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15701
Interventions for the management of post-COVID-19 condition (long COVID): protocol for a living systematic review and network meta-analysis
Published 2025-02-01“…Our outcomes of interest will include patient-reported fatigue, pain, postexertional malaise, changes in education or employment status, cognitive function, mental health, dyspnoea, quality of life, physical function, recovery and serious adverse events.For each outcome, when possible, we will perform a frequentist random-effects network meta-analysis. …”
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15702
Artificial intelligence-based prediction of second stage duration in labor: a multicenter retrospective cohort analysisResearch in context
Published 2025-02-01“…After the optimal features selected by recursive feature elimination (RFE) method, four ML algorithms were employed to build the models. The best model would be selected with the predictive performance and interpreted with Shapley Additive exPlanations method. …”
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15703
Analyzing the impact of glycemic metabolic status on cardiovascular mortality and all-cause mortality related to the estimated glucose disposal rate: a nationwide cohort study
Published 2025-01-01“…Multivariable Cox regression was employed to explore the relationships between eGDR and mortality rates under varying glycemic states. …”
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15704
N6-methyladenosine RNA modification regulates the transcription of SLC7A11 through KDM6B and GATA3 to modulate ferroptosis
Published 2025-01-01“…RNA sequencing (RNA-seq) was employed to analyze the factors regulating ferroptosis. …”
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15705
A Neural Circuit From Paraventricular Nucleus of the Thalamus to the Nucleus Accumbens Mediates Inflammatory Pain in Mice
Published 2025-01-01“…To investigate the role of PVTGlut→NAc in the modulation of pain, we used optogenetics to modulate this neural circuit, and nociceptive behavioral tests were employed to investigate the functional role of the PVTGlut→NAc circuit in the modulation of inflammatory pain. …”
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15706
Dynamic monitoring and drivers of ecological environmental quality in the Three-North region, China: Insights based on remote sensing ecological index
Published 2025-03-01“…Additionally, a SHapley Additive eXplanation (SHAP) interpretable machine learning model was employed to identify the dominant factors and thresholds influencing the EEQ in the TNEP and its sub-regions. …”
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15707
The prognostic association of triglyceride-glucose index and its derived indicators with stable coronary artery disease patients undergoing percutaneous coronary intervention
Published 2025-01-01“…Kaplan-Meier survival analysis was employed to assess the prognostic differences among groups.ResultsAfter a median follow-up of 26.1 months, a total of 352 patients (15.3%) experienced MACCE. …”
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15708
The temporal change of heat exposure and adaptation capacity in Chinese adults from 1994 to 2023
Published 2025-01-01“…The Chi square test was employed to compare the difference between different demographic subgroups during 2014–2023. …”
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15709
Correlations between primary tumour location, biomarkers of inflammation and lung injury, and postoperative pulmonary complications in patients underwent laparoscopic colorectomy:...
Published 2025-01-01“…IntroductionThe impact of distinct primary colorectal cancer (CRC) sites on lung injury and complications remains largely unexplored, despite the palpable differences in surgical positions, procedures, and the resulting mechanically induced respiratory pressures at each site.Materials and methodsThis study employed a forwards-looking approach utilising the propensity score matching (PSM) method; 300 patients with pathological CRC after laparoscopic surgery from April 2019 to May 2023 were enrolled. …”
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15710
β-synuclein in cerebrospinal fluid as a potential biomarker for distinguishing human prion diseases from Alzheimer’s and Parkinson’s disease
Published 2025-02-01“…The Mann–Whitney U test and Kruskal–Wallis H test were employed to analyze two or more sets of continuous variables. …”
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15711
Risk factors associated with mortality and pathogen characteristics of bloodstream infection-induced severe sepsis in the pediatric intensive care unit: a retrospective cohort stud...
Published 2025-02-01“…Logistic regression analysis was employed to identify independent risk factors associated with 28-day mortality.ResultsA total of 192 patients with bloodstream infection (BSI)-induced severe sepsis were identified, with a 28-day in-hospital mortality rate of 36.98% (71/192). …”
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15712
Fibroblast growth factor receptor 3 mutation promotes HSPB6-mediated cuproptosis in hypochondroplasia by impairing chondrocyte autophagy
Published 2025-03-01“…Radiography and micro-computed tomography were employed to assess the bone-specific phenotype in Fgfr3 (V376D)mutant mice. …”
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15713
Life cycle assessment and life cycle cost of tofu production and its extended recycling scenario
Published 2024-01-01“…The impact of waste recycling on the eco-efficiency of small and medium-sized enterprises in Sugihmanik Village, Grobogan Regency, Indonesia is also examined.METHODS: To achieve this goal, this study employed life cycle assessment and life cycle cost methodologies to evaluate eco-efficiency. …”
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15714
Multi-omics uncovers immune-modulatory molecules in plasma contributing to resistance exercise-ameliorated locomotor disability after incomplete spinal cord injury
Published 2025-02-01“…Moreover, it was emphasized that resistance exercise interventions could effectively modulate these pathways. Through employing plasma proteomic profiling and transcriptomic profiling of PBMC and muscle tissues in mice, our study revealed immunomodulatory responses that parallel those observed in human trials. …”
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15715
High-throughput methylation sequencing reveals novel biomarkers for the early detection of renal cell carcinoma
Published 2025-01-01“…Comparative analysis and Least Absolute Shrinkage and Selection Operator (LASSO) regression methods were employed to identify RCC methylation signatures.Subsequently, methylation markers-based diagnostic and prognostic models for RCC were independently trained and validated using random forest and Cox regression methodologies, respectively. …”
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15716
Social-ecological perspective on the suicidal behaviour factors of early adolescents in China: a network analysis
Published 2024-02-01“…Network analysis was employed to examine the correlates of suicidal ideation, plans and attempts at four levels, namely individual (sex, academic performance, serious physical illness/disability, history of self-harm, depression, impulsivity, sleep problems, resilience), family (family economic status, relationship with mother, relationship with father, family violence, childhood abuse, parental mental illness), school (relationship with teachers, relationship with classmates, school-bullying victimisation and perpetration) and social (social support, satisfaction with society).Results In total, 37.9%, 19.0% and 5.5% of the students reported suicidal ideation, plans and attempts in the past 6 months, respectively. …”
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15717
Pragmatic algorithm for visual assessment of 4-Repeat tauopathies in [18F]PI-2620 PET Scans
Published 2025-02-01“…Conclusion: Visual reading of [18F]PI-2620 tau-PET scans demonstrated reliable detection of 4R-tauopathies, particularly when standardized processing methods and early imaging windows were employed. Parametric images should be preferred for visual assessment of 4R-tauopathies.…”
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15718
Co-benefits of nature-based solutions: A health impact assessment of the Barcelona Green Corridor (Eixos Verds) plan
Published 2025-02-01“…We computed the percentage increase in GS (land use) and tree cover and converted them into Normalized Difference Vegetation Index (NDVI) to conduct the HIA, employing a Generalized Additive Model (GAM). We used the Weather Research and Forecasting model (WRF) coupled with the urban parameterizations “Building Effect Parameterization” (BEP) and “Building Energy Model” (BEM) for temperature modelling. …”
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15719
An integrative analysis of ASCL1 in breast cancer and inhibition of ASCL1 increases paclitaxel sensitivity by activating ferroptosis via the CREB1/GPX4 axis
Published 2025-02-01“…The TIP database was employed to investigate the connection between ASCL1 expression and immunoreactivity scores, and six computational approaches were applied to evaluate immune cell infiltration. …”
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15720
Identification and validation of a prognostic signature of drug resistance and mitochondrial energy metabolism-related differentially expressed genes for breast cancer
Published 2025-01-01“…By merging these genes with differentially expressed genes observed in normal and tumor tissues from the TCGA-BRCA and GEO databases, we successfully identified the DMRDEGs. Employing unsupervised consensus clustering, we divided breast cancer patients into two distinct groups based on the DMRDEGs. …”
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