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Risk Factors in Normal-Tension Glaucoma and High-Tension Glaucoma in relation to Polymorphisms of Endothelin-1 Gene and Endothelin-1 Receptor Type A Gene
Published 2015-01-01“…The aim of the research is to analyse the influence of polymorphisms of endothelin-1 gene and endothelin-1 receptor type A gene on the clinical condition of patients with primary open angle glaucoma. …”
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Fluorescence Correlation Spectroscopy in Drug Discovery: Study of Alexa532-Endothelin 1 Binding to the Endothelin ETA Receptor to Describe the Pharmacological Profile of Natural Products
Published 2012-01-01“…Dose-dependent increase of inositol phosphate production was seen for Alexa532-ET1, and its binding was reduced to 8% by the selective endothelin ETA antagonist BQ-123, confirming the specific binding of Alexa532-ET1 to the endothelin ETA receptor. …”
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The Matrix Metalloproteases and Endothelin-1 in Infection-Associated Preterm Birth
Published 2010-01-01“…Several lines of evidence also suggest a role for endothelin-1 (ET-1) in infection-associated preterm delivery. …”
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The Role of the Endothelin System in the Vascular Dysregulation Involved in Retinitis Pigmentosa
Published 2015-01-01“…Moreover, several investigations have studied the augmentation of endothelin-1 plasma levels systemically in the body and locally in the eye. …”
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Increased aqueous humor levels of endothelin-1 in patients with open angle glaucoma
Published 2025-01-01Subjects: “…Endothelin-1…”
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Endothelin-A Receptor Blockade Inhibits the Effects of Hypoxia on the Newborn Lung Vasculature
Published 2006-01-01Get full text
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Serum Endothelin-1 and Transforming Growth Factor-β Levels in the Newborns With Respiratory Distress
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Endothelin-1 and Norepinephrine Overflow from Cardiac Sympathetic Nerve Endings in Myocardial Ischemia
Published 2012-01-01“…In protracted myocardial ischemia, sympathetic activation with carrier-mediated excessive norepinephrine (NE) release from its nerve endings due to reversal of NE transporter in an outward direction is a prominent cause of arrhythmias and cardiac dysfunction. Endothelin-1 (ET-1) and its receptors are intimately involved in the regulation of this carrier-mediated NE overflow in protracted myocardial ischemia. …”
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Turnour necrosis factor stimulates endothelin-1 gene expression in cultured bovine endothelial cells
Published 1992-01-01“…We have studied the effect of human recombinant tumour necrosis factor-α (TNF-α) on gene expression and production of endothelin-1 in cultured bovine aortic endothelial cells. …”
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Clinical and endoscopical and morphofunctional scores in evaluation of development of gastroesophageal reflux disease in various age groups
Published 2012-09-01Subjects: Get full text
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Up-Regulation of Endothelin Receptors Induced by Cigarette Smoke — Involvement of MAPK in Vascular and Airway Hyper-Reactivity
Published 2010-01-01“…Recent studies have demonstrated that endothelin receptor up-regulation mediates vascular and airway hyper-reactivity in response to endothelin-1 (ET-1, endothelin receptor agonist) in cardiovascular and airway diseases. …”
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Endothelin Receptors Expressed by Immune Cells Are Involved in Modulation of Inflammation and in Fibrosis: Relevance to the Pathogenesis of Systemic Sclerosis
Published 2015-01-01“…Endothelin-1 (ET-1) plays a pivotal role in vasoconstriction, fibrosis, and inflammation, the key features of systemic sclerosis (SSc). …”
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Endothelin but Not Angiotensin II May Mediate Hypertension-Induced Coronary Vascular Calcification in Chronic Kidney Disease
Published 2011-01-01“…To understand the relationship between putative neurohormonal factors operative in hypertension and coronary artery calcification (CAC), the relevant cellular actions of angiotensin (Ang II) and endothelin-1 (ET-1) are reviewed. There is compelling evidence to implicate ET-1 in CAC. …”
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Elevated plasma levels of endothelin are associated with the severity of sepsis and presence of shock in contrast to the levels of atrial natriuretic peptide
Published 1992-01-01“…Immunoreactive endothelin (ETi) and atrial natriuretic peptide (ANPi) blood levels were measured by radioimmunoassay in patients with clinically defined sepsis. …”
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Targeting the activated allosteric conformation of the endothelin receptor B in melanoma with an antibody-drug conjugate: mechanisms and therapeutic efficacy
Published 2025-01-01“…Abstract Background Endothelin 1 receptors are one of the drivers of tumor progression in many cancers. …”
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Possible Involvement of Endothelin Peptides and L-Arginine-Nitric Oxide Pathway on the Effect of Endotoxin in the Rabbit Isolated Perfused Kidney
Published 1994-01-01“…This effect was predominant in kidneys from rabbits pretreated with LPS. Endothelin-1 at a concentration of 10−10 M and big endothelin-1 at a concentration of 10−8 M produced equal vasoconstrictor effects in kidney. …”
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Efficacy and Safety of Aprocitentan in the Treatment of Hypertension: A Meta-Analysis of Evidence from Randomized Controlled Trials
Published 2025-01-01Subjects: Get full text
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