Development of Prevascularized Synthetic Block Graft for Maxillofacial Reconstruction by Borvornwut Buranawat, Abeer Shaalan, Devy F. Garna, Lucy Di Silvio

“…The co-culture of endothelial cells (ECs) with human alveolar osteoblasts (aHOBs) on the scaffold led to the formation of tube-like structures and intrinsic VEGF release, reaching 10,455.6 pg/mL This level approached the optimal dose for vascular formation. …”
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The extraction of effective components and an antioxidant activity study of Tulipa edulis by Doudou Zhang, Dong Xiao, Tingting Yin, Shuangzhi Zhao, Olena Zhur, Xun Xiao, Hailun He, Leilei Chen

“…Human umbilical vein endothelial human umbilical vein endothelial cells (HUVEC) cells were treated with 35 mmol/L glucose to construct a model of oxidative stress. …”
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Molecular Modulation of Fetal Liver Hematopoietic Stem Cell Mobilization into Fetal Bone Marrow in Mice by Huihong Zeng, Jiaoqi Cheng, Ying Fan, Yingying Luan, Juan Yang, Feixuan Wang, Shuo Yang, Lijian Shao

“…Components from vascular endothelial cells and bones might also modulate the lodging of fetal liver HSCs into the bone marrow. …”
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Abcg2a is the functional homolog of human ABCG2 expressed at the zebrafish blood–brain barrier by Joanna R. Thomas, William J. E. Frye, Robert W. Robey, Andrew C. Warner, Donna Butcher, Jennifer L. Matta, Tamara C. Morgan, Elijah F. Edmondson, Paula B. Salazar, Suresh V. Ambudkar, Michael M. Gottesman

“…Abstract Background A principal protective component of the mammalian blood–brain barrier (BBB) is the high expression of the multidrug efflux transporters P-glycoprotein (P-gp, encoded by ABCB1) and ABCG2 (encoded by ABCG2) on the lumenal surface of endothelial cells. The zebrafish P-gp homolog Abcb4 is expressed at the BBB and phenocopies human P-gp. …”
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Novel full-thickness biomimetic corneal model for studying pathogenesis and treatment of diabetic keratopathy by Zekai Cui, Xiaoxue Li, Yiwen Ou, Xihao Sun, Jianing Gu, Chengcheng Ding, Zhexiong Yu, Yonglong Guo, Yuqin Liang, Shengru Mao, Jacey Hongjie Ma, Hon Fai Chan, Shibo Tang, Jiansu Chen

“…This study developed a novel biomimetic full-thickness corneal model for the first time, incorporating corneal epithelial cells, stromal cells, endothelial cells, and nerves to simulate DK conditions in vitro. …”
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Scutellarin Prevents Angiogenesis in Diabetic Retinopathy by Downregulating VEGF/ERK/FAK/Src Pathway Signaling by Lingli Long, Yubin Li, Shuang Yu, Xiang Li, Yue Hu, Tengfei Long, Liqin Wang, Wenwen Li, Xiaoxin Ye, Zunfu Ke, Haipeng Xiao

“…This study demonstrates the antiangiogenic effects of scutellarin (SCU) on high glucose- and hypoxia-stimulated human retinal endothelial cells (HRECs) and on a diabetic rat model by oral administration. …”
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Volumetric trans-scale imaging of massive quantity of heterogeneous cell populations in centimeter-wide tissue and embryo by Taro Ichimura, Taishi Kakizuka, Yoshitsugu Taniguchi, Satoshi Ejima, Yuki Sato, Keiko Itano, Kaoru Seiriki, Hitoshi Hashimoto, Ko Sugawara, Hiroya Itoga, Shuichi Onami, Takeharu Nagai

“…We also performed time-lapse imaging of a 1-cm-wide vascular network during quail embryo development for over 24 hr, visualizing the movement of over 4.0×105 vascular endothelial cells and quantitatively analyzing their dynamics. …”
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SARS-CoV-2 infection of human pluripotent stem cell-derived vascular cells reveals smooth muscle cells as key mediators of vascular pathology during infection by Alexsia Richards, Andrew S. Khalil, Max Friesen, Troy W. Whitfield, Xinlei Gao, Tenzin Lungjangwa, Roger D. Kamm, Zhengpeng Wan, Lee Gehrke, David Mooney, Rudolf Jaenisch

“…Here, we develop a model of SARS-CoV-2 infection using human-induced pluripotent stem cell-derived endothelial cells (ECs), pericytes (PCs), and smooth muscle cells (SMCs) to recapitulate the vascular pathology associated with SARS-CoV-2 exposure. …”
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Physically engineered extracellular vesicles targeted delivering miR-21-5p to promote renoprotection after renal ischemia-reperfusion injury by Di Wu, Wenjie Ma, Liucheng Wang, Chengcheng Long, Silin Chen, Jingyu Liu, Yiguan Qian, Jun Zhao, Changcheng Zhou, Ruipeng Jia

“…Moreover, N-EVs effectively promoted the proliferation, migration, and tube-formation abilities of injured endothelial cells (ECs) and contributed to overall renal function improvement in IRI kidneys through targeted delivery of miR-21-5p. …”
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Single-Cell RNA Sequencing Reveals Macrophage Dynamics During MASH in <i>Leptin</i>-Deficient Rats by Xiaoming Xin, Yaohua Ni, Jing Wang, Fenglin Wu, Meichen Liu, Lingjuan Wu, Jiaxing Dai, Chenglin Wu, Xiaolei Song, Wang Zhang, Guangrui Yang, Ruling Shen, Xianmin Zhu

“…By scRNA-seq, we found an increase in the number of macrophages and endothelial cells and a decrease in that of NK and B cells. …”
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Single-cell RNA sequencing reveals intrahepatic signature related to pathobiology of duck hepatitis A virus type 3 (DHAV-3) infection by Yunsheng Zhang, Dingbang Ding, Shaofei Li, Qiong Pan, Jinlong Ru, Haonan Zhao, Guang Yao, Jie Wei, Shuaiqin Wang, Shuisheng Hou, Xia Wang

“…We identified significant dysregulation of various genes in complement and coagulation cascades in hepatocytes2 exclusive to S ducks, together with over-secretion of ANGPTL4 from endothelial cells in S ducks which is confirmed to promote cellular migration, suggesting etiology of coagulopathic complications in ducks with severe DVH. …”
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Exosomes Derived from SW480-Resistant Colon Cancer Cells Are Promote Angiogenesis via BMP-2/Smad5 Signaling Pathway by Song Yang, Lei Yao, Xiaolong Wang, Hao Sun, Chaogang Du, Chengpeng Song, Jingyu Fu, Yongjun Wu, Hongwu Huang, Chuansi Wang, Yongsen Wang, Yixiang Xie

“…The CCK-8 assay, migration assay, tube formation assay, qPCR, and Western blotting were performed in human umbilical vein endothelial cells (HUVECs). The underlying mechanisms were detected by Western blotting assays and BMP-2 si-RNA silencing assay in vitro and in vivo. …”
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Hyperglycemia Does Not Affect Iron Mediated Toxicity of Cultured Endothelial and Renal Tubular Epithelial Cells: Influence of L-Carnosine by Shiqi Zhang, Emmanouil Ntasis, Sarah Kabtni, Jaap van den Born, Gerjan Navis, Stephan J. L. Bakker, Bernhard K. Krämer, Benito A. Yard, Sibylle J. Hauske

“…We sought to assess if high glucose (HG) exposure makes cultured human umbilical vein endothelial cells (HUVECs) and renal proximal tubular epithelial cells (PTECs) more susceptible to metal induced toxicity and if this is ameliorated by L-carnosine. …”
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Effects of metal ion implantation (Fe, Ti, Zn and Zr) on mechanical properties, corrosion resistance and biocompatibility of WE43 Mg alloy by Lianhui Li, Zhiqiang Zhang, Dechuang Zhang, Fugang Qi, Yilong Dai, Wenwen Wei, Xiaoping Ouyang

“…Moreover, the alloys implanted with Fe, Ti and Zn ions significantly promoted proliferation of human umbilical vein endothelial cells (HUVEC) compared with the unmodified alloy. …”
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Generalized lymphatic anomaly in a pediatric patient manifesting as a rare presentation of hemorrhagic pleural effusion: a case report by Xuehong Zhang, Jiuling Wang, Shouxing Duan, Yongping Yan, Libin Wang

“…The mass in the left mediastinum was removed, and pathological examination confirmed hyperplasia and expansion of the papillary endothelial cells within the lymphatic vessels. After intensive anti-infection therapy and symptomatic and supportive treatment, the patient’s condition improved significantly. …”
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Understanding Cardiovascular Events With JAK Inhibitors: Tofacitinib Reduces Synovial and Vascular Inflammation but not the Prothrombotic Effects of Inflammatory Cytokines on Endot... by Aliki Zavoriti, Pierre Miossec

“…Methods Activated human peripheral blood mononuclear cells (PBMCs) were cocultured with RA synoviocytes or endothelial cells (ECs) mimicking the cellular interactions in synovium and vessels responsible for cytokine production. …”
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First International Conference on Lysophospholipids and Related Bioactive Lipids in Biology and Disease Sponsored by the Federation of American Societies of Experimental Biology by Edward J. Goetzl, Gabor J. Tigyi, Timothy Hla

“…The receptor subfamilies formerly were designated endothelial differentiation gene-encoded receptors or Edg Rs for their original discovery in endothelial cells. A currently active nomenclature committee at this conference suggested the ligand-based names: S1P1 = Edg-1, S1P2 = Edg-5, S1P3 = Edg-3, S1P4 = Edg-6, and S1P5 = Edg-8; LPA1 = Edg-2, LPA2 = Edg-4, and LPA3 = Edg-7 receptors. …”
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Early detection of canine hemangiosarcoma via cfDNA fragmentation and copy number alterations in liquid biopsies using machine learning by Soohyun Ko, Jinhee Jang, Sun Shin Yi, Sun Shin Yi, ChangHyuk Kwon

“…Hemangiosarcoma is a highly malignant tumor commonly affecting canines, originating from endothelial cells that line blood vessels, underscoring the importance of early detection. …”
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Tc-Labeled Cyclic RGD Peptides for Noninvasive Monitoring of Tumor Integrin αβ Expression by Yang Zhou, Young-Seung Kim, Sudipta Chakraborty, Jiyun Shi, Haijuan Gao, Shuang Liu

“…On the basis of these, it was concluded that radiotracer tumor uptake is contributed by integrin α V β 3 expressed on tumor cells and activated endothelial cells of the tumor neovasculature. 99m Tc-3P-RGD 2 has the capability to monitor integrin α v β 3 expression in a noninvasive fashion.…”
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Neuroblastoma-derived hypoxic extracellular vesicles promote metastatic dissemination in a zebrafish model. by Anna Fietta, Pina Fusco, Giuseppe Germano, Sara Micheli, Marco Sorgato, Giovanni Lucchetta, Elisa Cimetta

“…We first demonstrated that EVs released under hypoxic conditions promote angiogenesis and are more easily internalized by endothelial cells than those purified from normoxic cells. …”
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