Endothelial cells under disturbed flow release extracellular vesicles to promote inflammatory polarization of macrophages and accelerate atherosclerosis by Zhe Hou, Li Deng, Fei Fang, Ting Zhao, Yaojia Zhang, Gang Li, Michael Z. Miao, Yongcang Zhang, Hongchi Yu, Xiaoheng Liu

“…Interestingly, under disturbed flow stimulation, ECs-derived EVs promoted monocyte accumulation and enhanced their invasion of the endothelium. More important, these EVs initiated the inflammatory polarization of macrophages from the M2 to the M1 phenotype. …”
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Identification of Target Genes of Antiarrhythmic Traditional Chinese Medicine Wenxin Keli by Yusi Yao, Yuhong Liu, Zhihuan Zeng, Yanqun Zhao, Tudi Li, Rong Chen, Rendan Zhang

“…A pig model of myocardial ischemia (MI) was established by balloon-expanding the endothelium of the left coronary artery. Pigs were divided into the model group and WXKL group (n = 6). …”
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Infective agents and polymyalgia rheumatica: key discussion points emerging from a narrative review of published literature by Ciro Manzo, Marco Isetta, Alberto Castagna

“…Conclusions Finally, some infectious agents are able to replicate in human arteries or have an endothelium tropism. Whilst these can theoretically trigger GCA, their role in isolated PMR seems minimal.…”
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The role of olfactory transport in the penetration of manganese oxide nanoparticles from blood into the brain by A. V. Romashchenko, M. B. Sharapova, К. N. Morozova, E. V. Kiseleva, K. E. Kuper, D. V. Petrovskii

“…Also, experiments with the administration of chlorpromazine, a specific inhibitor of clathrin-dependent endocytosis, and methyl-β-cyclodextrin, inhibitor of the lipid rafts involved in the capture of substances by endothelium cells, showed differences in the mechanisms of NP uptake from the nasal cavity and from the bloodstream. …”
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Comprehensive Screening of Cell Surface Markers Expressed by Adult-Derived Human Liver Stem/Progenitor Cells Harvested at Passage 5: Potential Implications for Engraftment by Pierre-Edouard Dollet, Joachim Ravau, Floriane André, Mustapha Najimi, Etienne Sokal, Catherine Lombard

“…Collectively, these results suggest that binding to the endothelium may be the critical weak point in the engraftment process.…”
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Physiological premature aging of ovarian blood vessels leads to decline in fertility in middle-aged mice by Lu Mu, Ge Wang, Xuebing Yang, Jing Liang, Huan Tong, Lingyu Li, Kaiying Geng, Yingnan Bo, Xindi Hu, Ruobing Yang, Xueqiang Xu, Yan Zhang, Hua Zhang

“…Instead, through single-cell sequencing, we identify the aging of the ovarian vascular endothelium as the primary factor contributing to oBV decline. …”
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The opposite effect of convulsant drugs on neuronal and endothelial nitric oxide synthase – A possible explanation for the dual proconvulsive/anticonvulsive action of nitric oxide... by Vega Rasgado Lourdes A., Ramón-Gallegos Eva, Rodríguez-Páez Lorena, Alcántara-Farfán Verónica

“…Nitric oxide (NO) participates in processes such as endothelium-dependent vasodilation and neurotransmission/neuromodulation. …”
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Increasing Donor Endothelial Cell Pool by Culturing Cells from Discarded Pieces of Human Donor Corneas for Regenerative Treatments by Mohit Parekh, Vito Romano, Alessandro Ruzza, Stephen B. Kaye, Diego Ponzin, Sajjad Ahmad, Stefano Ferrari

“…To investigate if the peripheral corneal endothelium that is usually discarded after a corneal transplant could be used for endothelial cell culture. …”
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Instationary metabolic flux analysis reveals that NPC1 inhibition increases glycolysis and decreases mitochondrial metabolism in brain microvascular endothelial cells by Bilal Moiz, Matthew Walls, Viviana Alpizar Vargas, Anirudh Addepalli, Callie Weber, Andrew Li, Ganesh Sriram, Alisa Morss Clyne

“…Finally, we found that co-treatment with hydroxypropyl-β cyclodextrin (HPβCD) partially restored metabolic phenotype in U18666A-treated BMECs, suggesting that this drug may have therapeutic effects on the brain endothelium in NP-C. Together, our data highlight the importance of NPC1 in BMEC metabolism and implicate brain endothelial dysfunction in NP-C pathogenesis.…”
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Ovario- protective effect of Moringa oleifera leaf extract against cyclophosphamide-induced oxidative ovarian damage and reproductive dysfunction in female rats by Seham Samir Soliman, Ahmed A. Suliman, Khaled Fathy, Ahmed A. Sedik

“…Consequently, a marked improvement was observed in the ovarian and uterine architectures, with a normal ovarian reserve and a normal endothelium with normal tubular glands. In conclusion, M. oleifera leaf extract (250 mg/kg) could be used as a pharmaceutical supplement because it protects female rats against CP-induced ovarian damage and reproductive dysfunction.…”
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Performance outcomes from a DMEK peeling and preparation wet lab by Sajjad Ahmad, Vito Romano, Mohit Parekh, Stefano Ferrari, Alessandro Ruzza, Matteo Airaldi, Alexander George Wallace

“…At the wet lab, graft stripping was performed by scoring the peripheral endothelium. The trypan blue positive cells (TBPC) and cell density (cells/mm2—reticule count) were counted manually before and after stripping. …”
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3D bioprinting for the production of a perfusable vascularized model of a cancer niche by Federico Maggiotto, Federico Maggiotto, Lorenzo Bova, Lorenzo Bova, Lorenzo Bova, Sara Micheli, Sara Micheli, Camilla Pozzer, Pina Fusco, Pina Fusco, Paolo Sgarbossa, Fabrizio Billi, Elisa Cimetta, Elisa Cimetta

“…We proved the formation of an endothelium layer lining the vascular channel after 14 days of perfused culture. …”
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Systemic Lupus Erythematosus, Its Impact on Selected Cardiovascular Risk Factors, and Correlation with Duration of Illness: A Pilot Study by Brygida Przywara-Chowaniec, Dominika Blachut, Jan Harpula, Marcin Bereś, Agnieszka Nowak, Ewa Nowalany-Kozielska

“…It leads to an increased production of proinflammatory molecules that accelerates atherogenesis and could cause an endothelium dysfunction. The aim of the study was to assess cardiovascular risk factors such as BMI and lipid profile as well as left ventricular ejection fraction among patients with SLE, and a correlation of these factors with duration of the disease. …”
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Mechanical forces pattern endocardial Notch activation via mTORC2-PKC pathway by Yunfei Mu, Shijia Hu, Xiangyang Liu, Xin Tang, Jiayi Lin, Hongjun Shi

“…By transiently blocking the heartbeat of E9.5 mouse embryos, we found that Notch activation in the arterial endothelium was dependent on its ligand Dll4, whereas the reduced expression of Dll4 in the endocardium led to a ligand-depleted field, enabling Notch to be specifically activated in AVC and OFT by regional increased shear stress. …”
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Clinical Comparison of the Performance of Two Marketed Ophthalmic Viscoelastic Devices (OVDs): The Bacterially Derived Healon PRO OVD and Animal-Derived Healon OVD by Loay Daas, Jose Manuel Larrosa, Alicia Gavin, Carlos Isanta, Achim Langenbucher, Beth E. Jackson, Linda Tsai, Priya Janakiraman, Rafael Guerrero, Berthold Seitz

“…Both test and control OVDs were used, at a minimum, to inflate the anterior chamber and protect the endothelium prior to cataract extraction according to the standard procedure. …”
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Inhibitory Effect of Natural Anti-Inflammatory Compounds on Cytokines Released by Chronic Venous Disease Patient-Derived Endothelial Cells by Veronica Tisato, Giorgio Zauli, Erika Rimondi, Sergio Gianesini, Laura Brunelli, Erica Menegatti, Paolo Zamboni, Paola Secchiero

“…Large vein endothelium plays important roles in clinical diseases such as chronic venous disease (CVD) and thrombosis; thus to characterize CVD vein endothelial cells (VEC) has a strategic role in identifying specific therapeutic targets. …”
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Hematohidrosis in Pediatric Practice  – a Case Report and Review of the Literature by Oksana Matsyura, Lesya Besh, Svitlana Jefimova, Khrystyna Slivinska-Kurchak, Sergiy Gerasymov

“…Capillary endothelial cells are known to contain β2-adrenoceptors, which, through the modulation of nitric oxide release, cause endothelium-dependent vasodilation. Blocking β-adrenoceptors (for example, propranolol) prevents excessive vasodilation of blood vessels and, accordingly, their rupture and blood flow to the sweat gland.We managed to find out that the patient’s bloody sweat was a manifestation of a separate pathological phenomenon, and not one of the symptoms of another disease. …”
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Association between Visual Acuity and Retinal Layer Metrics in Diabetics with and without Macular Edema by LakshmiPriya Rangaraju, Xuejuan Jiang, J. Jason McAnany, Michael R. Tan, Justin Wanek, Norman P. Blair, Jennifer I. Lim, Mahnaz Shahidi

“…In subjects without DME, increased INL thickness was associated with reduced VA, whereas in subjects without DME but with previous antivascular endothelium growth factor treatment, thickening of OPL was associated with reduced VA. …”
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Aberrant methylation of placental development genes in chorionic villi of spontaneous abortions with trisomy 16 by О. Yu. Vasilyeva, E. N. Tolmacheva, A. E. Dmitriev, Ya. A. Darkova, E. A. Sazhenova, T. V. Nikitina, I. N. Lebedev, S. A. Vasilyev

“…Spiral artery remodeling involves the migration of trophoblast cells into the maternal spiral arteries, replacing their endothelium and remodeling to ensure a stable embryonic nutrition and oxygen supply. …”
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Effect of Pien Tze Huang on Lymphangiogenesis Mediated by LncRNA-ANRIL in Colorectal Cancer by Yao LU, Min ZHANG, Jie LIU, Qianqian MAO, Zhiyun CAO, Jiumao LIN

“…Treat HCT-116 cells with Si-NC, Si-ANRIL and Si-NC+PZH(0.25 mg/mL) respectively and collect cell culture supernatants (Tumor culture supernatants, TSNs) for theculture of human lymphatic endothelium cell (HLEC). CCK-8 assay was used to detect cell proliferation, cell migration and invasion were evaluated by Transwell assay. …”
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