Dispensing antiretrovirals during Covid-19 lockdown: re-discovering community-based ART delivery models in Uganda by Henry, Zakumumpa, Christopher, Tumwine, Kiconco, Milliam, Spicer, Neil

“…Results: Five broad strategies for distributing antiretrovirals during ‘lockdown’ emerged in our analysis: accelerating home-based delivery of antiretrovirals,; extending multi-month dispensing from three to six months for stable patients; leveraging the Community Drug Distribution Points (CDDPs) model for ART refill pick-ups at outreach sites in the community; increasing reliance on health information systems, including geospatial technologies, to support ART refill distribution in unmapped rural settings. …”
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Advances in CAR T cell therapy: antigen selection, modifications, and current trials for solid tumors by Safwaan H. Khan, Safwaan H. Khan, Yeonjoo Choi, Mysore Veena, Mysore Veena, John K. Lee, John K. Lee, Daniel Sanghoon Shin, Daniel Sanghoon Shin

“…Finally, we address critical therapeutic limitations, including cytokine release syndrome (CRS), immune effector cell-associated neurotoxicity syndrome (ICANS), and suboptimal persistence of CAR T cells. An examination of emerging strategies for countering these limitations reveals that CRISPR-Cas9-mediated genetic modifications and combination therapies utilizing checkpoint inhibitors can improve CAR T cell functionality and durability. …”
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Risk of hereditary spherocytosis misdiagnosis due to limited effective diagnostic methods by Hien Thanh Dao, Triet Hy Van, Tuyet Thi Bach Tran, Dat Quoc Ngo, Anh Thi Mai Nguyen

“…The Eosin-5'-maleimide binding assay has emerged as a reliable diagnostic method. Objective: Evaluate the effectiveness of Eosin-5'-maleimide binding assay in diagnosing hereditary spherocytosis in pediatrics with negative-direct-antiglobulin-test-hemolytic anemia. …”
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Response strategies to maintain emotional resonant brand reputations when targeted by user-generated brand parodies by Maritha Pritchard, De la Rey Van der Waldt, David Pieter Conradie

“… Mostly satirising top-of-mind brands, user-generated parody accounts are a phenomenon mostly associated with Twitter. As an emerging trend in South Africa, parody accounts using cleverlywritten satire attract a large and loyal following as social media communities enjoy the shared pleasure of sharing funny content and the intense positive emotions felt when making fun of brands that they care about. …”
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The Role of Gut Microbiota in Hypertension Management - A Review by Alicja Kot, Marta Wojtczak, Natalia Myśliwiec, Adrian Różycki, Michał Pniak, Paweł Miklis, Maciej Mawlichanów, Aleksandra Ciesielska, Aleksandra Sieradzka, Krzysztof Szerej

“…According to the World Health Organization (WHO), hypertension affects approximately 1.13 billion people worldwide, contributing significantly to global morbidity and mortality. Emerging research has revealed a significant connection between gut microbiota—the diverse community of microorganisms residing in the gastrointestinal tract—and the regulation of blood pressure. …”
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Sex Differences in Lung Cancer Characteristics at Diagnosis: A Nationwide Register‐Based Study From the Faroe Islands (2015–2020) by Annika H. Lindenskov, Halla Potts, Marnar F. Kristiansen, Maria S. Petersen, Marin Strøm

“…Gender‐specific patterns also emerged: women hadlonger symptomatic periods, while men experienced longer diagnostic and treatment times, though with overlapping confidence intervals. …”
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Dynamics of the relationship between stock markets and exchange rates during quantitative easing and tightening by Farzaneh Ahmadian-Yazdi, Amin Sokhanvar, Soheil Roudari, Aviral Kumar Tiwari

“…The Toronto Stock Exchange (TSX) emerges as the principal net driver among the markets under study. …”
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Blockchain Applications in the Military Domain: A Systematic Review by Nikos Kostopoulos, Yannis C. Stamatiou, Constantinos Halkiopoulos, Hera Antonopoulou

“…The most researched aspects are its integration with emerging technologies, such as artificial intelligence, the IoT, application in uncrewed aerial vehicles, and secure communications. …”
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Social vulnerability index associated with higher COVID-19 seroprevalence in Nigeria by Natalia Blanco, Olanrewaju Lawal, Jibreel Jumare, Christina Riley, James Onyemata, Thomas Kono, Anna Winters, Chenfeng Xiong, Alash’le Abimiku, Manhattan Charurat, Kristen A. Stafford, for The INFORM Africa Research Study Group

“…In conclusion, SVI can potentially be a useful tool to effectively prioritize communities for resource allocation as part of emergency response and preparedness in Africa.…”
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Vector‐Free Deep Tissue Targeting of DNA/RNA Therapeutics via Single Capacitive Discharge Conductivity‐Clamped Gene Electrotransfer by Jeremy L. Pinyon, Georg vonJonquieres, Stephen L. Mow, Amr Al Abed, Keng‐Yin Lai, Mathumathi Manoharan, Edward N. Crawford, Stanley H. Xue, Sarah Smith‐Moore, Lisa J. Caproni, Sarah Milsom, Matthias Klugmann, Nigel H. Lovell, Gary D. Housley

“…Abstract Viral vector and lipid nanoparticle based gene delivery have limitations around spatiotemporal control, transgene packaging size, and vector immune reactivity, compromising translation of nucleic acid (NA) therapeutics. In the emerging field of DNA and particularly RNA‐based gene therapies, vector‐free delivery platforms are identified as a key unmet need. …”
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Tackling the primary healthcare workforce crisis: time to talk about health systems and governance—a comparative assessment of nine countries in the WHO European region by Ellen Kuhlmann, Michelle Falkenbach, Monica Georgina Brînzac, Tiago Correia, Maria Panagioti, Bernd Rechel, Anna Sagan, Milena Santric-Milicevic, Marius-Ionuț Ungureanu, Iris Wallenburg, Viola Burau

“…Abstract Background Primary healthcare has emerged as a powerful global concept, but little attention has been directed towards the pivotal role of the healthcare workforce and the diverse institutional setting in which they work. …”
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Protective Effect of Laminaria japonica with Probiotics on Murine Colitis by Seok-Jae Ko, Youngmin Bu, Jinhyun Bae, Yu-mi Bang, Jinsung Kim, Hyejung Lee, Lee Beom-Joon, Yoo Hye Hyun, Jae-Woo Park

“…Most IBD treatments are unsatisfactory; therefore, various dietary supplements have emerged as promising interventions. Laminaria japonica (LJ) is an edible seaweed used to regulate digestive symptoms. …”
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Association of Body Mass Index trajectory with thyroid nodules during young adulthood in China by Hang Yan, Su Yan, Jingfeng Chen, Yang Yang, Suying Ding, Qian Qin

“…Moreover, controlling BMI growth rate in early adulthood (27–47 years old) emerged as a critical age window for reducing TN prevalence, underscoring its importance in TN prevention strategies.…”
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Population Structure Based on Microsatellite Length Polymorphism, Antifungal Susceptibility Profile, and Enzymatic Activity of <i>Candida auris</i> Clinical Isolates in Russia by Ellina Oganesyan, Victoria Klimenteva, Irina Vybornova, Valentina Venchakova, Ekaterina Parshikova, Sergey Kovyrshin, Olga Orlova, Alexander Kruglov, Svetlana Gordeeva, Natalya Vasilyeva, Anastasiya Taraskina

“…<i>Candida auris</i> is an emerging multidrug-resistant fungal pathogen causing nosocomial transmission and invasive infections with high mortality. …”
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SHASI-ML: a machine learning-based approach for immunogenicity prediction in Salmonella vaccine development by Ottavia Spiga, Ottavia Spiga, Ottavia Spiga, Anna Visibelli, Francesco Pettini, Bianca Roncaglia, Annalisa Santucci, Annalisa Santucci, Annalisa Santucci

“…When applied to the Salmonella enterica serovar Typhimurium proteome, the model identified 292 novel immunogenic protein candidates. Global properties emerged as the most influential feature group in prediction accuracy, followed by structural and sequence information. …”
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Unveiling the molecular mechanisms of recurrent miscarriage through endoplasmic reticulum stress related gene expression by Xiaodan Yin, Wei Yang, Mingwei Xin, Qian Han, Siqi Guan, Junqin He

“…The underlying molecular mechanisms remain elusive, even though emerging evidence has implicated endoplasmic reticulum stress (ERS). …”
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Legislative framework of career guidance and counselling in Serbia by Miljković Jovan, Čairović-Pavlović Neda, Robertson Kristina

“…Within this context, career guidance and counselling (CGC) has emerged as a leading concept in various sector polities, both in the European Union and in Serbia, and is undoubtedly at the forefront of educational polities. …”
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Forecasting Dissolved Organic Carbon Levels Utilizing Metaheuristic Optimization with Artificial Intelligence Techniques by Peng He, Chengjun Ma

“…Upon comprehensive review, the SVR-SSA hybrid model emerged as the most promising, exhibiting an R2 value of 0.997293, a Root Mean Square Error (RMSE) of 0.2906, and a Normalized Mean Square Error (NMSE) of 5×10-4 at the thousandth iteration in the train dataset. …”
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Knowledge of Mpox, Media Exposure, and Clinical Experience: by Aime Fidele Ndayiragije Mvuyekure, Simon Pierre Ndayishimye Mvuyekure, Daniel Muhayimana, Jean Claude Tuyishime, Anifa Munderere

“…Based on these findings, it is recommended to integrate media literacy, structured clinical training, and disaster preparedness workshops into nursing education curricula to strengthen students’ capacity to respond to public health emergencies effectively.…”
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Soil organic matter composition affects ecosystem multifunctionality by mediating the composition of microbial communities in long-term restored meadows by Wenyin Wang, Sisi Bi, Fei Li, A. Allan Degen, Shanshan Li, Mei Huang, Binyu Luo, Tao Zhang, Shuai Qi, Tianyun Qi, Yanfu Bai, Peipei Liu, Zhanhuan Shang

“…We leveraged high-throughput sequencing, liquid chromatography and mass spectrometry to characterize soil microbial communities and soil organic matter composition, measured microbial carbon metabolism and determined EMF. Results It emerged that the similarity of soil microorganisms in meadows decreased with increasing heterogeneity of soil properties. …”
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