Development of an individualized dementia risk prediction model using deep learning survival analysis incorporating genetic and environmental factors by Shiqi Yuan, Qing Liu, Xiaxuan Huang, Shanyuan Tan, Zihong Bai, Juan Yu, Fazhen Lei, Huan Le, Qingqing Ye, Xiaoxue Peng, Juying Yang, Yitong Ling, Jun Lyu

“…A multi-model comparison strategy was employed to evaluate the predictive performance of four survival analysis models: DeepSurv, DeepHit, Kaplan–Meier estimation, and the Cox proportional hazards model (CoxPH). …”
Get full text

New evidence on the nephrotoxicity of fine particulate matter: Potential toxic components from different emission sources by Fu-Jen Cheng, Chien-Er Huang, Pei-Shih Chen, Yu-Lun Tseng, Chung-Shin Yuan, Ching-Shu Lai

“…The study used a chelating resin to remove the influence of heavy metals from the water extract and employed a Toll-like receptor 4 (TLR4) antagonist to eliminate the effects of endotoxin, thereby evaluating the cellular inflammatory responses induced by various PM2.5 components. …”
Get full text

Vulnerability, Resilience and Adaptation of Lagos Coastal Communities to Flooding by Prince Emeka Ndimele, Akinloye Emmanuel Ojewole, Gabriel Olarinde Mekuleyi, Lateef Akorede Badmos, Christopher Monday Agosu, Emmanuel Sunday Olatunbosun, Oluseyi Olaide Lawal, Jamiu Adebayo Shittu, Olufemi Olabode Joseph, Kehinde Moyosola Ositimehin, Felix Chinsom Ndimele, Catherine Oluwalopeye Ojewole, Iman Olawunmi Abdulganiy, Odunayo Temitope Ayodele

“…Thereafter, PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analysis) guidelines was employed for the study selection criteria, search strategies and data extraction methods. …”
Get full text

Evaluation of the resistome and gut microbiome composition of hospitalized patients in a health unit of southern Brazil coming from a high animal husbandry production region by Elisa Pires Coltro, Elisa Pires Coltro, Lucas Cafferati Beltrame, Lucas Cafferati Beltrame, Lucas Cafferati Beltrame, Caroline Ribeiro da Cunha, Caetana Paes Zamparette, Clarissa Feltrin, Vilmar Benetti Filho, Patrícia de Almeida Vanny, Sérgio Beduschi Filho, Taíse Costa Ribeiro Klein, Mara Cristina Scheffer, Jussara Kasuko Palmeiro, Jussara Kasuko Palmeiro, Glauber Wagner, Thaís Cristine Marques Sincero, Thaís Cristine Marques Sincero, Carlos Rodrigo Zárate-Bladés, Carlos Rodrigo Zárate-Bladés

“…Metagenomic sequencing and resistome analysis were employed to identify antimicrobial resistance genes (ARGs) and their associated bacterial taxa. …”
Get full text

Hybridization-based discovery of novel quinazoline-2-indolinone derivatives as potent and selective PI3Kα inhibitors by Changqun Liu, Yuening Cao, Yi Zuo, Chaozheng Zhang, Senmiao Ren, Xin Zhang, Chuanqi Wang, Yingjie Zeng, Jie Ling, Yilan Liu, Zixian Chen, Xiujun Cao, Zhengzhi Wu, Chuantao Zhang, Jun Lu

“…The biological evaluation of compound 8 was performed by transwell, flow cytometry, laser scanning confocal microscopy, Western blot, CTESA and immunohistochemistry. Results: Here, we employed molecular hybridization methods to construct a series of quinazoline-2-indolinone derivatives as PI3Kα selective inhibitors. …”
Get full text

Negative childbirth experience in Dutch women: A socio-ecological analysis of individual, interpersonal, and organisational factors from the birth experience study by Tamool A.S. Muhamed, Viola Angelini, Laura Viluma, Hazel Keedle, L. Lilian Peters

“…Methods: We conducted the Birth Experience Study Netherlands (BESt-NL) survey in 2022 with two languages versions (Dutch-English), and incorporated validated measures, such as Mothers' autonomy in decision-making, the Mothers On Respect index, and the Nijmegen Continuity of Care questionnaire. We employed socio-ecological modelling of individual (e.g., sociodemographic, ethnicity, parity, adverse mental health, interpersonal (e.g., autonomy in decision-making, respect, partner support), and organisational factors (e.g., place of birth, continuity of care). …”
Get full text

Older adults’ Internet use behavior and its association with accelerometer-derived physical activity by Yen-Yu Chung, Jiaren Chen, Mei-Chun Lin, Ruo-Lan Liu, Jenn-Bang Wu, Hsin-Chang Tsai, Ting-Fu Lai, Ting-Fu Lai, Yung Liao, Yung Liao, Jong-Hwan Park, Jong-Hwan Park, Jong-Hwan Park

“…Thus, we aimed to investigate the association between the frequency of Internet use and PA levels in older adults.MethodsFor this cross-sectional study, we employed convenience sampling. The participants were 172 adults aged 65 and older without cognitive impairment who could walk independently. …”
Get full text

The causal relationship between serum metabolites and the risk of psoriasis: a Mendelian randomization and meta-analysis study by Yujie Yang, Xuwei Zheng, Haiying Lv, Bin Tang, Bin Tang, Bin Tang, Bin Tang, Bin Tang, Yiyuan Zhong, Qianqian Luo, Yang Bi, Kexin Yang, Haixin Zhong, Haiming Chen, Haiming Chen, Haiming Chen, Haiming Chen, Haiming Chen, Chuanjian Lu, Chuanjian Lu, Chuanjian Lu, Chuanjian Lu, Chuanjian Lu

“…MR-Steiger Test was employed to check for reverse causality. In the validation stage, we sought other sources of psoriasis GWAS data to verify the initial results and used meta-analysis to combine the effect sizes to obtain robust causal relationships. …”
Get full text

The spatiotemporal changes and influencing mechanisms of the coastline in the Yellow River Delta, China by Zhuo Yang, Wei Gao, Wei Gao, Wenjie Yu, Jie Liu, Jie Liu, Jun Du, Jun Du, Ping Li, Ping Li, Yuanqin Xu, Yuanqin Xu, Ping Li, Ping Li

“…Using remote sensing imagery of the Yellow River Delta (YRD) from 1984 to 2024, the Digital Shoreline Analysis System (DSAS) model was employed to analyze the coastline position, migration rate, and characteristics of four typical coastal sections. …”
Get full text

Site-specific immunoglobulin G N-glycosylation is associated with gastric cancer progression by Tingting Xu, Jianmin Huang, Jiajing Lin, Yuanyuan Liu, Yi Wang, Wenkang Shen, Jianjie He, Shuyun Chen, Xi Zhu, Yuqin Que, Mengting Hu, Yu Chen, Liming Cheng, Honghao He, Xin Liu, Si Liu

“…Multivariate analysis was employed to identify and assess glycomic alterations. …”
Get full text

Revealing the heterogeneity of treatment resistance in less‐defined subtype diffuse large B cell lymphoma patients by integrating programmed cell death patterns and liquid biopsy by Wei Hua, Jie Liu, Yue Li, Hua Yin, Hao‐Rui Shen, Jia‐Zhu Wu, Yi‐Lin Kong, Bi‐Hui Pan, Jun‐Heng Liang, Li Wang, Jian‐Yong Li, Rui Gao, Jin‐Hua Liang, Wei Xu

“…To identify robust prognostic biomarkers that can guide personalized management for less‐defined subtype DLBCL patients, we integrated multi‐omics data derived from 339 standard R‐CHOP‐treated patients diagnosed with less‐defined subtype DLBCL from three independent cohorts. By employing various machine learning algorithms, we pinpointed eight pivotal genes linked to PCD, specifically FLT3, SORL1, CD8A, BCL2L1, COL13A1, MPG, DYRK2 and CAMK2B. …”
Get full text

Identifying joint association between body fat distribution with high blood pressure among 7 ∼ 17 years using the BKMR model: findings from a cross-sectional study in China by Manman Chen, Xijie Wang, Yanhui Li, Di Gao, Ying Ma, Tao Ma, Yi Zhang, Li Chen, Jieyu Liu, Qi Ma, Mengjie Cui, Xinxin Wang, Tongjun Guo, Wen Yuan, Yanhui Dong, Jun Ma

“…The chi-square test was utilized to compare differences between groups. The BKMR model was employed to analyze the joint effects of body fat indicators on HBP while accounting for potential confounders. …”
Get full text

Presenting a merit-oriented service compensation system model for veterans in sports by Hoseain Aeinehchi, Mohammad reza Esmaeilzadeh Ghandehari, Hoseain peymanizad, Hasan Fahim Davin

“…., 2022).Service compensation is one of the main elements of the employment relationship between individuals and organizations, and in addition to being the largest operational cost for many organizations, it is considered as a tool to increase organizational performance and sustainable competition (Ivana et al, 2019). …”
Get full text

Professionalisation and governance in sports organisations: towards an integrated understanding by Raphael Stieger, Siegfried Nagel, Grazia Lang

“…Third, the analysis showed that professionalisation and governance in sports organisations are discussed with a focus on the employment of paid staff and associated changes in governance. …”
Get full text

Impact of COVID-19 on Corporate Cash Holdings and Speed of Adjustment by Abbas Aflatooni, Mohammad Khatiri, Farzad Eivani

“…Additionally, the study conducted robustness tests by considering the years 2020-2021 (318 firm-years) as the COVID-19 pandemic period and employing the two-stage approach suggested by Orlova and Rao (2018). …”
Get full text

Perceived effects of the hidden curriculum of return to entrepreneurship with the mediation of goal orientation by Ahmad KarimiDashtaki, Mohammadbagher Akbarpour Zangalani

“…Since perhaps the biggest challenge of Iran's economy right now is the issue of employment, and research shows that schools are the best place to find the source of entrepreneurial problems; in response to this problem of unemployment, the bodies responsible for the planning of educational centers are encouraging them to take steps towards self-employment and entrepreneurship (Heidari, 2023). …”
Get full text

Designing a Policy Making Model in Iran' Sport with the Approach of Sport for All Development by Behdad Sadeghi, Rahmatollah Gholipour, Mojtaba Amiri, Marjan Saffari

“…Methods A mixed qualitative-quantitative method was employed in this study. The qualitative component was conducted using a situation analysis approach, which is one of the methods of grounded theory. …”
Get full text

Comprehensive characterization of tobacco-induced changes in enamel surface topography by Tamanna Kaur, Ramya Ramadoss, Nitya Krishnasamy, Sandhya Sundar, Suganya Panneer Selvam, Hema Shree K

“…High-resolution AFM imaging was employed to assess surface roughness, porosity, and microstructural changes induced by tobacco staining. …”
Get full text

Genetic profiling of extended-spectrum β-Lactamase and carbapenemase-producing Escherichia coli O157:H7 from clinical samples among diarrheal patients in Shashemene, Ethiopia by Shimelis Teshome Ayalneh, Biruk Yeshitela Beshah, Yeonji Jeon, Ashenafi Alemu Wami, Seifegebriel Teshome, Solomon Gebreselassie, Se Eun Park, Mekonnen Teferi, Woldaregay Erku Abegaz

“…Data analysis was performed using SPSS version 27.0, employing logistic regression and descriptive statistics. …”
Get full text

La mise en œuvre d’un aqueduc : l’exemple de la Brévenne à Lyon by Catherine Coquidé, Antoine Valois

“…Ultimately, although none of the components of the canal adheres strictly to a single template, it remains a coherent structure, while water containment –particularly on this channel– is the main concern.This stratigraphic reading cannot be separated from the planimetric perspective, made necessary by the requirement to break down a large scale construction in order to handle uneven landscapes and to employ a variety of hydraulic engineering techniques. …”
Get full text