Enhanced Osteogenic and Vasculogenic Differentiation Potential of Human Adipose Stem Cells on Biphasic Calcium Phosphate Scaffolds in Fibrin Gels by Fransisca A. S. van Esterik, Behrouz Zandieh-Doulabi, Cornelis J. Kleverlaan, Jenneke Klein-Nulend

“…BCP20/80-based composites also showed enhanced expression of the vasculogenic markers CD31 and VEGF189, but not VEGF165 and endothelin-1. Collagen-1 and collagen-3 expression was similar in both composites. …”
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A Multivariate prediction model for amlodipine therapeutic efficacy in pediatric primary hypertension by Yao Lin, Hui Wang, Yaqi Li, Yang Liu, Yanyan Liu, Hongwei Zhang, Yanjun Deng, Lin Shi

“…After statistical adjustment, 4 variables were found to be independently associated with therapeutic efficacy, including hyperinsulinemia (OR = 3.000, 95% CI: 1.409-6.386, p  = 0.004), insulin resistance (OR = 2.354, 95% CI: 1.032-5.370, p = 0.042), the baseline plasma Endothelin-1 level (OR = 0.627, 95% CI: 0.532-0.740, p < 0.001) and amlodipine dosages (OR = 1.743, 95% CI: 1.400-2.169, p <0.001). …”
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Effect and curative effect of Sanqitongshu capsule combined with argatroban on neurological deficits elderly patients with acute ischemic stroke by Fang Hu, Yunping Liu, Jia Li, Hui Xuan, Huijuan Wang, Xuehai Lv

“…[Objective] To explore the effects of Sanqitongshu capsule combined with argatroban on neurological deficits and peripheral blood endothelin-1 (ET-1), CD41, CD62P and soluble intercellular adhesion molecule-1 (sICAM-1) expressions in elderly patients with acute ischemic stroke. …”
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L-arabinose alleviates constipation through gastrointestinal peptide，gut microbiota，and Phlpp2 of gastrointestinal rhythms in rats by Ting Gong, Linzheng Liao, Yong Tang, Weiwei Liu, Ling Yao, Zhen Wu, Jianmei Li, Fulai Bai, Qian Zhang, Liling Tang

“…It also improved gastric, liver, and kidney function, while modulating key gastrointestinal peptides, including motilin (MTL), substance P (SP), vasoactive intestinal peptide (VIP), acetylcholinesterase (AchE), endothelin-1 (ET-1), serotonin (5-HT), somatostatin (SS), gastrin (Gas), and nitric oxide (NO). …”
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Efficacy and compatibility mechanism of bear bile powder in Shexiang Tongxin dropping pills for acute myocardial infarction treatment by Yu Luo, Fangmin Zhang, Lidan Zhu, Jianfeng Ye, Hong-ye Pan, Xiaoyan Lu, Xiaohui Fan

“…Additionally, the combination treatment induced a 62.34% gene reversion rate compared with 55.56% for BBP and 30.20% for CF treatment alone. Modulation of endothelin 1 and growth factor receptor-bound protein 2 was identified as a key synergistic mechanism underlying the anti-AMI effects of BBP in STDP. …”
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Transition from Ambrisentan to Bosentan in Pulmonary Arterial Hypertension: A Single-Center Prospective Study by Su-Gang Gong, Lan Wang, Bigyan Pudasaini, Ping Yuan, Rong Jiang, Qin-Hua Zhao, Jing He, Rui Zhang, Wen-hui Wu, Jin-Ming Liu, Cai-cun Zhou

“…Background and objective: Two endothelin receptor antagonists (ETRAs), bosentan and ambrisentan, are approved for patients with pulmonary arterial hypertension (PAH). …”
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Management of eight cases of subarachnoid hemorrhage using transpulmonary thermodilution during clazosentan therapy by Hiroto Iyota, Yasumasa Kawano, Hironori Fukumoto, Takato Tajiri, Mitsutoshi Iwaasa, Sinichi Morimoto, Yoshito Izutani, Shintaro Yamasaki, Kazuya Yamauchi, Hiroki Hatomoto, Hiroshi Abe, Yoshihiko Nakamura

“…Clazosentan, an endothelin receptor antagonist, is used to prevent delayed neurological deterioration in patients with subarachnoid hemorrhage due to ruptured cerebral aneurysms. …”
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Effects of Functional Red Pine Seed Direct-Drinking Oil on Constipation and Intestinal Barrier Function in Mice by Jie Li, Haonan Zheng, Jiahui Liu, Jie Ding, Qingqi Guo, Na Zhang

“…Red pine seed direct-drinking oil intake improved defecation, reduced serum levels of vasoactive intestinal peptide (VIP), endothelin-1 (ET-1), and nitric oxide (NO), and increased substance P (SP) levels. …”
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Protection Effect of Endomorphins on Advanced Glycation End Products Induced Injury in Endothelial Cells by Jing Liu, Liping Yan, Ruilan Niu, Limin Tian, Qi Zhang, Jinxing Quan, Hua Liu, Suhong Wei, Qian Guo

“…Then, HUVEC survival rate was calculated by MTT assay, the levels of NO, endothelial nitric oxide synthase (eNOS), and inducible nitric oxide synthase (iNOS) were detected by colorimetric analysis, and the contents of endothelin-1 (ET-1) were detected by ELISA. The mRNA levels of eNOS and ET-1 were measured by RT-PCR. …”
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Significant Contribution of Mouse Mast Cell Protease 4 in Early Phases of Experimental Autoimmune Encephalomyelitis by Louisane Desbiens, Catherine Lapointe, Marjan Gharagozloo, Shaimaa Mahmoud, Gunnar Pejler, Denis Gris, Pedro D’Orléans-Juste

“…Among the latter, the chymase mouse mast cell protease 4 (mMCP-4) can contribute to the inflammatory response by producing endothelin-1 (ET-1). The aim of this study was to determine the impact of mMCP-4 on acute inflammatory stages in EAE. …”
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Structural characteristics, anticoagulant and antithrombotic mechanism of a novel polysaccharide from Rosa Chinensis Flos by Xiaofeng Zhang, Zhenhua Liang, Geoffrey Ivan Neil Waterhouse, Shengjun Jiang, Dongxiao Sun-Waterhouse, Jinmei Wang, Changyang Ma, Wenyi Kang

“…The anticoagulant effect of RCJ2-Ib evaluated by using rabbit ear venous blood and an acute blood stasis rat model showed that RCJ2-Ib had obvious anticoagulant activity in regulating endogenous and exogenous coagulation pathways and reducing serum thromboxane B2 and endothelin-1. In addition, RCJ2-Ib could also increase the number of Lactobacillus and Escherichia coli. …”
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Observation on the Efficacy of Ginkgo Ketone Ester Drop Pill in Improving Hypertension Combined with Carotid Atherosclerotic Plaque by Jie Zhang, Yingli Ma

“…The observation indexes were the improvement of blood pressure (systolic blood pressure (SBP) and diastolic blood pressure (DBP)), blood lipids (low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglyceride (TG), and total cholesterol (TC)), vascular endothelial function (nitric oxide (NO) and endothelin-1 (ET-1)), inflammatory factors (C-reactive protein (CRP) and interleukin-6 (IL-6)), plaque (intimal medial thickness (IMT) of carotid artery and plaque area), and efficacy after intervention and adverse effects during intervention in both groups. …”
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Molecular-genetic bases of plumage coloring in chicken by A. V. Makarova, O. V. Mitrofanova, A. B. Vakhrameev, N. V. Dementeva

“…The formation of a marble feather pattern is associated with the mutation of the endothelin B2 receptor (EDNRB2), in the coding part of the gene of which a polymorphism is found associated with the mo locus. …”
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Urinary NGAL and RBP Are Biomarkers of Normoalbuminuric Renal Insufficiency in Type 2 Diabetes Mellitus by Aimei Li, Bin Yi, Yan Liu, Jianwen Wang, Qing Dai, Yuxi Huang, Yan Chun Li, Hao Zhang

“…Levels of urinary neutrophil gelatinase-associated lipocalin (NGAL), retinol-binding protein (RBP), plasminogen activator inhibitor-1 (PAI-1), vascular cell adhesion molecule-1 (VCAM-1), and E-cadherin were detected, and their correlations with eGFR, plasma TNF-α, IL-6, endothelin-1 (ET-1), and 8-hydroxydeoxyguanosine (8-OHdG) were assessed. …”
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Effects of colchicine adjuvant therapy on disease control, serum NALP3, sICAM-1, MMP-9 and MMP-13 in patients with coronary heart disease and acute gout attack by Bingxun Wang, Yongqing Liu, Wenya Han, Bing Li, Pang Jie, Wenwen Yang, Zengcai Ma, Zesheng Xu

“…Before and after treatment, cardiac function indicators (left ventricular ejection fraction (LVEF), left ventricular end-diastolic diameter (LVEDD), left ventricular posterior wall thickness (LVPWT)), vascular endothelial function indicators (sICAM-1, endothelin-1 (ET-1), and vascular endothelial growth factor (VEGF)), inflammatory factors (NALP3, MMP-9, MMP-13) levels, changes in immune cell populations (CD3+ lymphocytes, CD3+CD4+ lymphocytes, CD3+CD8+ lymphocytes ratio, and CD3+CD4+/CD3+CD8+ ratio) were compared, and the incidence of adverse reactions was recorded. …”
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