Elevation of ganglioside degradation pathway drives GM2 and GM3 within amyloid plaques in a transgenic mouse model of Alzheimer's disease by Wenxuan Wang, Sarah J. Myers, Nikita Ollen-Bittle, Shawn N. Whitehead

“…To address this gap, matrix-assisted laser desorption/ionization (MALDI) mass spectrometry imaging (MSI) was employed to investigate the age-dependent expression profiles of the A-series ganglioside species GD1a, GM1, GM2, and GM3 in the APP/PS1 transgenic mouse model of AD in which age-dependent amyloid-beta (Aβ) plaques develop. …”
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Explaining the Antecedents and Consequences of the Glass Cliff in Service Organizations by Sara Kavoosi, Ali Safari, Ali Shaemi Barzoki

“…Methods The research is developmental in its intent and employs a mixed-methods sequential exploratory design, integrating both qualitative and quantitative approaches. …”
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Derivation of a simple risk calculator for predicting clinical worsening in patients with pulmonary hypertension due to interstitial lung disease by K. El-Kersh, R. Bag, N. Bhatt, C. King, A. Waxman, F. Rischard, H. Kim, D. Cella, E. Shen, SD Nathan

“…The calculators are easy to employ in clinical practice, since they utilize assessments commonly collected in the care of patients with ILD-PH. …”
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Association between the atherogenic index of plasma and non-alcoholic fatty liver disease in Korean pregnant women: secondary analysis of a prospective cohort study by Rong Shuai, Yuxing He, Dongqian Yang, Yingying Zhang, Li Zhang

“…Restricted cubic spline (RCS) curve fitting was employed to investigate potential non-linear associations.ResultsAfter excluding data on missing variables, 586 singleton pregnant women were finally included. …”
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Prescription pattern, glycemic control status, and predictors of poor glycemic control among diabetic patients with comorbid chronic kidney disease in Ethiopia: a facility-based cr... by Oumer Sada Muhammed, Minimize Hassen, Samuel Mamusha

“…Descriptive statistics was employed for analyzing quantitative variables. Logistic regression analysis was performed to identify predictors of poor glycemic control status. …”
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Association of blood manganese and selenium levels with hepatic steatosis among adolescents: a nationwide cross-sectional analysis by Bin You, Bin You, Bin You, Bin You, Zhiyuan Chen, Zhiyuan Chen, Zhiyuan Chen, Zhiyuan Chen

“…Multivariate logistic regression models were used to assess the associations between blood manganese and selenium levels and hepatic steatosis, while restricted cubic splines (RCS) were employed to examine the dose-response relationships.ResultsThe mean age of the participants was 15.37 years, with 52.22% boy. …”
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Magnitude and Factors Associated with Precervical Cancer among Screened Women in Southern Ethiopia by Terefu Teka, Mesfin Kote, Gemechu Kejela, Tagel Getachew

“…After cleaning the data, descriptive analysis was done and multivariable logistic regression model was employed to identify predictors of precervical cancer. …”
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Transcriptome Analysis of Effect of Cordyceps militaris Aqueous Extract in Human Gastric Cancer Cell BGC-823 on Different RCD Pathways by Mingqi CUI, Kaiwen YU, Yang SONG, Fangxu XU, Shenghou WANG, Ze WANG

“…Laser confocal microscopy, flow cytometry, and quantitative real time polymerase chain reaction (qRT-PCR) were employed to further validate the induction of apoptosis in gastric cancer cells by the XG aqueous extract. …”
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Identification of EGR1 as a Key Diagnostic Biomarker in Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) Through Machine Learning and Immune Analysis by Wu X, Pan T, Fang Z, Hui T, Yu X, Liu C, Guo Z, Liu C

“…In this study, we aim to identify effective diagnostic biomarkers for MASLD using microarray data combined with machine learning techniques, which will aid in further understanding the pathogenesis of MASLD.Methods: We collected six datasets from the Gene Expression Omnibus (GEO) database, using five of them as training sets and one as a validation set. We employed three machine learning methods—LASSO, SVM, and Random Forest (RF)—to identify hub genes associated with MASLD. …”
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The carbon footprint of pasture-based buffalo milk production in Colombia by Andrés F. Pérez, Felipe Vélez S., Juan F. Naranjo R.

“…The global warming potential indices GWP100 and GWP* were employed to calculate the impact of emissions. Milk carbon footprints (CFs) ranged from 0.7 to 1.41 kgCO2 -eq kg FPCM-1, but when calculated with the GWP* index, they decreased by nearly 35% for both scenarios. …”
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Burden of early neonatal mortality in Sub-Saharan Africa. A systematic review and meta-analysis. by Natnael Moges, Anteneh Mengist Dessie, Denekew Tenaw Anley, Melkamu Aderajew Zemene, Natnael Atnafu Gebeyehu, Getachew Asmare Adella, Gizachew Ambaw Kassie, Misganaw Asmamaw Mengstie, Mohammed Abdu Seid, Endeshaw Chekol Abebe, Molalegn Mesele Gesese, Yenealem Solomon Kebede, Sefineh Fenta Feleke, Tadesse Asmamaw Dejenie, Natnael Amare Tesfa, Wubet Alebachew Bayih, Ermias Sisay Chanie, Berihun Bantie

“…The studies were evaluated using the JBI appraisal check list. STATA 17 was employed for the analysis. Measures of study heterogeneity and publication bias were conducted using the I2 test and the Eggers and Beggs tests, respectively. …”
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The role of exercise-based prehabilitation in enhancing surgical outcomes for patients with digestive system cancers: a meta-analysis by Shasha Xu, Rong Yin, Haiou Zhu, Yin Gong, Jing Zhu, Changxian Li, Qin Xu

“…The Cochrane Collaboration tool was employed for evaluating the risk of bias in each study, and the PRISMA 2020 checklist provided by the EQUATOR network was utilized. …”
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The saprotrophic Pleurotus ostreatus species complex: late Eocene origin in East Asia, multiple dispersal, and complex speciation by Jing Li, Li-Hong Han, Xiao-Bin Liu, Zhi-Wei Zhao, Zhu L. Yang

“…In addition, the evolutionary history is poorly understood due to limited sampling and insufficient gene fragments employed for phylogenetic analyses. Comprehensive sampling from Asia, Europe, North and South America and Africa was used to run phylogenetic analyses of the P. ostreatus species complex based on 40 nuclear single-copy orthologous genes using maximum likelihood and Bayesian inference analyses. …”
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Differences in EEG complexity of cognitive activities among subtypes of schizophrenia by Hang Qi, Jilin Zou, Zhenzhen Yao, Gaofeng Zhao, Jing Zhang, Chunlei Liu, Min Chen

“…The NeuroScan EEG/ERP System, comprising 64 channels and utilising standard 10-20 electrode placements, was employed to record EEG signals. The multiscale entropy and sample entropy of the EEG signals were calculated.ResultsThe healthy controls demonstrated superior task performance compared to both the non-deficit (p < 0.001) and deficit groups(p < 0.001). …”
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Who is engaging with lateral flow testing for COVID-19 in the UK? The COVID-19 Rapid Survey of Adherence to Interventions and Responses (CORSAIR) study by Nicola T Fear, Susan Michie, Richard Amlot, G James Rubin, Louise E Smith, Henry WW Potts

“…Increased uptake of testing was associated with being vaccinated (adjusted ORs (aORs)=1.52–2.45, 95% CI 1.25 to 3.07, analysed separately by vaccine dose), employed (aOR=1.94, 95% CI 1.63 to 2.32), having been out to work in the last week (aOR=2.30, 95% CI 1.94 to 2.73) and working in a sector that adopted LFT early (aOR=2.54, 95% CI 2.14 to 3.02) . …”
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Analyzing Maternal Needs for “Internet+ Nursing Service” After Hospital Discharge: A SERVQUAL-KANO Model Approach by Ding L, Ding Y, Wang Y, Li X, Liu Y

“…Given the prevalence of “Internet+ Nursing Services”, there has been a paucity of research exploring the internet-based home care needs of mothers following their discharge from hospital. This study employs a combination of the SERVQUAL and KANO models to investigate maternal requirements for Internet+ nursing services and to establish a foundation for enhancing the quality of postnatal nursing services.Patients and Methods: A questionnaire was designed by combining SERVQUAL and KANO models, and a cross-sectional survey was conducted in the obstetrics department of a tertiary hospital in China after expert correspondence. …”
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Genetic context modulates aging and degeneration in the murine retina by Olivia J. Marola, Michael MacLean, Travis L. Cossette, Cory A. Diemler, Amanda A. Hewes, Alaina M. Reagan, Jonathan Nyandu Kanyinda, Daniel A. Skelly, Gareth R. Howell

“…Methods Transcriptomics and proteomics were employed to elucidate retinal aging signatures in nine genetically diverse mouse strains (C57BL/6J, 129S1/SvlmJ, NZO/HlLtJ, WSB/EiJ, CAST/EiJ, PWK/PhK, NOD/ShiLtJ, A/J, and BALB/cJ) across lifespan. …”
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Food taboo practices and associated factors among pregnant women in Sub-Sahara Africa: a systematic review and meta-analysis by Aysheshim Kassahun Belew, Berhanu Mengistu, Ayenew Molla Lakew, Esmeal Ali Muhammad

“…Heterogeneity was assessed using Cochran's Q test and the I2 statistic, with a random effects model employed for meta-analysis. Publication bias was evaluated and addressed using Duval and Tweedie's Trim and Fill analysis. …”
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Identification of disease-specific gut microbial markers in vitiligo by Yimin Dou, Yi Niu, Hexiao Shen, Lan Wang, Yongling Lv, Suwen Liu, Xiafei Xie, Aiping Feng, Xinxin Liu

“…There is a potential correlation between vitiligo and gut microbiota, although research in this area is currently limited. The research employed high-throughput sequencing of 16S rRNA to examine the gut microbiome in the stool samples of 49 individuals with vitiligo and 49 without the condition. …”
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Digital interactive experience- and game-based fall interventions for community-dwelling healthy older adults: a cross-disciplinary systematic review by Celina Ciemer, Celina Ciemer, Lisa Kröper, Thomas Jürgen Klotzbier, Sabiha Ghellal, Nadja Schott

“…It focuses on integrating Human Movement Science and User Experience & Game Design perspectives, emphasizing the cross-disciplinary nature of this research.MethodsWe employed a cross-disciplinary literature search framework, searching the databases ACM-DL, IEEE-Xplore, ScienceDirect, PubMed, Scopus, and Web of Science. …”
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