dyphAI dynamic pharmacophore modeling with AI: a tool for efficient screening of new acetylcholinesterase inhibitors by Yasser Hayek-Orduz, Dorian Armando Acevedo-Castro, Dorian Armando Acevedo-Castro, Juan Sebastián Saldarriaga Escobar, Brandon Eli Ortiz-Domínguez, María Francisca Villegas-Torres, Paola A. Caicedo, Álvaro Barrera-Ocampo, Natalie Cortes, Edison H. Osorio, Andrés Fernando González Barrios

“…In this study, we developed and employed dyphAI, an innovative approach integrating machine learning models, ligand-based pharmacophore models, and complex-based pharmacophore models into a pharmacophore model ensemble. …”
Get full text

Intraoperative Electrical Nerve Stimulation as a Prognostic Tool in Patients Undergoing Peripheral Nerve Neurolysis by Christoph A. Schroen, BS, Yufan Yan, MD, Christian E. Awah, MD, Unwana Abasi, MD, Paul J. Cagle, MD, Michael R. Hausman, MD, Steven M. Koehler, MD

“…Fisher exact tests were employed to test for an association between stimulation thresholds and functional recovery. …”
Get full text

Diversity and seasonal variation of zooplankton community in a large deep-water reservoir of Eastern China using eDNA and morphological methods by Lei Hao, Lei Hao, Xinting Xu, Xinting Xu, Yan Zhou, Yan Zhou, Dan Liu, Dan Liu, Jianqiang Shao, Jiayong Pan, Guangxi He, Zhongjun Hu, Zhongjun Hu, Qigen Liu, Qigen Liu

“…Environmental DNA (eDNA) has been increasingly employed in this field due to its efficiency and accuracy. …”
Get full text

Innovative determination of phytohormones in Aloe vera by Muhammad K. Hakeem, Meera Maraqa, Sampath K. Elangovan, Sampath K. Elangovan, Esam Eldin Saeed, Ajay Kumar Mishra, Khaled M. Hazzouri, Iltaf Shah, Iltaf Shah, Khaled M. A. Amiri

“…A C-18 column was used for separation, and a triple quadrupole mass spectrometer was employed for quantification. The method’s performance was assessed in terms of linearity, sensitivity, and limits of detection.ResultsThe LC-MS/MS method exhibited excellent linearity (R2 > 0.99) and low limits of detection for all six phytohormones. …”
Get full text

Automatic GPR detection of grouting defects behind the tunnel shield segments based on wavelet coherence analysis combined with modified Res-RCNN by Dengyi Wang, Ming Peng, Liu Liu, Xiongyao Xie, Zhenming Shi, Yaoying Liang, Jian Shen, Qiyu Wu

“…To address these, this paper introduces an automated approach using wavelet coherence and a modified Res-RCNN. The approach employs wavelet coherence to transform the time-series GPR profile into the time-frequency images and reveal the weak defect reflections. …”
Get full text

Characterization and Probiotic Potential of <i>Levilactobacillus brevis</i> DPL5: A Novel Strain Isolated from Human Breast Milk with Antimicrobial Properties Against Biofilm-Formi... by Ivan Iliev, Galina Yahubyan, Elena Apostolova-Kuzova, Mariyana Gozmanova, Daniela Mollova, Iliya Iliev, Lena Ilieva, Mariana Marhova, Velizar Gochev, Vesselin Baev

“…Lactobacillus is a key genus of probiotics commonly utilized for the treatment of oral infections The primary aim of our research was to investigate the probiotic potential of the newly isolated <i>Levilactobacillus brevis</i> DPL5 strain from human breast milk, focusing on its ability to combat biofilm-forming pathogens such as <i>Staphylococcus aureus</i>. Employing in vitro approaches, we demonstrate <i>L. brevis</i> DPL5′s ability to endure at pH 3 with survival rates above 30%, and withstand the osmotic stress often found during industrial processes like fermentation and freeze drying, retaining over 90% viability. …”
Get full text

Unleashing the potential of a low CpG Passer transposon for superior CAR-T cell therapy by Jianyao Zeng, Yan Sun, Yan Sun, Yuan Fang, Xiaodie Wang, Qian Huang, Pingjing Zhang, Meiqi Shao, Pei Wang, Jingbo Cheng, Meng Di, Tao Liu, Qijun Qian, Qijun Qian, Qijun Qian

“…Flow cytometry and luciferase reporter assays were employed for mutation screening. BALB/c mice and M-NSG mice were used to evaluate the inflammatory response and efficacy of LCG CAR-T in vivo, with TIL grouping detected via immunohistochemistry.ResultsIn this study, we modified the newly discovered Passer (JL) transposon to construct a low-CpG content transposon for CAR-T cell (LCG CAR-T cell) preparation. …”
Get full text

Dietary inflammatory index and disability among older adults in Guangzhou: a cross-sectional analysis by Junbin Liao, Junbin Liao, Wenfeng Cai, Danrong Lin, Yuanyun Xiao, Yanxi Liu, Yahui Wang, Yuquan Zhong, Fan Xiao, Heng Fang, Yilu Yao, Yunfeng Lin, Jiewen Su, Siyu Sun, Bo Zhang, Yan Wang, Wei Zhu, Wei Zhu

“…A multivariable ordinal logistic regression model was employed to analyze the influence of various factors and the DII on the degree of disability among older adults. …”
Get full text

Ionizing radiation-induced disruption of Rela-Bclaf1-spliceosome regulatory axis in primary spermatocytes causing spermatogenesis dysfunction by Hongjian Zhou, Zhipeng Xu, Chun Jiang, Qiuyue Wu, Chuanyue Zhang, Zhenyu Liu, Xiaoxue Zhang, Weiwei Li, Yujia Pang, Jing Zhang, Wenju Pan, Min Chen, Xinyi Xia

“…Abstract Introduction Ionizing radiation (IR) poses a significant threat to male fertility by inducing substantial changes in the testis, yet the mechanisms underlying IR-induced spermatogenesis disorders remain poorly understood, necessitating the development of more effective radioprotective agents. Methods We employed Bulk RNA-seq and single-cell RNA-seq (scRNA-seq) on Balb/c mice testes models following IR exposure to assess cellular and transcriptional alterations. …”
Get full text

Effects of biochar on the chemical properties of soils and the volume of wood in a plantation of Acacia mangium Willd in the Colombian Orinoquía (highlands) by Giovanni Reyes-Moreno, Aquiles Enrique Darghan, Carlos Rivera-Moreno

“…Method: We used a design including nine treatments and three repetitions of each treatment, employing two materials: biochar from Acacia mangium W. …”
Get full text

Analysis of the spatial pattern and causes of ecological environmental quality in Myanmar based on the RSEI model and the Geodetector-GCCM method by Shuangfu Shi, Shuangfu Shi, Shuangyun Peng, Shuangyun Peng, Zhiqiang Lin, Zhiqiang Lin, Bangmei Huang, Dongling Ma, Dongling Ma, Ziyi Zhu, Ziyi Zhu, Yilin Zhu, Yilin Zhu, Rui Zhang, Ting Li

“…This study took Myanmar as the research area, employing a Remote Sensing Ecological Index (RSEI) model and spatial autocorrelation analysis to quantitatively evaluate the spatial distribution characteristics of Myanmar’s EEQ in 2020 and reveal its spatial dependence. …”
Get full text

Impact of nurturing care educational videos focusing on children with nutritional problems aged 6-23 months on mothers' knowledge and child growth by Fitri Haryanti, Lely Lusmilasari, Sri Hartini, Ayyu Sandhi, Ika Parmawati, Akhmadi Akhmadi, Nisa Nur Hasanah, Fitriana Andarwati, Hani Risnawati, Alissa Nur Pratiwi, Ananda Sekar Kusumawati, Redyta Dwi Cahyani

“…Methods: A quasi-experimental design with non-equivalent and untreated control groups was employed. Seventy-three mothers and their children aged 6-23 months, facing nutritional challenges, were recruited through consecutive sampling. …”
Get full text

Therapeutic target genes and regulatory networks of gallic acid in cervical cancer by Zhixi You, Ye Lei, Yongkang Yang, Zhihui Zhou, Xu Chao, Keyi Ju, Songyi Wang, Yuanyuan Li, Yuanyuan Li

“…This analysis revealed that 221 biological processes, 82 cellular components, 63 molecular functions, and 36 KEGG pathways were employed to identify three therapeutic candidate genes, including CDC20, DLGAP5, and KIF20A. …”
Get full text

The Prevalence of Metabolic Syndrome and Hypertriglyceridemic Waist Based on Sociodemographic Variables and Healthy Habits in Healthcare Workers: A Retrospective Study by Pedro Javier Tárraga Marcos, Ángel Arturo López-González, Emilio Martínez-Almoyna Rifá, Hernán Paublini Oliveira, Cristina Martorell Sánchez, Pedro Juan Tárraga López, José Ignacio Ramírez-Manent

“…<b>Methodology</b>: This study employed a mixed-methods approach, consisting of a retrospective longitudinal study and a cross-sectional descriptive study, analyzing 44,939 healthcare workers with MS and HTW across four professional categories to evaluate the relationship between age, sex, smoking, physical activity, and adherence to the Mediterranean diet using three diagnostic criteria. …”
Get full text

Brain compensatory activation during Stroop task in patients with mild cognitive impairment: a functional near-infrared spectroscopy study by Chenyu Fan, Hanfei Li, Hanfei Li, Ke Chen, Ke Chen, Guohui Yang, Hongyu Xie, Haozheng Li, Yi Wu, Meng Li, Meng Li, Meng Li

“…PurposeThis study investigated the disparities in brain activation patterns during the Stroop task among individuals with mild cognitive impairment (MCI) and those without any cognitive impairments (healthy controls, HCs) using functional near-infrared spectroscopy (fNIRS).MethodsWe analyzed the cortical activation patterns of 73 patients with MCI and 63 HC individuals as they completed the Stroop task, employing fNIRS. The regions of interest (ROIs) included the dorsal prefrontal cortex (dPFC), ventrolateral prefrontal cortex (VLPFC), and parietal lobe (PL). …”
Get full text

MultiTax-human: an extensive and high-resolution human-related full-length 16S rRNA reference database and taxonomy by Zhiwei Bao, Bin Zhang, Jianhua Yao, Ming D. Li

“…By integrating data from multiple sources and employing advanced classification techniques, this database offers an accurate and detailed map of the human microbiome. …”
Get full text

Study on exhaled volatile organic compounds identifying cognitive fatigue induced by N-back task in healthy young adults by Xiaoyu Zhang, Xiaoyan Dong, Qiang Huang, Zhe Liu, Qin Wang

“…The Chalder Fatigue Scale was employed to assess the cognitive fatigue of the subjects before and after the induction and film watching. …”
Get full text

Assessing anxiety symptoms and Traumatic Event Scale scores among medical staff during the COVID-19 pandemic in Colombia: a descriptive cohort study in Bogotá by Pablo Vásquez-Hoyos, Jhon Camacho-Cruz, Sara Marcela Torres Ayala, Susan Tatiana Cárdenas Rojas, Carolina Alexandra Zambrano Pérez, Juanita Yolanda Atuesta-Fajardo, Licet Villamizar-Gómez

“…The Zung Anxiety Scale and the Traumatic Event Scale (TES) were employed and completed four times during the pandemic. …”
Get full text

Multi-task aquatic toxicity prediction model based on multi-level features fusion by Xin Yang, Jianqiang Sun, Bingyu Jin, Yuer Lu, Jinyan Cheng, Jiaju Jiang, Qi Zhao, Jianwei Shuai

“…Furthermore, to validate the advantages of multi-task learning, we independently construct prediction models, named ATFPGT-single, for each fish species. We employ cross-validation in our experiments to assess the performance and generalization ability of ATFPGT-multi. …”
Get full text

The relationship between stress levels and the habits of consuming high-sugar food among undergraduate students by Zulfa 'Azizah, Dittasari Putriana, Agil Dhiemitra Aulia Dewi

“…This analytical observational research employed a cross-sectional design. The sample consisted of 168 students aged 18 to 25 who were selected using purposive sampling. …”
Get full text