Identification and verification of autophagy-related gene signatures and their association with immune infiltration and drug responsiveness in epilepsy by Han-han He, Xiao-ge Zhang, Fen-fang Chen

“…Differential expression genes (DEGs) analysis and weighted gene co-expression network analysis (WGCNA) were employed to screen for autophagy related differential expression genes (ARDEGs) in GSE143272 database. …”
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Peripheral blood complement factors C2 and C3 as biomarkers of clinical efficacy in patients with first-episode schizophrenia after aripiprazole treatment by Yin Cao, Jun Liang, Biao Dai, Feng Shan, Qingrong Xia

“…Pearson’s correlation test was employed to evaluate the relationships between changes in serum complement factor levels and the reduction rates of PANSS/BPRS scores. …”
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c-FLIP and microRNA 708-5p gene expression in newly diagnosed and chemotherapy in acute myeloid leukemia of Iraqi patient by Jaafar Sadiq Jaafar, Hiba Muneer Abdual Hassan Al-Kafagi, Israa Hussein Hamzah

“…The study was conducted at the National Center of Hematology/Mustansiriyah University. The methods employed in the analysis include total RNA extraction, complementary cDNA synthesis, and quantitative real-time polymerase chain reaction (PCR) were used to evaluate the gene expression of cFLIP and miRNA-708-5p. …”
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Prevalence and Determinants of Hypertension Awareness, Treatment, and Control in Botswana: A Nationally Representative Population-Based Survey by Neo M. Tapela, Lei Clifton, Gontse Tshisimogo, Moagi Gaborone, Tebogo Madidimalo, Virginia Letsatsi, Tiny Masupe, Mosepele Mosepele, Joseph Makhema, Shahin Lockman, David J. Hunter

“…Multivariable logistic regression was employed to explore factors associated with hypertension, awareness (report of previous diagnosis), treatment (antihypertensives), and control (BP < 140/90). …”
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Relationship Between the Salivary Microbiome and Oral Malodor Metabolites in Older Thai Individuals with Periodontitis and the Cytotoxic Effects of Malodor Compounds on Human Oral... by Witsanu Srila, Kritsana Sripilai, Thunwa Binlateh, Peungchaleoy Thammanichanon, Watcharaphol Tiskratok, Parinya Noisa, Paiboon Jitprasertwong

“…<b>Background/Objectives</b>: Halitosis is primarily caused by the activity of oral microorganisms. In this study, we employed metagenomic sequencing and metabolomic approaches to investigate the differences in salivary microbiota and metabolite profiles between individuals with halitosis and periodontitis and healthy controls. …”
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Analysing DNA methylation and transcriptomic signatures to predict prostate cancer recurrence risk by Fahad M. Aldakheel, Hadeel Alnajran, Shatha A. Alduraywish, Ayesha Mateen, Mohammed S. Alqahtani, Rabbani Syed

“…There is a pressing need for novel biomarkers to enhance precision medicine approaches for PCa. This study employs a machine learning approach to identify DNA methylation and RNA expression biomarkers predictive of PCa recurrence using datasets from The Cancer Genome Atlas (TCGA). …”
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A supervised model to identify wolf behavior from tri-axial acceleration by Charlotte Lorand, Léa Bouet, Olivier Devineau, Marianna Chimienti, Alina L. Evans, Peggy Callahan, Mark Beckel, Timothy G. Laske, Ane Eriksen

“…These models can be employed to support future behavioral studies examining questions such as conflict mitigation, wolf responses to human disturbances, or specific activity budgets.…”
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Frailty Is Associated With Decreased Survival in Adult Patients With Nonoperative and Operative Traumatic Subdural Hemorrhage: A Retrospective Cohort Study of 381,754 Patients by Evan N. Courville, MD, Oluwafemi P. Owodunni, MD, MPH, Jordyn T. Courville, BS, Syed F. Kazim, MD, PhD, Alexander J. Kassicieh, BS, Allyson M. Hynes, MD, Meic H. Schmidt, MD, MBA, Christian A. Bowers, MD

“…A retrospective study examining tSDH patients ≥18 years and assigned an abbreviated injury scale score ≥3, and entered into ACS-TQIP between 2007 and 2020. We employed multivariable analyses for risk-adjusted associations of frailty and our outcomes, and Kaplan-Meier plots for survival probability. …”
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Development of a Cell-Based High-Throughput Screening Assay to Identify Porcine Host Defense Peptide-Inducing Compounds by Zhuo Deng, Jing Wang, Wentao Lyu, Xuwen Wieneke, Robert Matts, Xi Ma, Guolong Zhang

“…Such a stable reporter cell line was employed in a high-throughput screening of 148 epigenetic compounds and 584 natural products, resulting in the identification of 41 unique hits with a minimum strictly standardized mean difference (SSMD) value of 3.0. …”
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Development and approval of a Lasso score based on nutritional and inflammatory parameters to predict prognosis in patients with glioma by Huixian Li, Hui Hong, Jinling Zhang

“…The Least Absolute Shrinkage and Selection Operator (Lasso) was employed to select relevant hematological indicators and generate a Lasso score. …”
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Major Aortopulmonary Collateral Arteries and Their Effects on Perioperative Parameters and Mortality of Children with Tetralogy of Fallot: A Case-control Study by Mohammadreza Edraki, Amir Naghshzan, Hamid Amoozgar, Kambiz Keshavarz, Nima Mehdizadegan, Hamid Mohammadi

“…The significant aspects of MAPCAs, including their quantity, the presence of dual or single supply lung segments, and the employed devices for closure were evaluated. The patients were divided into three groups: TOF patients without MAPCAs as the control group, those with preoperative percutaneous MAPCA closure (Closed MAPCA), and those with small MAPCAs deemed unsuitable for percutaneous closure (Open MAPCA). …”
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Emission Characteristics of Hazardous Air Pollutants from Construction Equipment by Sungwoon Jung, Sunmoon Kim, Yunsung Lim, Jongtae Lee, Taekho Chung, Heekyoung Hong, Sunhee Mun, Seunghwan Lee, Woojun Jang, Jaehyun Lim

“…Hence, the present study employed an engine dynamometer to evaluate the emissions of a diesel engine complying with Tier 3 standards during various driving modes (KC1-8, NRSC, and NRTC) and a portable emissions measurement system (PEMS) to assess those of two excavators, one complying with Tier 3 and the other with Tier 4 standards, during real-world working and driving conditions. …”
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Feasibility of implementing family-integrated newborn care for hospitalised preterm and low birthweight infants in newborn care units of Ethiopia: a mixed-methods design by Hege Langli Ersdal, Araya Abrha Medhanyie, Damen Haile Mariam, Siren Rettedal, Znabu Hadush Kahsay

“…Despite the WHO’s call for family engagement in newborn care, evidence of the feasibility of implementation remains scarce.Design An observational feasibility study employing a mixed-methods design comprising a quantitative cross-sectional survey among 157 healthcare providers (HCPs) and a qualitative Participatory Rural Appraisal.Setting The study was conducted in 30 neonatal care units (NCUs) of hospitals in Tigray, Northern Ethiopia.Participants HCPs who were on duty in NCUs during the data collection period were included in the study.Analysis Descriptive statistics were obtained for the quantitative data using STATA V.16, while qualitative data were coded and analysed using a framework analysis approach with qualitative data analysis software (Atlas.ti V.9).Results In total, 157 HCPs were enrolled with a mean (SD) age of 32 (±6.8) years. …”
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Incidence of alexithymia in worsening symptoms and quality of life of Systemic Lupus Erythematosus patients (SLE) by Fabio Rapisarda, Concetta Mezzatesta, Antonina Butticè, Alessandro Raffa, Stefano Boca

“…The selection of these instruments allowed us to assess attachment styles, the presence of maladaptive personality traits, defence mechanisms employed, in order to define any symptoms indicative of a psychiatric diagnosis, and evaluate the quality of life in relation to the severity of the pathology. …”
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The role of CTGF and MFG-E8 in the prognosis assessment of SCAP: a study combining machine learning and nomogram analysis by Tingting Lin, Tingting Lin, Huimin Wan, Jie Ming, Yifei Liang, Linxin Ran, Jingjing Lu

“…The ELISA method was employed to measure the levels of MFG-E8 and CTGF in the three groups. …”
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Comprehensive safety evaluation of isatuximab in multiple myeloma using disproportionality analysis of FAERS and meta-analysis of randomized controlled trials by Muhammed Favas Karimbanathottathil, Beema T Yoosuf, M Mamatha, Dipika Bansal

“…For the meta-analysis, safety outcomes of isatuximab in adult patients were reviewed from RCTs sourced from databases such as PubMed, EMBASE, and ClinicalTrials.gov, employing a random-effects meta-analysis to determine the risk ratio (RR) with 95% CI. …”
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EXPLORING THE INFLUENCES ON DISPLACED CITIZENS' DECISION TO REPATRIATE: A CLASSIFICATION OF POSITIVE AND NEGATIVE FACTORS by Volodymyr Filippov, Iryna Bashynska, Elvin Yangulov

“…Moreover, the case-study method was employed to examine specific examples from various countries where citizens confronted analogous circumstances and made decisions regarding returning or resettling. …”
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Stabilizing behaviors of Pseudomonas putida and Pseudomonas alcaligenes bacteria on heavy metal ions in electrolytic manganese residue by Hongliang Chen, Xiangqian Li, Yingxian Zhao, Yutao Zhang

“…Fortunately, when P. putida and P. alcaligenes were synergized together, they exhibited a stronger performance in stabilizing heavy metal ions present in the EMR compared to the bacteria employed alone. After 12 days of fermentation in the EMR slurry, almost all Mn ions were eliminated through the formation of deposits, while the concentrations of Zn, Cu and Cd ions decreased to 0.28 mg/L, 0.2 mg/L and 0.1 mg/L respectively after 10 days fermentation. …”
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Preparation of curcumin submicron particles by supercritical antisolvent method with external adjustable annular gap nozzle by Yechen Wang, Zirui Li, Sun Fayu, Fei Li, Weiqiang Wang

“…Building on single-factor experiments, a Box-Behnken Design-Response Surface Methodology (BBD-RSM) was employed to systematically investigate the effects of four process parameters—crystallizer pressure (12–16 MPa), crystallizer temperature (313–323 K), solution concentration (1–2 mg/mL), and CO2/solution flow rate ratio (133–173 g/g)—on the morphology and particle size of curcumin particles. …”
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Exome sequencing in Nigerian children with early‐onset epilepsy syndromes by Ibitayo Abigail Ademuwagun, Yagoub Adam, Solomon Oladapo Rotimi, Steffen Syrbe, Maximilian Radtke, Julia Hentschel, Johannes R. Lemke, Ezekiel Adebiyi

“…Exome sequencing (ES) offers a diagnostic yield of 24%–62%, but these figures primarily reflect data from high‐income countries (HICs) and may not be applicable to low‐ and middle‐income countries (LMICs). In this study, we employed ES to investigate the genetic basis of early‐onset epilepsy in 22 affected children from Nigeria. …”
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