Identification of Lauric Acid as a Potent Sodium Channel NaV1.5 Blocker from Compound Chinese Medicine Wenxin Keli by Xie W, Gao J, Liang Y, Huang C, Zhang B, Chen X, Yao X, Nan G, Wu H, Wang Y, Wu L, Wang T, Zhu Y

“…We evaluated the SCN5A inhibitory potential of Wenxin Keli effective monomer employing molecular docking and molecular dynamics simulation approaches.Results: A primary screen of the WXKL chemical library identified five fractions that significantly inhibited the NaV 1.5 channel, with one of them rich in poly-saturated fatty acids. …”
Get full text

أسلوب التعامل مع الخلافات الفقهية: مراجعة كتاب الموافقات للإمام الشاطبي. دار الكتب العلمية، ٢٠٠٥، ٥٨٠ صفحة، ISBN: ٢-٧٤٥١-١٥٣٠-٨، (غلاف صلب)... by Muhammad Najib Abdullah, Muhammad Nazir Alias, Syaryanti Hussin, Ibrahim Zakariyya Moosa

“…This study examines the efforts of Imam al-Shātibī in reconciling the viewpoints of jurists and legal theorists on issues amenable to convergence and unity, and his proposed approach to dealing with madhhab (school of thought) differences, through an analysis of his seminal work "al-Muwāfaqāt fī Uṣūl al-Sharīcah". This study employs an inductive-analytical approach, tracing and analyzing the relevant content in al-Shātibī's al-Muwāfaqāt, as well as a comparative method to contrast Imam al-Shatibi's views with those of others, in order to highlight his contributions and limitations, and validate the findings. …”
Get full text

MathVision: An Accessible Intelligent Agent for Visually Impaired People to Understand Mathematical Equations by Muhammad Awais Ahmad, Tauqir Ahmed, Muhammad Aslam, Amjad Rehman, Faten S. Alamri, Saeed Ali Bahaj, Tanzila Saba

“…In the subsequent phase, an attention mechanism-based LSTM network is employed to generate natural language descriptions for mathematical equations. …”
Get full text

Association of dietary quality and mortality in the non-alcoholic fatty liver disease and advanced fibrosis populations: NHANES 2005–2018 by Xingyong Huang, Xiaoyue Zhang, Xuanyu Hao, Tingting Wang, Peng Wu, Lufan Shen, Yuanyuan Yang, Wenyu Wan, Wenyu Wan, Wenyu Wan, Kai Zhang

“…Weighted Cox proportional hazard regression models along with restricted cubic splines and subgroup analyses were employed in this study.ResultsThe analysis encompassed 3,634 NAFLD patients. …”
Get full text

Cohort retention in a pandemic response study: lessons from the SARS-CoV2 Immunity & Reinfection Evaluation (SIREN) study by Anna Howells, Katie Munro, Sarah Foulkes, Atiya Kamal, Jack Haywood, Sophie Russell, Dominic Sparkes, Erika Aquino, Jennie Evans, Dale Weston, Susan Hopkins, Jasmin Islam, Victoria Hall

“…The top three reasons for participant withdrawal were workload, leaving site employment and medical reasons. Themes identified from focus-groups included: the need to monitor and understand participant motivation over time, the necessity of inclusive and comprehensive communication, the importance of acknowledging participant contributions, building collaboration with local research teams, and investing in the research team skillset. …”
Get full text

A novel α-conotoxin [D1G, ΔQ14] LvIC decreased mouse locomotor activity by Wen Wang, Wen Wang, Meiting Wang, Huanbai Wang, Weifeng Xu, Conggang Wang, Jie Pei, Xiaodan Li, Dongting Zhangsun, Dongting Zhangsun

“…To investigate the molecular alterations in the mice’s brains, untargeted metabolomics and label-free Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) were employed. Subsequently, Western blot (WB) and quantitative reverse transcription PCR (RT-qPCR) techniques were utilized to detect specific molecular changes induced by [D1G, ΔQ14] LvIC.ResultsThe injection of [D1G, ΔQ14] LvIC led to a decrease in locomotor activity in mice. …”
Get full text

Potential public health impacts of gonorrhea vaccination programmes under declining incidences: A modeling study. by Lin Geng, Lilith K Whittles, Borame L Dickens, Martin T W Chio, Yihao Chen, Rayner Kay Jin Tan, Azra Ghani, Jue Tao Lim

“…<h4>Methods and findings</h4>We employed an integrated transmission-dynamic model, calibrated using Bayesian methods to local surveillance data to understand the potential public health impact of 4CMenB in reducing gonorrhea acquisition and transmission in men who have sex with men (MSM) in Singapore. …”
Get full text

Ginsenoside Rd protects against acute liver injury by regulating the autophagy NLRP3 inflammasome pathway by Xiaomei Zhong, Yibin Sun, Yanxiang Lin, Shan Deng, Huan Wang, Xian Zhou, Jinjian Lu, Yanfang Zheng, Ruoyin Luo, Mingqing Huang, Jianyuan Song

“…Immunofluorescence staining, qPCR and Western blot were employed to analyze the expressions of genes and proteins associated with inflammation and autophagy. …”
Get full text

The role of FTO in m6A RNA methylation and immune regulation in Staphylococcus aureus infection-related osteomyelitis by Sijing Liu, Sijing Liu, Sijing Liu, Kai Li, Changhai Long, Mingwu Lao, Biao Ma, Changquan Liu, Haoyuan He, Chunjiang Wang, Wangzhu Chen, Bin Yu

“…Further, unsupervised clustering analysis, gene set enrichment analysis (GSEA), and gene set variation analysis (GSVA) were employed to assess immune cell infiltration. Additionally, we validated the expression of fat mass and obesity-associated protein (FTO) in S. aureus-infected Raw264.7 macrophages using qPCR and western blotting. …”
Get full text

Efficacy and safety of single and double catheter intrathecal drug delivery systems in patients with refractory neck and abdominal cancer pain by Qin Li, Huaiming Wang, Qiju Li, Maoxia Xu, Bo Zhong, Xin Hu, Jiang Zou, Pengjiu Feng, Aimin Zhang

“…Propensity score matching was employed to create a balanced cohort of 48 patients. …”
Get full text

A c-type lectin HcLec1 with dual function of immunology and mineralization from the freshwater oyster (Hyriopsis cumingii Lea) by Xiaofeng Chen, Xiaoya Shen, Shijun Liu, Wenjuan Li, Wenjuan Li, He Wang, Jiale Li, Jiale Li, Zhiyi Bai, Zhiyi Bai

“…MethodsImmune challenge, RNA interference (RNAi) experiments, ELISA, and antibacterial assays were employed to investigate the role of HcLec1 in innate immunity. …”
Get full text

Biosynthesis and activity of Zn-MnO nanocomposite in vitro with molecular docking studies against multidrug resistance bacteria and inflammatory activators by Samy Selim, Tarek M. Abdelghany, Mohammed S. Almuhayawi, Mohammed K. Nagshabandi, Muyassar K. Tarabulsi, Mohammed Yagoub Mohammed Elamir, Asmaa A. Alharbi, Soad K. Al Jaouni

“…Both the values of minimum inhibitory concentration (MIC) and minimum bactericidal concentration of Zn-MnO nanocomposite extended from 15.62 to 125 µg/mL employing the examined bacteria. The antibiofilm activity of Zn-MnO nanocomposites was 82.07, 75.43, 43.65, and 41.35% at 25% MIC, and 96.54, 93.0, 94.53, and 91.11% at 75% MIC against S. aureus, MRSA, K. pneumoniae, and S. typhi, respectively. …”
Get full text

Implications of water management on methane emissions and grain yield in paddy rice: A case study under subtropical conditions in Brazil using the CSM-CERES-Rice model by Evandro H. Figueiredo Moura da Silva, Gerrit Hoogenboom, Kenneth J. Boote, Santiago Vianna Cuadra, Cheryl H. Porter, Walkyria Bueno Scivittaro, Silvio Steinmetz, Carlos E. Pellegrino Cerri

“…The objective of this study was to evaluate the performance of the Cropping System Model (CSM)-CERES-Rice model and DSSAT-GHG module to predict daily methane emissions and rice grain yield for different irrigation practices in a subtropical environment. The study employed a comprehensive approach, including measurements of daily CH4 emissions, phenological stages, final aboveground biomass, and grain yield for rice cultivars BRS Pampa, BRS Pampeira, A705, and XP113 conducted over four consecutive crop seasons (2019–2023) and two irrigation systems: continuous flooding (CF) or alternate wetting and drying (AWD) in Capão do Leão, RS, Brazil. …”
Get full text

Screening and identification of vascular endothelial cell targeting peptide in gastric cancer through novel integrated in vitro and in vivo strategy by Yan-ting Zhang, Sheng-hui Wang, Li Zhao, Hui-min Wang, Lin Wang, Rong-rong Shi, Si-chao Liang, Bao-feng Li, Bei Chen

“…Our further exploration employs it as a vehicle for mediating drug accumulation in gastric cancer tissue.…”
Get full text

Knowledge, Attitude, and Practice of Pediculus Capitis Prevention and Control and Their Predictors among Schoolchildren in Woreta Town, Northwest Ethiopia, 2018: A School-Based Cro... by Henok Dagne, Awel Aba Biya, Amanuel Tirfie, Walelegn Worku Yallew, Zewudu Andualem, Baye Dagnew

“…Binary logistic regression was employed to test the association of covariates with the outcome/response variables. …”
Get full text

Specifically blocking αvβ8-mediated TGF-β signaling to reverse immunosuppression by modulating macrophage polarization by Cuicui Guo, Hui Sun, Yulei Du, Xiaodong Dai, Yu Pang, Zhen Han, Xinhui Xiong, Shaowei Li, Junhua Zhang, Qingbing Zheng, Xun Gui

“…Cryo-EM single-particle analysis was employed to study the detailed interaction between αvβ8 and the antibody Fab fragment. …”
Get full text

Mpox Preparedness and Response 2024: Position Statement of The Disaster Management Experts Club by Heetaf Aloqaily, Rania Abdurhman Alnafea, Shahad Abdullah Alotaibi, Mohamad Bakir, Sharafaldeen Bin Nafisah, Bandr Mzahim

“…The need to augment early warning systems encompasses not only case identification, but also indirect indicators such as absenteeism from employment or education. • Enhancedresilience of healthcare systems: A resilient healthcare infrastructure that facilitates early case detection, isolation, and infection control is essential. …”
Get full text

Digital Platforms’ Adoption by Educational Stakeholders in Private Secondary Schools During and after the Lockdown in Port Harcourt Local Government Area, Rivers State by Ella Gogo Blaise, Ebi Bio Awotua-Efebo

“…The research methodology employed was a descriptive survey. A multi-stage sampling procedure was utilised to select a sample size of seven hundred and forty-two (742) participants, comprising four hundred and nine (409) students, two hundred and ninety-seven (297) teachers, and thirty-six (36) administrators from thirty-two (32) private secondary schools in Port Harcourt, Rivers State. …”
Get full text

Factors influencing pregnancy rate following estradiol-free fixed TAI protocols in water buffaloes by Adriana Camacho de Gutiérrez, Obdulio Camacho, Steward Fernández, Yerixo González, Juan Carlos Gutiérrez-Añez

“…Additionally, technical factors such as time employed to perform the AI and animal behaviour when applying TAI successfully affected the PR and warrant further investigation. …”
Get full text

Deciphering the oncogenic network: how C1QTNF1-AS1 modulates osteosarcoma through miR-34a-5p and glycolytic pathways by Yu Zhang, Hailong Lun, Naiqiang Zhu, Naiqiang Zhu, Ning Yang, Kaikai Ding, Bin Chen, Chengbing Chang, Haipeng Gu, Yanqi Liu

“…Dual-luciferase reporter assays and RNA immunoprecipitation were employed to validate these interactions. Expression profiles of C1QTNF1-AS1, miR-34a-5p, LDHA, and PDK3 in osteosarcoma cells were analyzed using RT-PCR and western blot analyses, revealing their intricate relationships. …”
Get full text