An adenoviral vector encoding an inflammation-inducible antagonist, HMGB1 Box A, as a novel therapeutic approach to inflammatory diseases by Kari Ann Shirey, John Joseph, Lynda Coughlan, Haye Nijhuis, Alan W. Varley, Jorge C. G. Blanco, Stefanie N. Vogel

“…We anticipate that this strategy will apply to the treatment of multiple diseases in which HMGB1-mediated signaling is a central driver of inflammation.IMPORTANCEMany inflammatory diseases are mediated by the action of a host-derived protein, HMGB1, on Toll-like receptor 4 (TLR4) to elicit an inflammatory response. We have engineered a non-replicative AdV vector that produces HMGB1 Box A, an antagonist of HMGB1-induced inflammation, under the control of an endogenous complement component C3 (C3) promoter sequence, that is inducible by LPS and influenza in vitro and ex vivo in macrophages (Mϕ) and protects mice and cotton rats therapeutically against infection with mouse-adapted and human non-adapted influenza strains, respectively, in vivo. …”
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A novel USP4 inhibitor that suppresses colorectal cancer stemness by promoting β-catenin and Twist1 degradation by Fengtian Li, Yi Zhou, Xinyue Lin, Yaxin Zhang, Qingyong Hu, Enen Zhao, Huali Li, Xingyan Pan, Feng Shu, Kun Zhang, Chengmei Huang, Na Tang, Wenting Liao

“…Treatment with U4-I05 also inhibited tumor metastasis and extended survival in a genetically engineered CRC mouse model. Conclusions This study identifies U4-I05 as a USP4 inhibitor with significant therapeutic efficacy against CRC, offering a promising avenue for the development of new treatments targeting cancer stemness and chemotherapy resistance. …”
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Monoallelic variants resulting in substitutions of MAB21L1 Arg51 Cause Aniridia and microphthalmia. by Hildegard Nikki Hall, Hemant Bengani, Robert B Hufnagel, Giuseppe Damante, Morad Ansari, Joseph A Marsh, Graeme R Grimes, Alex von Kriegsheim, David Moore, Lisa McKie, Jamalia Rahmat, Catia Mio, Moira Blyth, Wee Teik Keng, Lily Islam, Meriel McEntargart, Marcel M Mannens, Veronica Van Heyningen, Joe Rainger, Brian P Brooks, David R FitzPatrick

“…These mutations occurred de novo in 3/5 families, with the remaining families being compatible with autosomal dominant inheritance. Mice engineered to carry the p.Arg51Leu change showed a highly-penetrant optic disc anomaly in heterozygous animals with severe microphthalmia in homozygotes. …”
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Dual Role of Bacteria in Carcinoma: Stimulation and Inhibition by Suad A Al-Hilu, Wisam H Al-Shujairi

“…Therefore, the world has turned to an alternative solution, which is the use of genetically engineered microorganisms; thus, the use of living bacteria targeting cancerous cells is the unique option to overcome these challenges. …”
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Comparison of survival outcomes and anatomically specific severe injuries following traffic accidents among occupants of standard and K-car vehicles: A retrospective cohort study a... by Yuko Ono, Tasuku Uzawa, Jun Sugiyama, Nozomi Tomita, Takeyasu Kakamu, Tokiya Ishida, Joji Kotani, Kazuaki Shinohara

“…K-car vehicles, also known as "mini vehicles," are defined as those having an engine displacement <660 cc, vehicle length <3.4 m, width <1.48 m, and height <2.0 m. …”
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Second-Generation Triple Reporter for Bioluminescence, Micro–Positron Emission Tomography, and Fluorescence Imaging by Aparna H. Kesarwala, Julie L. Prior, Jinwu Sun, Scott E. Harpstrite, Vijay Sharma, David Piwnica-Worms

“…To exploit the combined strengths of each and facilitate multimodality imaging, we engineered a dual-reporter construct in which firefly luciferase (FLuc) and a 12–amino acid nonstructural linker were fused in frame to the N-terminus of a mutant herpes simplex virus thymidine kinase (mNLS-SR39TK) kinetically enhanced for positron emission tomography (PET). …”
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Coupling genome-wide continuous perturbation with biosensor screening reveals the potential targets in yeast isopentanol synthesis network by Qi Xiao, Jingjing Shi, Lixian Wang, Guoping Zhao, Yanfei Zhang

“…The F2 strain, in particular, achieved an isopentanol titer of 1.57 ± 0.014 g/L and a yield of 14.04 ± 0.251 mg/g glucose (10% glucose), surpassing the highest values reported to date in engineered Saccharomyces cerevisiae. Systematic transcriptome analysis of the isopentanol synthesis, glycolysis, glycerol metabolism, and ethanol synthesis pathways revealed that MPC, OAC1, BAT2, GUT2, PDC6, and ALD4 are linked to efficient isopentanol production. …”
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International experience in mobilising mechanisms to combat organised crime by O. Kopan, V. Melnyk

“…According to the purpose and specifics of the subject under study, the study employed a set of social engineer- ing methods in the organisation of the system of combating organised crime. …”
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DATA MINING ALGORITHMS FOR PREDICTION OF STUDENT TEACHERS’ PERFORMANCE IN ICT: A SYSTEMATIC LITERATURE REVIEW by Juma Habibu Shindo, Mohamedi Mohamedi Mjahidi, Mohamed Dewa Waziri

“…On November 6, 2022, about 196 scholarly articles were downloaded from three digital libraries: Science Direct (38), ACM Digital Library (72), IEEE Xplore (51), and 35 from the Google Scholar search engine. After screening and eligibility checking, 28 scholarly articles were selected and analysed through content analysis in terms of the most commonly used algorithms, the year of publication, the study purposes, and the accuracy performance metrics. …”
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Potential of Hydrogen Fuel Cell Aircraft for Commercial Applications with Advanced Airframe and Propulsion Technologies by Stanislav Karpuk, Yannik Freund, Richard Hanke-Rauschenbach

“…Future technologies considered in the present work include laminar flow control, active load alleviation, new materials and structures, ultra-high bypass ratio turbofan engines, more efficient thermal management systems, and superconducting electric motors. …”
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The Steel Industry and The Development Of Local Community: Case Study of Tembo Steel Industry in Kasolo Division Iganga District. by Kibirige, Eriasafu

“…The findings on contributions of Tembo Steel Industry, the responses were obtained from the statements that were given to respondents as follows; it provides employment opportunities to people like; drivers, engineers, cleaners and accountants, it is strengthening the economy through paying tax that are used to provide social services like medical, security and transport, transformation of agriculture from use of rudimentary tools to modem machines which increase productivity and the extraction of steel products generates significant foreign exchange and according to the research findings the study went ahead to find the challenges faced by the local community in Kasolo division around Tembo steel industry and responses were obtained from statements that it has caused environmental drawbacks which include; pollution of air, water and soil, accidents that lead to workers losing their limbs, fingers, sight and respiratory disorders, increased theft of steel materials in search for materials like saucepans, goal posts and road signs and displacement of people due to need of land for expansion of the steel plant. …”
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On the Graph Isomorphism Completeness of Directed and Multidirected Graphs by Sebastian Pardo-Guerra, Vivek Kurien George, Gabriel A. Silva

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Lepidium sativum Seed Extract-Mediated Synthesis of Zinc Oxide Nanoparticles: Structural, Morphological, Optical, Hemolysis, and Antibacterial Studies by Adnan Alnehia, Annas Al-Sharabi, Abdel-Basit Al-Odayni, A. H. Al-Hammadi, Fares H. AL-Ostoot, Waseem Sharaf Saeed, Naaser A. Y. Abduh, Ali Alrahlah

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Satellite-Driven Hydrological Modelling in Ungauged Moroccan bassins: Case study Ouzoud river by Zilali Abdessamad, Larabi Abdelkader, Ajdor Youssef

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Generalizing the Brady-Yong Algorithm: Efficient Fast Hough Transform for Arbitrary Image Sizes by Danil D. Kazimirov, Ekaterina O. Rybakova, Vitalii V. Gulevskii, Arseniy P. Terekhin, Elena E. Limonova, Dmitry P. Nikolaev

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Time-series forest age estimation in Xinjiang based on forest disturbance and recovery detection by Lili Zhai, Mei Zan, Mao Ye, Jia Zhou, Cong Xue, Shunfa Yang, Yuntong Liu

“…Utilizing Landsat Time Series Stacked (LTSS) Data from 1991 to 2022, the LandTrendr(LT) algorithm was applied to identify forest disturbance and recovery events from 1992 to 2022 using the Google Earth Engine (GEE) platform. Finally, the forest age distribution in Xinjiang from 1991 to 2022 was mapped in conjunction with the forest disturbance events. …”
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The role of gut microbiota in disease management: Ayurvedic perspectives on metabolic diseases and health by Bhawana Jangra, Shreyanshi Kulshreshtha, Alok Goyal, Sanjay M. Jachak

“…Study design and methods: Consultation of various Databases and search engines such as PubMed, ScienceDirect, ResearchGate, Google Scholar, SciFinder, and other published/unpublished resources provided an overview of the published literature on the topic. …”
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Capacity and market potential for local production and distribution of electric two-wheelers in Southeast Asia, focused on Thailand, Indonesia and Vietnam by Hyung Ju Kim, Shritu Shrestha, Kanya Pranawengkapti

“…However, the vast majority of 2Ws in the region still rely on internal combustion engine (ICE), contributing significantly to urban air pollution and greenhouse gas emissions. …”
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The Effect of Occupational Engagement on Lifestyle in Adults Living with Chronic Pain: A Systematic Review and Meta-analysis by Svetlana Solgaard Nielsen, Søren T. Skou, Anette Enemark Larsen, Alessio Bricca, Jens Søndergaard, Jeanette Reffstrup Christensen

“…We sought the databases Ovid MEDLINE, Embase, PsycINFO, CINAHL, Cochrane, Scopus, Web of Science, OTseeker, ClinicalTrials.gov, OpenGrey, and the web engine Google Scholar and citations and references of relevant publications. …”
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Microbial Safety of Sachet Water in Ghana: A Systematic Review by Wisdom K Ahiabor, Eric S Donkor

“…A thorough literature search was conducted across multiple databases, including PubMed, Web of Science, ScienceDirect, Scopus and the search engine Google Scholar, using relevant search terms. …”
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