Salt Stress Enhanced Bioactivity of Quinoa Leaf Extracts: An In Vitro and In Silico Study of Acetylcholinesterase and Tyrosinase Inhibition for Sustainable Drug Development by Narmine Slimani, Soumaya Arraouadi, Hafedh Hajlaoui, Antonio Cid-Samamed, Mohamed Ali Borgi, Mejdi Snoussi

“…HPLC-DAD-ESI-MS/MS was employed to identify the major compounds in the water extract. …”
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Unraveling the individual and interactive effects of climate and competition on branch growth dynamics in Pinus koraiensis in Northeast China by Xuehan Zhao, Zheng Miao, Zheng Miao, Fengri Li, Fengri Li, Yuanshuo Hao, Yuanshuo Hao, Yumeng Jiang, Lihu Dong, Lihu Dong

“…In the face of the current challenges posed by climate change, accurate information to inform forest management and policy-making is urgently needed.MethodsWe collected 745 branches from 54 sampled trees of Korean pine and, we employed a mixed-effects model to assess the effects of tree variables, competition, climate, and their interactions on branch growth. …”
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Staphylococcus aureus induces mitophagy via the HDAC11/IL10 pathway to sustain intracellular survival by Yaji Yang, Haotian Zhou, Feilong Li, Yanhao Zhang, Jianye Yang, Yidong Shen, Ning Hu, Quanming Zou, Leilei Qin, Hao Zeng, Wei Huang

“…Although macrophages play a vital role as innate immune cells, the mechanisms by which S. aureus survives within them and suppresses host immune functions remain incompletely understood. Methods This study employed confocal microscopy, flow cytometry, ELISA, and siRNA technology to assess the survival capacity of S. aureus within macrophages and the impact of inflammatory cytokines on its persistence. …”
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In vitro and in vivo investigations of selected varieties of Areca catechu L - Phytochemical analysis, antiulcer, and wound healing activity by R. Deveswaran, D.J. Madhu Kumar, V. Madhavan, Soma Chaki, Misbah Khan, Govind R. Kadambi, B.V. Basavaraj, J. Anbu

“…High-performance thin Layer Chromatography (HPTLC) was employed to quantify the percentage of arecoline, ranging from 0.12 % to 0.95 % in the samples. …”
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Immune microenvironment spatial landscapes of tertiary lymphoid structures in gastric cancer by Yi Xie, Haoxin Peng, Yajie Hu, Keren Jia, Jiajia Yuan, Dan Liu, Yanyan Li, Xujiao Feng, Jian Li, Xiaotian Zhang, Yu Sun, Lin Shen, Yang Chen

“…Multispectral fluorescence imaging was employed to evaluate variations in immune cell infiltration across different TLS sites among 110 GC patients, by quantifying immune cell density and spatial characteristics. …”
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Adhesion-induced MoS2 layer transfer via in-situ TEM-nanoindentation: Effects of curvature and substrate mediated residual stress by Jhih H. Liang, Mehdi Rouhani, J. David Schall, Takaaki Sato, Christopher Muratore, Nicholas R. Glavin, Robert W. Carpick, Yeau-Ren Jeng

“…Our pioneering in situ experiments, utilizing TEM-based nanoindentation, provided precise imaging and force monitoring of MoS2's interaction with a diamond. We employed four MoS2-coated AFM tips with varying radii and preparation methods, with films prepared on two Si wafers subjected to different oxidation protocols. …”
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Analyzing Gait Dynamics and Recovery Trajectory in Lower Extremity Fractures Using Linear Mixed Models and Gait Analysis Variables by Mostafa Rezapour, Rachel B. Seymour, Suman Medda, Stephen H. Sims, Madhav A. Karunakar, Nahir Habet, Metin Nafi Gurcan

“…Using a chest-mounted inertial measurement unit (IMU) device for gait analysis and collecting patient-reported outcome measures, we focused on 12 key gait variables, including Mean Leg Lift Acceleration, Stance Time, and Body Orientation. We employed a linear mixed model (LMM) to analyze these variables over time, incorporating both fixed and random effects to account for individual differences and the time since injury. …”
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Targeted inhibition of the PTEN/PI3K/AKT pathway by YSV induces cell cycle arrest and apoptosis in oral squamous cell carcinoma by Lin Qiu, Qian Gao, Yiheng Liao, Xinxin Li, Cuiying Li

“…RNA sequencing (RNA-seq), molecular docking, and western blotting were employed to investigate the molecular mechanisms. Additionally, a subcutaneous tumor model was established to validate the in vitro findings. …”
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Efficacy of natural and synthetic inhibitors in the elimination of viruses in potato (<i>Solanum tuberosum</i> L.) by E. V. Shishchenko, I. V. Kim, E. N. Barsukova, I. M. Yermak, A. O. Kravchenko, A. G. Klykov

“…A highly sensitive PCR method was employed to detect viral infections in plant samples. …”
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Dietary index for gut microbiota and its protective role against kidney stones: evidence of diabetes as a mediator from NHANES cross-sectional data by Lei Wang, Junjun Wu, Ziwen Jiang, Chao Wang, Fuxiang Lin, Yuxiang Zhong, Pengpeng Zhao, Wei Wei, Jianhua Huang, Zhanping Xu

“…Multivariable logistic regression was employed to assess the association between DI-GM and KS prevalence, with statistical significance set at p &lt; 0.05. …”
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Unraveling the genetic mysteries of spinal muscular atrophy in Chinese families by Shanshan Gao, Duo Chen, Qianqian Li, Xuechao Zhao, Chen Chen, Lina Liu, Miao Jiang, Zhenhua Zhao, Yanhua Wang, Xiangdong Kong

“…Various molecular techniques, including multiplex ligation-dependent probe amplification analysis, long-range polymerase chain reaction (PCR) combined with nested PCR, Sanger sequencing, and whole-exome sequencing were employed to establish a thorough genetic variant profile in 680 Chinese pedigrees with clinically suspected SMA. …”
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Temporal trends and future projections of incidence rate and mortality for asthma in China: an analysis of the Global Burden of Disease Study 2021 by Xi Chen, Xi Chen, Dandan Ma, Hangyu Li, Yilin Liu, Guixing Xu, Xinyu Deng, Qi Li, Junqi Li, Hui Pan

“…Understanding the trends and future projections of asthma incidence and mortality is crucial for healthcare planning.MethodsWe analyzed asthma incidence and mortality data sourced from the Global Burden of Disease (GBD) 2021 study from 1990 to 2021, calculated the age-standardized incidence and mortality rates (ASIR and ASMR) and the estimated annual percentage change (EAPC), meanwhile, employed Joinpoint regression model to assess the trends. …”
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Drying kinetic for moisture content prediction of peels Tahiti lemon (Citrus latifolia): Approach by machine learning and optimization - genetic algorithms and nonlinear programmin... by Maressa O. Camilo, Romero F. Carvalho, Ariany B.S. Costa, Esly F.C. Junior, Andréa O.S. Costa, Robson C. Sousa

“…Heuristic optimization methods, including genetic algorithms (GA) and nonlinear programming (NLP), were employed to identify the best empirical and semi-empirical models for estimating moisture content during the drying process of lemon peel layers. …”
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Auditory confounds can drive online effects of transcranial ultrasonic stimulation in humans by Benjamin R Kop, Yazan Shamli Oghli, Talyta C Grippe, Tulika Nandi, Judith Lefkes, Sjoerd W Meijer, Soha Farboud, Marwan Engels, Michelle Hamani, Melissa Null, Angela Radetz, Umair Hassan, Ghazaleh Darmani, Andrey Chetverikov, Hanneke EM den Ouden, Til Ole Bergmann, Robert Chen, Lennart Verhagen

“…To this end, we include tightly matched control conditions across four experiments, one preregistered, conducted independently at three institutions. We employed a combined transcranial ultrasonic and magnetic stimulation paradigm, where TMS-elicited motor-evoked potentials (MEPs) served as an index of corticospinal excitability. …”
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Online tools to predict individualised survival for primary oesophageal cancer patients with and without pathological complete response after neoadjuvant therapy followed by oesoph... by Jie Zhang, Xiang Chen, Dong Dong, Lijie Tan, Yajie Zhang, Hecheng Li, Yuqin Cao, Binhao Huang, Han Tang, Tianzheng Shen, Xijia Feng, Jiahao Zhang, Liqiang Shi, Chengqiang Li, Heng Jiao

“…The calibration plot, concordance index and decision curve analysis were employed to assess calibration, discrimination and clinical usefulness of the predictive models.Results In total, 13 and 15 variables were used to predict OS for pCR and non-pCR patients undergoing neoadjuvant therapy followed by oesophagectomy, respectively. …”
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Explore the evolution of winter wheat production and its response to climate change under varying precipitation years in the Loess Plateau of China by Donglin Wang, Yanbin Li, Binbin Zhang, Tengcong Jiang, Siyu Wu, Wenjie Wu, Yi Li, Jianqiang He, Deli Liu, Qinge Dong, Hao Feng

“…To clarify the transformation process of precipitation and the mechanism how it change the crop yield, particularly in the Loess Plateau where precipitation frequently alternates between dry and wet years, this study used the down-scaling global climate model (GCMs) data to simulate and predict the change trend of winter wheat yield from 1961 to 2100 under varying precipitation conditions in two future climate scenarios (SSP245 and SSP585), employing the APSIM model. In this study, parameters of APSIM-Wheat model were refined based on experimental data. …”
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Extraction of tree branch skeletons from terrestrial LiDAR point clouds by Jimiao Gao, Liyu Tang, Honglin Su, Jiwei Chen, Yuehui Yuan

“…The density-based spatial clustering of applications with noise (DBSCAN) algorithm is then employed to cluster each layer of the point clouds and detect the main trunk. …”
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Association between geriatric nutritional risk index and overactive bladder in the elderly population: a cross-sectional study by Wei Zheng, Wei Zheng, Chuanzan Zhou, Jia Miao, Yunkai Yang, Xuanhan Hu, Heng Wang, Xinyu Zhang, Qi Zhang, Yifan Wang

“…A multifactorial logistic regression analysis was employed to evaluate the independent association between the Geriatric Nutritional Risk Index (GNRI) and the prevalence of OAB. …”
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Comparison of the effectiveness of the helmet interface using flow meters versus the mechanical ventilator for non-invasive ventilation in patients with coronavirus disease 2019. C... by Fernanda dos Reis Ferreira, João Carlos Ferrari Correa, Eduardo Storopoli, Diego Restivo Faria, Karina Cassaro, Natália Feitosa da Hora, Raphael Ritti, Rafael Akira Becker, Simone Dal Corso, Ivan Peres Costa, Luciana Maria Malosá Sampaio

“…Participants were randomly assigned to two groups: one using the helmet interface with a flow meter and positive end-expiratory pressure valve and the other employing conventional mechanical ventilation. Our study included participant selection, blood gas analysis, assessment of respiratory rate, peripheral oxygen saturation, modified Borg scale scores, and a visual analog scale. …”
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Optimization and potential assessment of CO2 geological storage caprock in the saline aquifers of the Qingjiang Basin, middle and lower reaches of the Yangtze River by Yuchen Tian, Shiqi Liu, Sijian Zheng, Shuxun Sang, Yinghai Liu, Shiheng Chen, Helong Zhang, Yanzhi Liu, Yuntian Jiang, Zekun Yue, Wenkai Wang

“…This analysis provided critical geological factor evaluations for CO2 storage. Employing the calculation method proposed by the Carbon Sequestration Leadership Forum (CSLF), the study estimated the CO2 storage capacity in the deep saline aquifers of the Qingjiang Basin. …”
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