Reactive Oxygen Species, a Potential Therapeutic Target for Vascular Dementia by Amanda Louise White, Grant M. Talkington, Blake Ouvrier, Saifudeen Ismael, Rebecca J. Solch-Ottaiano, Gregory Bix

“…VaD has been shown to develop when reactive oxygen species (ROS) form from damaged targets at different levels of organization—mitochondria, endothelial cells, or cerebrovasculature. In this review, we highlight how specific ROS molecules may be important in the development of VaD and how they can be targeted as a potential therapeutic for VaD.…”
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New approach to modeling of antiangiogenic treatment on the basis of Hahnfeldt et al. model by Jan Poleszczuk, Marek Bodnar, Urszula Foryś

“…However, in our opinion the formulation of that model is valid only for the antivascular treatment, that is treatment that is focused on destroying endothelial cells. Therefore, we propose a modification of the original model which is valid in the case of the antiangiogenic treatment, that is treatment which is focused on blocking angiogenic signaling. …”
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TMA Vessel Segmentation Based on Color and Morphological Features: Application to Angiogenesis Research by M. Milagro Fernández-Carrobles, Irene Tadeo, Gloria Bueno, Rosa Noguera, Oscar Déniz, Jesús Salido, Marcial García-Rojo

“…The tool also improves the accuracy of vascular density measurements, since the set of endothelial cells forming a vessel is considered as a single object.…”
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Masson’s Tumor of the Hand: An Uncommon Histopathological Entity by Parviz Mardani, Amir Askari, Reza Shahriarirad, Keivan Ranjbar, Amirhossein Erfani, Mohammad Hossein Anbardar, Shirin Moradmand

“…The microscopic section demonstrated the papillary proliferation of endothelial cells in favor of Masson’s hemangioma, which was sufficiently treated with excision alone.…”
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Protocol to generate a 3D atherogenesis-on-chip model for studying endothelial-macrophage crosstalk in atherogenesis by Katie M.L. Hanford, Kim E. Dzobo, Miranda Versloot, Jorge Peter, Jeffrey Kroon

“…We describe a model for studying endothelial-macrophage interactions during atherogenesis in human aortic endothelial cells and human macrophages using qPCR and secretome analysis, fluorescence microscopy, and flow cytometry. …”
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Leukocyte Adhesion Molecules in Diabetic Retinopathy by Kousuke Noda, Shintaro Nakao, Susumu Ishida, Tatsuro Ishibashi

“…During inflammation leukocytes undergo sequential adhesive interactions with endothelial cells to migrate into the inflamed tissues, a process known as the “leukocyte recruitment cascade” which is orchestrated by precise adhesion molecule expression on the cell surface of leukocytes and the endothelium. …”
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Annexin A8 deficiency delays atherosclerosis progression by Carmen Gutiérrez‐Muñoz, Rafael Blázquez‐Serra, Irene San Sebastian‐Jaraba, Sandra Sanz‐Andrea, Maria J. Fernández‐Gómez, Gonzalo Nuñez‐Moreno, Pablo Mínguez, Joan Carles Escolá‐Gil, Paula Nogales, Veronique Ollivier, Jose L. Martín‐Ventura, Benoit Ho‐Tin Noe, Ursula Rescher, Nerea Méndez‐Barbero, Luis M. Blanco‐Colio

“…Interventions capable of reducing AnxA8 expression in endothelial cells may delay atherosclerotic plaque progression. …”
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Markers of vascular autoregulation in primary open-angle glaucoma by N.E. Fomin, A.V. Kuroyedov

“…VEGF is a multifunctional cytokine which provides mitogenic effects on endothelial cells and monocytes/macrophages due to the presence of surface VEGF receptors on these cells. …”
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hnRNPA2/B1 Ameliorates LPS-Induced Endothelial Injury through NF-κB Pathway and VE-Cadherin/β-Catenin Signaling Modulation In Vitro by Yi Chen, Dan Tang, Linjie Zhu, Tianjie Yuan, Yingfu Jiao, Hexin Yan, Weifeng Yu

“…However, the effect of hnRNPA2/B1 on injured endothelial cells (ECs) remains unclear. We investigated the effect of hnRNPA2/B1 on lipopolysaccharide- (LPS-) induced vascular endothelial injury in human umbilical vein endothelial cells (HUVECs) and the underlying mechanisms. …”
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β-Endorphin Mediates the Development and Instability of Atherosclerotic Plaques by Taisuke Okano, Kengo Sato, Remina Shirai, Tomomi Seki, Koichiro Shibata, Tomoyuki Yamashita, Ayaka Koide, Hitomi Tezuka, Yusaku Mori, Tsutomu Hirano, Takuya Watanabe

“…We assessed the effects of β-endorphin on the inflammatory response and monocyte adhesion in human umbilical vein endothelial cells (HUVECs), foam cell formation, and the inflammatory phenotype in THP-1 monocyte-derived macrophages, and migration and proliferation of human aortic smooth muscle cells (HASMCs) in vitro. …”
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Angiogenesis and Its Therapeutic Opportunities by So Young Yoo, Sang Mo Kwon

“…The sophisticated multistep process is tightly regulated in a spatial and temporal manner by “on-off switch signals” between angiogenic factors, extracellular matrix components, and endothelial cells. Uncontrolled angiogenesis may lead to several angiogenic disorders, including vascular insufficiency (myocardial or critical limb ischemia) and vascular overgrowth (hemangiomas, vascularized tumors, and retinopathies). …”
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Modulation of Immunity by Antiangiogenic Molecules in Cancer by Magali Terme, Orianne Colussi, Elie Marcheteau, Corinne Tanchot, Eric Tartour, Julien Taieb

“…These antiangiogenic molecules, which target VEGF or VEGFR, PDGFR, and c-kit, can act not only on endothelial cells but also on immune cells. Some antiangiogenic molecules inhibit the development of immunosuppressive mechanisms developed by the tumors to escape the immune system (such as regulatory T cells, myeloid-derived suppressor cells, and immunosuppressive cytokines). …”
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Nicotine addiction is the main risk factor for the formation and development of chronic obstructive pulmonary disease: A review by Anna V. Dzyubailo, Viacheslav S. Lotkov

“…The article considers the issue of studying the effect of nicotine dependence on the development of chronic obstructive pulmonary disease, as the main factor in the formation of inflammation mediated through the use of tobacco-containing, as well as alternative tobacco products, not only the epithelium of the bronchi, but also the endothelial cells of large and small vessels. Morphological changes in bronchopulmonary structures lead to pronounced tissue hypoxia, which in turn aggravates the course of the underlying disease, leads to the formation of concomitant pathology in the form of cardiovascular diseases, pathology of blood rheology, increased risks of thrombosis. …”
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Cannabinoids and the endocannabinoid system in liver diseases by Anna Parfieniuk-Kowerda, Diana Martonik, Aleksandra Andrzejuk, Aleksander Tarasik, Robert Flisiak

“…Their expression in myofibroblasts and liver endothelial cells is reported to be elevated in chronic liver diseases. …”
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Sepsis, leukocytes, cytokines and disseminated intravascular coagulation by Ramazan Çöl, Zafer Durgun

“…Cytokines such as tumor necrosis factor* a (TNF-a) and inlerleukin-1 3 (IL-1 P) activate monocytes, neutrophils and endothelial cells. Inflammatory cytokines initate coagulation mechanism by converting endothelium from an antithrombotic surface to a prothrombotic surface. …”
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Masson's tumor of the parotid gland: A case report and literature review by Fawaz Alotaibi, Abdulrahman Hesham, Marwa Hatem, Yousef Alshamrani, Areil Cuevas Ocampo, Chinedum Okafor

“…Masson's tumor, also known as intravascular papillary endothelial hyperplasia (IPEH), is a rare benign vascular lesion characterized by an abnormal proliferation of endothelial cells within blood vessels, forming papillary structures that can occur in various parts of the body, including the parotid gland. …”
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Generation of human induced pluripotent stem cell lines (iPSC) from adipose-derived mesenchymal stromal cells from two patients with systemic sclerosis by Mélanie Velier, Romain Appay, Robin Arcani, Romain Desprat, Stéphanie Simoncini, Anouck Zavarro, Danièle Noel, Lenha Bendaass, Christian Jorgensen, Quentin Gomes De Pinho, Audrey Benyamine, Brigitte Granel, Aurélie Daumas, Francoise Dignat George, Florence Sabatier, Jérémy Magalon

“…These SSc-specific iPSC lines can be differentiated into endothelial cells, providing a valuable model to elucidate vascular dysfunction and develop personalized therapeutic approaches.…”
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Association of Toll-Like Receptor Signaling and Reactive Oxygen Species: A Potential Therapeutic Target for Posttrauma Acute Lung Injury by Meng Xiang, Janet Fan, Jie Fan

“…Recent studies have reported that the mechanism underlying the priming of pulmonary inflammation involves the complicated cross-talk between Toll-like receptors (TLRs) and interactions between neutrophils (PMNs) and alveolar macrophages (AMϕ) as well as endothelial cells (ECs), in which reactive oxygen species (ROS) are the key mediator. …”
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Caffeine's Vascular Mechanisms of Action by Darío Echeverri, Félix R. Montes, Mariana Cabrera, Angélica Galán, Angélica Prieto

“…Caffeine is a xanthine with various effects and mechanisms of action in vascular tissue. In endothelial cells, it increases intracellular calcium stimulating the production of nitric oxide through the expression of the endothelial nitric oxide synthase enzyme. …”
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Disturbed shear stress promotes atherosclerosis through TRIM21‐regulated MAPK6 degradation and consequent endothelial inflammation by Feng Wang, Shu‐Yu Wang, Yue Gu, Shuai Luo, Ai‐Qun Chen, Chao‐Hua Kong, Wen‐Ying Zhou, Li‐Guo Wang, Zhi‐Mei Wang, Guang‐Feng Zuo, Xiao‐Fei Gao, Jun‐Jie Zhang, Shao‐Liang Chen

“…Key points Disturbed flow activates the ubiquitin‒proteasome degradation pathway of MAPK6 in endothelial cells, which is contingent on the binding of the ubiquitin ligase TRIM21 to MAPK6. …”
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