Disproportionality analysis of upadacitinib-related adverse events in inflammatory bowel disease using the FDA adverse event reporting system by Shiyi Wang, Xiaojian Wang, Jing Ding, Xudong Zhang, Hongmei Zhu, Yihong Fan, Changbo Sun

“…This study evaluates upadacitinib-related adverse events (AEs) utilizing data from the US Food and Drug Administration Adverse Event Reporting System (FAERS).MethodsWe employed disproportionality analyses, including the proportional reporting ratio (PRR), reporting odds ratio (ROR), Bayesian confidence propagation neural network (BCPNN), and empirical Bayesian geometric mean (EBGM) algorithms to identify signals of upadacitinib-associated AEs for treating inflammatory bowel disease (IBD).ResultsFrom a total of 7,037,004 adverse event reports sourced from the FAERS database, 37,822 identified upadacitinib as the primary suspect drug in adverse drug events (ADEs), including 1,917 reports specifically related to the treatment of inflammatory bowel disease (IBD). …”
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Associations of combined exposure to selected metal mixtures with thyroid hormones in children: a cross-sectional study in China by Yuhan Cao, Shiting Xiang, Yuwei Du, Meiling Chen, Rumeng Xue, Qi Li, Jun Qiu, Yanying Duan

“…Generalized linear regression (GLR) model and Quantile-based g-computation (QGC) were employed to estimate the association between metal exposure and thyroid hormone homeostasis.ResultsGLR model showed that a unit increase in ln-transformed Fe was associated with increases in TT3 (β = 0.163; PFDR < 0.001), TT4 (β = 12.255; PFDR < 0.001) and FT3 (β = 0.615; PFDR < 0.001), as well as decreases in TSH (β = −0.471; PFDR = 0.005) and FT4 (β = −1.938; PFDR < 0.001). …”
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Comparative Evaluation of AI-Based Multi-Spectral Imaging and PCR-Based Assays for Early Detection of <i>Botrytis cinerea</i> Infection on Pepper Plants by Dimitrios Kapetas, Eleni Kalogeropoulou, Panagiotis Christakakis, Christos Klaridopoulos, Eleftheria Maria Pechlivani

“…However, symptoms often appear after the pathogen has begun to spread. This study employs the Deep Learning algorithm YOLO for single-class segmentation on plant images to extract spatial details of pepper leaves. …”
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Correcting forest aboveground biomass biases by incorporating independent canopy height retrieval with conventional machine learning models using GEDI and ICESat-2 data by Biao Zhang, Zhichao Wang, Tiantian Ma, Zhihao Wang, Hao Li, Wenxu Ji, Mingyang He, Ao Jiao, Zhongke Feng

“…Random Forest (RF) and Monte Carlo-based uncertainty analysis were employed to evaluate the most suitable spaceborne LiDAR dataset for CH estimation. …”
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Exosomes and their distinct integrins transfer the characteristics of oxaliplatin- and 5-FU-resistant behaviors in colorectal cancer cells by Zeynab Vakili-Ghartavol, Hoda Deli, Amir Shadboorestan, Roxana Sahebnasagh, Elahe Motevaseli, Mohammad Hossein Ghahremani

“…Western blot analysis was employed to identify exosomal markers. The effects of exosomes on parental cells were examined using various methods, including MTT assay for proliferation, wound healing assay for migration, flow cytometry for cell cycle and apoptosis analysis, Matrigel-coated transwell inserts for invasion, and western blot for integrin expression evaluation. …”
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Determinants of Anemia among HIV-Positive Children on Highly Active Antiretroviral Therapy Attending Hospitals of North Wollo Zone, Amhara Region, Ethiopia, 2019: A Case-Control St... by Biruk Beletew, Ayelign Mengesha, Mohammed Ahmed, Awet Fitwi, Mesfin Wudu

“…An adapted, interviewer-administered, and pretested questionnaire and chart review were employed to collect the data. Besides, blood and stool samples were investigated to determine hematologic indices and malaria and to investigate intestinal parasites, respectively. …”
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Is the topical application of sesame oil (Sesamum indicum L.) combined with standard care valuable and safe for managing infusion-related phlebitis: Evidence from a systematic revi... by Morteza Nasiri, Leila Amirmohseni, Mohammad Farzollah Abbasi, Fatemeh Yarahmadi, Sahar Zonoori, Mahya Torkaman, Elham Sadeghi Moghimi, Mehrnaz Ardaneh, Masoomeh Asadi

“…The Cochrane risk-of-bias tool and GRADE framework were employed to appraise the quality of the evidence. Results: Eight studies of 755 records in the initial search met the inclusion criteria, which investigated inpatients and/or outpatients with chemotherapy-induced phlebitis (n = 6) and amiodarone-induced phlebitis (n = 2). …”
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Chromium "(VI)" phytoremediation using Azolla pinnata: effects on Vicia faba growth, physiology, cytogenetics, and gene expression profiling by Elham R. S. Soliman, Kareem Moustafa, Mohamed Khamis, Zeinab A. Shedeed

“…In the present investigation, Azolla pinnata, a pteridophyte (fern), was employed to phytoremediate Cr (VI) from chromium-polluted water. …”
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On the tracks of an uninvited guest, the Asian tiger mosquito, Aedes albopictus in Cyprus by Riccardo Piccinno, Giulia Fiorenza, Marlen Ines Vasquez, Jeremy Bouyer, Gregoris Notarides, Ludvik Marcus Gomulski, Soteris Meletiou, Mustafa Akiner, Antonios Michaelakis, Federico Forneris, Giovanni Maga, Giuliano Gasperi, Anna Rodolfa Malacrida

“…Bayesian clustering analyses using STRUCTURE and BayesAss version 3 were employed to derive information on the degree of ancestry among Cypriot and Mediterranean mosquitoes and on recent mosquito movements both within Cyprus and between Cyprus and the Central Mediterranean areas. …”
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Identification of potential druggable targets for endometriosis through Mendelian randomization analysis by Peng Chen, Xin Wei, Xiao-Ke Li, Yi-Hang Zhou, Yi-Hang Zhou, Qi-Fang Liu, Ling Ou-Yang

“…Although hormonal therapies are frequently employed for EM, their side effects and outcome limitations underscore the need to explore the genetic basis and potential drug targets for developing innovative therapeutic approaches. …”
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Historical snow measurements in the central and southern Apennine Mountains: climatology, variability, and trend by V. Capozzi, F. Serrapica, A. Rocco, C. Annella, C. Annella, G. Budillon

“…Subsequently, focusing on the number of days with snowfall and snow cover duration on the ground, we have carried out a linear trend analysis, employing the Theil–Sen estimator and the Mann–Kendall test. …”
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Combinatorial functionomics identifies HDAC6-dependent molecular vulnerability of radioresistant head and neck cancer by Sharon Pei Yi Chan, Celestia Pei Xuan Yeo, Boon Hao Hong, Evelyn Mui Cheng Tan, Chaw Yee Beh, Eugenia Li Ling Yeo, Dennis Jun Jie Poon, Pek Lim Chu, Khee Chee Soo, Melvin Lee Kiang Chua, Edward Kai-Hua Chow

“…Comparative transcriptomic analyses were employed to determine the prognostic significance of targeting HDAC6. …”
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Assessment of borehole water quality in Nwadzekudzeku village, Giyani, Limpopo Province, South Africa: Implication for potential human health risks by Tsakane Patience Maluleke, Sifelani Dube, Emmanuel Daanoba Sunkari, Abayneh Ataro Ambushe

“…A multi-methods approach involving water quality analysis, geospatial mapping, multivariate statistical analysis, and human health risk analysis were employed in this study. Results and Discussion: The results showed that borehole water had a pH ranging from 6.96 - 7.76, an electrical conductivity (EC) of 132 - 2740 µS.cm−1, total dissolved solids (TDS) of 381 - 1336 mg.L−1, resistivity in the range of 62 - 1030 Ω, salinity from 0.32 - 1.34 ppt and an oxidation–reduction potential (ORP) of 9.20 - 233 mV. …”
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Late-season source limitation practices to cope with climate change: delaying ripening and improving colour of Cabernet-Sauvignon grapes and wine in a hot and arid climate by Luca Pallotti, Guadalupe Partida, Eve Laroche-Pinel, Vania Lanari, Miguel Pedroza, Luca Brillante

“…However, it is essential to avoid grape overexposure by employing the appropriate techniques to ensure grape quality is not compromised. …”
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Exploring the upper ocean characteristics of a bay using coastal and regional ocean community model by D. Jaishree, P.T. Ravichandran

“…To accomplish this, advanced high-resolution numerical simulations were employed, utilizing the coastal and regional ocean community model. …”
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Use of supervised and unsupervised approaches to make zonal application maps for variable-rate application of crop growth regulators in commercial cotton fields by Maria C. da S. Andrea, Cristiano F. de Oliveira, Fabrícia C. M. Mota, Rafael C. dos Santos, Edilson F. Rodrigues Junior, Lucas M. Bianchi, Rodrigo S. de Oliveira, Caio M. de Gouveia, Victor G. S. Barbosa, Marco A. Bispo E Silva

“…During 2022–2023 agricultural seasons, an UF was employed to generate zonal maps based on locally collected field data on plant height of cotton, satellite imagery, soil texture, and phenology data. …”
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Spatial and social relevance perceptions by pre-service teachers of learning about oil palm management as a local or nonlocal socioscientific issue by Finn Kristen Matthiesen, Gina Nolte, Finn Rehling, I Gede Arjana, Lola Utama Sitompul, Upik Yelianti, Susanne Bögeholz, Susanne Bögeholz

“…We followed a mixed-method approach, employing measurements of utility value. Utility value is a specific construct of perceived relevance, which refers to the usefulness of learning about objects for a person's life, profession, and society. …”
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Lifestyle risk factors for overweight and obesity among rural Indian adults: a community-based prospective cohort study by Rajesh Kumar Rai, Sabri Bromage, Jan-Walter De Neve, Anamitra Barik

“…Modified Poisson regression model was employed to attain the study objective. From 2017–2018 to 2022–2023, the prevalence of overweight/obesity increased from 15.2% (95% CI: 14.1%–16.4%) to 21.0% (95% CI: 19.7%–22.3%) among men and from 24.1% (95% CI: 22.9%–25.2%) to 33.8% (95% CI: 32.5%–35.1%) among women. …”
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Machine learning prediction of anxiety symptoms in social anxiety disorder: utilizing multimodal data from virtual reality sessions by Jin-Hyun Park, Yu-Bin Shin, Dooyoung Jung, Ji-Won Hur, Seung Pil Pack, Heon-Jeong Lee, Hwamin Lee, Chul-Hyun Cho, Chul-Hyun Cho

“…It utilized multimodal (physiological and acoustic) data from VR sessions to simulate social anxiety scenarios. This study employed extended Geneva minimalistic acoustic parameter set for acoustic feature extraction and extracted statistical attributes from time series-based physiological responses. …”
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Bio-ecological characteristics of Malus genus species in the context of prospective directions in horticulture and landscape forestry by Tetiana Moskalets, Oleksandr Kratiuk, Mariana Ivankiv, Sergii Shevchenko, Nataliia Shevchuk

“…The study aimed to conduct a comparative assessment of representatives of the genus Malus based on morphological traits, biological characteristics, physiological mechanisms of resistance to fungal pathogens, ornamental value, and significance within the frameworks of horticulture, landscape forestry, and shelterbelt afforestation. Employing an integrative approach, the research examined the morphological traits and biological characteristics of domestic apple, European wild apple, Siberian crab apple, hybrid crab apple, and plum-leaved apple. …”
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