An experimental study of the effects of SNPs in the TATA boxes of the <i>GRIN1, ASCL3</i> and <i>NOS1</i> genes on interactions with the TATA-binding protein by E. B. Sharypova, I. A. Drachkova, I. V. Chadaeva, M. P. Ponomarenko, L. K. Savinkova

“…Double-stranded oligodeoxyribonucleotides identical to the TATA-containing promoter regions of the GRIN1, ASCL3, and NOS1 genes (reference and minor alleles) and recombinant human TBP were employed to study in vitro (by an electrophoretic mobility shift assay) kinetic characteristics of the formation of TBP–TATA complexes and their affinity. …”
Get full text

Global Transcriptional Profiling Reveals Novel Autocrine Functions of Interleukin 6 in Human Vascular Endothelial Cells by Liza U. Ljungberg, Mulugeta M. Zegeye, Caroline Kardeby, Knut Fälker, Dirk Repsilber, Allan Sirsjö

“…Knockdown efficiency was evaluated using ELISA. RNA sequencing was employed to characterize the transcriptional consequence of IL6 knockdown, and Ingenuity Pathway Analysis was used to further explore the functional roles of IL6. …”
Get full text

Ecological corridor design for ecoclimatic regulation: Species as eco-engineers by Lirong Wu, Matteo Convertino

“…For the structural evaluation, we employed key connectivity metrics such as the Integral Index of Connectivity (IIC) and delta IIC (dIIC). …”
Get full text

Exercise-induced methylation of the Serhl2 promoter and implication for lipid metabolism in rat skeletal muscle by Mutsumi Katayama, Kazuhiro Nomura, Jonathan M. Mudry, Alexander V. Chibalin, Anna Krook, Juleen R. Zierath

“…Methods: We utilized endurance-trained rats, cultured L6 myotubes, and human skeletal muscle cells, employing MeDIP sequencing, gene silencing, and palmitate oxidation assays. …”
Get full text

Impact of the COVID-19 Pandemic and Vaccine Availability on Utilization of Breast Imaging in a Multistate Radiology Practice by Andrew K. Hillman, Phil Ramis, Patrick Nielsen, Eric M. Rohren

“…The increase can be best explained by vaccination rollout, reopening of elective/nonemergency healthcare services, insurance coverage expansion, the decline in the US uninsured rate due to government interventions and policies, and the recovery of jobs with employer-provided medical insurance post-pandemic.…”
Get full text

The association between maternal tobacco smoking during pregnancy and the risk of attention-deficit/hyperactivity disorder (ADHD) in offspring: A systematic review and meta-analysi... by Mahdi Mohammadian, Lusine G Khachatryan, Filipp V Vadiyan, Mostafa Maleki, Fatemeh Fatahian, Abdollah Mohammadian-Hafshejani

“…Egger's test indicated no publication bias (p = 0.204), but Begg's test did (p = 0.042). By employing the trim and fill method, the revised OR was estimated to be 1.54 (95% CI: 1.40-1.70; P < 0.001). …”
Get full text

Carcinogenic and non-carcinogenic risk estimation of indoor TVOCs, RSPM, FPM and SFPM on young women dwellers: a case study from the capital city of Uttar Pradesh, India by Farheen Zehra, Samridhi Dwivedi, Mohd Akbar Ali, P. S. Rajinikanth, Alfred Lawrence

“…To elucidate the spatial dynamics of these pollutants, the Inverse Distance Weighting (IDW) interpolation technique was employed. Additionally, site-specific analysis of PM mass ratios (PM2.5/PM10, PM1/PM2.5 and PM1/PM10) elucidated the particle size distribution and their sources, significantly enhancing the scientific understanding of aerosol dynamics in these urban settings.…”
Get full text

Global leukemia burden and trends: a comprehensive analysis of temporal and spatial variations from 1990—2021 using GBD (Global Burden of Disease) data by Pengyu Huang, Jie Zhang

“…Methods Data were sourced from the GBD study, utilizing the Global Health Data Exchange (GHDx) query tool. We employed descriptive, trend, cluster, and forecasting analyses using age-standardized rates (ASRs) and the Estimated Annual Percentage Change (EAPC) to quantify changes over time. …”
Get full text

Trimetazidine: Activating AMPK Signal to Ameliorate Coronary Microcirculation Dysfunction after Myocardial Infarction by Xiaolong Qu, Pan Yang, Li Jiao, Yuehui Yin

“…Griess reaction method, immunofluorescence, and western blotting (WB) were employed to detect the expressions of nitric oxide (NO), platelet endothelial cell adhesion molecule-1 (CD31) and vascular endothelial (VE)-cadherin, zonula occludens protein 1 (ZO-1), occludin, vascular endothelial growth factor (VEGF) and adenosine monophosphate (AMP)-activated protein kinase (AMPK) signaling-related proteins in endothelial cells and mouse cardiomyocytes. …”
Get full text

Over-Response Correction of SNC 350p ROOS and PTW Markus Chambers in the Surface Dose and Build-Up Region Dosimetry of 6MV Photon Beam by Deepali Patil, Mukesh Zope, DINESH SAROJ, Aslam P. A., Basil George

“…Conclusion: The application of over-response correction using Rawlinson's equation improved the accuracy of measurements for both chambers, emphasizing the significance of employing appropriate correction techniques to ensure precise dose measurements in the build-up region using ionization chambers.…”
Get full text

Professional Barriers in Energy Efficiency Retrofits—A Solution Based on Information Flow Modeling by Xilong Liao, Chun Wang, Baiyi Li, Baizhan Li, Chenqiu Du

“…In order to pinpoint the main barriers hindering building retrofits, this study employs the bibliometric software VOSviewer. The analysis uncovers that the primary obstacles to energy-saving renovations are categorized into technical, economic, environmental, and other barriers. …”
Get full text

Modeling vegetation density with remote sensing, normalized difference vegetation index and biodiversity plants in watershed area by R.Z. Ekaputri, T. Hidayat, H.K. Surtikanti, W. Surakusumah

“…Spatial data encompass maps and field data.FINDING: By employing normalized difference vegetation index data, the study pioneers a novel approach to environmental monitoring, setting an example for effective resource management and ecological conservation in watershed regions. …”
Get full text

Meta-analysis of nifedipine and enalapril combination therapy for hypertensive patients with coronary heart disease: A systematic review and meta-analysis by Kun Wang, Wenchao Ma, Leina Sun, Fangcheng Su

“…To analyze and assess the clinical impact of nifedipine combined with enalapril on hypertension complicated with coronary heart disease, and provide evidence for rational drug use in clinic. Methods: We employed a revised version of the Jadad scale to assess the quality of the research literature following a rigorous screening process. …”
Get full text

Health-related dimensions of fishers for sustainable commercial fisheries in the Atlantic Gulf of Guinea: Ecological and social assessments by Isa Oalekan Elegbede, Saud. M Al Jufaili, Toheeb Lekan Jolaosho, Babalola Tesleem, Awe Folalu Adekunle, Olarinmoye Oluwatosin Modupe, Salisu Monsuru Adekunle, Adedeji-Adenola Halimat

“…A mixed-methods approach was employed, combining qualitative and quantitative data collection techniques. …”
Get full text

Genetic Mapping for Seed Aging Tolerance Under Multiple Environments in Sweet Corn by Yanchao Du, Jianting Lin, Haoxuan Jiang, Huating Zhao, Xuebiao Zhang, Ruigang Wang, Faqiang Feng

“…Composite interval mapping was employed to detect quantitative trait loci (QTLs) associated with five seed vigor traits, namely the seedling fresh weight (SFW), germination potential (GP), germination rate (GR), germination index (GI), and vigor index (VI), at three days after artificial aging treatment. …”
Get full text

The potential of the amaranth collection maintained at VIR in the context of global plant breeding and utilization trends by D. V. Sokolova, A. E. Solovieva, A. M. Zaretsky, T. V. Shelenga

“…Meanwhile, mutation breeding and polyploidy have been successfully employed to increase its seed yield and protein content. …”
Get full text

Atypical Mucin Expression Predicts Worse Overall Survival in Resectable Pancreatic Ductal Adenocarcinoma by Yunzhen Qian, Yitao Gong, Yu Liu, Yusheng Chen, Ruijie Wang, Zhengjie Dai, Xuan Zou, Yesiboli Tasiheng, Guopei Luo, Xuan Lin, Xu Wang, He Cheng, Xianjun Yu, Chen Liu

“…Kaplan-Meier methods and Mantel-Cox tests were used to compare the survival curves, and the Cox regression model was employed for multivariate analyses to determine the independent risk factors. …”
Get full text

Professional propaedeutic council in the university by N. N. Malyarchuk, G. M. Krinitzyna, E. V. Pashchenko, V. V. Pivnenko

“…In the course of the research, a complex of theoretical and empirical research methods was employed: analysis, synthesis, moving from abstract to concrete, systematisation, and generalisation.Results and scientific novelty. …”
Get full text

Burnout in Healthcare Professionals during Covid-19 Crisis by Nasim Hajipoor Kashgsaray, Maryam Soleimanpour, Sina Behmanesh, Hassan Soleimanpour

“…Conclusion: The level of mental burnout of doctors and nurses employed in the Emergency Department of Imam Reza General Hospital during the COVID-19 crisis was at an average high. …”
Get full text

Effects of Adoption of Agricultural Technologies on Irish Potato Yield in Ol Kalou Sub-County Kenya: Application of Endogenous Switching Regression Model by David Kihoro, Geofrey Kingori Gathungu, Rael Nkatha Mwirigi, Vicky Nyambura Wairimu

“…A multiple-stage sampling technique was employed to generate a sample size of 385 respondents who provided primary data. …”
Get full text