Diagnosis and Management of Pulmonary Arterial Hypertension by Jeanne Houtchens, Douglas Martin, James R. Klinger

“…These include the prostanoids, endothelin receptor antagonists, and phosphodiesterase-5 inhibitors.…”
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Nobiletin Protects Endothelial Cell Function via Upregulation of eNOS/ET-1 and Antioxidant Status-Related Genes under Nonstimulated and Inflammatory Conditions by Lu Li, Biyun Zhang, Ludovica De Pieri, Yue Wu, Karen Birch, Christine Boesch

“…To this end, gene expression relevant to nitric oxide (NO) production, endothelin 1 (ET-1), and antioxidant status in human endothelial cells EA.hy926 was determined using real-time PCR. …”
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Hypertension in Metabolic Syndrome: Vascular Pathophysiology by Yolanda Mendizábal, Silvia Llorens, Eduardo Nava

“…There is a vasodilatory pathway with activation of NO synthase through Akt, and a vasoconstrictor pathway that involves the release of endothelin-1 via MAPK. IR is associated with an imbalance between both pathways in favour of the vasoconstrictor one. …”
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Possible bi-directional link between ETA receptors and protein kinase C in rat blood vessels by A. M. Northover, B. J. Northover

“…Possible links have been investigated between activation of protein kinase C (PKC) and endothelin (ET) production by small blood vessels. Perfusion pressures were recorded from rat isolated mesenteric artery, with or without the small intestine attached, before and after addition to the perfusate of either ET-1, ET-3 or the PKC activator 12-deoxyphorbol 13-phenylacetate (DOPPA). …”
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Current Controversies in the Prediction, Diagnosis, and Management of Cerebral Vasospasm: Where Do We Stand? by Young Lee, Scott L. Zuckerman, J. Mocco

“…Finally, the recent literature regarding interventions for the prophylaxis and treatment of vasospasm, including hyperdynamic therapy, albumin, calcium channel agonists, statins, magnesium sulfate, and endothelin antagonists is summarized. Recent studies regarding each topic were reviewed for consensus recommendations from the literature, which were then presented.…”
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The Possible Potential Therapeutic Targets for Drug Induced Gingival Overgrowth by Tamilselvan Subramani, Vidhya Rathnavelu, Noorjahan Banu Alitheen

“…Proteins such as transforming growth factor (TGF), endothelin-1 (ET-1), angiotensin II (Ang II), connective tissue growth factor (CCN2/CTGF), insulin-like growth factor (IGF), and platelet-derived growth factor (PDGF) appear to act in a network that contributes to the development of gingival fibrosis. …”
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Transition from Hepatopulmonary Syndrome to Portopulmonary Hypertension: A Case Series of 3 Patients by Radhika Zopey, Irawan Susanto, Igor Barjaktarevic, Tisha Wang

“…Another theory involves the possible differential binding of endothelin-1, a vasoactive signaling peptide that induces vasoconstriction when bound to receptor A and vasodilation when bound to receptor B. …”
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Resistin as a Prooxidant Factor and Predictor of Endothelium Damage in Patients with Mild Acute Pancreatitis Exposed to Tobacco Smoke Xenobiotics by Milena Ściskalska, Grzegorz Marek, Zygmunt Grzebieniak, Halina Milnerowicz

“…The study was aimed to assess the influence of tobacco smoke exposure on the intensity of inflammation measured by IL-6, α1-antitripsin (AAT) and α1-acid glycoprotein (AGP) concentrations, and Cd level and oxidative stress intensity measured by advanced oxidation protein product (AOPP) concentration in the blood of healthy subjects and AP patients during hospitalization. Endothelin-1 (ET-1) and resistin concentrations, markers of endothelium injury, were determined. …”
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Impact of Peritoneal Dialysis Treatment on Arterial Stiffness and Vascular Changes in Diabetic Type 2 and Nondiabetic Patients with End-Stage Renal Disease by Damir Rebić, Senija Rašić, Velma Rebić

“…Significant reduction in median serum endothelin-1 concentration after 12 months on PD treatment was observed in the group of patients with DM (7.6–5.9 pg/mL) and also in group of patients without DM (3.6–3.3 pg/mL). …”
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Antihypertensive effect of sinapine extracted from rapeseed meal in 2K1C hypertensive rats by Gaoyuan Yang, Lin Zhu, Yu Wang, Yang Yu, Xiaoguang Liu, Jingbo Xia, Yunjie Yang, Huiguo Wang, Baomin Feng

“…The renin angiotensin aldosterone system (RAAS), including the levels of renin, angiotensin I (Ang I), angiotensin II (Ang II), aldosterone (ALD), angiotensin-converting enzyme (ACE) and other molecules related to blood pressure, such as NO, prostacyclin (PGI2), endothelin-1 (ET1), and thromboxane A2 (TXA2), were measured in rat blood. …”
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The Effects of the COVID-19 Pandemic on Abnormal Uterine Bleeding According to the PALM-COEIN Classification by Onur Bektas, Kivilcim Bektas, Sirin Aydin, Gulsen Dogan Durdag, Husnu Celik

“…Additionally, increased production of vasodilatory substances such as prostaglandin E2 and prostacyclin, decreased production of local vasoconstrictors like prostaglandin F2α and endothelin-1, as well as increased plasminogen activator activity leading to enhanced thrombolysis and disruptions in endometrial hemostatic mechanisms. …”
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Effect of Fluid Shear Stress on Portal Vein Remodeling in a Rat Model of Portal Hypertension by Bin Wen, Jian Liang, Xin Deng, Ran Chen, Peichun Peng

“…Nitric oxide (NO), synthase (NOS), and endothelin-1 (ET-1) of the portal vein blood were measured. …”
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Interactions between and Shared Molecular Mechanisms of Diabetic Peripheral Neuropathy and Obstructive Sleep Apnea in Type 2 Diabetes Patients by Hong Shen, Junrong Zhao, Ying Liu, Guangdong Sun

“…Numerous molecular mechanisms have been documented that underlie diabetic peripheral neuropathy and OSA, including oxidative stress, inflammation, endothelin-1, vascular endothelial growth factor (VEGF), accumulation of advanced glycation end products, protein kinase C (PKC) signaling, poly ADP ribose polymerase (PARP), nitrosative stress, plasminogen activator inhibitor-1, and vitamin D deficiency. …”
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Identification and characterization of a novel tetrapeptide from enzymatic hydrolysates of Baijiu byproduct by Qiang Wu, Changqing Zhong, Guirong Zeng, Xu Zhang, Liping Xiang, Chang Wan, Yougui Yu

“…Moreover, it showed no significant cytotoxicity toward human umbilical vein endothelial cells (HUVECs), and significantly induced phosphorylation of endothelial nitric oxide synthase (p-eNOS) and decreased endothelin 1 (END1) expression in angiotensin I (Ang I)-treated HUVECs, demonstrating the potential antihypertensive effect. …”
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Value of Caffeic Acid Phenethyl Ester Pretreatment in Experimental Sepsis Model in Rats by Ozlem Alici, Havva Sahin Kavakli, Cemile Koca, Neriman Defne Altintas, Murat Aydin, Suleyman Alici

“…The aim of this study was to determine the actions of caffeic acid phenethyl ester (CAPE) on the changes of endothelin-1 (ET-1) level, tumor necrosis factor- (TNF-) alpha, and oxidative stress parameters such as superoxide dismutase (SOD) activities and malondialdehyde (MDA) levels in experimental sepsis model in rats. …”
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Extra-Articular Symptoms in Constellation with Selected Serum Cytokines and Disease Activity in Spondyloarthritis by Hanna Przepiera-Będzak, Katarzyna Fischer, Marek Brzosko

“…In 191 SpA patients, we measured serum interleukin-6 (IL-6), interleukin-18 (IL-18), interleukin-23 (IL-23), endothelin-1 (ET-1), vascular endothelial growth factor (VEGF), and epidermal growth factor (EGF). …”
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Laxative Effect of Lacticaseibacillus rhamnosus Glory LG12: from the Perspective of the Stem Cell Factor/C-kit Signaling Pathway by XIANG Fangqin, LI Yuxing, LI Bailiang

“…In addition, both treatments elevated the serum levels of motilin (MTL), gastrin (Gas), substance P (SP), and interleukin 10 (IL-10), reduced the levels of endothelin-1 (ET-1), somatostatin (SS), vasoactive intestinal peptide (VIP), and IL-6, up-regulated the relative mRNA expression of SCF and C-kit in colonic tissue was (P < 0.01, P < 0.001), and restored damaged colonic barrier. …”
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ET-1 Plasma Levels, Aqueous Flare, and Choroidal Thickness in Patients with Retinitis Pigmentosa by Ernesto Strobbe, Mauro Cellini, Michela Fresina, Emilio C. Campos

“…Purpose. To assess endothelin-1 (ET-1) plasma levels, choroidal thickness, and aqueous flare in patients with early stage retinitis pigmentosa (RP) and to search for possible correlations. …”
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Selenoprotein S Attenuates Tumor Necrosis Factor-α-Induced Dysfunction in Endothelial Cells by Siyuan Cui, Lili Men, Yu Li, Yingshuo Zhong, Shanshan Yu, Fang Li, Jianling Du

“…The levels of TNF-α-induced endothelin-1 and reactive oxygen species are also reduced by the upregulation of SelS. …”
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Using Real World Evidence to Describe Pulmonary Arterial Hypertension Treatment Patterns, Healthcare Resource Utilization, and Costs Associated with PDE-5 Inhibitor Monotherapy by George Ruiz, Jason Yeaw, Cassandra A. Lickert, Ajita P. De, Rolin L. Wade, Janis Pruett, William Drake

“…Research confirms long-term improvement in composite morbidity and mortality endpoints on some endothelin receptor antagonists alone and in combination with phosphodiesterase type 5 inhibitors (PDE-5is) but not with PDE-5i monotherapy. …”
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