Genetic variation reveals the therapeutic potential of BRSK2 in idiopathic pulmonary fibrosis by Zhe Chen, Mingyang Tang, Nan Wang, Jiangjiang Liu, Xiaoyan Tan, Haitao Ma, Jing Luo, Kai Xie

“…This study aimed to identify key targets involved in the progression of IPF. Methods We employed Mendelian randomization (MR) with three genome-wide association studies and four quantitative trait loci datasets to identify key driver genes for IPF. …”
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Association between triglyceride glucose index and adverse cardiovascular prognosis in patients with atrial fibrillation without diabetes: a retrospective cohort study by Aobo Gong, Ying Cao, Zexi Li, Wentao Li, Fanghui Li, Yao Tong, Xianjin Hu, Rui Zeng

“…Kaplan–Meier curve, Cox proportional hazards regression model, and restricted cubic spline were employed to explore the relationship between the Tyg index and outcomes. …”
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Enhancing collaborative clinical reasoning among multidisciplinary healthcare teams in a neurosurgery ICU: insights from video-reflexive ethnography by Ching-Yi Lee, Ching-Hsin Lee, Sze-Yuen Yau, Hung-Yi Lai, Po-Jui Chen, Mi-Mi Chen

“…The study utilizes video-reflexive ethnography (VRE) to examine the factors influencing CCR, the cognitive processes involved, and the efficacy of VRE in promoting CCR. Methods The study employed a qualitative research design, utilizing VRE. …”
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Cancer vaccines compensate for the insufficient induction of protective tumor-specific immunity of CD3 bispecific antibody therapy by Sjoerd H van der Burg, Marjolein Sluijter, Thorbald van Hall, Jim Middelburg, Kristel Kemper, Janine Schuurman, Gaby Schaap, Katy Lloyd, Vitalijs Ovcinnikovs

“…Here, we examined multiple combination strategies aiming to improve survival rates in solid tumors and, simultaneously, install endogenous immunity capable of protection to tumor rechallenge.Methods Two syngeneic mouse tumor models were employed: The immunologically “cold” B16F10 melanoma and the immunologically “hot” MC38.TRP1 colon carcinoma model. …”
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Verbascoside Inhibits the Activation of NLRP3 Inflammasome and Improves BV-2 Cell Inflammatory Damage by Wenjing HUANG, Fang CHENG, Min DU, Jiayi CHEN, Wei XIANG, Ke SHI, Xingliang XIE, Yanmei SHENG

“…Methods: A model of inflammatory damage induced by oxygen-glucose deprivation (OGD) in BV-2 cells was employed. The experiment was divided into 4 groups: The normal control group, the OGD model group, the Osmanthus fragrans ethanol extract group (OGD+OEE), and VB group (OGD+VB). …”
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Prognostic Value of Cerebrospinal Fluid and Serum Neurofilament Light Chain in Amyotrophic Lateral Sclerosis: A Correlation Study by Siqi Dong, Xiaoni Liu, Yanni Zhou, Jiatong Li, Zihan Qi, Zihan Wang, Wenbo Yang, Xiangjun Chen

“…Furthermore, baseline sNfL concentrations, as well as cNfL levels, emerged as predictive indicators of subsequent disease progression rate (sNfL: p < 0.0001, cNfL: p = 0.0005) and overall survival (sNfL: p = 0.0073, cNfL: p = 0.0044). Employing a Cox regression model, we identified baseline sNfL level (HR = 1.01, p = 0.013), and diagnostic delay (HR = 0.94, p = 0.003) as independent prognostic factors for mortality. …”
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The small GTPases FoRab5, FoRab7, and FoRab8 regulate vesicle transport to modulate vegetative development and pathogenicity in Fusarium oxysporum f. sp. conglutinans by Xiangyu Tan, Lin Chen, Ying Chen, Yuxin Li, Lihan Lu, Erfeng Li

“…In addition, we also employed a PEG-mediated homologous recombination approach to create deletion mutants and complementary strains for the FoRab5, FoRab7, and FoRab8 genes, thereby facilitating a comprehensive investigation into the functional roles of these genes. …”
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Impact of chemoradiotherapy for first primary lung cancer on the prognosis and re-chemoradiotherapy sensitivity of second primary lung cancer by Zhe Chen, Gaoming Wang, Nan Wang, Jiangjiang Liu, Yu Yao, Haitao Ma, Haitao Ma, Jing Luo, Kai Xie

“…Among these, 5,302 FPLC patients developed SPLC within 5 years of their initial diagnosis. We employed the Fine-Gray competitive risk model, Cox proportional hazards model, and restricted mean survival time analysis to assess the effects of FPLC radiotherapy and chemotherapy on SPLC risk and survival differences.ResultsThe competitive risk model indicated that FPLC radiotherapy and chemotherapy did not significantly change the risk of developing SPLC. …”
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Linking employee voice to service recovery performance in the hotel sector: The mediating role of tacit knowledge sharing and employee innovation by Sultan Alzyoud, Waed Ensour, Ayman Harb

“…PLS-SEM (Partial Least Squares Structural Equation Modeling) was employed in this research to analyze the data using Smart PLS 3 software. …”
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Assessing caregiver stress and resource needs in pediatric cancer care by Shaimaa Mohamed Amin, Mahmoud Abdelwahab Khedr, Azza Medhat Aziz Mansy, Ahmed Hashem El-Monshed, Mohamed Gamal Noaman Malek, Ayman Mohamed El-Ashry

“…Descriptive statistics, t-tests, ANOVA, and Pearson correlation coefficients were employed for data analysis using SPSS version 29, with a significance level set at p < 0.05. …”
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The Efficacy and Brain Network Mechanism of Acupuncture for Knee Osteoarthritis: A Study Protocol for Randomized Controlled Neuroimaging Trial by Sun YY, Wang ML, Zhao RH, Hao MY, Song S, Zhou Y, Zhang N

“…The primary efficacy indicator will be the change in NRS score after four weeks of treatment, with secondary outcomes including WOMAC, STAI, and safety assessments. fMRI observations will employ independent component analysis, brain network construction, and functional connectivity, complemented by Pearson correlation analysis to explore the relationship between brain responses and clinical improvements.Conclusion: This study will initially uncover how acupuncture intervention for chronic KOA pain centrally regulates and exerts therapeutic effects through the modulation of abnormal brain network functional connectivity patterns, with a demonstrated long-term effect.Ethics and Dissemination: This study has been approved by the ethics committee of Shandong University of Traditional Chinese Medicine Affiliated Hospital ((2024) Lunshen No. (028) - KY).Clinical Trial Registration: This study has been approved by registered in the Chinese Clinical Trial Registry (ChiCTR2400083695).Keywords: acupuncture, knee osteoarthritis, neuroimaging, RCT, protocol…”
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Evaluation of the Psychiatric Disorders among Amphetamine Addicts in Rehabilitation Centers: A Cross-Sectional Analysis by Saud D. AlOtaibi, Hossam A. Elsisi, Mohammed J. AlShammary, Saud A. AlQader, Hejab A. AlHarbi, Bayan R. AlOlaiyan, Ahmad O. Alanazi, Firas S. AlMendeel, Yazeed N. AlHarbi, Ibrahim AlKhalaf, Ahmad H. Alhowail, Abdelhamid Mohamed Elwy, Ashraf M. Emara

“…Pearson correlation coefficients (r) were employed. Results. A total of 60 subjects participated in this study. …”
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Assessing and optimizing the potential for climate change mitigation and carbon sequestration in urban residential green spaces: energizing sustainable cities by Hancheng Liu, Jialong Zhang, Zijun Wang

“…The assimilation method was employed to calculate carbon sequestration per unit canopy area and for entire plants.ResultsThe results showed that the carbon sequestration capacities of different plant species and types exhibited significant differences, with p-values less than 0.05. …”
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“Unmasking the Uncommon”: A case series of multi-drug resistant Elizabethkingia meningoseptica causing late-onset sepsis and meningitis in preterm neonates [version 2; peer review:... by Anisha Maria Fernandes, Sinchana Bhat, Suchitra Shenoy M., Prajnha U.P.

“…It exhibits resistance to many commonly employed first-line antibiotics used to treat gram-negative pathogens. …”
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A genetic exploration of the relationship between posttraumatic stress disorder and cardiovascular diseases by Eva Lukas, Rada R. Veeneman, Dirk J. A. Smit, Tarunveer S. Ahluwalia, Jentien M. Vermeulen, Gita A. Pathak, Renato Polimanti, Karin J. H. Verweij, Jorien L. Treur

“…Next, we assessed biological, behavioural, and psychosocial factors as potential mediators. Finally, we employed multivariable Mendelian randomization to examine causal pathways between PTSD and CVD, incorporating the same potential mediators. …”
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Postacute Myocardial Infarction Differences in Physical Activity Behavior, Anxiety, and Depression Levels by Abedalmajeed Methqal Shajrawi PhD, RN, CNS, Hekmat Yousef Al-Akash PhD, Ahmed Mohammad Al-Smadi PhD, Rami Masa'deh PhD, RN, Mohannad Eid Aburuz PhD, RN, CNS, Heba Khalil PhD, RN, Issa Moh'd Hweidi BSN, PhD, Ahmad Rajeh Saifan PhD, RN

“…Methods A descriptive cross-sectional study design was employed with a convenience sample of 254 patients with post-AMI, 4 weeks after hospitalization. …”
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Associations between lipid-lowering drugs and urate and gout outcomes: a Mendelian randomization study by Min Liu, Na Yin, Yuhang Zhu, Aili Du, Chunyuan Cai, Pengyuan Leng

“…The aim of this study was to investigate the genetic association between lipid-lowering drugs and urate and gout.MethodsIn this study, two genetic proxies were employed to approximate lipid-lowering drug exposure: expression quantitative trait loci (eQTL) associated with drug-target genes and genetic variations proximal to or within genes targeted by these drugs, which are linked to low-density lipoprotein cholesterol (LDL-C) levels. …”
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LightweightUNet: Multimodal Deep Learning with GAN-Augmented Imaging Data for Efficient Breast Cancer Detection by Hari Mohan Rai, Joon Yoo, Saurabh Agarwal, Neha Agarwal

“…The proposed model boasts a low computational cost due to its smaller number of layers in its architecture, and its adaptive nature stems from its use of depth-wise separable convolution. We have employed a multimodal approach to validate the model’s performance, using 13,000 images from two distinct modalities: mammogram imaging (MGI) and ultrasound imaging (USI). …”
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Evaluation of Elemental and Chemical Compositions of Some Fuelwood Species for Energy Value by A. M. Dadile, O. A. Sotannde, B. D. Zira, M. Garba, I. Yakubu

“…Four fuel materials were obtained from each tree sample; these include wood without bark (100% wood sample), wood with 5% bark inclusion, wood with 10% bark inclusion, and whole bark samples and they were evaluated for their inherent elemental and chemical compositions by employing ASTM and TAPPI methods. The results showed that there were significant differences in the tree species and fuel material types obtained from all the ten fuelwood species used. …”
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The Clinical and Economic Impact of Employees Who Are Care Partners of Patients with Multiple Sclerosis by Disease Severity by Barry Hendin, Richard A. Brook, Ian A. Beren, Nathan Kleinman, Cindy Fink, Amy L. Phillips, Carroline Lobo

“…Treatment strategies that improve patient outcomes may reduce employee care partner burden and lower costs for employers in some instances. **Conclusions:** Comorbidities and direct/indirect costs of employees whose spouses/partners have MS were considerable and varied with MS severity.…”
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