Significant role of biomass burning in heavy haze formation in Nanjing, a megacity in China: molecular-level insights from intensive PM_2.5 sampling on winter hazy days by M. Kang, M. Kang, M. Bao, M. Bao, M. Bao, W. Song, W. Song, A. Abulimiti, A. Abulimiti, C. Wu, C. Wu, F. Cao, F. Cao, S. Szidat, Y. Zhang, Y. Zhang

“…<p>Reports on the molecular-level characterization of primary and secondary constituents in PM<span class="inline-formula">_2.5</span> at high temporal resolution, particularly during haze events, are still limited. This study employed comprehensive analytical methods to examine the molecular composition and source contributions of PM<span class="inline-formula">_2.5</span>, with samples collected approximately every 2 h during hazy winter days. …”
Get full text

Does pregabalin offer potential as a first-line therapy for generalized anxiety disorder? A meta-analysis of efficacy, safety, and cost-effectiveness by Narcis Cardoner, Narcis Cardoner, Narcis Cardoner, Narcis Cardoner, Luis Gutiérrez-Rojas, Luis Gutiérrez-Rojas, Pilar Saiz, Pilar Saiz, Pilar Saiz, Pilar Saiz, Pilar Saiz, Guillermo Lahera, Guillermo Lahera, Guillermo Lahera, Guillermo Lahera, Miguel Ángel Álvarez-Mon, Miguel Ángel Álvarez-Mon, Miguel Ángel Álvarez-Mon, Miguel Ángel Álvarez-Mon, Pino Alonso Ortega, Pino Alonso Ortega, Pino Alonso Ortega, Pino Alonso Ortega, María Pérez-Páramo

“…Meta-analyses were conducted using Review Manager 5.4 software, employing odds ratios (ORs) and mean differences (MDs) with 95% confidence intervals (CIs). …”
Get full text

Peritoneal chemotherapy delivery systems for ovarian cancer treatment: systematic review of animal models by Marcelo Simonsen, Marcelo Simonsen, Rossana Verónica Mendoza López, Simone Maistro, Lucas Takeshi Ikeoka, Glaucia Fernanda de Lima Pereira, Ademar Benévolo Lugão, José Carlos Sadalla, Maria Lúcia Hirata Katayama, Maria Aparecida Azevedo Koike Folgueira

“…Analysis was based on drugs employed and treatment duration.ResultsMost studies were performed on mice. …”
Get full text

Genetic evidence for the causal effects of air pollution on the risk of respiratory diseases by Yanjuan Wu, Yuting Zhang, Jingcun Wang, Qiming Gan, Xiaofen Su, Sun Zhang, Yutong Ding, Xinyan Yang, Nuofu Zhang, Kang Wu

“…Sensitivity analyses, including MR-Egger regression and leave-one-out analyses, were employed to ensure result consistency. Multivariate MR (MVMR) was performed to adjust for potential smoking-related confounders, such as cigarettes per day, household smoking, exposure to tobacco smoke at home, ever smoked, second-hand smoke, smoking initiation, and age at smoking initiation, as well as the independent effects of each air pollutant. …”
Get full text

Iodine activates NLRP3 inflammasomes in PBMCs of patients with autoimmune thyroiditis and regulates Th1 and Th17 cell differentiation by Ying Wu, Qingling Guo, Yongping Liu, Xun Gong, Wei Sun, Yushu Li, Chenling Fan, Weiping Teng, Zhongyan Shan

“…Enzyme-linked immunosorbent assays (ELISAs) assessed the serum levels of IL-1β and IL-18. Flow cytometry was employed to examine NLRP3 expression on CD14+ monocytes and Th1 and Th17 cell percentages in the groups. …”
Get full text

Prediction model for type 2 diabetes mellitus and its association with mortality using machine learning in three independent cohorts from South Korea, Japan, and the UK: a model de... by Hayeon Lee, Seung Ha Hwang, Seoyoung Park, Yunjeong Choi, Sooji Lee, Jaeyu Park, Yejun Son, Hyeon Jin Kim, Soeun Kim, Jiyeon Oh, Lee Smith, Damiano Pizzol, Sang Youl Rhee, Hyunji Sang, Jinseok Lee, Dong Keon Yon

“…The Korean cohort (NHIS-NSC cohort; discovery cohort; n = 973,303), conducted between 1 January, 2002 and 31 December, 2013, was used for training and internal validation, whereas the Japanese cohort (JMDC cohort; validation cohort A; n = 12,143,715) and UK cohort (UK Biobank; validation cohort B; n = 416,656) were used for external validation. We employed various machine learning (ML)-based models, using 18 features, to predict the incidence of T2DM within five years of regular health checkups and calculated the Shapley Additive Explanation (SHAP) values. …”
Get full text

Spatiotemporal and genomic analysis of carbapenem resistance elements in Enterobacterales from hospital inpatients and natural water ecosystems of an Irish city by Mark Maguire, Carlos Serna, Natalia Montero Serra, Aneta Kovarova, Louise O’Connor, Niamh Cahill, Brigid Hooban, Niall DeLappe, Wendy Brennan, Genevieve Devane, Martin Cormican, Dearbháile Morris, Simone C. Coughlan, Georgios Miliotis, Bruno Gonzalez-Zorn, Liam P. Burke

“…Understanding the dynamics of CPE and carbapenemase-encoding gene encoding mobile genetic element (MGE) flux between human and environmental reservoirs is important for One Health surveillance of these priority organisms. We employed hybrid assembly approaches for improved resolution of CPE genomic surveillance, typing, and plasmid characterization. …”
Get full text

Fact-finding and risk factor analysis of chemotherapy-induced nausea and vomiting in children with solid tumors: a prospective observational study by Miaomiao Shao, Ying Li, Jing Qin, Yuchen Zhou, Yixin Sun, Peiyi Yang, Xisi Wang, Cheng Huang, Yan Su, Wen Zhao

“…A structured diary was used to record CINV data, and the pediatric nausea assessment tool (PeNAT) was employed to assess the degree of nausea. The primary outcome was achieving complete CIV control in the acute phase for all children, and secondary outcomes included the control of acute phase CINV, CIV, and chemotherapy-induced nausea (CIN) in children aged ≥ 4 years. …”
Get full text

Productivity of water and heat resources and cotton yield response to cropping pattern and planting density in cotton fields in arid area by Zhenlin Dong, Sumei Wan, Yunzhen Ma, Jinbin Wang, Lu Feng, Yunlong Zhai, Tiantian Li, Zhengjun Cui, Jian Wang, Beifang Yang, Ze Yang, Zhan Zhao, Fei Yan, Shiwu Xiong, Yabing Li, Guodong Chen

“…To test this, a two-year field experiment (2022–2023) employed a split-plot design with two main planting patterns (four rows per film and six rows per film) and three planting densities (low, medium, and high) as subplots. …”
Get full text

Enhanced fibrotic potential of COL1A1hiNR4A1low fibroblasts in ischemic heart revealed by transcriptional dynamics heterogeneity analysis at both bulk and single-cell levels by Cheng Luo, Cheng Luo, Cheng Luo, Baoping Tan, Luoxiang Chu, Liqiang Chen, Xinglong Zhong, Yangyang Jiang, Yuluan Yan, Fanrui Mo, Hong Wang, Fan Yang, Fan Yang

“…Multiple machine learning models were employed to identify the optimal gene panel for diagnosing ischemic heart disease (IHD) based on the intersected DEGs. …”
Get full text

RECQL4 affects MHC class II‐mediated signalling and favours an immune‐evasive signature that limits response to immune checkpoint inhibitor therapy in patients with malignant melan... by Sara Egea‐Rodriguez, Renáta Váraljai, Thierry M. Nordmann, Restuan Lubis, Manuel Philip, Florian Rambow, Alexander Roesch, Michael Flaig, Susanne Horn, Raphael Stoll, Fang Zhao, Annette Paschen, Bert Klebl, Ian D. Hickson, Dirk Schadendorf, Matthias Mann, Iris Helfrich

“…Finally, we generated genetically engineered RECQL4 variants and conducted comprehensive multi‐omic profiling, employing techniques such as liquid chromatography with tandem mass spectrometry, to elucidate mechanistic insights. …”
Get full text

Development and interpretation of a pathomics-driven ensemble model for predicting the response to immunotherapy in gastric cancer by Jing Wang, Zhe Li, Wei Wang, Md Tauhidul Islam, Xiaoyan Wang, Zhen Han, Zihan Li, Guoxin Li, Yuming Jiang, Taojun Zhang, Wenjun Xiong, Zepang Sun, Lequan Yu, Zhicheng Zhang, Xianqi Yang, Shengtian Sang, Alyssa A Guo

“…Pathogenomics analysis was employed to explain the molecular mechanisms underlying the model’s predictions.Results Our pathomics-driven ensemble model effectively stratified the response to ICIs in training cohort (AUC 0.985 (95% CI 0.971 to 0.999)), which was further validated in internal validation cohort (AUC 0.921 (95% CI 0.839 to 0.999)), as well as in external validation cohort 1 (AUC 0.914 (95% CI 0.837 to 0.990)), and external validation cohort 2 (0.927 (95% CI 0.802 to 0.999)). …”
Get full text

Spatial and temporal changes of breast-conserving surgery rates and its influential factors among Chinese patients with breast cancer from 2013 to 2019: a registry-based study by Pengpeng Ye, Yuan Yang, Wei Hu, Lingyan Dai, Erwei Song, Shunrong Li, Liling Zhu, Kai Chen, Yanjie Xu, Xiaoyu Wang, Jianli Zhao, Jianrong He, Queran Lin, Tongrui Shang, Xiujuan Gui, Ziliang Zhong, Qianru Chen, Qing Yan, Xiaoliang Huang, Zijian Liang

“…Patients who were older (vs &lt;40 years, 40–49 years: adjusted OR 0.72, 95% CI 0.68 to 0.76; 50–59 years: 0.51, 95% CI 0.48 to 0.54; ≥60 years: 0.37, 95% CI 0.35 to 0.40) and married (vs unmarried, 0.64, 95% CI 0.59 to 0.70) were less likely to undergo BCS. Patients who were employed (vs unemployed, 1.58, 95% CI 1.49 to 1.68), received cross-city surgery (vs local surgery, 1.37, 95% CI 1.31 to 1.44), lived in a high-income city (vs low-income city, β=4.40, 95% CI 1.55 to 7.24) or in a city with a higher number of physicians per 100 000 residents (0.57, 95% CI 0.31 to 0.82) were more likely to receive BCS.Conclusions and relevance This study suggests a significant increase in BCS rates from 2013 to 2019 in Guangdong, China. …”
Get full text

Upper Oligocene to Pleistocene planktonic foraminifera stratigraphy at North Atlantic DSDP Site 407, Reykjanes Ridge: diversity trends and biozonation using modern Neogene taxonomi... by T. M. Weitkamp, T. M. Weitkamp, M. J. Razmjooei, M. J. Razmjooei, P. N. Pearson, H. K. Coxall, H. K. Coxall

“…Initially investigated in 1979 by Poore, this study presents a taxonomic reassessment of upper Oligocene to Pleistocene planktonic foraminifera at Site 407, including species range documentation, assemblage analysis, biostratigraphic zonation, and age modelling based on planktonic foraminifera, calcareous nannofossils, and scanning electron microscopy. This study employs modern taxonomic perspectives that integrate morphological and stratophenetic frameworks for fossil species with genetic data for taxa having living representatives. …”
Get full text

Regulatory role of lnc-MAP3K13-3:1 on miR-6894-3p and SHROOM2 in modulating cellular dynamics in hepatocellular carcinoma by Kuai Chen, Manqin Zhu, Qinghua Hu, Hui Huang, Ka Chen, Xia Shuai, Jinshi Huang, Qiang Tao, Zhibin Guo

“…Methods Quantitative PCR (qPCR) was initially employed to measure the expression levels of lnc-MAP3K13-3:1 and miR-6894-3p in three HCC cell lines: HepG2, HuH-7, and Li-7. …”
Get full text

Application of “Tree Hole Listening” psychological support service in emotional management of neurology nurses (“树洞倾听”心理支持服务在神经内科护士情绪管理中的应用)... by FEI Cailian (费才莲), WANG Yu (王瑜), ZHANG Jingyi (张静怡), XIE Juan (谢娟)

“…Emotional Management Ability Scale and self-made Nurse Satisfaction Assessment were employed before and after the intervention. Results The positive emotional score had increased and negative emotional score had decreased after introducing the emotional management of Tree Hole Listening psychological support service( P＜0. 01). …”
Get full text

New Sources and Old Methods. Reconstructing and Applying the Music-Theoretical Paratext of Johann Sebastian Bach’s Compositional Pedagogy by Derek Remeš

“…Fascinatingly, many newly-rediscovered chorale books from Bach’s milieu contain multiple basses under each melody, suggesting that Bach too may have employed this technique. What theoretical perspectives shall we bring to bear on this long-lost multiple-bass chorale tradition? …”
Get full text

Mise au point d'un protocole d'évaluation du stress chez les primates captifs et sauvages by Morgane Debuigne, Victor Narat, Baptiste Sadoughi, Michel Saint Jalme, Sabrina Krief

“…Ces résultats préliminaires permettent de valider les protocoles employés et la mise en place d'études plus approfondies sur l'évaluation du stress par dosage de cortisol chez les primates en milieu naturel et en captivité…”
Get full text

Utilization of fish bone charcoal in feed on growth and physiological responses of catfish fry Clarias gariepinus by Rizqiyatul Fardila Putri, Mia Setiawati, Dedi Jusadi, Julie Ekasari

“… This study aimed to assess the impact of charcoal inclusion in feed on the physiological responses and growth of catfish. The experiment employed a completely randomized design (CRD) with five treatments and four replicates. …”
Get full text