miR-26a-5p/ADAM17-Mediated Proteolysis of TREM2 Regulates Neuroinflammation in Hypertensive Mice Following Lead Exposure by Yuran Wang, Zeming Wang, Han Hao, Yuwei Zhao, Jian Wang, Weixuan Wang

“…This decline in TREM2 expression was associated with increased proteolysis of TREM2 by a disintegrin and metalloproteases 10 (ADAM10) as well as a disintegrin and metalloproteases 17 (ADAM17), in which ADAM17 was verified as the main cleavage enzyme in terms of TREM2 proteolytic cleavage in hypertensive mice following Pb exposure. …”
Get full text

Qingfei Tongluo Mixture Attenuates Bleomycin-Induced Pulmonary Inflammation and Fibrosis through mTOR-Dependent Autophagy in Rats by Shuyu Ge, Zhenghong Guo, Ting Xiao, Pingping Sun, Bo Yang, Yin Ying

“…Body weight and lung coefficient were examined, combined with hematoxylin and eosin (H&E) and Masson staining to observe lung tissue lesions. The enzyme-linked immunosorbent assay (ELISA) and the hydroxyproline (HYP) assay kit were used to detect changes in proinflammatory factors (transforming growth factor-β (TGF-β), tumor necrosis factor-α (TNF-α), and interleukin-1β (IL-1β)) and HYP. …”
Get full text

Promising LOX proteins for cartilage-targeting osteoarthritis therapy by Luca Morici, Eric Allémann, Olivier Jordan, Ines Nikolić

“…Finally, lysyl oxidase and lysyl oxidase-like are enzymes expressed intracellularly (in chondrocytes' cytoplasm) involved in elastin biosynthesis and collagen cross-linking in cartilage extracellular matrix. …”
Get full text

Role of Local Biofertilizer in Enhancing the Oxidative Stress Defence Systems of Date Palm Seedling (Phoenix dactylifera) against Abiotic Stress by Oumaima Harkousse, Afafe Slimani, Issam Jadrane, Mohamed Aitboulahsen, Mouaad Amine Mazri, Abdelmjid Zouahri, Lahcen Ouahmane, Tayeb Koussa, Mohamed Najib Al Feddy

“…The present study investigated the effects of inoculation with arbuscular mycorrhizal fungi (AMF) and PGPR on the water status and antioxidant enzyme activities of date palm seedlings grown under water stress conditions. …”
Get full text

Long noncoding RNA GDIL acts as a scaffold for CHAC1 and XRN2 to promote platinum resistance of colorectal cancer through inhibition of glutathione degradation by Xuan Deng, Lu Chang, Lingyu Tang, Haoqin Jiang, Xiao Xu, Xinju Zhang, Jian Chen, Liu Dong, Qianqian Xu, Ruoshui Cao, Jianbin Xiang, Ming Guan

“…This is attributed by downregulation of CHAC1, an enzyme that specifically degrades intracellular GSH. …”
Get full text

Identification of meibomian gland testosterone metabolites produced by tissue-intrinsic intracrine deactivation activity by Khanh Tien Nguyen Pham, Takahito Miyake, Tomo Suzuki, Shigeru Kinoshita, Yuki Hamada, Hikari Uehara, Mamiko Machida, Takeshi Nakajima, Emi Hasegawa, Masao Doi

“…Here, we performed radioactive tracer studies in combination with pharmacological enzyme inhibition, followed by targeted liquid chromatography-tandem mass spectrometry (LC-MS/MS) analysis, and found three androgen metabolites—androstanedione, androsterone, and epiandrosterone—in mouse and human meibomian glands. …”
Get full text

Biodegradability of Cellulose Fibers, Films, and Particles: A Review by Martin A. Hubbe, Jesse S. Daystar, Richard A. Venditti, Joel J. Pawlak, Marielis C. Zambrano, Morton Barlaz, Mary Ankeny, Steven Pires

“…Although cellulose is subject to well-known enzyme-promoted mechanisms of biodegradation, the evolution of plant materials has favored development of some resistance to decay, i.e. recalcitrance. …”
Get full text

Electroacupuncture Mitigates Hippocampal Cognitive Impairments by Reducing BACE1 Deposition and Activating PKA in APP/PS1 Double Transgenic Mice by Yinshan Tang, Shujun Shao, Yu Guo, You Zhou, Jin Cao, Anping Xu, Jihong Wu, Zhigang Li, Dulian Xiang

“…Increased amyloid-β (Aβ) plaque deposition is thought to be the main cause of Alzheimer’s disease (AD). β-Site amyloid precursor protein cleaving enzyme 1 (BACE1) is the key protein involved in Aβ peptide generation. …”
Get full text

A model for predicting acute heart failure in patients with acute myocardial infarction by taking into account energy and adipokine metabolism indicators by M.Yu. Koteliukh

“…Concentrations of adropin, irisin, insulin, FABP4 and CTRP3 were determined by enzyme-linked immunosorbent assay. Fasting capillary blood glucose level was measured by glucoseoxidase method. …”
Get full text

Evaluation of serum amylase and lipase in diagnosed Covid-19 survivors in a North Indian Hospital, Lucknow, India by Nabeela Usmani, Mukhtar Ahmad, Saba Khan, Mohammad Mustufa Khan, Haseeb Ahsan, Sadaf Parveen, Roshan Alam

“…It was suggested that upregulation of angiotensin-converting enzyme II (ACE-II) cell receptors or inflammatory cytokines play a major role in predisposing pancreatic injury in SARS-CoV-2 patients. …”
Get full text

Suppressive Activity of a Macrolide Antibiotic, Roxithromycin, on Pro-Inflammatory Cytokine Production in Vitro and in Vivo by H. Suzaki, K. Asano, S. Ohki, K. Kanai, T. Mizutani, T. Hisamitsu

“…After 24 h, the culture supernatants were obtained and assayed for IL-1β and TNF-α contents by enzyme-linked immunosorbent assay. RXM suppressed the in vitro production of IL-1β and TNF-α in response to LPS stimulation. …”
Get full text

Meta-analysis examining the association between low platelet monoamine oxidase levels and Zuckerman's sensation seeking scale in a sex dependent manner by Jordan Winfield, Ian A. Mendez, Gabriel A. Frietze

“…Monoamine oxidase (MAO) is an enzyme in the brain responsible for breaking down neurotransmitters. …”
Get full text

Development of an optimized protocol for protoplast-to-plant regeneration of selected varieties of Brassica oleracea L. by Katarzyna Stelmach-Wityk, Kamil Szymonik, Ewa Grzebelus, Agnieszka Kiełkowska

“…The protoplast isolation efficiency after digestion of young leaves in optimized enzyme solution reached on average 2.5 × 106 of cells per gram of fresh weight. …”
Get full text

Development of tolerance to bedaquiline by overexpression of trypanosomal acetate: succinate CoA transferase in Mycobacterium smegmatis by Gloria Mavinga Bundutidi, Kota Mochizuki, Yuichi Matsuo, Mizuki Hayashishita, Takaya Sakura, Yuri Ando, Gregory Murray Cook, Acharjee Rajib, Frédéric Bringaud, Michael Boshart, Shinjiro Hamano, Masakazu Sekijima, Kenji Hirayama, Kiyoshi Kita, Daniel Ken Inaoka

“…We introduced into Mycobacterium smegmatis an alternative ATP production pathway by substrate-level phosphorylation, specifically through overexpression of trypanosomal acetate:succinate co-enzyme A (CoA) transferase (ASCT). Intriguingly, the overexpression of ASCT partially restored intracellular ATP levels and resulted in acquired tolerance to BDQ growth inhibition at low, but not high concentrations of BDQ. …”
Get full text

Hubungan Obesitas dengan Hormon Testosteron pada Mahasiswa STIKes Indonesia Padang by Ibrahim , Fadil Oenzil, Arni Amir

“…<br />Keywords: obesity, testosterone, adiponecty, enzym aromatase<br /><br /></p>…”
Get full text

First evidence of immunomodulation of the renin-angiotensin system through substance P/neurokinin 1 receptor: a case and control study in hypertension and cardiac patients by Ibrahim M. Alanazi, Riffat Mehboob, Ayesha Tariq, Sajid Hameed, Uzma Malik, Noreen Sarwar, Imran Shahid, Khurram Mehboob

“…Serum samples were obtained, and the levels of SP and NK1R were measured using the enzyme-linked immunosorbent assay. When compared to the control group, the levels of SP and NK1R in hypertension patients were considerably higher. …”
Get full text

Serum levels of interleukin-6 type cytokines and soluble interleukin-6 receptor in patients with rheumatoid arthritis by T. Robak, A. Gladalska, H. Stepień, E. Robak

“…We investigated the serum concentrations of interleukin-6 (IL-6) and two IL-6 family of cytokines (leukaemia inhibitory factor (LIF) and ciliary neurotrophic factor (CNTF) as well as IL-6 soluble receptor (sIL-6R) using an enzyme-linked immunosorbent assay (ELISA) in 66 patients with rheumatoid arthritis (RA) and 24 healthy controls. …”
Get full text

Super Dosing of IP6 Phytase in Phosphorus-Deficit Diets to Replace Added Phosphorus and Evaluate Growth Performance, Nutrient Digestibility and Bone Mineralization of Broiler Chick... by Bahadur Ali, Muhammad Irfan

“… Phosphorus in phytate is poorly available to monogastric animals due to their lack of the phytase enzyme, leading to increased phosphorus excretion and environmental pollution. …”
Get full text

Plant growth-promoting bacteria and nanomaterials synergism to enhance Lolium perenne growth and phytoremediation in cadmium-contaminated soil by Asifa Farooqi, Ejaz ul Haq, Anders Johansen, Lea Ellegaard-Jensen, Mazhar Iqbal, Sohail Yousaf, Maximilian Lackner

“…PGPB also increased the dehydrogenase, catalase, phosphatase, and urease enzyme activity in soil. The PGPB-GNPs combination also reduced the Cd-induced stress injury to ryegrass through increased production of antioxidants. …”
Get full text

Mechanisms of phenolic biosynthesis induced by ultrasound stress in fresh-cut red cabbages based on energy metabolism analysis by Ningning Ouyang, Chen Hong, Lina Guo, Xinyan Zhang, Wenjuan Qu, Haile Ma

“…The effects of exogenous adenosine triphosphate (ATP) and 2,4-dinitrophenol (DNP) on the phenolic biosynthesis and antioxidant enzymes of fresh-cut red cabbages were also studied. …”
Get full text