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15721
Causal role of plasma liposome in diabetic retinopathy: mendelian randomization (MR) study
Published 2025-02-01“…To investigate this matter further, we employed a two-sample Mendelian randomization (MR) analysis to comprehensively assess the causality between lipidome levels and DR. …”
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15722
IL-6/GATA2/SERPINE1 pathway is implicated in regulating cellular senescence after acute kidney injury
Published 2025-02-01“…Additionally, the levels of IL-6 were detected by employing ELISA kits. RNA sequencing analysis was performed on cells treated with myoglobin and tocilizumab. …”
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15723
Using Human-Centered Design to Bridge Zero-Dose Vaccine Gap: A Case Study of Ilala District in Tanzania
Published 2025-01-01“…A home-to-home interpersonal sensitization approach accompanied by the household delivery of vaccination services was employed. The findings reveal that the HCD framework was impactful in increasing collaborations/cooperation with local government leaders and community ownership of the under-five vaccination initiative. …”
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15724
Identification of WDR74 and TNFRSF12A as biomarkers for early osteoarthritis using machine learning and immunohistochemistry
Published 2025-01-01“…Additionally, ML analysis was performed to identify core URGs and construct a diagnostic model. We employed XGBoost, a gradient-boosting ML algorithm, to identify core URGs and construct a diagnostic model. …”
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15725
Social learning activities to improve community engagement in waste management program
Published 2023-07-01“…Several education-based initiatives have been employed to improve community engagement in waste management programs, but the effects were not satisfied in changing resident behavior for sustainable engagement. …”
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15726
Construction and Pathogenicity Analysis of a GFPuv-labeled Peanut Ralstonia solanacearum Strain
Published 2024-11-01“…The suicide plasmid pK18mobsacB and homologous recombination double exchange technology were employed to integrate the GFPuv gene into the designated site of PeaFJ1 genome. …”
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15727
Derivation and validation of a clinical predictive model for longer duration diarrhea among pediatric patients in Kenya using machine learning algorithms
Published 2025-01-01“…We conducted split-sampling and employed K-fold cross-validation with over-sampling technique in the model development. …”
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15728
Serum uric acid/creatinine ratio and 1-year stroke recurrence in patient with acute ischemic stroke and abnormal renal function: results from the Xi'an stroke registry study of Chi...
Published 2025-02-01“…Multivariable Cox regression, curve fitting, and stratified analyses were employed to assess the relationship between SUA/SCr and 1-year stroke recurrence in patients with AIS and abnormal renal function, considering SUA/SCr as both a continuous variable and in quartiles (Q1–Q4).ResultsOf 1,932 enrolled patients (65.3% male; mean age 66.7 ± 11.3 years), each unit of increase in SUA/SCr was associated with a 17% decrease in 1-year stroke recurrence (HR = 0.83, 95% CI 0.73 to 0.96, P = 0.009). …”
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15729
Barriers to 12-month treatment of common anxiety, mood, and substance use disorders in the World Mental Health (WMH) surveys
Published 2025-02-01“…Barriers were predicted by low education, disorder type, age, employment status, and financial obstacles. Predictors varied as a function of barrier type. …”
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15730
Therapeutic role of miR-26a on cardiorenal injury in a mice model of angiotensin-II induced chronic kidney disease through inhibition of LIMS1/ILK pathway
Published 2025-01-01“…Immunofluorescence reporter assays were used to detect downstream genes of miR-26a, and immunoprecipitation was employed to identify the interacting protein of LIM and senescent cell antigen-like domain 1 (LIMS1). …”
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15731
Diversity and distribution of nitrifying bacteria play an important role in the nitrogen cycle in mangrove sediments
Published 2024-10-01“…Data collection was carried out by utilizing 6 databases and journal search engines including Scopus, PubMed, ResearchGate, Google Scholar, and Springer in order to achieve more comprehensive findings. This study employed the widely recognized and commonly used technique of defining the review's scope in a focused manner by first identifying the population, intervention, comparison, and outcome. …”
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15732
Placental trophoblast aging in advanced maternal age is related to increased oxidative damage and decreased YAP
Published 2025-01-01“…Cellular experiments demonstrated that oxidative damage from H2O2 triggered trophoblast cell senescence and resulted in a reduction of YAP levels. Furthermore, employing molecular modification to silence YAP expression in these cells led to an induction of aging. …”
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15733
Residence-based disparities of composite index of anthropometric failures in East African under five children; multivariate decomposition analysis
Published 2025-02-01“…To appreciate the residence-based differences of composite index of anthropometric failure in under-5 children, the Blinder-Oaxaca decomposition analysis and its extensions were employed to determine the effects of covariates and coefficients. …”
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15734
Prevalence of peptic ulcer disease and its associated factors in Jeddah Saudi Arabia
Published 2025-01-01“…Data was collected through an online survey using convenience sampling and analyzed with SPSS and Excel, employing both descriptive and inferential statistical methods. …”
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15735
Steatohepatitis-induced vascular niche alterations promote melanoma metastasis
Published 2025-01-01“…Levels of adhesion molecules (VCAM1, ICAM1, E-selectin) were monitored, and ICAM1 and VCAM1 antibody therapy was employed. Results Feeding a CDAA diet, in contrast to a HFD, led to increased metastasis before the development of liver fibrosis. …”
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15736
Chemical Composition Analysis of the Patented Naoxueshuan Formula Based on UPLC-Q-TOF MS and GC-MS
Published 2025-01-01“…For GC-MS analysis, the Agilent DB-5MS capillary column (30 m×0.25 mm, 0.25 μm) was employed to analyze the volatile components of the decoction of Naoxueshuan formula. …”
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15737
PLGA-based biocompatible nanoparticles improved anti-breast tumor efficacy of 1,25(OH)2D3 through the SOCS3/STAT3/EMT signaling axis
Published 2025-03-01“…The FDA-approved nanomaterial poly (lactic-co-glycolic acid) (PLGA) had the potential for utilization in clinical settings. It could be employed to helps in maintaining and extending the biological activity of the drugs, thereby enhancing their therapeutic efficacy. …”
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15738
Therapeutic depletion of CCR8+ tumor-infiltrating regulatory T cells elicits antitumor immunity and synergizes with anti-PD-1 therapy
Published 2021-02-01“…Background Modulation and depletion strategies of regulatory T cells (Tregs) constitute valid approaches in antitumor immunotherapy but suffer from severe adverse effects due to their lack of selectivity for the tumor-infiltrating (ti-)Treg population, indicating the need for a ti-Treg specific biomarker.Methods We employed single-cell RNA-sequencing in a mouse model of non-small cell lung carcinoma (NSCLC) to obtain a comprehensive overview of the tumor-infiltrating T-cell compartment, with a focus on ti-Treg subpopulations. …”
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15739
The Impact of Acute Aerobic Exercise on General and Food-Related Inhibitory Function Among Young Adults with Obesity: An Event-Related Potential (ERP) Study
Published 2025-01-01“…<b>Design</b>: A within-subject design comprising three sessions (control, low-intensity exercise, moderate-intensity exercise) × three picture types (high-calorie food, low-calorie food, neutral picture) was employed. <b>Methods</b>: Eighteen young adult males with obesity [body mass index (BMI): 34.60 ± 4.21 kg/m<sup>2</sup>, aged 24.50 ± 5.13 years (Mean ± SD)] were recruited. …”
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15740
Efficacy and safety of PD-1/PD-L1 inhibitors in advanced or recurrent endometrial cancer: a meta-analysis with trial sequential analysis of randomized controlled trials
Published 2025-01-01“…To evaluate heterogeneity, we employed Cochran’s Q test, I2 statistics, and 95% prediction intervals (PIs). …”
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