Determinants of handwashing practice and its associated factors among mothers of under-5 children in Kolladiba town, Northwest Ethiopia: cross-sectional study by Getayeneh Antehunegn Tesema, Maereg Wolde, Meshehsa Abate, Gebremeskel Mandefro, Ezedin Beru, Aysheshim Kassahun

“…Bivariable and multivariable binary logistic regression was employed. A p<0.05 was used to declare statically significant variables.Results The proportion of good handwashing practice among mothers at critical times was 51.2% (95% CI 45.8% to 56.5%). …”
Get full text

Experimental investigation on the effect of concentration on the resonance frequency of lipid coated ultrasonically excited microbubbles by Hossein Haghi, Mahshid Yaali, Agata A. Exner, Michael C. Kolios

“…Expanding on theoretical models and numerical simulations from previous research, this work experimentally investigates the effect of MB size on the rate of resonance frequency increase with concentration, a phenomenon observed across MBs with two different lipid compositions: propylene glycol (PG) and propylene glycol and glycerol (PGG). Employing a custom-designed ultrasound attenuation measurement setup, we measured the frequency-dependent attenuation of MBs, isolating MBs based on size to generate distinct monodisperse sub-populations for analysis. …”
Get full text

Funding liquidity on bank lending growth: The case of India by Erum Shaikh, Muhammad Nawaz Tunio, Vishal Dagar

“…The GMM approach was what we employed. This strategy is typically utilized in situations in which the distribution of the data is uncertain and there is a concern with over identification. …”
Get full text

Integrating machine learning with mendelian randomization for unveiling causal gene networks in glioblastoma multiforme by Lixin Du, Pan Wang, Xiaoting Qiu, Zhigang Li, Jianlan Ma, Pengfei Chen

“…Despite advances in understanding its molecular mechanisms, effective therapeutic strategies remain elusive due to the tumor’s genetic complexity and heterogeneity. Methods This study employed a comprehensive analysis approach integrating 113 machine learning algorithms with Mendelian Randomization (MR) analysis to investigate the molecular underpinnings of GBM. …”
Get full text

The prognostic value of circulating tumor DNA in malignant melanoma patients treated with immune checkpoint inhibitors: a systematic review and meta-analysis by Lei Liu, Shufu Hou, Aiping Zhu, Bing Yan, Linchuan Li, Dandan Song

“…Additionally, funnel plots, Begg’s test, and Egger’s test were employed to assess potential publication bias.ResultsTwelve studies from eleven articles, involving a total of 1063 eligible MM patients receiving ICI therapy, were included. …”
Get full text

Functional and effective EEG connectivity patterns in Alzheimer’s disease and mild cognitive impairment: a systematic review by Elizabeth R. Paitel, Christian B. D. Otteman, Mary C. Polking, Henry J. Licht, Kristy A. Nielson, Kristy A. Nielson

“…When greater connectivity was reported in MCI, it was primarily during task engagement, suggesting compensatory resources may be employed. In AD, greater connectivity was most common during rest, suggesting compensatory resources during task engagement may already be exhausted.ConclusionThe review highlighted EEG connectivity as a powerful tool to advance understanding of AD-related changes in brain communication. …”
Get full text

A novel 2D nickel coordination polymer based on Trimesic acid with glyphosate coordination capabilities by João M. R. Gonçalves, Ademar Wong, Pedro H. O. Santiago, Guilherme Arroyos, Augusto H. Piva, Javier A. Ellena, Benedito S. Lima-Neto, Regina C. G. Frem

“…Finally, the bidentate molecule Glyphosate (GLY), widely used as a pesticide and recognized as an environmental pollutant, was employed for coordination with Ni-BTC, as in this structure, the axial DMF ligands are labile and can be replaced by glyphosate molecules. …”
Get full text

A Case Study on Multi-Real-Option-Integrated STO-PF Models for Strengthening Capital Structures in Real Estate Development by Jung Kyu Park, Jun Bok Lee, Young Mee Ahn, Ga Young Yoo

“…In order to address these limitations, this study employs a multi-real-option model with a binomial lattice framework, thereby facilitating flexible decision-making in various investment stages. …”
Get full text

Evaluating the dual impact of microbial activity and aged refuse layers on landfill leachate clogging: An experimental and LCA perspective by Zhaobin Li, Waifan Tang, Shulun Mak, Siukei Lam, Qingwen Li

“…Significance: This study provides an in-depth analysis combining a review of existing literature and experimental insights into the role of microbial communities in clogging formation and the effectiveness of aged refuse layers as a mitigation measure.To provide a comprehensive assessment, a life cycle assessment (LCA) framework is employed to analyze the environmental impacts of various clogging control methods.This study contributes to theoretical advancements by integrating a comprehensive review of LCA frameworks in the context of landfill management, addressing a gap in current literature. …”
Get full text

Loading rate, geometry, and damage state influence vertical extraction biomechanics in an ex vivo swine dental model by Timothy J. Gadzella, Karyne N. Rabey, Michael R. Doschak, Lindsey Westover, Owen Addison, Owen Addison, Dan L. Romanyk, Dan L. Romanyk

“…Damage imposed in the FEA model was able to predict experimental results from experiments on similarly-damaged dental complexes.ConclusionThis study presents a comprehensive experimental and numerical characterization of vertical tooth extraction biomechanics employing an ex vivo swine model. The results of these experiments suggest that the axisymmetric FEA model is a powerful tool for predicting a range of conditions and dental complex geometries. …”
Get full text

Prevalence of Self-Medication Practice and Associated Factors among Pregnant Women Who Attended Antenatal Care at Public Hospitals of North Shewa Zone, Amhara Region, Ethiopia by Abrham Demis, Birhanetensay Masresha Altaye, Mulugeta Emiru, Mitiku Tefera

“…A multistage sampling technique was employed. The questionnaires were pretested. A structured interviewer-administered questionnaire and reviewed medical records were used for data collection. …”
Get full text

The <i>Meq</i> Genes of Nigerian Marek’s Disease Virus (MDV) Field Isolates Contain Mutations Common to Both European and US High Virulence Strains by Joseph N. Patria, Luka Jwander, Ifeoma Mbachu, Levi Parcells, Brian Ladman, Jakob Trimpert, Benedikt B. Kaufer, Phaedra Tavlarides-Hontz, Mark S. Parcells

“…The present work reports on <i>meq</i> mutations identified in MDV field strains in Nigeria, arising at farms employing different vaccination practices. Materials and Methods: DNA was isolated from FTA cards obtained at 12 farms affected by increased MD in the Plateau State, Nigeria. …”
Get full text

Identification of natural compound inhibitors for substrate-binding site of MTHFD2 enzyme: Insights from structure-based drug design and biomolecular simulations by Nisarg Rana, Priyanka Solanki, Rukmankesh Mehra, Anu Manhas

“…A computational structure-based drug design approach was employed to identify inhibitors targeting the active site of the MTHFD2 enzyme. …”
Get full text

The role of ultrasound combined with water bath in the establishment of animal models of rat urethral stricture by Xiaojian Ye, Xianjing Lin, Yehui Chen, Rongquan Xu, Jiawei Zhou

“…High-frequency ultrasonography using a GE E10 device combined with a water bath method was employed to evaluate the urethral conditions of all rats. …”
Get full text

Risk Prediction of Liver Injury in Pediatric Tuberculosis Treatment: Development of an Automated Machine Learning Model by Zeng Y, Lu H, Li S, Shi QZ, Liu L, Gong YQ, Yan P

“…The area under the receiver operating characteristic curve (AUC) was used to evaluate model’s performance, and then the TreeShap algorithm was employed to interpret the variable contributions.Results: A total of 184 children were enrolled in this study, of whom 19 (10.33%) developed ATB-DILI. …”
Get full text

Determinants of knowledge of preconception care among healthcare providers in Ethiopia: a systematic review and meta-analysis by Biruk Beletew Abate, Gizachew Yilak, Befkad Derese Tilahun, Nimona Amena, Tegene Atamenta Kitaw, Mulat Ayele, Addis Wondmagegn Alamaw, Eyob Shitie Lake

“…Key elements influencing their comprehension encompass advanced educational credentials beyond a BSc degree, adherence to institutional guidelines, employment in hospital settings and exposure to specialised training. …”
Get full text

Transitioning to residency: a qualitative study exploring residents’ perspectives on strategies for adapting to residency by Gerbrich Galema, Jasperina Brouwer, Tineke Bouwkamp-Timmer, Debbie A. D. C. Jaarsma, Götz J. K. G. Wietasch, Robbert R. J. Duvivier

“…To identify residents’ perceptions of their own and other healthcare professionals’ strategies, our template consisted of the individual and organizational strategies originating from the Organizational Socialization theory. Results Residents employed five individual strategies: observing, asking questions, establishing social relationships, and seeking information. …”
Get full text

Piloting of a Screen-Triage-Treat Surgical Approach Model for Management of Anal Cancer in Liberia by Christopher W. Reynolds, Whitney Lieb, Andrea Schecter, Michael M Gaisa, Stephen K. McGill, Evans L. Adofo, Ann Marie Beddoe

“…Findings: Among 110 participants, most were single (n = 94, 88%) and without formal employment (n = 21, 75%). Participants engaged in regular anal (n = 64, 60%), oral (n = 62, 58%), and receptive sex (n = 58, 54%), and sex with women (n = 51, 48%). …”
Get full text

GATA1-mediated macrophage polarization via TrkB/cGMP–PKG signaling pathway to promote the development of preeclampsia by Wushan Li, Fei Hou, Di Cheng, Fengchun Gao, Jin Wang, Baoxia Cui

“…This study aims to investigate the role of GATA1 in the pathogenesis of PE, with a specific focus on how GATA1-regulated TrkB/cGMP–PKG signaling in macrophages and its dysregulation contribute to the development of preeclampsia. Methods By employing THP-1 cells, co-culture systems of THP-1 cells and HTR-8/Svneo, HPVECs and Sprague–Dawley (SD) rats, in conjunction with gene knockdown and overexpression techniques, we explored the effects of GATA1 on the TrkB/cGMP–PKG signaling pathway. …”
Get full text

Knowledge regarding human monkeypox among a sample of undergraduate and post-graduate students from selected tertiary institutions in Bangladesh: An online-based cross-sectional st... by Md Hasan Al Banna, Abdul-Aziz Seidu, Trisha Mallick, Nahidur Rahman, Mst Sadia Sultana, Humayra Alam Mouly, Najim Z Alshahrani, Nargees Akter, Tareq Mahmud, Susmita Hossain, Anannya Sheikh, Ashish Biswas, Sumaia Sahrin, Md Nazmul Hassan, Md Shafiqul Islam Khan

“…The Kruskal-Wallis test, Mann-Whitney test, and multivariable quantile regression model were employed.<h4>Results</h4>The median age of the study participants was 23 years (IQR: 25-22). …”
Get full text