Combined prognostic value of the cancer stem cell markers CD47 and CD133 in esophageal squamous cell carcinoma by Jian‐Hua Wang, Shu‐Ting Huang, Lan Zhang, Zi‐Gang Liu, Rong‐Xin Liang, Sen‐Wei Jiang, Yi‐Nan Jiang, Xing‐Juan Yu, Yu‐Chuan Jiang, Xi‐Zhao Li, Pei‐Fen Zhang, Zhe‐Sheng Wen, Min Zheng

“…Methods Immunohistochemistry was employed to identify the characteristics of CD47 and CD133 in 26 pairs of tumor tissues and adjacent non‐tumor tissues and 136 ESCC tissues. …”
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A Study of Volatile Organic Compounds in Patients with Obstructive Sleep Apnea by Chuan Hao Gui, Zhunan Jia, Zihao Xing, Fuchang Zhang, Fang Du, Alex Chengyao Tham, Ming Yann Lim, Yaw Khian Chong, Agnes Si Qi Chew, Khai Beng Chong

“…To as-sess the differences in VOC concentrations between OSA patients and control subjects, the Wilcoxon rank-sum test was employed. partial least squares discriminant analysis (PLS-DA) analysis and heatmap plot was conducted to visualize the differentiation between OSA patients and control subjects based on their VOC profiles.In order to further investigate the correlation between identified biomarkers and the severity of OSA measured by Apnea–Hypopnea Index (AHI), regression analysis was conducted between biomarkers and AHI Index. …”
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Machine learning-based identification and validation of amino acid metabolism related genes as novel biomarkers in chronic kidney disease by Guoqing Zhang, Hongyan Luo, Xiaohua Lu, Yonghua Liu, Mei Wang, Bo Li, Haixia Lu, Yali Zheng

“…Also, we mapped the ROC curves.Meanwhile, in order to determine the underlying mechanism and relevant biological features of CKD, we conducted differential analysis between high and low risk subgroups in CKD. Moreover,we employed ssGSEA algorithm to evaluate the infiltration abundance of immune cells and calculated the correlation among the immune cells with the key genes. …”
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Shedding light on biochemical changes in single neuron-like pheochromocytoma cells following exposure to synchrotron sourced terahertz radiation using synchrotron source Fourier tr... by Palalle G. Tharushi Perera, Jitraporn Vongsvivut, Denver Linklater, Zoltan Vilagosh, Dominique Appadoo, The Hong Phong Nguyen, Mark J. Tobin, Rodney Croft, Elena P. Ivanova

“…Synchrotron sourced Fourier transform infrared (SS FTIR) microspectroscopy was employed to investigate the biological effects on the neuron-like pheochromocytoma (PC 12) cells after exposure to synchrotron sourced terahertz (SS THz) radiation. …”
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Investigating POU3F4 in cancer: Expression patterns, prognostic implications, and functional roles in tumor immunity by Weiwei Chen, Yaya Ji, Rui Wang, Ruijie Ji, Yujian Lin, Yuhang Wu, Lehan Liu, Tianle Sha, Wen Li, Lei Zhang, Longfei Yang, Xinhua Zhang, Jianxiang Song

“…Based on data from The Cancer Genome Atlas (TCGA), Cancer Cell Line Encyclopedia (CCLE), Genotype-Tissue Expression (GTE), and Gene Set Cancer Analysis (GSCA), we employed various bioinformatics approaches to investigate the potential carcinogenic effects of POU3F4. …”
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Green Extraction of Bioactives from <i>Curcuma longa</i> Using Natural Deep Eutectic Solvents: Unlocking Antioxidative, Antimicrobial, Antidiabetic, and Skin Depigmentation Potenti... by Jelena Jovanović, Marko Jović, Jelena Trifković, Katarina Smiljanić, Uroš Gašić, Maja Krstić Ristivojević, Petar Ristivojević

“…Fourier transform infrared spectroscopy was employed to characterize the synthesized NADES and confirm their chemical composition. …”
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Mitochondria-targeted photothermal-chemodynamic therapy enhances checkpoint blockade immunotherapy on colon cancer by Benchao Zheng, Hongbo Wang, Shiyi Zhai, Jiangsheng Li, Kuangda Lu

“…Photothermal therapy (PTT), which employs light energy to ablate tumors, can also activate tumor-specific immune responses. …”
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Outcomes of an Emergency Department opioid alternatives Program implemented within a safety-net hospital system by Magda Montague, Charlotte Hopson, Claire Layton, Jennifer Fishe, Ashley Norse, L. Kendall Webb, Petra Duran-Gehring, Andrew Bertrand, Jennifer Brailsford, Taylor Munson, Rui Wang, Nolan Menze, Katelyn Perl, Phyllis Hendry, Sophia Sheikh

“…The PAMI-ED ALT program employed a multifaceted approach in the Emergency Department (ED) developing electronic health record (EHR) pain management order panels and discharge panels, as well as educating patients, clinicians, and ED staff on opioid alternatives, including non-pharmacologic interventions. …”
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Molecular cloning and expression dynamics of Atrogin-1 in muscle tissue of Russian sturgeon (Acipenser gueldenstaedtii) under high salt stress by Yong-Juan Mo, Yi-Li Gao, Shi-Jjian Xu, Bin Wang, Jingping Wu, Peng Yu, Ming Li, Xiangtao Kang, Zhi-Qiang Han

“…Quantitative PCR (qPCR) and western blot analysis were employed to assess Atrogin-1 expression levels under high salt stress. …”
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Self-reported determinants for subjective financial distress: a qualitative interview study with German cancer patients by Eva Winkler, Katja Mehlis, Bastian Surmann, Wolfgang Greiner, Andrea Züger, Viktoria Mathies, Sophie Pauge, Luise Richter, Thomas Ernst, Natalja Menold

“…The self-reported determinants can be classified into material (savings, good salary, shared rent through shared living, employed partner, paid-off house, potential financial support from family and friends, work-related specifics, consumer restrictions, out-of-pocket-costs and anticipated financial changes), social (social support from friends and family), systemic (administrative hurdlers and insurance cover) and inner personal determinants (coping strategies, change of attitude, character traits).Conclusion Subjective financial distress depends not only on material but also on social, systemic and inner personal determinants. …”
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The association of HIV status and depressive symptoms in the Ndlovu Cohort study by Li Xiang Y. den Boer, Karine Scheuermaier, Hugo A. Tempelman, Roos E. Barth, Walter L. J. M. Devillé, Roel A. Coutinho, Diederick E. Grobbee, Francois Venter, Alinda G. Vos-Seda, Kerstin Klipstein-Grobusch

“…Logistic regression analysis on the relationship between HIV status and depressive symptoms was used while adjusting for age, sex, level of education, employment status, income, and ever smoking. The study included 1,927 participants; 46% were PLHIV and 239 (12.5%) had depressive symptoms. …”
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Characterisation of HBV and co-infection with HDV and HIV through spatial transcriptomics by Upkar S Gill, Patrick T F Kennedy, Andrew Hall, Rageshri Dhairyawan, Alberto Quaglia, James M Harris, Colin Nixon, Fadi Issa, Amy Cross, Edward Arbe-Barnes, Jane A McKeating, Dimitra Peppa

“…Our aim is to evaluate this method characterising the intrahepatic transcriptional landscape, cellular composition and biological pathways in liver biopsy samples from patients with hepatitis B virus (HBV) and HDV or HIV co-infection.Method The NanoString GeoMx digital spatial profiling platform was employed to assess expression of HBV surface antigen and CD45 in formalin-fixed paraffin-embedded (FFPE) biopsies from three treatment-naïve patients with chronic HBV and HDV or HIV co-infection. …”
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Preclinical study and parallel phase II trial evaluating antisense STAT3 oligonucleotide and checkpoint blockade for advanced pancreatic, non-small cell lung cancer and mismatch re... by Heather Lin, Vivek Subbiah, Siqing Fu, Aung Naing, Courtney Nicholas, Shubham Pant, Chad Tang, Michael A Curran, David S Hong, Ying Yuan, Sarina A Piha-Paul, Jordi Rodon Ahnert, Timonthy A Yap, Apostolia M Tsimberidou, Daniel D Karp, Anupallavi Srinivasamani, Coline Couillault, Genevieve P Hartley, James Dai, Ecaterina E Ileana Dumbrava, Paola Guerrero, Sarah Dhebat, Theresa Proia

“…In vitro experiments evaluated STAT3 inhibition in pancreatic stellate cells (PSCs) and myeloid-derived suppressor cells (MDSCs).A phase II trial employing a Simon II stage design tested the clinical efficacy of danvatirsen and durvalumab in non-small cell lung cancer (NSCLC), PDAC and mismatch repair-deficient colorectal cancer (MRD CRC). …”
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Identification and validation of immune and diagnostic biomarkers for interstitial cystitis/painful bladder syndrome by integrating bioinformatics and machine-learning by Tao Zhou, Can Zhu, Wei Zhang, Qiongfang Wu, Mingqiang Deng, Zhiwei Jiang, Longfei Peng, Hao Geng, Zhouting Tuo, Zhouting Tuo, Ci Zou

“…To address these challenges, we employed a comprehensive approach aimed at identifying diagnostic biomarkers that could facilitate the assessment of immune status in individuals with IC/BPS.MethodsTranscriptome data from IC/BPS patients were sourced from the Gene Expression Omnibus (GEO) database. …”
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Natural Resource Rent and Financial Development: Testing Financial Resource Curse Hypothesis in Iran by Majid Aghaei, Mahdieh Rezagholizadeh, mohammad abdi, rawa mosavi

“…Methodology: In order to investigate and empirically analyze the long-term and short-term dynamic relationship between variables, this research employs the Autoregressive Distributed Lag (ARDL) bounding test approach. …”
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INTERNATIONAL FORUM OF AMERICAN SOCIETY FOR ENGINEERING EDUCATION by Vasily Ivanov, Yulia Ziyatdinova

“…The President of Global Engineering Deans Council Jose Carlos Quadrado focused on Portugal, where engineering universities are overcoming a crisis and going through restructuring aimed at training engineers capable of creating new job instead of being employed. The Executive Director of LACCEI Maria M. …”
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MUC5B modulation of early oral biofilm glucose metabolism by Carolina Robertsson, Carolina Robertsson, Julia Davies, Gunnel Svensäter, Anders Bay Nord, Niclas Norrström, Claes Wickström

“…IntroductionSalivary mucin MUC5B has been suggested to support eubiosis in early oral biofilms by regulating the attachment of commensals, while downregulating dysbiotic activities related to dental caries development, such as microbial carbohydrate transport and metabolism.MethodsTo investigate how the metabolism of glucose, a potential driver for dental caries, in early mono- and dual-species biofilms of oral Actinomyces naeslundii and Streptococcus gordonii clinical isolates was affected by the presence of the complex salivary mucin MUC5B, this study employed nuclear magnetic resonance (NMR)-based metabolomics with the interpretation of network integration.Results and discussionMUC5B reduced early attachment in the presence of glucose compared with uncoated surfaces but maintained even species distribution. …”
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Research on the multi-agent motivation coupling evolution and synergy improvement for farmland ecological protection in China by Adila Ainiwaerjiang, Xueying Jin, Zhen Xie, Tian Tian, Yuxuan Dang

“…Policy implementers’ motivation, however, has remained consistent. Employing a coupling and coordination model to assess the collaborative effectiveness among these actors, this study identifies a downward trend in synergistic effectiveness across three phases: primary coupling, approaching decoupling, and mild decoupling. …”
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A Hybrid Model for Soybean Yield Prediction Integrating Convolutional Neural Networks, Recurrent Neural Networks, and Graph Convolutional Networks by Vikram S. Ingole, Ujwala A. Kshirsagar, Vikash Singh, Manish Varun Yadav, Bipin Krishna, Roshan Kumar

“…In this paper, the state of the art in yield prediction has been advanced due to the employment of multi-source data fusion, sophisticated feature engineering, and advanced neural network architectures. …”
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Emergence of Self-Identity in Artificial Intelligence: A Mathematical Framework and Empirical Study with Generative Large Language Models by Minhyeok Lee

“…To validate this theoretical framework, we conducted empirical experiments using the Llama 3.2 1B model, employing low-rank adaptation (LoRA) for efficient fine-tuning. …”
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