Conjugation of Triterpenic Acids with 3-Aminoquinuclidine Moiety: An Approach to Acetylcholinesterase Mixed or Uncompetitive Type Inhibitors by Anastasiya V. Petrova, Ha T. T. Nguyen, Irina V. Zueva, Konstantin A. Petrov, Alexander N. Lobov, Oxana B. Kazakova

“…In the search for new potential inhibitors of cholinesterase enzymes, eight new derivatives of 3-oxo- or 2,3-indolo-triterpenic acid conjugated with amino-quinuclidine bicyclic cores were designed and synthesized. …”
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CircTRRAP Knockdown Has Cardioprotective Function in Cardiomyocytes via the Signal Regulation of miR-370-3p/PAWR Axis by Yuan Zhang, Zhenggong Li, Jiao Wang, Hao Chen, Rui He, Hongkun Wu

“…The protein levels were measured through western blot. Enzyme-linked immunosorbent assay was used to examine the release of inflammatory cytokines. …”
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Genetic aspects of lactase deficiency in indigenous populations of Siberia by B. A. Malyarchuk

“…The ability to metabolize lactose in adulthood is associated with the persistence of lactase enzyme activity. In European populations, lactase persistence is determined mainly by the presence of the rs4988235-T variant in the MCM6 gene, which increases the expression of the LCT gene, encoding lactase. …”
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A Prospective Study to Assess the Best Optimal Dose of Tacrolimus before Renal Transplantation and Its Impact on Graft Survival and Patient Outcome in Renal Transplant Recipients by Niranjan Gogoi, Charu Jain, Megha Agarwal, Dhananjay Agarwal, Ajay Gupta, Munesh Kumar

“…There is a wide variation in the expression of cytochrome p450 enzyme for TAC metabolization in Indian population. …”
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Seroprevalence of COVID-19 among voluntary blood donors by Arumugam Pothipillai, Swathandran Hamsavardhini, Deepa Duraisamy, Lincy Thiyagarajan, Chandrasekaran Kaliyaperumal, Jyotsnaa Grace Velure Mohan Rao

“…AIM: The main aim of this study is to assess the seroprevalence of SARS-CoV-2 antibodies among healthy and asymptomatic voluntary blood donors by enzyme-linked immunosorbent assay (ELISA). SETTING AND DESIGN: This cross-sectional study was conducted among voluntary blood donors using a consecutive sampling technique in the Department of Transfusion Medicine, the Tamil Nadu Dr. …”
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The Effect of IL-35 on the Expression of Nasal Epithelial-Derived Proinflammatory Cytokines by Mingrong Nie, Qingxiang Zeng, Luo Xi, Yiquan Tang, Renzhong Luo, Wenlong Liu

“…The expression of IL-33, IL-25, TSLP, eotaxin-1, eotaxin-2, and eotaxin-3 from supernatant was measured using real-time reverse transcription-polymerase chain reaction (RT-PCR) and enzyme-linked immunosorbent assay (ELISA). AR mice were developed to verify the effect of IL-35 on nasal epithelial cells in vivo. …”
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PBPK modeling: What is the role of CYP3A4 expression in the gastrointestinal tract to accurately predict first‐pass metabolism? by Justine Henriot, André Dallmann, François Dupuis, Jérémy Perrier, Sebastian Frechen

“…However, a correct bottom‐up prediction of GI first‐pass metabolism is challenging and depends on various model parameters like the level of enzyme expression and the basolateral intestinal mucosa permeability (Pmucosa). …”
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Structural requirements and interaction mechanisms of ACE inhibitory peptides: molecular simulation and thermodynamics studies on LAPYK and its modified peptides by Biying Zhang, Jingbo Liu, Hedi Wen, Feng Jiang, Erlei Wang, Ting Zhang

“…The understanding of the structural requirements and the intermolecular-interaction mechanism are important for discovering potent angiotensin-converting enzyme (ACE) inhibitory peptides. In this study, we modified an egg-white derived peptide, LAPYK, using the amino acids with different properties to produce the LAPYK-modified peptides. …”
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How to resolve cryptic species of polypores: an example in Fomes by Ursula Peintner, Regina Kuhnert-Finkernagel, Viana Wille, Franco Biasioli, Anton Shiryaev, Claudia Perini

“…This hypothesis was tested based on phylogenetic analysis of the rDNA ITS region, morphological characters of basidiomes and pure cultures, growth rates and optimum growth temperature experiments, mycelial confrontation tests, enzyme activity tests and volatile organic compound (VOC) production. …”
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Data mining and analysis of adverse events of Vedolizumab based on the FAERS database by Qinyun Xu, Jing Zhang, Weihong Tang, Minhong Zhou, Xiaoling Zhang, Pu Yuan

“…Although less frequent, strong signals were noted for Incisional hernia, Intestinal fistula infection, Anastomotic complication, Drug metabolising enzyme increased, Gingival graft, Intestinal anastomosis complication, Anorectal infection, Perineal rash, and Abdominal hernia obstructive. …”
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ClaPEPCK4: target gene for breeding innovative watermelon germplasm with low malic acid and high sweetness by Congji Yang, Jiale Shi, Yuanyuan Qin, ShengQi Hua, Jiancheng Bao, Xueyan Liu, Yuqi Peng, Yige Gu, Wei Dong

“…In the knockout transgenic watermelon plants, two SNP mutations and one base deletion occurred in the ClaPEPCK4 gene, with the malic acid content in the leaves increasing considerably and the PEPCK enzyme activity reduced to half of the wild-type. …”
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Heart Rate Variability: A Psychophysiological Factor Related to Both Regular Physical Activity and Eudaimonic Well‐Being Among Young Adults by Yoshino Murakami, Daisuke Goto, Hayato Tsukamoto, Kazuho Yamaura, Takeshi Hashimoto

“…Plasma 5‐HT, OXT, and DA levels were obtained via blood samples from the brachial vein and were analyzed with enzyme‐linked immunosorbent assays (ELISAs), and HRV was obtained via 5‐min electrocardiograms (ECGs), with participants in the supine position. …”
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The Roles of Autophagy, Mitophagy, and the Akt/mTOR Pathway in the Pathogenesis of Chronic Rhinosinusitis with Nasal Polyps by Chen Wang, Min-Li Zhou, Yong-Cai Liu, Ke-Jia Cheng

“…Levels of eosinophilic inflammation-related cytokines in nasal tissues were quantified by enzyme-linked immunosorbent assay. Immunohistochemistry was also used to evaluate autophagy, mitophagy, and Akt/mTOR pathway-related protein expression and distribution in nasal polyps and control tissues. …”
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Bisphosphonate Treatment in a Patient Affected by MPS IVA with Osteoporotic Phenotype by Albina Tummolo, Orazio Gabrielli, Alberto Gaeta, Maristella Masciopinto, Lucia Zampini, Luigi Michele Pavone, Paola Di Natale, Francesco Papadia

“…No treatment with allogenic bone marrow transplantation or gene therapy is currently available for Morquio A syndrome, and enzyme replacement therapy is under evaluation. We report a case of MPS IVA, who manifested tardily attenuated phenotype and significant bone mass reduction, which was treated with a bisphosphonate (BPN), resulting in an improvement of X-ray skeletal aspects and functional bone performance. …”
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Symmetric Dimethylarginine Is Not Associated with Cumulative Inflammatory Load or Classical Cardiovascular Risk Factors in Rheumatoid Arthritis: A 6-Year Follow-Up Study by Theodoros Dimitroulas, James Hodson, Aamer Sandoo, Jacqueline P. Smith, Karen M. Douglas, George D. Kitas

“…At follow-up (2012) SDMA levels were measured by enzyme-linked immunosorbent assay. Mean SDMA levels in RA population were 0.40 (0.40–0.53) μmol/L. …”
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Genotypic variability in stress responses of Sorghum bicolor under drought and salinity conditions by Yahya Alzahrani, Abdulbaki Shehu Abdulbaki, Abdulbaki Shehu Abdulbaki, Hameed Alsamadany

“…This study evaluates how different sorghum genotypes respond to separate and combined stresses of drought and salinity.MethodsCarried out with three replications using a randomized complete block design, the experiment measured biochemical and physiological parameters, including stomatal conductance, chlorophyll content, and antioxidant enzyme activities. Molecular analysis focused on stress-responsive gene expression.ResultsResults indicated enhanced stress responses under combined conditions, with significant variation in antioxidant enzymatic activities among genotypes. …”
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Renin-angiotensin-aldosterone system in ISIAH rats with stressinduced arterial hypertension by A. D. Dubinina, E. V. Antonov, L. A. Fedoseeva, E. N. Pivovarova, A. L. Markel, L. N. Ivanova

“…We estimated the serum levels of renin, the angiotensin-converting enzyme, angiotensin II and aldosterone by an enzymelinked immunosorbent assay, and mRNA expression of RAS genes in kidney, adrenals and brain tissues was measured by the real-time polymerase chain reaction. …”
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The Assessment of Cholinesterase from the Liver of Puntius Javanicus as Detection of Metal Ions by Mohd Khalizan Sabullah, Mohd Rosni Sulaiman, Mohd Yunus Abd Shukor, Mohd Arif Syed, Nor Aripin Shamaan, Ariff Khalid, Siti Aqlima Ahmad

“…Screening of heavy metals shows that chromium, copper, and mercury strongly inhibited P. javanicus ChE by lowering the activity below 50%, while several pairwise combination of metal ions exhibited synergistic inhibiting effects on the enzyme which is greater than single exposure especially chromium, copper, and mercury. …”
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Process optimization studies on xylanase production and bioethanol fermentation by Chia Zhi Tan, Thien Sze Chen Ivory, Yi Peng Teoh, Kok Chang Lee, Balakrishnan Kunasundari, Xian Ooi Zhong

“…Xylanase is one of the hydrolytic enzymes with a broad industrial application in several industries. …”
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Prevalence and factors associated with non-alcoholic fatty liver disease among women with polycystic ovary syndrome by Maria Elisa Franciscatto, Juliana Bosso Taniguchi, Raquel Wohlenberg, Isadora Luísa Riedi, Karen Oppermann

“…Metabolic and hepatic enzyme abnormalities were more prevalent in this group compared to the group without the disease. …”
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