Cyclophilin–CD147 interaction enables SARS-CoV-2 infection of human monocytes and their activation via Toll-like receptors 7 and 8 by Gabor Tajti, Laura Gebetsberger, Gregor Pamlitschka, Katharina Aigner-Radakovics, Judith Leitner, Peter Steinberger, Hannes Stockinger, Anna Ohradanova-Repic

“…Surprisingly, we observed that recombinant SARS-CoV-2 Spike (S) and Nucleocapsid (N) proteins triggered only a weak proinflammatory response in human peripheral blood monocytes. By employing THP-1 and Jurkat NF-κB::eGFP reporter cell lines expressing specific TLRs, various TLR ligands and blocking antibodies, we determined that surface TLRs, including TLR2/1, TLR2/6 and TLR4 do not play a major role in SARS-CoV-2 sensing. …”
Get full text

Microbial assisted alleviation of nickel toxicity in plants: A review by Xinyu Mao, Bilal Ahmad, Sabir Hussain, Farrukh Azeem, Muhammad Waseem, Yousef Alhaj Hamoud, Hiba Shaghaleh, Amany H.A. Abeed, Muhammad Rizwan, Jean Wan Hong Yong

“…To tackle any metal-linked pollution issues, various remediation approaches are employed to remove heavy metals (especially nickel) and metalloids including physicochemical, and biological methods. …”
Get full text

Aesthetic Transformation of Morsal (Simple) Prose Texts with an Emphasis upon Semantics by Mohsen Vesaghati Jalal

“…To fulfill aesthetic goals, two approaches have been employed in Persian prose works; the first approach is to dress up the exterior of language, while in the second approach, the innermost of the language is embellished by semantics. …”
Get full text

Critical Appraisal of Materials and Methods in Observational Studies Published in Pathology Journals: A Cross-sectional Study by Supriya Siddavatam, BN Kumarguru

“…The Chi-square test was employed to analyse the data and the p-value of <0.05 was considered as statistically significant. …”
Get full text

Hypoxia specifically induces CADM3 expression in pulmonary endothelial cells and promotes monocyte adhesion by MENG Xiangqiong, MENG Xiangqiong, CHEN Ting, CHEN Ting

“…Iron chelator deferoxamine （DFX） and shRNA interference were employed to enhance the expression of HIF-1α， and the effect of HIF-1 transcriptional activity on CADM3 expression was analyzed. …”
Get full text

Removal of direct navy blue dye from aqueous solutions using banana peels by F. Fuentes Gandara, I. Piñeres Ariza, A. Zambrano Arevalo, G. Castellar Ortega, C. Herrera Herrera, S. Castro Muñoz, G. Peluffo Foliaco, J. Pinedo-Hernández

“…Fourier transform infrared spectroscopy and the Boehm method were employed to analyze and measure organic functional groups, specifically acidic groups, for identification and quantification purposes. …”
Get full text

The dual anti-inflammatory and anticoagulant effects of Jianpi Huashi Tongluo prescription on Rheumatoid Arthritis through inhibiting the activation of the PI3K/AKT signaling pathw... by Fanfan Wang, Fanfan Wang, Jian Liu

“…However, the specific mechanisms underlying its actions remain to be further investigated.ObjectiveThis study aims to elucidate the anti-inflammatory and anticoagulant mechanisms of XFC in the treatment of RA.MethodsA multidimensional methodological framework was employed. Firstly, through retrospective clinical data mining, combined with the Apriori algorithm and random walk models, an in-depth analysis was conducted to explore the potential associations between XFC treatment and improvements in clinical inflammatory and coagulation markers among RA patients. …”
Get full text

Integrative application of licorice root extract and melatonin improves faba bean growth and production in Cd-contaminated saline soil by Shimaa A. Abd El Mageed, Ali A. S. Sayed, Ahmed Shaaban, Khaulood A. Hemida, Abdelsattar Abdelkhalik, Wael M. Semida, Ibrahim A. A. Mohamed, Mohammed A. H. Gyushi, Yasmine H. Abd Elmohsen, Taia A. Abd El Mageed

“…Plant extracts have lately been employed as exogenous adjuvants to improve endogenous plant defense mechanisms when grown under various environmental stresses, such as salinity. …”
Get full text

Association Between Diurnal Temperature Range and Risk of Cardiomyopathy-Induced Hospitalisation in Henan, China: A Time-Series Study by Zhang Z, Wang Y, Zhou Y, Pei J, Zhao G, Dong P, Yang K, Liu H, Xie N, Li X, Zang X, Lin F, Chen Z

“…Attributable fractions (AF) and attributable numbers (AN) were employed to illustrate the disease burden and investigate the association between temperature and DTR.Results: Overall, 5,757 CM cases were identified. …”
Get full text

Biogenic Waste from Two Varieties of Plantain in Ghana Contain Pectin with Potential Binding Properties in Conventional Tablets by Desmond Asamoah Bruce Otu, Frederick William Akuffo Owusu, Mariam El Boakye-Gyasi, Raphael Johnson, Prince George Jnr Acquah, Yayra Edzor-Agbo, Marcel Tunkumgnen Bayor, Mary-Ann Archer

“…Acid (D) and alkaline (L) mediums of extraction were employed for each ripening stage for both varieties. …”
Get full text

The impact of side and top arm techniques during the backstroke breakout phase on 15-meter swimming performance by Zhenyu Jin, Yuhang Zhou, Dapeng Wang, Yuhong Wen

“…Pearson’s correlation analysis was used to explore the relationship between segment velocity and 15-m performance, and hierarchical regression was employed to investigate the impact of breakout velocity on the 15-m performance. …”
Get full text

Re-examining the Division of Candi Borobudur into Kāmadhātu, Rūpadhātu, and Arūpadhātu by So Tju Shinta LEE, Agus Aris Munandar, Lilawati Kurnia

“…Comparative analysis was employed by comparing the key themes depicted on each group of narrative reliefs with the characteristics of each realm of existence. …”
Get full text

Preparation, Modification, Characterization and Antioxidant Activities of Apigenin Liposomes by Siyu DAI, Ying TANG, Nian LIU, Lu HE, Miao GU, Chenbo FENG, Jin REN, Zhengjie FANG

“…Encapsulation efficiency served as the evaluation criterion to compare the AP-L preparation methods employing the film dispersion-ultrasound and ethanol injection-ultrasound techniques. …”
Get full text

Proteomic analysis of spinal dorsal horn in prior exercise protection against neuropathic pain by Binglin Chen, Jiabao Guo, Chan Gong, Chenchen Zhu, Yang Wu, Shengbo Wang, Yili Zheng, Haixia Lu

“…Gene Ontology (GO) annotations, the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways, and protein–protein interaction networks were employed to explore the biological importance of DEPs. …”
Get full text

Bergapten alleviates senescence of chondrocytes in osteoarthritis by YE Yuanlan, LIU Kaiwen, PAN Yiming

“…Senescence β-galactosidase (SA-β-Gal) staining kit was employed to detect the change of SA-β-Gal level in the cells. …”
Get full text

Linear Programming as a Tool for Managing the Training Process of Esports Teams by Oksana Shynkaruk, Nataliia Byshevets, Alla Aloshyna, Olena Iakovenko, Kostiantyn Serhiienko, Valerii Pinchuk, Oleksandr Petryk, Ivan Lut

“…Reliable statistical methods were employed: the dichotomous scale (results were processed using Cochran’s Q concordance coefficient, which determined the consistency of expert opinions regarding each type of training); and the ratio scale (ranking) – the consistency of opinions was analyzed using Kendall’s W concordance coefficient. …”
Get full text

Socio-demographic and clinical determinants of self-care in adults with type 2 diabetes: a multicenter cross-sectional study in Zhejiang province, China by Xuefen Lan, Xiaozhen Ji, Xiaojia Zheng, Xiaoyu Ding, Hongyi Mou, Shunfei Lu, Bin Ye

“…Multiple quantile regression models were employed to identify the determinants of each self-care component and self-care self-efficacy. …”
Get full text

Bi-level data-driven enterprise-wide optimization with mixed-integer nonlinear scheduling problems by Hasan Nikkhah, Zahir Aghayev, Amir Shahbazi, Vassilis M. Charitopoulos, Styliani Avraamidou, Burcu Beykal

“…Nonetheless, the bi-level optimization of such interdependent and holistic formulations is still difficult, particularly when dealing with mixed-integer nonlinear programming (MINLP) problems, due to a lack of effective algorithms. In this study, we employ the Data-driven Optimization of bi-level Mixed-Integer NOnlinear problems (DOMINO) framework, a data-driven algorithm developed to handle single-leader single-follower bi-level mixed-integer problems, to solve single-leader multi-follower planning and scheduling problems subject to MINLP scheduling formulations. …”
Get full text

CX3CR1+ age-associated CD4+ T cells contribute to synovial inflammation in late-onset rheumatoid arthritis by Mitsuhiro Akiyama, Sohma Wakasugi, Keiko Yoshimoto, Koichi Saito, Sho Ishigaki, Risa Inukai, Yoshiyuki Matsuno, Waleed Alshehri, Yasushi Kondo, Yuko Kaneko

“…Methods Fresh peripheral blood samples were collected from 78 treatment-naïve active RA patients, 12 with difficult-to-treat RA, and 16 healthy controls. Flow cytometry was employed to measure the proportions of CX3CR1+cytotoxic CD4+ and CD8+ T cells in these samples. …”
Get full text

The revival of spiritual practices: factors influencing the “seeking deities and offering prayers” behavior of China’s Generation Z on social media in an atheistic context by Jing Wang, Balamuralithara Balakrishnan, Xiaohui Wan, Qirui Yu, Qiqi Ye

“…This study fills this gap by extending the Theory of Planned Behavior (TPB) to predict additional influencing factors of digital religious intentions and behavior.MethodsThis study employed a quantitative design, disseminating surveys via Sina Weibo and the Douyin platform. …”
Get full text