GLP-1 Relaxes Rat Coronary Arteries by Enhancing ATP-Sensitive Potassium Channel Currents by Qian-Feng Xiong, Shao-Hua Fan, Xue-Wen Li, Yu Niu, Jing Wang, Xin Zhang, Yi-Fan Chen, Ya-Wei Shi, Li-Hui Zhang

“…Vasorelaxation was attenuated by denuding the endothelium, L-NAME (nitric oxide synthase inhibitor), and glyburide (KATP channel blocker) but was not affected by indomethacin (cyclooxygenase inhibitor), iberiotoxin [Ca2+-activated K+ channel (KCa) blocker], or 4-aminopyridine (KV channel blocker). …”
Get full text

Attempted Depletion of Passenger Leukocytes by Irradiation in Pigs by Hao-Chih Tai, Xiaocheng Zhu, Yih Jyh Lin, Hidetaka Hara, Mohamed Ezzelarab, Michael Epperley, Mubina A. Quader, David K. C. Cooper

“…The lack of effect may have been related to (i) inadequate depletion of passenger leukocytes, thus not preventing a direct T cell response, (ii) the presence of dead or dying leukocytes (antigens), thus not preventing an indirect T cell response, or (iii) constitutive expression of MHC class II and B7 molecules on the porcine vascular endothelium, activating recipient T cells.…”
Get full text

Severe Plasmodium falciparum malaria is associated with circulating ultra-large von Willebrand multimers and ADAMTS13 inhibition. by Deirdre Larkin, Bas de Laat, P Vince Jenkins, James Bunn, Alister G Craig, Virginie Terraube, Roger J S Preston, Cynthia Donkor, George E Grau, Jan A van Mourik, James S O'Donnell

“…Plasmodium falciparum infection results in adhesion of infected erythrocytes to blood vessel endothelium, and acute endothelial cell activation, together with sequestration of platelets and leucocytes. …”
Get full text

Protective role of Pannexin1 in lymphatic endothelial cells in the progression of atherosclerosis in female mice. by Avigail Ehrlich, Graziano Pelli, Bernard Foglia, Filippo Molica, Brenda R Kwak

“…Altogether, our results reveal differential sex-dependent effects of Panx1 in lymphatic endothelium on the progression of atherosclerosis.…”
Get full text

Comparative Efficacy of Antihypertensive Agents in Flow-Mediated Vasodilation of Patients with Hypertension: Network Meta-Analysis of Randomized Controlled Trial by Hong Ding, Shu Liu, Ke-Xin Zhao, Jie Pu, Ya-Fei Xie, Xiao-Wei Zhang

“…A popular and widely used noninvasive tool, flow-mediated dilation (FMD), is used to examine peripheral artery endothelium-dependent dilation. This study aimed to compare the efficacies of different classes of antihypertensive agents based on their effects on FMD. …”
Get full text

Low Ethanol Concentrations Promote Endothelial Progenitor Cell Capacity and Reparative Function by Lars Brodowski, Bianca Schröder-Heurich, Berina Kipke, Cara Schmidt, Constantin S. von Kaisenberg, Frauke von Versen-Höynck

“…Endothelial progenitor cells (EPCs) are recruited to injured endothelium and contribute to its regeneration. There is evidence that moderate ethanol consumption prevents the development and progression of atherosclerosis in a variety of in vitro and in vivo models and increases the mobilization of progenitor cells. …”
Get full text

Endothelial SHANK3 regulates tight junctions in the neonatal mouse blood-brain barrier through β-Catenin signaling by Yong-Eun Kim, Minseong Kim, Sunwhi Kim, Raham Lee, Yusuke Ujihara, Esther Magdalena Marquez-Wilkins, Yong-Hui Jiang, Esther Yang, Hyun Kim, Changhoon Lee, Changwon Park, Il Hwan Kim

“…Here we report that SHANK3, an ASD-risk gene, expresses in the BBB-forming brain endothelial cells (BECs) and regulates tight junctional (TJ) integrity essential for BBB’s barrier function. Endothelium-specific Shank3 (eShank3) knockout (KO) neonatal mice exhibit male-specific BBB-hyperpermeability, reduced neuronal excitability, and impaired ultra-sonic communications. …”
Get full text

Altered shear stress of blood flow causes plasma membrane damage in endothelial cells by Nikita Raj, Chang Pan, Ann Marleen Starke, Anna L. L. Matos, Oliver Soehnlein, Volker Gerke

“…Thus, shear stress alterations, which frequently occur at sites of endothelial dysfunction and before associated pathophysiology, cause membrane wounds in the endothelium, which are repaired efficiently to maintain a functional vasculature.…”
Get full text

Influence of the Clinical Status on Stress Reticulocytes, CD 36 and CD 49d of SSFA2 Homozygous Sickle Cell Patients Followed in Abidjan by Duni Sawadogo, Aïssata Tolo-Dilkébié, Mahawa Sangaré, Nelly Aguéhoundé, Hermance Kassi, Toussaint Latte

“…Interactions between sickle cells involving CD 49d, CD36, and the vascular endothelium may initiate vasoocclusion leading to acute painful episodes and multiple organ failure. …”
Get full text

Clinical Outcomes of Primary Posterior Continuous Curvilinear Capsulorhexis in Postvitrectomy Cataract Eyes by Mengting Yu, Duan Yan, Wenjie Wu, Yingbin Wang, Xinna Wu

“…The outcome measures were corrected distance visual acuity (CDVA), intraocular pressure (IOP), corneal endothelium cell counts (CECC), central macular thickness (CMT), the occurrence of intraoperative or postoperative complications, and the incidence of posterior capsular opacification (PCO). …”
Get full text

Changes in Angiotensin Receptor Distribution and in Aortic Morphology Are Associated with Blood Pressure Control in Aged Metabolic Syndrome Rats by Verónica Guarner-Lans, Elizabeth Soria-Castro, Rocío Torrico-Lavayen, Araceli Patrón-Soberano, Karla G. Carvajal-Aguilera, Vicente Castrejón-Tellez, María Esther Rubio-Ruiz

“…Electron microscopy images showed premature aging in MS since the increased fibrosis, enlarged endothelium, and invasion of this layer by muscle cells that was present in control 18-month-old aortas were also found in 6-month-old aortas from MS rats. …”
Get full text

Angiogenic Potential of Human Neonatal Foreskin Stromal Cells in the Chick Embryo Chorioallantoic Membrane Model by Radhakrishnan Vishnubalaji, Muhammad Atteya, May Al-Nbaheen, Richard O. C. Oreffo, Abdullah Aldahmash, Nehad M. Alajez

“…When hNSSCs were seeded onto the top of the CAM, human von Willebrand factor (hVWF), CD31, smooth muscle actin (SMA), and factor XIIIa positive cells were observed in the chick endothelium. CAMs transplanted with endothelial-differentiated hNSSCs displayed a higher number of blood vessels containing hNSSCs compared to CAMs transplanted with undifferentiated hNSSCs. …”
Get full text

An atypical case of infective endocarditis initially diagnosed as myopericarditis by Negin Ceraolo, Rachel Dietz, Spencer Prete, Erin L Simon

“…Infective endocarditis is an infection of the cardiac endothelium. Diagnosis relies on clinical evaluation, blood cultures to identify the causative organism, and echocardiography to visualize vegetations on heart valves. …”
Get full text

Data-independent LC-MS/MS analysis of ME/CFS plasma reveals a dysregulated coagulation system, endothelial dysfunction, downregulation of complement machinery by Massimo Nunes, Mare Vlok, Amy Proal, Douglas B. Kell, Etheresia Pretorius

“…The findings from this experiment further implicate the coagulation and immune system in ME/CFS, and bring to attention the pathology of or imposed on the endothelium. This study highlights potential systems and proteins that require further research with regards to their contribution to the pathogenesis of ME/CFS, symptom manifestation, and biomarker potential, and also gives insight into the hematological and cardiovascular risk for ME/CFS individuals affected by diabetes mellitus. …”
Get full text

A Rare Case Presentation of Synovial Haemangioma of the Knee by Arun Karthik Ravichandran, Rajavel, Gowtham Senguttavan, Sharath Rajkumar, Saravanan Vasudevan

“…Sodium tetradecyl sulfate acts by damaging the endothelium of the feeder vessel, resulting in a thrombus, which later leads to fibrous tissue formation around the feeder vessel. …”
Get full text

Chronic C-Type Natriuretic Peptide Infusion Attenuates Angiotensin II-Induced Myocardial Superoxide Production and Cardiac Remodeling by Yasuhiro Izumiya, Satoshi Araki, Hiroki Usuku, Taku Rokutanda, Shinsuke Hanatani, Hisao Ogawa

“…C-type natriuretic peptide (CNP) is an endothelium-derived cardioprotective factor, although its effect on cardiac superoxide generation has not been investigated in vivo. …”
Get full text

Surface Modification with NGF-Loaded Chitosan/Heparin Nanoparticles for Improving Biocompatibility of Cardiovascular Stent by Haixin Song, Tao Wu, Xiaotian Yang, Yangzheng Li, Ye Ye, Bo Li, Tao Liu, Shihui Liu, Jianhua Li

“…Biofunctional modification to endow the surface with selective anticoagulation and promote endothelium regeneration has become a hotpot recently. …”
Get full text

Urine amino acid and gamma aminobutyric acid level in COVID 19 patients by Cemal Kazezoglu, Arzu İrvem, Yasemin Tuba Sutasir, Büşra Çakiroglu, Banu Kirgiz, Habip Yilmaz, Ali Kocatas

“… Background and Objectives: SARS CoV2 has tropism for various tissues, including the respiratory tract, brain, endothelium, heart, kidney and liver. Neurological symptoms can also be seen in the clinical course of the disease, and anosmia is the most common. …”
Get full text

Relationship between Sustained Reductions in Plasma Lipid and Lipoprotein Concentrations with Apheresis and Plasma Levels and mRNA Expression of PTX3 and Plasma Levels of hsCRP in... by Claudia Stefanutti, Fabio Mazza, Michael Steiner, Gerald F. Watts, Joel De Nève, Daniela Pasqualetti, Juergen Paal

“…Our findings suggest that LA has anti-inflammatory and endothelium protective effects beyond its well-established efficacy in lowering apoB100-containing lipoproteins.…”
Get full text

Antidiabetic Rosiglitazone Reduces Soluble Intercellular Adhesion Molecule-1 Level in Type 2 Diabetic Patients with Coronary Artery Disease by Guang Wang, Zhe Zhang, Jie Yu, Fuchun Zhang, Liyun He, Jinru Wei, Jieming Mao, Xian Wang

“…PPAR-γ agonist may have a beneficial effect on the vascular endothelium through its anti-inflammatory mechanism and may be useful as therapy in patients undergoing PCI.…”
Get full text