Dual role of ramR mutation in enhancing immune activation and elevating eravacycline resistance in Klebsiella pneumoniae by Wei Yu, Peiyao Jia, Xiaobing Chu, Shengjie Li, Xinmiao Jia, Ying Zhu, Xiaoyu Liu, Yingchun Xu, Qiwen Yang

“…Then, the CRISPR‐Cas9 technology was employed to construct specific ramR mutations into K. pneumoniae, which were then subjected to phenotypic and functional assays in both in vitro and in vivo (mouse models, macrophage, and blood‐killing experiment) settings. ramR L58P and F165L genetic alterations disrupt the binding affinity of RamR to the ramA promoter, thereby upregulating the efflux pump expression and increasing ERV minimum inhibitory concentration values up to 64‐fold compared to the wild‐type. …”
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Novel organophosphate esters and their transformation products in offshore sediment from Eastern China: Occurrence, temporal trend, and risk assessment by Meng Gao, Yu Wang, Liman Wei, Siyuan Li, Qiuyue Zhang, Zhongkang Yang, Mohan Bai, Yiming Yao, Lei Wang, Hongwen Sun

“…Furthermore, a risk quotient (RQ) model was employed to assess the ecological risks posed by OPEs. …”
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Adaptive spatial-channel feature fusion and self-calibrated convolution for early maize seedlings counting in UAV images by Zhenyuan Sun, Zhenyuan Sun, Zhenyuan Sun, Zhi Yang, Zhi Yang, Yimin Ding, Yimin Ding, Boyan Sun, Boyan Sun, Saiju Li, Saiju Li, Zhen Guo, Zhen Guo, Lei Zhu, Lei Zhu

“…Additionally, transfer learning was employed to integrate pre-trained weights with RSCconv, facilitating faster convergence and improved accuracy. …”
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Inorganic constituents in cassava derivatives: Total concentration, dietary intake and bioaccessibility by Leilane R. Santos, Filipe B. Santana, Hilária F.A. Silveira, Wellington C. de Carvalho, Laís A. Souza, Rennan Geovanny O. Araujo, Maria Graças A. Korn, Daniele Cristina M.B. Santos

“…Methods: The concentrations of As, Ba, Cd, Ca, Co, Cu, Fe, K, Mg, Mn, Na, Pb, Se, Sr, V, and Zn were determined in cassava samples using inductively coupled plasma optical emission spectrometry and inductively coupled plasma mass spectrometry after sample decomposition employed closed digester block and diluited nitric acid. …”
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Prognostic Implications of the Number of Lymph Node Metastases in Oral Tongue Squamous Cell Carcinoma: A Population Study of the SEER Database and an Institutional Registry by Wenjie Huang, Yu Zhang, Hao Li, Zhiying Liang, Shumin Zhou, Jie Pan, Hui Xie, Chao Luo, Shuqi Li, Guangying Ruan, Fei Ai, Yanfeng Chen

“…Multivariate Cox proportional hazards model was employed to calculate hazard ratios (HRs) and 95% confidence intervals (CIs) of pathological nodal features. …”
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Status of cerebrovascular autoregulation relates to outcome in severe paediatric head injury: STARSHIP, a prospective multicentre validation studyResearch in context by Shruti Agrawal, Claudia Smith, Stefan Y. Bogli, Michal M. Placek, Manuel Cabeleira, Deborah White, Esther Daubney, Adam Young, Erta Beqiri, Riaz Kayani, Diarmuid O'Donnell, Nazima Pathan, Suzanna Watson, Anna Maw, Matthew Ganrett, Hari Krishan Kanthimathianathan, Harish Bangalore, Santosh Sundararajan, Gayathri Subramanian, Dusan Raffaj, Avishay Sarfatti, Simona Lampareillo, Anton Mayer, Oliver Ross, Marek Czosnyka, Peter J. Hutchinson, Peter Smielewski, Carly Tooke, Caroline Payne, Holly Belfield, Amisha Mistry, Collette Spencer, Claire Jennings, Lara Bunni, Laura Anderson, Emily Morgan, Melanie James, Rebecca Beckley, Tahnima Khatun, Hafiza Khatun, Olivia Nugent, Richard Aldridge, Ruth Morgan, Julie Morcombe, Martin Quinton, Catherine Postlethwaite, Jenny Pond, Jessica Cutler, Caitlin Oxford

“…Univariable and multivariable analyses including propensity score matching, were employed to determine the effect of PRx on outcome whilst considering covariates, centre-specific differences and other multimodal metrics. …”
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Systematic identification of secondary bile acid production genes in global microbiome by Yuwei Yang, Wenxing Gao, Ruixin Zhu, Liwen Tao, Wanning Chen, Xinyue Zhu, Mengping Shen, Tingjun Xu, Tingting Zhao, Xiaobai Zhang, Lixin Zhu, Na Jiao

“…To bridge this gap, we employed hidden Markov models to systematically search in a large-scale and high-quality search library comprising 28,813 RefSeq multi-kingdom microbial complete genomes, enabling us to construct a secondary bile acid production gene catalog. …”
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Mechanism of salvianolic phenolic acids and hawthorn triterpenic acids combination in intervening atherosclerosis: network pharmacology, molecular docking, and experimental validat... by Qu Zhai, Shixi Shang, Zihan Zhang, Lihua Sun, Ying Huang, Shuyi Feng, Qian Wu, Haifeng Cui, Xiaolu Shi

“…BackgroundThis study employs network pharmacology and molecular docking methods in conjunction with animal experimentation to elucidate the underlying mechanism by which the combination of salvianolic phenolic acids and hawthorn triterpenic acids (SHC) exerts its therapeutic effect on carotid atherosclerosis (AS) in ApoE−/− mice.MethodsA network pharmacology research approach was used to predict potential core targets for SHC intervention in atherosclerosis. …”
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A Review on Blockchain Applications in Operational Technology for Food and Agriculture Critical Infrastructure by Chengliang Zheng, Xiangzhen Peng, Ziyue Wang, Tianyu Ma, Jiajia Lu, Leiyang Chen, Liang Dong, Long Wang, Xiaohui Cui, Zhidong Shen

“…This study presents a comprehensive review of BT applications in OT security for food and agriculture CI, employing bibliometric and content analysis methods. …”
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A digital intervention to reduce home-office workers’ sedentary behaviour: protocol for the evaluation of the Click2Move programme, a cluster randomised controlled trial by Judit Bort-Roig, Iris Parés-Salomón, Bette Loef, Cristina Vaqué-Crusellas, Alan Coffey, Arnau Gustems-Morral, Anna M. Señé-Mir, Izabela Luznik, Maja Pajek, Kieran P. Dowd, Anna Puig-Ribera, Karin I. Proper

“…Linear mixed models, accounting for covariates, will be employed to determine the effects of the intervention. …”
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Heatwave warnings mitigate long-term cardiovascular diseases risk from heat-related illness: a real-world prospective cohort studyResearch in context by Qi Huang, Limei Ke, Linfeng Liu, Yuyang Liu, Yanjun Li, Guoqing Feng, Bo Yin, Wenxin Xiang, Jiarun Li, Keyi Lyu, Miao Wang, Qiannan Tian, Liqun Wu, Xiaofeng He, Wannian Liang, Huatang Zeng, Jiming Zhu, Kuiying Gu, Qian Di

“…We utilized Cox proportional hazards model to analyse CVD incidence among participants who had heat-related illness versus those who did not, and further assessed causal relationship using instrumental variable approach. We employed stratified logistic regression to explore the protective effects of heatwave warning policies. …”
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Designing a Future Study Model: Examining Bank Employees’ Attitudes Towards Job Security in the Era of Blockchain Technology (Horizon 2031) by Saeid Ghazi Nezhad, Hasan Darvish, Mohammad Mahmoudi Meymand

“…Keywords, such as "blockchain in the horizon of 2031", "job security", and "blockchain adoption", were utilized to identify authoritative sources. 3) Research content analysis: The directed content analysis technique, specifically the directed approach, was employed in this research. 4) Coding process: After collecting the articles and books, an open coding process was employed. …”
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Providing an entrepreneurial marketing model based on teamwork with an emphasis on start-up companies by Parastoo Bafghi, Mahmoud Ahmadi Sharif, Sina Nematizadeh

“…When setting goals, entrepreneurs must consider various factors such as their entrepreneurial goals and marketing strategy, the tactics they will employ, available resources, and the target market. …”
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Petrogenetic evidences in geodynamics and placement of Nordoz intrusive masses in Alborz-Azerbaijan structural zone by Shahryar Mahmoudi, Shiva Lavi, Shohreh Hassanpour, Amir Ali Tabakh Shabani, Mehran Yegane Far

“…The 143Nd/144Nd versus 87Sr/86Sr isotope correlation plots, as presented by Zindler and Hart (1986), were employed to ascertain the provenance of the intrusive rocks in the Nordoz region. …”
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Presenting a model of ecotourism and sustainable tourism development with an emphasis on foreign exchange and economic development of Qeshm Island by Naser Rajabi, Vahid Reza Mirabi, Khosro Moradi Shahdadi

“…Economic development means increasing production, employment, welfare and economic growth. These two concepts are directly related to each other (Cypher, 2014).Ruzbeh et al, (2023) investigated the presentation of the green governance model with a sustainable development approach in the health system (the case study of hospitals in Kerman city). …”
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Hypovitaminosis D in patients with oral leukoplakia: insights from a cross-sectional study by Andrea Maturana-Ramirez, Andrea Maturana-Ramirez, Juan Aitken-Saavedra, Dante Mora-Ferraro, Gabriel Rojas-Zúñiga, Iris Espinoza-Santander, Gonzalo Rojas-Alcayaga, Ana Ortega-Pinto, Montserrat Reyes, Diego Lazo, Egardo Caamanão

“…In both groups a pathology report was done, and for leukoplakia a binary classification of low- and high-grade epithelial dysplasia was employed. Serum 25(OH)D3 vitamin D levels, and data on smoking status, age, gender, comorbidities, and clinical and pathological characteristics were collected for both groups.Resultsvitamin D levels were lower in the oral leukoplakia group with a median of 19.1 ng/ml, while the control group had a median of 24.8 ng/ml. …”
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Latarjet procedure versus iliac crest autograft transfer for anterior shoulder instability: a systematic review and meta-analysis of comparative studies by Lang Li, Bofang Zeng, Meng Ding, Sha Wan, Kefu Lin, Zhen Tian

“…The Latarjet and iliac crest bone graft transfer (ICBGT) procedures are commonly employed for its management, but direct comparative evidence is insufficient. …”
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Exploration of neurometabolic alterations in adolescent patients with bipolar depression and non-suicidal self-injury based on proton magnetic resonance spectroscopy by Chengji Wang, Yuan Qu, Xiaoqin Shen, Xiaoxiao Tang, Xiaoxiao Tang, Gaiyu Tong, Meier Wati, Manzeremu Naibi, Manzeremu Naibi, Cheng Zhang, Shaohong Zou

“…Therefore, this study employed proton magnetic resonance spectroscopy (1H-MRS) technology to investigate the potential relationship between NSSI and neurometabolism in the ventromedial prefrontal cortex (vmPFC) of patients with ABD.MethodsThis study compared brain biochemical metabolism between ABD with and without NSSI. …”
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Research progress of auricular point therapy to relieve preoperative period anxiety before elective surgery in adults (耳穴压豆缓解成年人择期手术术前焦虑的研究进展)... by GAO Yuan (高原), XU Lingzhi (徐凌志), LI Suxia (李素霞)

“…To alleviate this issue, non-pharmacological interventions such as prayer, massage, music, imagery, and acupuncture have been widely employed. These methods have proven effective in reducing preoperative anxiety, lowering healthcare costs, and enhancing patient satisfaction. …”
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Understanding phage BX-1 resistance in Vibrio alginolyticus AP-1 and the role of quorum-sensing regulation by Xiaoyu Li, Xin Liu, Tianyi Ma, Haochen Su, Bingrui Sui, Lili Wang, Bilal Murtaza, Yongping Xu, Na Li, Demeng Tan

“…Collectively, these insights illuminate the evolutionary complexities of phage-defense systems and the broader strategies that bacteria employ to coexist with phages.…”
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