Linking evidence for targeted blood biomarkers in post-stroke cognitive impairment and dementia by Jinny Hong, Katherine Mun, Katherine Mun, Kyle C. Kern, Kyle C. Kern, Marissa Thirion, Jason D. Hinman, Jason D. Hinman

“…This review highlights the emerging role for blood biomarkers in evaluating risk for PSCID while also informing the underlying biology that creates synergy between stroke and dementia.…”
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Urethra-sparing prostate cancer radiotherapy: Current practices and future insights from an international survey by Jennifer Le Guévelou, Paul Sargos, Piet Ost, Filippo Alongi, Stefano Arcangeli, Alejandro Berlin, Pierre Blanchard, Anna Bruynzeel, Olivier Chapet, Alan Dal Pra, Robert T. Dess, Matthias Guckenberger, Andrew Loblaw, Amar U. Kishan, Barbara Alicja Jereczek-Fossa, David Pasquier, Mohamed Shelan, Shankar Siva, Alison C. Tree, Costantinos Zamboglou, Stephane Supiot, Vedang Murthy, Thomas Zilli

“…Urethra-sparing techniques have emerged as a promising approach to reduce urinary toxicity. …”
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Hybrid Nanocomposite Mini-Tablet to Be Applied into the Post-Extraction Socket: Matching the Potentialities of Resveratrol-Loaded Lipid Nanoparticles and Hydroxyapatite to Promote... by Viviana De Caro, Giada Tranchida, Cecilia La Mantia, Bartolomeo Megna, Giuseppe Angellotti, Giulia Di Prima

“…<b>Results</b>: PEG-based nanocomposites emerged as optimal and, following HXA insertion, the resulting powders revealed adequate bulk properties, making them useful as a pharmaceutical intermediate to produce ≈59 mm³ mini-tablets, compliant with the post-extraction socket. …”
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Liver metastases of colorectal cancer contain different subsets of tissue-resident memory CD8 T cells correlated with a distinct risk of relapse following surgery by Syrine Abdeljaoued, Alexandre Doussot, Marie Kroemer, Emilien Laloy, Jean René Pallandre, Antoine El Kaddissi, Laurie Spehner, Myriam Ben Khelil, Adeline Bouard, Virginie Mougey, Ugo Chartral, Angélique Vienot, Julien Viot, Zaher Lakkis, Franck Monnien, Romain Loyon, Christophe Borg

“…Tissue-resident memory (TRM) T cells have emerged as key players in cancer immunosurveillance, and their presence has been linked to a favorable clinical outcome in solid cancer patients. …”
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Accelerated symptom improvement in Parkinson’s disease via remote internet-based optimization of deep brain stimulation therapy: a randomized controlled multicenter trial by Alireza Gharabaghi, Sergiu Groppa, Marta Navas-Garcia, Alfons Schnitzler, Laura Muñoz-Delgado, Vicky L. Marshall, Jessica Karl, Lin Zhang, Ramiro Alvarez, Mary S. Feldman, Michael J. Soileau, Lan Luo, S. Elizabeth Zauber, Benjamin L. Walter, Chengyuan Wu, Hong Lei, Damian M. Herz, Ming-Hua Chung, Yagna Pathak, Bram Blomme, Binith Cheeran, Corneliu Luca, Daniel Weiss

“…Abstract Background Deep brain stimulation (DBS) has emerged as an important therapeutic intervention for neurological and neuropsychiatric disorders. …”
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Men’s Attitudes Towards Participation in Organised Prostate Cancer Testing: An Abductive Thematic Analysis by Markus Arvendell, Lottie Phillips, Sara Delilovic, Moa Backman Enelius, Karin Olsson, Anetta Bolejko, Olof Akre, Sigrid Carlsson, Anne Richter, Anna Lantz

“…We employed an abductive thematic analysis, a reflexive process of identifying theoretical explanations of emerging patterns, to identify themes in men’s responses. …”
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Projecting Water Yield Amidst Rapid Urbanization: A Case Study of the Taihu Lake Basin by Rui Zhou, Yanan Zhou, Weiwei Zhu, Li Feng, Lumeng Liu

“…Spatially, an uneven distribution pattern of WY depth emerged, with mountainous and hilly regions exhibiting higher WY compared to plain areas. …”
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Skatole Alleviates Osteoarthritis by Reprogramming Macrophage Polarization and Protecting Chondrocytes by Weiyun Wang, Yaru Chu, Yunkun Lu, Jie Xu, Weixuan Zhao, Zhuo Liang, Xueqiang Guo, Lingling Xi, Tao Han, Yaping Shen, Wenjuan Song, Yanhua Tang, Mengnan Wen, Zhuang Qian, Lei Wang, Zhenlin Fan, Guangdong Zhou, Wenjie Ren

“…Targeting macrophage polarization has emerged as a promising avenue for OA treatment. This study identified skatole through high-throughput screening as an efficient modulator of macrophage polarization. …”
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Hepatotoxicity of statins: a real-world study based on the US Food and Drug Administration Adverse Event Reporting System database by Bojing Wang, Shu Huang, Shu Huang, Shiqi Li, Yaqi Deng, Ziyan Li, Yizhou Wang, Xiaomin Shi, Wei Zhang, Lei Shi, Xiaohong Wang, Xiaowei Tang

“…However, with their widespread use in clinical practice, some adverse events have gradually emerged. In particular, the hepatotoxicity associated with statins use has become one of the clinical concerns that require sufficient attention.MethodsIn this study, we conducted a comprehensive and detailed analysis of the hepatotoxicity of statins based on the data of the US Food and Drug Administration Adverse Event Reporting System database from the first quarter (Q1) of 2004 to the Q1 of 2024 and used Reporting Odds Ratios and Empirical Bayes Geometric Mean to mine the signal of adverse events.ResultsIn this study, hepatic disorder related seven statins all exhibited positive signals. …”
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Remote-sensing-based forest canopy height mapping: some models are useful, but might they provide us with even more insights when combined? by N. Besic, N. Picard, C. Vega, J.-D. Bontemps, L. Hertzog, J.-P. Renaud, J.-P. Renaud, F. Fogel, M. Schwartz, A. Pellissier-Tanon, G. Destouet, F. Mortier, F. Mortier, M. Planells-Rodriguez, P. Ciais

“…Moreover, we observed that the forest stand vertical structure, the dominant tree species, and the type of forest ownership systematically emerge as statistically significant factors influencing the model divergences. …”
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Intravenous liposomal irinotecan in metastatic triple-negative breast cancer after ≥ 2 prior lines of chemotherapy: a phase Ib study by Ying Fan, Qingyuan Zhang, Min Yan, Xiujuan Qu, Yongmei Yin, Tao Sun, Jin Yang, Ying Wang, Xu Wang, Zhaofeng Niu, Xinshuai Wang, Sanyuan Sun, Weihong Zhao, Yanping Liu, Miao Niu, Xuemin Zhao, Binghe Xu

“…The primary endpoints were maximum tolerated dose (MTD) and recommended phase 2 dose (RP2D), and treatment emergent adverse events (TEAEs). The secondary endpoints were pharmacokinetic profiles and efficacy including objective response rate (ORR) and disease control rate (DCR) (all patients) and Central Nervous System ORR and clinical benefit rate (CBR, for patients with HER2-negative BCBM), duration of response, progression free survival (PFS), overall survival (OS). …”
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Opioid consumption frequency and its associations with potential life problems during opioid agonist treatment in individuals with prescription-type opioid use disorder: explorator... by Anne Bouthillier, Gabriel Bastien, Christina McAnulty, Hamzah Bakouni, Bernard Le Foll, M. Eugenia Socias, Didier Jutras-Aswad

“…The interaction was non-significant for employment (p = 0.264), family status (p = 0.352) and legal status (p = 0.050). Life improvements emerged with ≤ 21 days of opioid use per 28-day period. …”
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Distribution of air quality health benefits of medium and heavy-duty electrification policies in New York City by Brian Naess, Jonathan Buonocore, Veronica Southerland, Muskaan Khemani, Catherine Seppanen, Ananya Roy, Frederica Perera, Kaitlyn E Coomes, Rick Rykowski, Saravanan Arunachalam

“…We find that electrification of MHDVs would have substantial air pollution and health benefits for NYC, with full on-road electrification of MHDVs saving $2.4 billion in health costs in 2040, including the prevention of 248 deaths and 173 childhood asthma emergency departments visits. We find that NO _2 benefits contributed between 85% and 97% of the total health benefits, emphasizing its importance for on-road health studies. …”
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Polycaprolactone for Hard Tissue Regeneration: Scaffold Design and In Vivo Implications by Fernanda Ramírez-Ruiz, Israel Núñez-Tapia, María Cristina Piña-Barba, Marco Antonio Alvarez-Pérez, Vincenzo Guarino, Janeth Serrano-Bello

“…In the last thirty years, tissue engineering (TI) has emerged as an alternative method to regenerate tissues and organs and restore their function by implanting specific lineage cells, growth factors, or biomolecules functionalizing a matrix scaffold. …”
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Advances in Cell and Immune Therapies for Melanoma by Tanase Timis, Sanda Buruiana, Delia Dima, Madalina Nistor, Ximena Maria Muresan, Diana Cenariu, Adrian-Bogdan Tigu, Ciprian Tomuleasa

“…Current clinical trials are exploring various combinations of immune checkpoint inhibitors with costimulatory receptor agonists, chemotherapy, targeted therapies, and other immunotherapies, with the goal of improving outcomes and reducing side effects for melanoma patients. Emerging approaches, including adoptive cell therapy with tumor-infiltrating lymphocytes (TILs) and oncolytic virotherapy, are showing promise. …”
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Role of cash transfers in mitigating food insecurity in India during the COVID-19 pandemic: a longitudinal study in the Bihar state by Tinku Thomas, Anura V Kurpad, Sumathi Swaminathan, Patrick Webb, Sanchit Makkar, Jawahar Ramasamy Manivannan, Sandra M Travasso, Anjaly Teresa John

“…India is no exception, with insights into the impacts of lockdown on food insecurity now emerging. We contribute to the empirical evidence on the prevalence of food insecurity in Bihar state before and after lockdown, and whether the government’s policy of cash transfer moderated negative effects of food insecurity or not.Design This was a longitudinal study.Settings The study was conducted in Gaya and Nalanda district of Bihar state in India from December 2019 to September 2020.Participants A total of 1797 households were surveyed in survey 1, and about 52% (n=939) were followed up in survey 2. …”
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A Propulsion Neuroprosthesis Improves Overground Walking in Community-Dwelling Individuals After Stroke by Dabin K. Choe, Ashlyn J. Aiello, Johanna E. Spangler, Conor J. Walsh, Louis N. Awad

“…Plantarflexor neurostimulation has recently emerged to assist and retrain gait propulsion; however, safe and effective coordination of dorsiflexor and plantarflexor neurostimulation during overground walking has been elusive, restricting propulsion neuroprostheses to harnessed treadmill walking. …”
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Risk Factor Analysis of Ski and Snowboard Injuries During the 2023/2024 Winter Season: A Single, High-Volume Trauma Center Database Analysis by Michele Paolo Festini Capello, Pieralberto Valpiana, Giuseppe Aloisi, Giovanni Cristofolini, Svea Caren Misselwitz, Giuseppe Petralia, Mario Muselli, Salvatore Gioitta Iachino, Christian Schaller, Pier Francesco Indelli

“…<i>Materials and Methods:</i> A questionnaire containing 22 items was distributed to all adult patients admitted to the emergency department of the Brixen Hospital (Italy) during the 2023/24 winter season because of a ski/snowboard-related injury. …”
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Deriving and validating a risk prediction model for long COVID-19: protocol for an observational cohort study using linked Scottish data by Jennifer K Quint, Aziz Sheikh, Chris Robertson, Srinivasa Vittal Katikireddi, Emily Moore, Colin R Simpson, Luke Daines, Eleftheria Vasileiou, Syed Ahmar Shah, Rachel H Mulholland, Vicky Hammersley, Steven Kerr, Ting Shi, David Weatherill, Elisa Pesenti

“…We will identify potential indicators for long-COVID by identifying patterns in primary care data linked to information from out-of-hours general practitioner encounters, accident and emergency visits, hospital admissions, outpatient visits, medication prescribing/dispensing and mortality. …”
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Factors influencing choice of residency program among medical intern doctors and medical students: a cross-sectional survey by Ali Al Ajmi, Masoud Kashoub, Ibrahim S. Al-Busaidi, Mohammed Al Rashdi, Moza AlHussaini, Arwa Alsaidi, Mohammed Al Rawahi, Abdullah M. Al Alawi

“…Conclusion Internal medicine emerged as a popular specialty among Omani medical students and interns, driven by intellectual stimulation, job security, and work-life balance. …”
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