Investigating variability of craft microbreweries spent grains for classification and incorporation into precision diet formulation through multivariate analyses by Arturo Macias Franco, Aghata E.M. Silva, Tio Brody, Graham Holton, Macy Rockwell, Nelcino F. De Paula, Leilson R. Bezerra, Mozart A. Fonseca

“…Principal component analysis (PCA) was employed to identify the most significant nutrient variations, and hierarchical clustering of the principal components was used to group the samples into four distinct clusters. …”
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Exploring sex differences in Alzheimer’s disease: a comprehensive analysis of a large patient cohort from a memory unit by Maitee Rosende-Roca, Fernando García-Gutiérrez, Yahveth Cantero-Fortiz, Montserrat Alegret, Vanesa Pytel, Pilar Cañabate, Antonio González-Pérez, Itziar de Rojas, Liliana Vargas, Juan Pablo Tartari, Ana Espinosa, Gemma Ortega, Alba Pérez-Cordón, Mariola Moreno, Sílvia Preckler, Susanna Seguer, Miren Jone Gurruchaga, Lluís Tárraga, Agustín Ruiz, Sergi Valero, Mercè Boada, Marta Marquié

“…We obtained cognitive baseline data and follow up scores for the Mini-Mental State Examination (MMSE), the CDR scale, and the neuropsychological battery used in our center (NBACE). We employed various statistical techniques to assess the impact of sex on cognitive evolution in these dementia patients, accounting for other sex-related risk factors identified through Machine Learning methods. …”
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Novel loci for triglyceride/HDL-C ratio longitudinal change among subjects without T2D by Lihua Wang, Siyu Wang, Jason A. Anema, Vaha A. Moghaddam, Yanli Lu, Shiow Lin, E. Warwick Daw, Allison L. Kuipers, Iva Miljkovic, Michael Brent, Gary J. Patti, Bharat Thygarajan, Joseph M. Zmuda, Michael A. Province, Ping An

“…GWAS used a linear mixed model accounting for familial relatedness. GWLS employed haplotype-based identity-by-descent estimation with 0.5 cM average spacing. …”
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Preliminary Data on <i>Silybum marianum</i> Metabolites: Comprehensive Characterization, Antioxidant, Antidiabetic, Antimicrobial Activities, LC-MS/MS Profiling, and Predicted ADME... by Sabrina Lekmine, Ouided Benslama, Mohammad Shamsul Ola, Nabil Touzout, Hamza Moussa, Hichem Tahraoui, Haroun Hafsa, Jie Zhang, Abdeltif Amrane

“…Methods: The extraction was performed using microwave-enhanced techniques, and LC-MS/MS was employed to profile the metabolites in the extract. …”
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Targeting UGT2B15 and NR1H4 interaction: a novel therapeutic strategy for polycystic ovary syndrome using naftopidil enantiomers by Xiufen Zheng, Zikai Chen, Miao Liang, Liting Zhou, Miaoru Wang, Silin Zhang, Shuyun Zhang, Lei Ma, Wei Yi, Xiawen Liu

“…To modulate UGT2B15 expression, we employed siRNA and (R)/(S)-NAF (naftopidil), a chemical inducer of UGT2B15 identified in our previous studies on a prostate hyperplasia model. …”
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Impacts of plant root traits and microbial functional attributes on soil respiration components in the desert-oasis ecotone by Jinlong Wang, Jinlong Wang, Jinlong Wang, Guanghui Lv, Guanghui Lv, Guanghui Lv, Jianjun Yang, Jianjun Yang, Jianjun Yang, Xuemin He, Xuemin He, Xuemin He, Hengfang Wang, Hengfang Wang, Hengfang Wang, Wenjing Li, Wenjing Li, Wenjing Li

“…This study was strategically designed to investigate Rs and its components (Ra and Rh), soil properties, and root traits within the desert-oasis ecotone (encompassing the river bank, transitional zone, and desert margin) of northwest China. Employing metagenomics, we quantitatively characterized microbial taxonomic attributes (i.e., taxonomic composition) and functional attributes (specifically, functional genes implicated in microbial carbon metabolism). …”
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Prognostic value of inflammatory markers for all-cause mortality in patients with acute myocardial infarction in the coronary care unit: a retrospective study based on MIMIC-IV dat... by Fen Cao, Jun-jun Jiang, Gui Zhang, Jun Liu, Ping Xiao, Yang Tian, Wei Zhang, Sheng Zhang, Feng Hou, Zhong-Wu Bao, Kun Wu, Yong-zhi Zhu

“…Logistic regression models were employed to determine the correlation between NLR and in-hospital mortality, 30-day mortality, and 90-day mortality. …”
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Errors Associated With Medication Administration by a Nurse During Hospitalisation: A Prospective Observational Multicentric Study by Ondrej Tesar, Martin Dosedel, Ales Antonin Kubena, Katerina Mala‐Ladova, Radka Prokesova, Iva Brabcova, Hana Hajduchova, Martin Cerveny, Ivana Chloubova, Jiri Vlcek, Valerie Tothova, Josef Maly

“…Direct observation by the multidisciplinary team was employed. MAEs were classified as major MAEs (from the potentially most serious and common to all drug forms), specific MAEs (specific to a drug form), and procedural MAEs (e.g., patient identification, hygiene standards, or generic drug substitution). …”
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Spatiotemporal analysis of surface Urban Heat Island intensity and the role of vegetation in six major Pakistani cities by Shoaib Ahmad Anees, Kaleem Mehmood, Syed Imran Haider Raza, Sebastian Pfautsch, Munawar Shah, Punyawi Jamjareegulgarn, Fahad Shahzad, Abdullah A. Alarfaj, Sulaiman Ali Alharbi, Waseem Razzaq Khan, Timothy Dube

“…Specifically, imagery from Landsat-5 (2010−2013) and Landsat-8 (2014–2022), obtained from the US Geological Survey (USGS), was employed. Statistical analyses, including Pearson's correlation and linear regression, were conducted to assess relationships between these variables from 2010 to 2022. …”
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Development and Validation of a Nomogram for Predicting Long-Term Net Adverse Clinical Events in High Bleeding Risk Patients Undergoing Percutaneous Coronary Intervention by Junyan Zhang, Zhongxiu Chen, Ran Liu, Yuxiao Li, Hongsen Zhao, Yanning Li, Minggang Zhou, Hua Wang, Chen Li, Li Rao, Yong He

“…The least absolute shrinkage and selection operator (LASSO) regression algorithm was employed to select variables in the training set. Subsequently, a prediction model for 1-year net adverse clinical events (NACEs)-free survival was developed using a multivariable Cox regression model, and a nomogram was constructed. …”
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A lightweight wheat ear counting model in UAV images based on improved YOLOv8 by Ruofan Li, Xiaohua Sun, Kun Yang, Zhenxue He, Zhenxue He, Xinxin Wang, Xinxin Wang, Chao Wang, Chao Wang, Bin Wang, Fushun Wang, Fushun Wang, Hongquan Liu, Hongquan Liu

“…Then, the Spatial Pyramid Dilated Convolution (SPD-Conv) module is employed to improve the ability of the network to learn features, thereby enhancing the representation of weak features of small targets and preventing information loss caused by low image resolution or small target sizes. …”
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Exploring the allometry between ear saturated water accumulation and dry mass for diagnosing winter wheat water status during the reproductive growth by Tingxuan Zhuang, Ben Zhao, Syed Tahir Ata-Ul-Karim, Gilles Lemaire, Xiaojun Liu, Yongchao Tian, Yan Zhu, Weixing Cao, Qiang Cao

“…Previous studies used the allometric relationship between plant dry mass (PDM) and plant saturated water accumulation (SWAP) to develop critical SWAP curves, which were employed to assess the water status of winter wheat and maize during their vegetative growth phase. …”
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Effectiveness of using implementation frameworks to facilitate the implementation of a stroke management guideline in the traditional Chinese medicine hospitals in China: protocol... by Zhuo Chen, Yefeng Cai, Wenjun He, Yiyuan Cai, Lingrui Liu, Qing Zhao, Sensen lv, Dong (Roman) Xu, Chun Hao, Lanping Zhang, Pengfei Guo, Yuning Shi

“…This study aims to evaluate the effectiveness of three popular frameworks—Consolidated Framework for Implementation Research (CFIR), Theoretical Domains Framework (TDF) and Normalization Process Theory (NPT)—in improving implementation outcomes for the integrated TCM and Western medicine clinical practice guideline for stroke management.Methods and analysis This study employs a hybrid type III design with a factorial randomised controlled trial, where 45 TCM hospitals will be randomly assigned to one of eight experimental conditions based on the use or non-use of each framework (CFIR, TDF, NPT). …”
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Harnessing deep learning to detect bronchiolitis obliterans syndrome from chest CT by Mateusz Koziński, Doruk Oner, Jakub Gwizdała, Catherine Beigelman-Aubry, Pascal Fua, Angela Koutsokera, Alessio Casutt, Argyro Vraka, Michele De Palma, John-David Aubert, Horst Bischof, Christophe von Garnier, Sahand Jamal Rahi, Martin Urschler, Nahal Mansouri

“…Methods We trained a DNN to detect BOS in CT scans using a co-training method designed to enhance performance in low-data environments. Our method employs an auxiliary task that makes the DNN more sensitive to disease manifestations and less sensitive to the patient’s anatomical features. …”
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Impact of EML4‐ALK Variants and TP53 Status on the Efficacy of ALK Inhibitors in Patients With Non‐small Cell Lung Cancer by Zihua Zou, Lige Wu, Xuezhi Hao, Yan Li, Li Liang, Yangchun Gu, Jianming Ying, Junling Li, Puyuan Xing

“…Statistical analysis was employed to investigate the impact of different EML4‐ALK variants and TP53 status on the efficacy of first‐line ALK‐TKIs. …”
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Ice-proximal sea ice reconstruction in the Powell Basin, Antarctica, since the Last Interglacial by W. W. Khoo, J. Müller, J. Müller, J. Müller, O. Esper, W. Xiao, C. Stepanek, P. Gierz, G. Lohmann, G. Lohmann, G. Lohmann, W. Geibert, J. Hefter, G. Mollenhauer, G. Mollenhauer, G. Mollenhauer

“…Finally, despite similar findings between the proxy and model data, notable differences persist between both interglacials – emphasizing the necessity for different Antarctic ice sheet configurations to be employed and more robust paleoclimate data to enhance climate model performance close to the Antarctic continental margin.…”
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Exploring the synergistic effect of rose distillation waste and biostimulant beside other organic amendments onRosa damascena seedlings’ growth by Soumia El Malahi, Lahcen Irahoui, Wafaa Mokhtari, Mounia Ennami, Houda Taimourya, Jamaa Zim, Abdallah Zayani, Bahija Zakeri, Khalid Dhassi, Mimoun Mokhtari, Lalla Mina Idrissi Hassani

“…This study underscores the significance of employing rose distillation waste in cost-effective, sustainable, and easily accessible organic agricultural practices for rose production…”
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Quantification of Forest Regeneration on Forest Inventory Sample Plots Using Point Clouds from Personal Laser Scanning by Sarah Witzmann, Christoph Gollob, Ralf Kraßnitzer, Tim Ritter, Andreas Tockner, Lukas Moik, Valentin Sarkleti, Tobias Ofner-Graff, Helmut Schume, Arne Nothdurft

“…Local maxima in these raster images, assumed to be likely to contain tree saplings, were then used as seed points for a raster-based tree segmentation, which was employed to derive the final regeneration coverage estimate. …”
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Impact of carbapenem-resistant infections on mortality in mechanically ventilated acute respiratory distress syndrome patients: A comparison with hypoxemia severity – An observatio... by Thejesh Srinivas, Shwethapriya R, Gagana Hanumaiah, Pratibha Todur, Souvik Chaudhuri, Ganesh Paramasivam, Prithvishree Ravindra, Vinutha R. Bhat, Sagar Shanmukhappa Maddani, Shobha U. Kamath, Danavath Nagendra, Vishwas P, Likith Hanumaiah, Pratik Paran Medhi, Prabha Prakash

“…Univariate and multivariable logistic regression analyses and artificial neural network model, were employed to analyze mortality outcomes. Results: CRI was present in 32.9 % of ARDS patients. …”
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Postoperative radiotherapy improves survival in completely resected non-small cell lung cancer with pathologic N2 stage IIIA and positive lymph node count greater than one: a SEER-... by Diyang Zhu, Yuanyuan Xiao, Yuanyuan Xiao, Shancheng He, Shancheng He, Baochang Xie, Baochang Xie, Wenqi Zhao, Wenqi Zhao, Yuhui Xu

“…Kaplan-Meier survival curves were employed to estimate survival outcomes, while the COX proportional hazards model was utilized for comparative analysis. …”
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