Improvement in XIa Selectivity of Snake Venom Peptide Analogue BF9-N17K Using P2′ Amino Acid Replacements by Li Ding, Zhiping Zhai, Tianxiang Qin, Yuexi Lin, Zhicheng Shuang, Fang Sun, Chenhu Qin, Hongyi Luo, Wen Zhu, Xiangdong Ye, Zongyun Chen, Xudong Luo

“…In addition, according to the molecular diversity and sequence conservation, a common motif GR/PCR/KA/SXIP-XYGGC is proposed in the XIa-inhibitory Kunitz-type peptides, which might provide a new clue for further peptide engineering. In conclusion, through P2′ amino acid classification scanning with the snake venom Kunitz-type peptide scaffold, a new potent and selective XIa inhibitor, BF9-N17K-L19D, was discovered, which provides a new XIa-targeting lead drug template for the treatment of thrombotic-related diseases.…”
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Carbon stock dynamics of forest to oil palm plantation conversion for ecosystem rehabilitation planning by D. Frianto, E. Sutrisno, A. Wahyudi, E. Novriyanti, W.C. Adinugroho, A.S. Yunianto, H. Kurniawan, H. Khotimah, A. Windyoningrum, I.W.S. Dharmawan, H.L. Tata, S. Suharti, H.H. Rachmat, E.M. Lim

“…Additionally, it highlights their role in ecosystem restoration initiatives and the better management of forest peatland regions.METHODS: A spatial analysis was conducted on Landsat 5 and 8 satellite images by using shapefile data stored within the Google Earth Engine platform. Data analysis was carried out using Classification and Regression Tree, a decision tree algorithm used in machine learning for guided classification. …”
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Constructing TheKeep.Ca With Thrivers of Cancer in Manitoba, Canada, in Support of Enhancing Patient Engagement: Protocol for a Pragmatic Multimethods Study by Maclean Thiessen, Kellie Jewitt, Raina Stromberg, Janelle Marie Lamontagne, Genevieve Richardson Tanguay, Annette Albo, Chantale Thurston, Diana E McMillan

“…At the website launch, TheKeep.Ca will become publicly accessible and indexable on internet search engines, but no additional promotional interventions will take place in the initial 6 months resulting in visitors primarily from web search traffic. …”
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Evaluasi Heuristik Website berbasis Framework Sirius dengan Pengaturan Prioritas menggunakan Teknik Moscow by Gita Indah Marthasari, Nur Hayatin

“…Based on the ISO 9126, one of the quality characteristics in software engineering is usability. The usability measurement on a website is an essential topic nowadays along with the incremental growth of it. …”
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Nitrification and denitrification in pond by Yuni Puji Pujihastuti

“…Survival rate of tiger shrimp in the laboratory scale can be increase by administration of nitrification and denitrification bacteria should not just in the water kolom of pond engineering but also at the bottom pond layer at the preparation step.  …”
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Prevalence and determinants of metabolic syndrome among type2 diabetic patients using different diagnosis criteria in ethiopia: systematic review and meta-analysis by Chilot Kassa Mekonnen, Hailemichael Kindie Abate, Abere Woretaw Azagew, Alebachew Ferede Zegeye

“…Method First-hand studies about the metabolic syndrome among adult type 2 diabetic patients in Ethiopia were searched through known and international databases (PubMed, Scopus, Web of Science, and Cochran Library) and search engines (Google and Google Scholar). Data was extracted using a standard data extraction checklist developed according to Joanna Briggs Institute (JBI). …”
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Strategies for Customer Relationship Management Focused on Loyalty by J. Vasco, C. Guerra, F. Favicela, X. Granizo

“…A formal methodology was described for developing and implementing a CRM system that integrates aspects such as defining a customer strategy, re-engineering customer-oriented business processes, human resources management, the computer system, and management of change and continuous improvement. …”
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Modeling regional aboveground carbon stock dynamics affected by land use and land cover changes by A.D. Malik, M.C.W. Arief, S. Withaningsih, P. Parikesit

“…The application of the Integrated Valuation of Ecosystem Services and Tradeoffs model is efficient in analyzing the effect of land use and land cover change on aboveground carbon stock dynamics and can be widely used in environmental engineering studies involving remote sensing approaches.…”
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PLL-g-HPA Hydrogel Loaded Human Umbilical Cord Mesenchymal Stem Cells Promote Burn Wound Healing in Rat Model by Regulating Inflammation Response by Tian L, Wang Z, Lei T, Feng L, Li Y, Wang K, Zhang Y, Zhang C, Liu J, Xing H, Ren W

“…Linqiang Tian,1,2 Zhaodong Wang,1,2 Tingting Lei,1,3 Lili Feng,1 Yanyan Li,1 Kunxi Wang,1 Yue Zhang,1 Chengshu Zhang,4 Jie Liu,1 Hongxia Xing,3 Wenjing Ren5 1Henan Key Medical Laboratory of Traumatics and Orthopaedics’ Research, The Third Affiliated Hospital of Xinxiang Medical University, Xinxiang, People’s Republic of China; 2Department of Orthopedics Surgery, The Third Affiliated Hospital of Xinxiang Medical University, Xinxiang, People’s Republic of China; 3Department of Neurology, The Third Affiliated Hospital of Xinxiang Medical University, Xinxiang, People’s Republic of China; 4Department of Burn and Plastic Surgery, General Hospital of PINGMEI SHENMA Group, Pingdingshan, People’s Republic of China; 5Clinical Medical Center of Tissue Engineering and Regeneration, Xinxiang Medical University, Xinxiang, People’s Republic of ChinaCorrespondence: Hongxia Xing; Wenjing Ren, Email xhxwh02@163.com; xxmu_rwj@163.comPurpose: Treatment of severe burn wound injury remains a significant clinical challenge as serious infections/complex repair process and irregulating inflammation response. …”
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Peran Interaktivitas dalam Penggunaan E-learning: Perluasan Model UTAUT by Yuni Marlina Saragih, Erwin Setiawan Panjaitan, Roni Yunis

“…The poll was performed on active STMIK Mikroskil students majoring in Informatics and Information Systems Engineering, with a total of 348 responses. The structural equation model (SEM) and the SmartPLS software were used. …”
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Calidad y seguridad en la industria de la construcción en Palestina Quality and safety in the Palestinian construction industry by Adnan Enshassi, Rafiq M Choudhry, Moheeb Abu Alqumboz

“…Analysis of the responses found the most important factors that included: "safety organization formed with community culture considers safety is a vital need for people", "all managers are required to go through proper safety management training", "all engineers are needed to go through relevant safety management training", "lack of orientation training of new workers decreases quality and increases risks for them", and "safety organization formed in such a way that workers and top management exercise positive behavior towards safety". …”
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Repetitive Transcranial Magnetic Stimulation for the Treatment of Complex Regional Pain Syndrome: A Pilot Study by Foglia SD, Drapeau CC, Ramdeo KR, Adams FC, Soppitt DB, Rehsi RS, Shanthanna H, Nelson AJ

“…Stevie D Foglia,1 Chloe C Drapeau,2 Karishma R Ramdeo,2 Faith C Adams,2 Daniel B Soppitt,2 Ravjot S Rehsi,2 Harsha Shanthanna,1,3 Aimee J Nelson1,2 1School of Biomedical Engineering, McMaster University, Hamilton, ON, Canada; 2Department of Kinesiology, McMaster University, Hamilton, ON, Canada; 3Department of Anesthesia, McMaster University, Hamilton, ON, CanadaCorrespondence: Aimee J Nelson, Department of Kinesiology, McMaster University, 1280 Main Street West, Hamilton, ON, L8S 4K1, Canada, Tel +1 905-525-9140 x28053, Fax +1 905-523-6011, Email nelsonaj@mcmaster.caPurpose: Complex regional pain syndrome (CRPS) is a debilitating chronic pain condition characterized by sensory, motor, and autonomic dysfunction with a world-wide prevalence of 26.2 per 100,000 people per year and is 3 to 4 times more prevalent in females. …”
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Designing a Conceptual model for Evaluating the Performance of Software Developers in Fintech Organizations by Hassan Javadi, Fereshteh Amin

“…The statistical population during the fuzzy Delphi phase comprised 10 software engineering experts, who were selected through purposive sampling based on their expertise and experience in the field.ResultsThis research identified 197 primary codes from the semantic expressions gathered during the interviews, which were subsequently categorized into 12 sub-themes. …”
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Lentivirus‐mediated gene therapy for Fabry disease: 5‐year End‐of‐Study results from the Canadian FACTs trial by Aneal Khan, Dwayne L. Barber, William M. McKillop, C. Anthony Rupar, Christiane Auray‐Blais, Graeme Fraser, Daniel H. Fowler, Alexandra Berger, Ronan Foley, Armand Keating, Michael L. West, Jeffrey A. Medin

“…Their HSPCs were mobilized, enriched, and transduced with a recombinant lentivirus engineering expression of α‐gal A. Autologous transduced cells were infused after conditioning with a nonmyeloablative, reduced dose, melphalan regimen. …”
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Ontology of functional synergetics in virtual cognitive-semiotic design of information processes and systems by R. G. Bolbakov, V. A. Mordvinov, P. V. Berezkin, I. I. Sivitsky

“…In the theory of information processes and systems, it is manifested in updating ontologies accompanying scientific and engineering projects that use synergetics as an initial methodological basis. …”
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Computational and theoretical studies of nodal joints in monolithic buildings by T. A. Belash, A. V. Kuznetsov

“…Introduction. The civil engineering sector in large regions of Russia is mainly represented by monolithic housing construction. …”
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N-2-Hydroxypropyl Trimethyl Ammonium Chloride Chitosan-Aluminum Nano-Adjuvant Elicit Strong Immune Responses in Porcine Epidemic Diarrhea Inactivated Vaccine by Jin Z, Liu J, Guo S, Xu S, Gong X, Zhang C, Zhao K

“…Zheng Jin,1 Jiali Liu,1 Sihan Guo,2 Shangen Xu,1 Xiaochen Gong,1,3 Chunjing Zhang,3 Kai Zhao1,2 1Zhejiang Provincial Key Laboratory of Plant Evolutionary Ecology and Conservation, Taizhou Key Laboratory of Biomedicine and Advanced Dosage Forms, School of Life Sciences, Taizhou University, Taizhou, Zhejiang, 318000, People’s Republic of China; 2Engineering Research Center of Agricultural Microbiology Technology, Ministry of Education, Heilongjiang University, Harbin 150080, China; Key Laboratory of Microbiology, College of Heilongjiang Province, School of Life Sciences, Heilongjiang University, Harbin, Heilongjiang, 150080, People’s Republic of China; 3School of Medical Technology, Qiqihar Medical University, Qiqihar, Heilongjiang, 161006, People’s Republic of ChinaCorrespondence: Kai Zhao; Chunjing Zhang, Email zybin395@126.com; cjzhang2005@163.comBackground: Porcine epidemic diarrhea virus (PEDV) inactivated vaccine lacks an effective vaccine adjuvant as an immune activator. …”
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Genetic Associations Between Specific Sleep-Related Phenotypes and Idiopathic Sudden Sensorineural Hearing Loss: A Mendelian Randomization Analysis by Li M, He J, Liang Y, Zou F, Gou C, Lv J, Zhang X, Li D, Yu Z

“…Man Li,1,* Jinbo He,2,* Yiting Liang,3 Fan Zou,1 Changlong Gou,4 Jing Lv,2 Xicheng Zhang,5 Dan Li,6 Zizhong Yu1 1Department of Otolaryngology, Head and Neck Surgery, Taihe Hospital, Hubei University of Medicine, Shiyan, 442000, People’s Republic of China; 2Department of Anesthesiology, Taihe Hospital, Hubei University of Medicine, Shiyan, 442000, People’s Republic of China; 3First Clinical College, Hubei University of Medicine, Shiyan, 442000, People’s Republic of China; 4Department of Ultrasound Medicine, Taihe Hospital, Hubei University of Medicine, Shiyan, 442000, People’s Republic of China; 5Biomedical Engineering College, Hubei University of Medicine, Shiyan, 442000, People’s Republic of China; 6Clinical Molecular Diagnostic Center, Taihe Hospital, Hubei University of Medicine, Shiyan, 442000, People’s Republic of China*These authors contributed equally to this workCorrespondence: Zizhong Yu, Department of Otolaryngology, Head and Neck Surgery, Taihe Hospital, Hubei University of Medicine, No. 32 Renmin South Road, Maojian District, Shiyan, Hubei, 442000, People’s Republic of China, Tel +86-719-8801459, Email yurick0994@163.com Dan Li, Clinical Molecular Diagnostic Center, Taihe Hospital, Hubei University of Medicine, No. 32 Renmin South Road, Maojian District, Shiyan, Hubei, 442000, China, Tel +86-719-8801881, Email lidan198016@163.comPurpose: The relationship between idiopathic sleep-related phenotypes (SRPs) and sudden sensorineural hearing loss (ISSNHL) remains unclear. …”
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3D plants: the impact of integrating science, design, and technology on high school student learning and interests in STEAM subjects and careers by Sandra Arango-Caro, Tiffany Langewisch, Kaitlyn Ying, Michelle Arellano Haberberger, Nate Ly, Christopher Branton, Kristine Callis-Duehl

“…Abstract STEAM education is an educational approach of interdisciplinary teaching of science, technology, engineering, art, and mathematics. STEAM education, however, is often viewed as only including art elements into STEM teaching. …”
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Investigating the Use of Generative Adversarial Networks-Based Deep Learning for Reducing Motion Artifacts in Cardiac Magnetic Resonance by Ma ZP, Zhu YM, Zhang XD, Zhao YX, Zheng W, Yuan SR, Li GY, Zhang TL

“…Ze-Peng Ma,1,2,* Yue-Ming Zhu,3,* Xiao-Dan Zhang,4 Yong-Xia Zhao,1 Wei Zheng,3 Shuang-Rui Yuan,1 Gao-Yang Li,1 Tian-Le Zhang1 1Department of Radiology, Affiliated Hospital of Hebei University/ Clinical Medical College, Hebei University, Baoding, 071000, People’s Republic of China; 2Hebei Key Laboratory of Precise Imaging of inflammation Tumors, Baoding, Hebei Province, 071000, People’s Republic of China; 3College of Electronic and Information Engineering, Hebei University, Baoding, Hebei Province, 071002, People’s Republic of China; 4Department of Ultrasound, Affiliated Hospital of Hebei University, Baoding, Hebei Province, 071000, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xiao-Dan Zhang, Department of Ultrasound, Affiliated Hospital of Hebei University, No. 212 of Yuhua East Road, Lianchi District, Baoding, 071000, People’s Republic of China, Tel +86 17325535302, Email xiaodanzhangzxd@126.comObjective: To evaluate the effectiveness of deep learning technology based on generative adversarial networks (GANs) in reducing motion artifacts in cardiac magnetic resonance (CMR) cine sequences.Methods: The training and testing datasets consisted of 2000 and 200 pairs of clear and blurry images, respectively, acquired through simulated motion artifacts in CMR cine sequences. …”
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