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15841
An exploratory study of INPP4B, a biomarker of gemcitabine chemoresistance in pancreatic cancer
Published 2024-12-01“…Second-generation high-throughput RNA-seq sequencing was conducted on these resistant cells, and bioinformatics analysis was employed to identify four pancreatic cancer genes from the Gene Expression Omnibus (GEO) datasets (GSE106336, GSE110580, GSE35141, and GSE140077). …”
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15842
Targeting NANOS1 in triple-negative breast cancer: synergistic effects of digoxin and PD-1 inhibitors in modulating the tumor immune microenvironment
Published 2025-01-01“…In this context, Dig (Digoxin) and AA (Algestone acetophenide) have been identified as potential drug candidates for further exploration of their therapeutic effects and application potential in targeting NANOS1.MethodsRNA sequencing (RNA-seq) was employed to identify potential targets for triple-negative breast cancer (TNBC) from TOE. …”
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15843
Development, implementation, and evaluation of an innovative clinical trial operations training program for Africa (ClinOps)
Published 2025-01-01“…Results In the initial cohort, 88 study coordinators from 19 countries participated, including 56 (64%) females, with 57 (65%) actively employed as study coordinators during the training, and 85 (97%) possessing prior experience in clinical trial roles. …”
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15844
Short-Interval Self-Learning to Improve Retention of Resuscitation Skills: A Randomized Controlled Trial
Published 2019-12-01“…La population cible sera constituée d’employés de plusieurs organisation suivant une formation diplômante aux premiers secours de trois jours à la Croix Rouge belge. …”
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15845
Phenomenology of Organizational Silence (Case Study Farhangian University)
Published 2024-09-01“…Gender discrimination in the delegation of authority, lack of promotion based on merit, lack of recruitment and employment based on openness and creativity, absence of a meritocracy, lack of appreciation for employees' efforts, and job insecurity were grouped under the human resources theme. …”
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15846
Global, regional, and national burdens of heart failure in adolescents and young adults aged 10–24 years from 1990 to 2021: an analysis of data from the Global Burden of Disease St...
Published 2025-01-01“…In detail, we divided the study population into three age groups: 10–14 years old, 15–19 years old, and 20–24 years old. We also employed the Bayesian age-period-cohort models (BAPC) to predict the future burden of HF up to 2030. …”
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15847
Le voisinage entre hommes, forêt et les chimpanzés : point de vue depuis le territoire des villageois, à l’extérieur du Parc National de Kibale
Published 2015-03-01“…Nous avons combiné des entretiens semi-directifs et des observations participantes (N = 42 villageois et agriculteurs, gestionnaires, employés des usines de thé) avec des relevés floristiques en lisière de forêt (N = 8 transects soit 32 relevés situés entre 0 et 150 mètres de part et d’autre de la lisière de la forêt – janvier à avril 2013) dans un Système d’Information Géographique (SIG) pour spatialiser les rapports entre les hommes que nous avons interrogés et les chimpanzés que nous étudions. …”
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15848
The Study of Relative Clauses in Azeri Turkish and Persian: A Typological Approach
Published 2024-09-01“…The results show that Persian employs both gap and pronoun retention strategies in relativization, while Turkish uses only the gap strategy. …”
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15849
Network Meta-Analysis of Factors Influencing the Carbon Sink Capacity of Urban Park Green Spaces
Published 2025-01-01“…In light of the increasingly prominent role of urban green spaces in mitigating climate change, the research also seeks to highlight strategies that balance ecological functions with urban recreational and aesthetic needs.MethodThis research employs the network Meta-analysis method to explore the critical factors influencing the carbon sequestration potential of urban park green spaces, and conduct a systematic quantitative assessment of their respective carbon sink capacity. …”
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15850
Integrated microbiome, transcriptome and metabolome insight into the alleviating mechanisms of sheep milk in a DSS-induced colitis mouse model
Published 2025-02-01“…In this study, q-PCR, ELISA, IHC, microbiome, untargeted metabolome and transcriptome were employed to investigate the mechanisms of sheep milk treatment in colitis. …”
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15851
LGR4 is essential for maintaining β-cell homeostasis through suppression of RANK
Published 2025-02-01“…To determine the role of LGR4 we employed in vitro Lgr4 loss and gain of function in primary rodent and human β-cells and examined its mechanism of action in the rodent INS1 cell line. …”
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15852
Evaluation of the adherence of municipalities and states to the Ministry of Health’s microplanning for high-quality vaccination activities and the increase in vaccination coverage...
Published 2025-01-01“…Among the states, 37.04% showed full adherence by employing all evaluated actions, with 33.33% executing four actions. …”
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15853
A China dataset of soil properties for land surface modelling (version 2, CSDLv2)
Published 2025-02-01“…Data-splitting and independent-sample validation strategies were employed to evaluate the accuracy of the predicted maps' quality. …”
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15854
Proteomic profiling of the local and systemic immune response to pediatric respiratory viral infections
Published 2025-01-01“…Despite this, no studies have employed proteomics to characterize host immune responses to severe pediatric vLRTI in both the lower airway and systemic circulation. …”
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15855
SLC31A1 promotes chemoresistance through inducing CPT1A-mediated fatty acid oxidation in ER-positive breast cancer
Published 2025-03-01“…Tamoxifen (TAM), a commonly employed medication for ER-positive breast cancer, often yields suboptimal therapeutic outcomes due to the emergence of TAM resistance, leading to the recurrence and a poor prognosis. …”
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15856
Exploring in vivo human brain metabolism at 10.5 T: Initial insights from MR spectroscopic imaging
Published 2025-02-01“…Here, we present the preliminary findings from 3D MR spectroscopic imaging (MRSI) of the human brain conducted with the world's first 10.5 T whole-body MR system. Methods: Employing a custom-built 16-channel transmit and 80-channel receive MR coil at 10.5 T, we conducted MRSI acquisitions in six healthy volunteers to map metabolic compounds in the human cerebrum in vivo. …”
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15857
Peer support for adult social care in prisons in England and Wales: a mixed-methods rapid evaluation
Published 2025-01-01“…This study identified areas for improvement, for example the need for formal training for buddies and staff, and the need for clear standardised employment procedures. Buddy schemes are valued by staff, buddies and recipients. …”
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15858
Kontribusi Mazhab Teologis Mu'tazilah Dalam Perkembangan Sastra Arab Era Aabbasiyah Studi Analisis Kritis Historis
Published 2024-08-01“…The theoretical framework employed is historical criticism theory, as the study's object involves historical facts of the Islamic golden age. …”
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15859
HIV self-testing alone or with additional interventions, including financial incentives, and linkage to care or prevention among male partners of antenatal care clinic attendees in...
Published 2019-01-01“…The majority (2,201/2,233; 98.6%) of women were married, 254/2,107 (12.3%) were unable to read and write, and 1,505/2,247 (67.0%) were not employed. The mean age for male partners was 29.6 years (SD: 7.5), only 88/2,200 (4.0%) were unemployed, and 966/2,210 (43.7%) had never tested for HIV before. …”
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15860
Estimation of yield and nitrogen use efficiencies in hybrid maize varieties through site specific nitrogen management based on leaf color chart (LCC)
Published 2025-02-01“…Split Plot Design (SPD) employing three maize varieties (Shalimar Maize Hybrid-2 (SMH-2), Kanchan-517 and Vivek-45) in main plots and precision management of nitrogen (T1: Control, T2: Recommended Nitrogen (120 kg N ha–1), T3: 25% N as basal LCC @20 (≤ 3) kg N ha−1, T4: 25% N as basal LCC @30 (≤ 3) kg N ha−1, T5: 25% N as basal LCC @20 (≤ 4) kg N ha−1, T6: 25% N as basal LCC @30 (≤ 4) kg N ha−1, T7: 25% N as basal LCC @20 (≤ 5) kg N ha−1 and T8: 25% N as basal LCC @30 (≤ 5) kg N ha−1) in sub-plots was systemized. …”
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