Unleashing the potential of a low CpG Passer transposon for superior CAR-T cell therapy by Jianyao Zeng, Yan Sun, Yan Sun, Yuan Fang, Xiaodie Wang, Qian Huang, Pingjing Zhang, Meiqi Shao, Pei Wang, Jingbo Cheng, Meng Di, Tao Liu, Qijun Qian, Qijun Qian, Qijun Qian

“…Flow cytometry and luciferase reporter assays were employed for mutation screening. BALB/c mice and M-NSG mice were used to evaluate the inflammatory response and efficacy of LCG CAR-T in vivo, with TIL grouping detected via immunohistochemistry.ResultsIn this study, we modified the newly discovered Passer (JL) transposon to construct a low-CpG content transposon for CAR-T cell (LCG CAR-T cell) preparation. …”
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Investigating the Relationship between Automatic Negative Thoughts and Experiential Avoidance with Psychological Distress and the Mediating Role of Cognitive Emotion Regulation in... by Ahmad Alipour, Afsaneh Rahimi, Shahin Shadnia, Mitra Rahimi, Peyman Erfan Talab Evini, Sayed Masoud Hosseini, Babak Mostafazadeh

“…To analyze the direct and indirect associations between the input and output variables, Structural Equation Modeling (SEM) was employed. In addition, SPSS-28 and Amos 29 software were used to analyzed the data. …”
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Dietary inflammatory index and disability among older adults in Guangzhou: a cross-sectional analysis by Junbin Liao, Junbin Liao, Wenfeng Cai, Danrong Lin, Yuanyun Xiao, Yanxi Liu, Yahui Wang, Yuquan Zhong, Fan Xiao, Heng Fang, Yilu Yao, Yunfeng Lin, Jiewen Su, Siyu Sun, Bo Zhang, Yan Wang, Wei Zhu, Wei Zhu

“…A multivariable ordinal logistic regression model was employed to analyze the influence of various factors and the DII on the degree of disability among older adults. …”
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Ionizing radiation-induced disruption of Rela-Bclaf1-spliceosome regulatory axis in primary spermatocytes causing spermatogenesis dysfunction by Hongjian Zhou, Zhipeng Xu, Chun Jiang, Qiuyue Wu, Chuanyue Zhang, Zhenyu Liu, Xiaoxue Zhang, Weiwei Li, Yujia Pang, Jing Zhang, Wenju Pan, Min Chen, Xinyi Xia

“…Abstract Introduction Ionizing radiation (IR) poses a significant threat to male fertility by inducing substantial changes in the testis, yet the mechanisms underlying IR-induced spermatogenesis disorders remain poorly understood, necessitating the development of more effective radioprotective agents. Methods We employed Bulk RNA-seq and single-cell RNA-seq (scRNA-seq) on Balb/c mice testes models following IR exposure to assess cellular and transcriptional alterations. …”
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“Sleepless nights are a daily reality for us” how women experiencing homelessness in Addis Ababa, Ethiopia describe street life: a photovoice study by Kalkidan Yohannes, Kalkidan Yohannes, Kalkidan Yohannes, Mats Målqvist, Hannah Bradby, Yemane Berhane, Dagmawit Tewahido, Dagmawit Tewahido, Sibylle Herzig van Wees, Sibylle Herzig van Wees

“…They also emphasised the critical need for employment opportunities, non-discriminatory provision of social support, treatment programs for substance misuse, and legal and social protection.ConclusionThis study contributes to understanding how women experiencing homelessness describe and articulate their living circumstances and what they perceive needs to be addressed. …”
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The neural correlates of guilt highlight preclinical manifestations between bipolar and major depressive disorders by Yu-Chi Lo, Chenyi Chen, Yawei Cheng

“…An additional test of the classification model, employing a combined mask of the three ROIs to distinguish between the two mood disorders in ambiguous scenarios, achieved an accuracy of 78.6 % and an AUC value of 0.84. …”
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A study protocol for individualized prognostic counselling in the palliative phase by Boyd Noël van den Besselaar, A. Sewnaik, M. C. Dorr, A. Hoesseini, J. A. Hardillo, R. J. Baatenburg de Jong, M.P.J. Offerman

“…Methods This study will employ both quantitative and qualitative approaches. …”
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Effects of biochar on the chemical properties of soils and the volume of wood in a plantation of Acacia mangium Willd in the Colombian Orinoquía (highlands) by Giovanni Reyes-Moreno, Aquiles Enrique Darghan, Carlos Rivera-Moreno

“…Method: We used a design including nine treatments and three repetitions of each treatment, employing two materials: biochar from Acacia mangium W. …”
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Interactive effect of phenylalanine with duration of diabetes on the risk of small vessel disease in Chinese patients with T2DM by Jun Zheng, Wei Zhang, Yu-Yang Miao, Xue-Rui Li, Wei-Ming Luo, Xi-Lin Yang, Zhong-Ze Fang, Qiang Zhang

“…Additive interaction analysis was employed to test the interaction of low phenylalanine with a long duration of T2DM for SVD.ResultsAmong the 1,032 T2DM patients, 286 (27.7%) had SVD. …”
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Exploring segmented assimilation theory in health education utilization and its influencing factors among internal migrants in China: insights from the 2017 China migrants dynamic... by Ting Xu, Ting Xu, Zeyu Wang, Tingting Wang, Jiahua Shi, Aiyong Zhu, Enhong Dong, Enhong Dong

“…Additionally, factors such as ethnicity, marital status, employment status, educational attainment, hukou type, health insurance type, time of access to healthcare, social integration, social participation, establishment of health records, and issues encountered in host and origin places significantly influenced HEU.DiscussionThis study highlights diverse assimilation patterns among Chinese internal migrants regarding HEU, consistent with the theory of segmented assimilation. …”
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Calpain 2 promotes Lenvatinib resistance and cancer stem cell traits via both proteolysis-dependent and independent approach in hepatocellular carcinoma by Xiaolu Ma, Kaixia Zhou, Tianqing Yan, Ling Hu, Suhong Xie, Hui Zheng, Ying Tong, Heng Zhang, Yanchun Wang, Zhiyun Gong, Cuncun Chen, Yanan Tian, Lin Guo, Renquan Lu

“…However, clinical response towards Lenvatinib was limited, emphasizing the importance of understanding the underlying mechanism of its resistance. Herein, we employed integrated bioinformatic analysis to identify calpain-2 (CAPN2) as a novel key regulator for Lenvatinib resistance in HCC, and its expression greatly increased in both Lenvatinib-resistant HCC cell lines and clinical samples. …”
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Analysis of the spatial pattern and causes of ecological environmental quality in Myanmar based on the RSEI model and the Geodetector-GCCM method by Shuangfu Shi, Shuangfu Shi, Shuangyun Peng, Shuangyun Peng, Zhiqiang Lin, Zhiqiang Lin, Bangmei Huang, Dongling Ma, Dongling Ma, Ziyi Zhu, Ziyi Zhu, Yilin Zhu, Yilin Zhu, Rui Zhang, Ting Li

“…This study took Myanmar as the research area, employing a Remote Sensing Ecological Index (RSEI) model and spatial autocorrelation analysis to quantitatively evaluate the spatial distribution characteristics of Myanmar’s EEQ in 2020 and reveal its spatial dependence. …”
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Impact of nurturing care educational videos focusing on children with nutritional problems aged 6-23 months on mothers' knowledge and child growth by Fitri Haryanti, Lely Lusmilasari, Sri Hartini, Ayyu Sandhi, Ika Parmawati, Akhmadi Akhmadi, Nisa Nur Hasanah, Fitriana Andarwati, Hani Risnawati, Alissa Nur Pratiwi, Ananda Sekar Kusumawati, Redyta Dwi Cahyani

“…Methods: A quasi-experimental design with non-equivalent and untreated control groups was employed. Seventy-three mothers and their children aged 6-23 months, facing nutritional challenges, were recruited through consecutive sampling. …”
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Therapeutic target genes and regulatory networks of gallic acid in cervical cancer by Zhixi You, Ye Lei, Yongkang Yang, Zhihui Zhou, Xu Chao, Keyi Ju, Songyi Wang, Yuanyuan Li, Yuanyuan Li

“…This analysis revealed that 221 biological processes, 82 cellular components, 63 molecular functions, and 36 KEGG pathways were employed to identify three therapeutic candidate genes, including CDC20, DLGAP5, and KIF20A. …”
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The Prevalence of Metabolic Syndrome and Hypertriglyceridemic Waist Based on Sociodemographic Variables and Healthy Habits in Healthcare Workers: A Retrospective Study by Pedro Javier Tárraga Marcos, Ángel Arturo López-González, Emilio Martínez-Almoyna Rifá, Hernán Paublini Oliveira, Cristina Martorell Sánchez, Pedro Juan Tárraga López, José Ignacio Ramírez-Manent

“…<b>Methodology</b>: This study employed a mixed-methods approach, consisting of a retrospective longitudinal study and a cross-sectional descriptive study, analyzing 44,939 healthcare workers with MS and HTW across four professional categories to evaluate the relationship between age, sex, smoking, physical activity, and adherence to the Mediterranean diet using three diagnostic criteria. …”
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Biomechanical Modeling and Evaluation of Buttocks Automatic Assisted Repositioning in Bedridden Patients by Liqing Yang, Ganjun Song, Di Luo, Haotian Xu, Jiamei Han, Mingzhao Xiao, Dingqun Bai, Shan Tian, Wensheng Hou, Jisi Tang, Xin Zhang, Lin Chen

“…Inverse modeling was used to reconstruct the 3D shape of the buttocks, nodal equivalence techniques were employed to simplify the mesh and accurately represent internal tissue contacts, and soft tissue parameters were optimized using Response Surface Methodology (RSM). …”
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Brain compensatory activation during Stroop task in patients with mild cognitive impairment: a functional near-infrared spectroscopy study by Chenyu Fan, Hanfei Li, Hanfei Li, Ke Chen, Ke Chen, Guohui Yang, Hongyu Xie, Haozheng Li, Yi Wu, Meng Li, Meng Li, Meng Li

“…PurposeThis study investigated the disparities in brain activation patterns during the Stroop task among individuals with mild cognitive impairment (MCI) and those without any cognitive impairments (healthy controls, HCs) using functional near-infrared spectroscopy (fNIRS).MethodsWe analyzed the cortical activation patterns of 73 patients with MCI and 63 HC individuals as they completed the Stroop task, employing fNIRS. The regions of interest (ROIs) included the dorsal prefrontal cortex (dPFC), ventrolateral prefrontal cortex (VLPFC), and parietal lobe (PL). …”
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Nomogram-derived immune-inflammation-nutrition score could act as a novel prognostic indicator for patients with head and neck squamous cell carcinoma by Wen-Yan Wang, Yue Chen, Qian Chen, Hong-Wei Sun, Nuo-Xuan Niu, Hong-Hui Li, Yu-Dan Cao, Yan-Xia Bai, Xiang Li, Xiang Li

“…A LASSO Cox regression model was employed to identify significant biomarkers for constructing a SIIN nomogram and to create SIIN score from this nomogram. …”
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MultiTax-human: an extensive and high-resolution human-related full-length 16S rRNA reference database and taxonomy by Zhiwei Bao, Bin Zhang, Jianhua Yao, Ming D. Li

“…By integrating data from multiple sources and employing advanced classification techniques, this database offers an accurate and detailed map of the human microbiome. …”
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Study on exhaled volatile organic compounds identifying cognitive fatigue induced by N-back task in healthy young adults by Xiaoyu Zhang, Xiaoyan Dong, Qiang Huang, Zhe Liu, Qin Wang

“…The Chalder Fatigue Scale was employed to assess the cognitive fatigue of the subjects before and after the induction and film watching. …”
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