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14881
Understanding the educational inequalities in suicide attempts and their mediators: a Mendelian randomisation study
Published 2024-02-01“…We systematically evaluated 42 putative mediators within the causal pathway connecting reduced educational attainment to suicide attempts and employed two-step and multivariable MR to quantify the proportion of the mediated effect.Results In the combined analysis of iPSYCH and FinnGen, each standard deviation (SD) decrease in genetically predicted educational attainment (equating to 3.4 years of education) was associated with a 105% higher risk of suicide attempts (odds ratio (OR): 2.05; 95% confidence interval (CI): 1.81 to 2.31). …”
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14882
Ultra-Wideband 4-Bit Distributed Phase Shifters Using Lattice Network at <italic>K/Ka</italic>- and <italic>E/W</italic>-Band
Published 2024-01-01“…To achieve wider bandwidth, the proposed phase shifter employed an all-pass lattice network instead of the traditional low-pass ladder network. …”
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14883
Test-Retest Reliability and Validity of TecnoBody D-Wall to Assess the Range of Motion During Overhead Squat in Healthy Individuals
Published 2025-01-01“…Measurements were conducted for hip and knee joint angles in the sagittal plane, with three repetitions per participant analyzed using both systems. The D-Wall system employed a 3D Kinect V2 camera and force platform, while Kinovea used 2D video-based motion analysis. …”
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14884
Curdione combined with borneol treats bacterial mixed HPV infection by regulating the crosstalk among immune cells
Published 2025-01-01“…Bioinformatics and network pharmacology approaches were employed to identify therapeutic targets of Baofukang suppository for BV/HPV co-infections. qRT-PCR, Western blot, immunofluorescence staining, and flow cytometry were utilized to validate the therapeutic targets of curdione and borneol, along with the associated immune molecular changes. …”
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14885
The Assessment of Different Dietary Selenium Resources on Reproductive Performance, Spawning Indicators, and Larval Production of Red Tilapia (Oreochromis mossambicus × O. niloticu...
Published 2023-01-01“…Four experimental broodstock diets were prepared employing two types of selenium. The first diet was free of additives and acted as the control diet. …”
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14886
Treadmill training improves lung function and inhibits alveolar cell apoptosis in spinal cord injured rats
Published 2024-04-01“…Various techniques including arterial blood gas analysis, lung wet/dry weight ratio, HE staining, immunofluorescence staining, immunohistochemical staining, qRT-PCR, and Western blotting were employed to assess alterations in lung function and the expression levels of crucial apoptosis-related factors. …”
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14887
An endoscopic ultrasound-based interpretable deep learning model and nomogram for distinguishing pancreatic neuroendocrine tumors from pancreatic cancer
Published 2025-01-01“…The least absolute shrinkage and selection operator algorithm was employed to reduce the dimensionality of deep learning (DL) features extracted from pre-standardized EUS images. …”
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14888
Genetic variation reveals the therapeutic potential of BRSK2 in idiopathic pulmonary fibrosis
Published 2025-01-01“…This study aimed to identify key targets involved in the progression of IPF. Methods We employed Mendelian randomization (MR) with three genome-wide association studies and four quantitative trait loci datasets to identify key driver genes for IPF. …”
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14889
Association between triglyceride glucose index and adverse cardiovascular prognosis in patients with atrial fibrillation without diabetes: a retrospective cohort study
Published 2025-01-01“…Kaplan–Meier curve, Cox proportional hazards regression model, and restricted cubic spline were employed to explore the relationship between the Tyg index and outcomes. …”
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14890
Enhancing collaborative clinical reasoning among multidisciplinary healthcare teams in a neurosurgery ICU: insights from video-reflexive ethnography
Published 2025-02-01“…The study utilizes video-reflexive ethnography (VRE) to examine the factors influencing CCR, the cognitive processes involved, and the efficacy of VRE in promoting CCR. Methods The study employed a qualitative research design, utilizing VRE. …”
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14891
Verbascoside Inhibits the Activation of NLRP3 Inflammasome and Improves BV-2 Cell Inflammatory Damage
Published 2025-02-01“…Methods: A model of inflammatory damage induced by oxygen-glucose deprivation (OGD) in BV-2 cells was employed. The experiment was divided into 4 groups: The normal control group, the OGD model group, the Osmanthus fragrans ethanol extract group (OGD+OEE), and VB group (OGD+VB). …”
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14892
Prognostic Value of Cerebrospinal Fluid and Serum Neurofilament Light Chain in Amyotrophic Lateral Sclerosis: A Correlation Study
Published 2025-01-01“…Furthermore, baseline sNfL concentrations, as well as cNfL levels, emerged as predictive indicators of subsequent disease progression rate (sNfL: p < 0.0001, cNfL: p = 0.0005) and overall survival (sNfL: p = 0.0073, cNfL: p = 0.0044). Employing a Cox regression model, we identified baseline sNfL level (HR = 1.01, p = 0.013), and diagnostic delay (HR = 0.94, p = 0.003) as independent prognostic factors for mortality. …”
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14893
The small GTPases FoRab5, FoRab7, and FoRab8 regulate vesicle transport to modulate vegetative development and pathogenicity in Fusarium oxysporum f. sp. conglutinans
Published 2025-01-01“…In addition, we also employed a PEG-mediated homologous recombination approach to create deletion mutants and complementary strains for the FoRab5, FoRab7, and FoRab8 genes, thereby facilitating a comprehensive investigation into the functional roles of these genes. …”
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14894
Impact of chemoradiotherapy for first primary lung cancer on the prognosis and re-chemoradiotherapy sensitivity of second primary lung cancer
Published 2025-01-01“…Among these, 5,302 FPLC patients developed SPLC within 5 years of their initial diagnosis. We employed the Fine-Gray competitive risk model, Cox proportional hazards model, and restricted mean survival time analysis to assess the effects of FPLC radiotherapy and chemotherapy on SPLC risk and survival differences.ResultsThe competitive risk model indicated that FPLC radiotherapy and chemotherapy did not significantly change the risk of developing SPLC. …”
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14895
Assessing caregiver stress and resource needs in pediatric cancer care
Published 2024-12-01“…Descriptive statistics, t-tests, ANOVA, and Pearson correlation coefficients were employed for data analysis using SPSS version 29, with a significance level set at p < 0.05. …”
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14896
The Efficacy and Brain Network Mechanism of Acupuncture for Knee Osteoarthritis: A Study Protocol for Randomized Controlled Neuroimaging Trial
Published 2025-01-01“…The primary efficacy indicator will be the change in NRS score after four weeks of treatment, with secondary outcomes including WOMAC, STAI, and safety assessments. fMRI observations will employ independent component analysis, brain network construction, and functional connectivity, complemented by Pearson correlation analysis to explore the relationship between brain responses and clinical improvements.Conclusion: This study will initially uncover how acupuncture intervention for chronic KOA pain centrally regulates and exerts therapeutic effects through the modulation of abnormal brain network functional connectivity patterns, with a demonstrated long-term effect.Ethics and Dissemination: This study has been approved by the ethics committee of Shandong University of Traditional Chinese Medicine Affiliated Hospital ((2024) Lunshen No. (028) - KY).Clinical Trial Registration: This study has been approved by registered in the Chinese Clinical Trial Registry (ChiCTR2400083695).Keywords: acupuncture, knee osteoarthritis, neuroimaging, RCT, protocol…”
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14897
Evaluation of the Psychiatric Disorders among Amphetamine Addicts in Rehabilitation Centers: A Cross-Sectional Analysis
Published 2024-01-01“…Pearson correlation coefficients (r) were employed. Results. A total of 60 subjects participated in this study. …”
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14898
Assessing and optimizing the potential for climate change mitigation and carbon sequestration in urban residential green spaces: energizing sustainable cities
Published 2025-01-01“…The assimilation method was employed to calculate carbon sequestration per unit canopy area and for entire plants.ResultsThe results showed that the carbon sequestration capacities of different plant species and types exhibited significant differences, with p-values less than 0.05. …”
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14899
“Unmasking the Uncommon”: A case series of multi-drug resistant Elizabethkingia meningoseptica causing late-onset sepsis and meningitis in preterm neonates [version 2; peer review:...
Published 2025-02-01“…It exhibits resistance to many commonly employed first-line antibiotics used to treat gram-negative pathogens. …”
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14900
Associations between lipid-lowering drugs and urate and gout outcomes: a Mendelian randomization study
Published 2025-01-01“…The aim of this study was to investigate the genetic association between lipid-lowering drugs and urate and gout.MethodsIn this study, two genetic proxies were employed to approximate lipid-lowering drug exposure: expression quantitative trait loci (eQTL) associated with drug-target genes and genetic variations proximal to or within genes targeted by these drugs, which are linked to low-density lipoprotein cholesterol (LDL-C) levels. …”
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