Therapeutic depletion of CCR8+ tumor-infiltrating regulatory T cells elicits antitumor immunity and synergizes with anti-PD-1 therapy by James Dooley, Bart Neyns, Elizabeth Allen, Frank Tacke, Louis Boon, Damya Laoui, Julia Katharina Schwarze, Helena Van Damme, Bruno Dombrecht, Máté Kiss, Heleen Roose, Eva Van Overmeire, Daliya Kancheva, Liesbet Martens, Aleksandar Murgaski, Pauline Madeleine Rachel Bardet, Gillian Blancke, Maude Jans, Evangelia Bolli, Maria Solange Martins, Yvon Elkrim, Kiavash Movahedi, Niels Vandamme, Sebahat Ocak, Isabelle Scheyltjens, Lars Vereecke, Frank Aboubakar Nana, Pascal Merchiers, Jo Agnes Van Ginderachter

“…Background Modulation and depletion strategies of regulatory T cells (Tregs) constitute valid approaches in antitumor immunotherapy but suffer from severe adverse effects due to their lack of selectivity for the tumor-infiltrating (ti-)Treg population, indicating the need for a ti-Treg specific biomarker.Methods We employed single-cell RNA-sequencing in a mouse model of non-small cell lung carcinoma (NSCLC) to obtain a comprehensive overview of the tumor-infiltrating T-cell compartment, with a focus on ti-Treg subpopulations. …”
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The Impact of Acute Aerobic Exercise on General and Food-Related Inhibitory Function Among Young Adults with Obesity: An Event-Related Potential (ERP) Study by Chun Xie, Tao Huang, Yingying Wang, Peisi Wang, Yanxia Chen, Jiali Qian, Guozhuang Chen, Kun Wang

“…<b>Design</b>: A within-subject design comprising three sessions (control, low-intensity exercise, moderate-intensity exercise) × three picture types (high-calorie food, low-calorie food, neutral picture) was employed. <b>Methods</b>: Eighteen young adult males with obesity [body mass index (BMI): 34.60 ± 4.21 kg/m², aged 24.50 ± 5.13 years (Mean ± SD)] were recruited. …”
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Efficacy and safety of PD-1/PD-L1 inhibitors in advanced or recurrent endometrial cancer: a meta-analysis with trial sequential analysis of randomized controlled trials by Ji Ren, Jinghe Wang, Yanan Wang, Dongying Yang, Jianming Sheng, Shili Zhu, Yunli Liu, Xiaoqi Li, Wei Liu, Binbin Zhang

“…To evaluate heterogeneity, we employed Cochran’s Q test, I2 statistics, and 95% prediction intervals (PIs). …”
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Most prevalent jobs of doctoral degree graduates by detailed field of study by Marc Frenette, Tomasz Handler

“…Among the disciplines most highly linked to university professors and lecturers, female doctoral graduates were generally less likely than their male counterparts to be employed as university professors and lecturers. For example, the five disciplines most highly linked to university professors and lecturers among women were business administration and management, general (68.7%); registered nursing/registered nurse (61.0%); social work, general (56.6%); mathematics, general (56.2%); and exercise science and kinesiology (52.7%). …”
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Economic and environmental sustainability of agriculture production at the crop level by A.Z. Bi, K.B. Umesh, B. Md Abdul, D. Sivakumar, P. Srikanth

“…The use of land, water, fertilizer, and pesticides affects production costs and earnings.  Farmers can employ a variety of techniques, including as crop rotation, cover crops, agro forestry, organic farming, carbon sequestration and decreased tillage, which enhance soil health and lessen erosion, to preserve environmental sustainability. …”
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Modeling Factors Influencing Project Financing Risk by Gholamreza Sharafi, Kiamars Fathi Hafashjani, Faegh Ahmadi

“…MethodsTo explore these dynamics, this study employs an objective-oriented approach, leveraging a descriptive-correlational method for data collection. …”
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Predictors of Colorectal Cancer Screening and Screening Modalities among Patients seen at Federally Qualified Health Centers Funded by the United States Health Resources and Servic... by Megan R.M. Aaronson, Nadereh Pourat, Connie Lu, Jayraan Badiee, Helen Yu-Lefler, Benjamin Picillo, Hank Hoang, Folasade P. May

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Effect of chemoradiotherapy on the dynamics of circulating lymphocyte subsets in patients with non-metastatic nasopharyngeal carcinoma by Lilan Yi, Lilan Yi, Yinfang Gu, Yinfang Gu, Longhua Guo, Longhua Guo, Xiaofang Zou, Xiaofang Zou, Guowu Wu, Guowu Wu

“…This study aimed to characterize the dynamics of the proportions and absolute counts of peripheral circulating lymphocyte subsets in non-metastatic NPC before and after CRT, and to elucidate their association with clinical responses.MethodsA total of 91 patients with non-metastatic NPC were enrolled. Flow cytometry was employed to detect the expression of CD3, CD4, CD8, CD56, and CD19 on peripheral blood cells. …”
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Prevalence of common diarrheagenic enterobacteriaceae in Iran (2000–2023): a systematic review and meta-analysis by Mozhgan Derakhshan-Sefidi, Fereshteh Eidy, Somayyeh Nadi-Ravandi, Sareh Bagheri-Josheghani, Maryam Mirfakhraei

“…The criteria did not restrict patient demographics such as age, gender, health conditions, or occupation. This meta-analysis employed a 95% confidence interval (CI) for analysis. …”
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Loose cigarette purchase and adolescent smoking in Indonesia: a mixed-methods study by Vid Adrison, Dian Kusuma, Gea Melinda, Fariza Zahra Kamilah, Syifa Rizki Amelia, Sofwatun Nida

“…Objectives To investigate the relationship between purchasing loose cigarettes and adolescent smoking habits in Indonesia.Design and setting This study employed a mixed-methods sequential explanatory design. …”
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Outcome Mapping as a Monitoring and Evaluation Tool for Livestock Value Chain Interventions: The Case of imGoats by Hailemichael Taye Beyene, Kees Swaans, Birgit Boogaard, Ramkumar Bendapudi, Saskia Hendrickx

“…Intervention:  The project employed value chain (VC) and Innovations Systems (IS) approaches rather than traditional methods of technology transfer. …”
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Nitidine chloride inhibits the progression of hepatocellular carcinoma by suppressing IGF2BP3 and modulates metabolic pathways in an m6A-dependent manner by Dan-dan Xiong, Zhen-dong Chen, Jian-di Li, Yu-long Deng, Rong-quan He, Zhi-guang Huang, San-qi An, Yi-wu Dang, Gang Chen

“…Results In this study, utilizing HCC cell and zebrafish xenograft models, we validated NC’s ability to inhibit the growth, metastasis, and angiogenesis of HCC. Subsequently, employing RNA sequencing, RT-qPCR, WB, molecular docking, MD simulation, SPR, and CCK8 off-target assays, we pinpointed IGF2BP3 as a direct target of NC. …”
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Pemilihan Strategi Implementasi Kesehatan Digital Pada Kelompok Pengambil Keputusan Menggunakan Metode Vikor by Sri Kusumadewi, Rahadian Kurniawan

“…The geometric average was employed to determine the weight composition of the five decision-makers. …”
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The relationship between social support and depression among older adults with hypertension in urban communities: mediating effects of coping styles by Dan Li, Jin-Hua Jie, Hong Li, Xue-Mei Xia, Yilin Zhang, Yilin Zhang, Yan Yang, Yan Yang, Jianjun Xiang, Jianjun Xiang, Jianjun Xiang, Hai-Lin Zhuang

“…Pearson correlation analysis was employed to test the correlation between variables. …”
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Oncolytic influenza virus enhances killing effect of gemcitabine against pancreatic cancer cells by MENG Zihe, MENG Zihe, XU Yongru, DENG Zhaoda

“…Multi-immunofluorescence staining was employed to analyze T cell infiltration and proliferation in the tumor tissues. …”
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Association and Interaction Analysis of Lipid Accumulation Product with Impaired Fasting Glucose Risk: A Cross-Sectional Survey by Jian Song, Xue Chen, Yuhong Jiang, Jing Mi, Yuyuan Zhang, Yingying Zhao, Xuesen Wu, Huaiquan Gao

“…The assessment of interactive effects was conducted by employing the three indicators as follows: (1) RERI (the relative excess risk due to interaction), (2) AP (attributable proportion due to interaction), and (3) SI (synergy index). …”
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Myocardial Infarction-Associated Shock: A Comprehensive Analysis of Phenotypes, SCAI Classification, and Outcome Assessment by Stanislav Dil, Maria Kercheva, Oleg Panteleev, Sergey Demianov, Aleksandr Kanev, Nina Belich, Boris Kornienko, Vyacheslav Ryabov

“…Logistic regression analysis was employed to identify predictors of mortality and improved survival outcomes. …”
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أسلوب التعامل مع الخلافات الفقهية: مراجعة كتاب الموافقات للإمام الشاطبي. دار الكتب العلمية، ٢٠٠٥، ٥٨٠ صفحة، ISBN: ٢-٧٤٥١-١٥٣٠-٨، (غلاف صلب)... by Muhammad Najib Abdullah, Muhammad Nazir Alias, Syaryanti Hussin, Ibrahim Zakariyya Moosa

“…This study examines the efforts of Imam al-Shātibī in reconciling the viewpoints of jurists and legal theorists on issues amenable to convergence and unity, and his proposed approach to dealing with madhhab (school of thought) differences, through an analysis of his seminal work "al-Muwāfaqāt fī Uṣūl al-Sharīcah". This study employs an inductive-analytical approach, tracing and analyzing the relevant content in al-Shātibī's al-Muwāfaqāt, as well as a comparative method to contrast Imam al-Shatibi's views with those of others, in order to highlight his contributions and limitations, and validate the findings. …”
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Association of dietary quality and mortality in the non-alcoholic fatty liver disease and advanced fibrosis populations: NHANES 2005–2018 by Xingyong Huang, Xiaoyue Zhang, Xuanyu Hao, Tingting Wang, Peng Wu, Lufan Shen, Yuanyuan Yang, Wenyu Wan, Wenyu Wan, Wenyu Wan, Kai Zhang

“…Weighted Cox proportional hazard regression models along with restricted cubic splines and subgroup analyses were employed in this study.ResultsThe analysis encompassed 3,634 NAFLD patients. …”
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A novel α-conotoxin [D1G, ΔQ14] LvIC decreased mouse locomotor activity by Wen Wang, Wen Wang, Meiting Wang, Huanbai Wang, Weifeng Xu, Conggang Wang, Jie Pei, Xiaodan Li, Dongting Zhangsun, Dongting Zhangsun

“…To investigate the molecular alterations in the mice’s brains, untargeted metabolomics and label-free Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) were employed. Subsequently, Western blot (WB) and quantitative reverse transcription PCR (RT-qPCR) techniques were utilized to detect specific molecular changes induced by [D1G, ΔQ14] LvIC.ResultsThe injection of [D1G, ΔQ14] LvIC led to a decrease in locomotor activity in mice. …”
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