…Here, by a combination of in vivo and in vitro experimental models, we demonstrated that central acute and chronic administration of resistin enhance mRNA levels of the lipid metabolic enzymes which participated on lipolysis and moreover inhibiting mRNA levels of the lipid metabolic enzymes involved in lipogenesis. …”
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Role of Prostaglandins in Neuroinflammatory and Neurodegenerative Diseases by Isabel Vieira de Assis Lima, Leandro Francisco Silva Bastos, Marcelo Limborço-Filho, Bernd L. Fiebich, Antonio Carlos Pinheiro de Oliveira

“…In the present paper, we discuss the evidences that link prostaglandins, as well as the enzymes that produce them, to some neurological diseases.…”
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МATHEMATICAL MODELING OF ETHANOL AND LACTIC ACID BIOSYNTHESIS BY THERMOPHILIC Geobacillus BACTERIA by M. A. Nuriddinov, F. V. Kazantsev, A. S. Rozanov, K. N. Kozlov, S. E. Peltek, I. R. Akberdin, N. A. Kolchanov

“…It is shown that the mathematical model allows in silico design of genetic engineering experiments with the Geobacillus spp. bacterium and prediction of the dynamics of changes in synthesized ethanol and lactic acid concentrations depending on the molecular manipulations with the activity of enzymes of the metabolic system.…”
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Predictors of Successful Clinical and Laboratory Outcomes in Patients with Primary Sclerosing Cholangitis Undergoing Endoscopic Retrograde Cholangiopancreatography by R Enns, MA Eloubeidi, K Mergener, PS Jowell, MS Branch, J Baillie

“…Although there often appears to be initial radiological improvement after ERCP, the benefit as measured by serial estimations of subsequent liver enzymes is questionable. The fluctuating course of the inflammatory process makes the interpretation of serology even more difficult.…”
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Attenuation of Autoimmune Phenomena in a Patient with Autoimmune Polyglandular Syndrome Type 1 by Jill D. Jacobson, Julia R. Broussard, Courtney Marsh, Brandon Newell

“…She later developed elevated liver enzymes, primary adrenal insufficiency, and alopecia totalis. …”
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Vermicompost leachate reduces some negative effects of salt stress in pomegranate by Siamak Shirani Bidabadi, Safoora Dehghanipoodeh, Glenn C. Wright

“…Foliar application of VCL also improved the activity of antioxidant enzymes and caused a reduction in oxidative stress and electrolyte leakage. …”
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