Decoding gene expression dynamics in planktonic and biofilm cells of Streptococcus mutans: regulation and role of mutanofactin genes in biofilm formation by Muhammad Afzal, Miguel Carda-Diéguez, Susanne Bloch, Susanne Bloch, Leon G. S. Thies, Alex Mira, Christina Schäffer

“…Mutanofactins, a class of polyketide/non-ribosomal lipopeptide secondary metabolites, are emerging as potential modulators of S. mutans biofilm development.MethodsTranscriptomic analysis was conducted to examine gene expression patterns in S. mutans NMT4863 across distinct growth phases and lifestyles, aiming to identify metabolic factors influencing biofilm formation. …”
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Going, going, gone: Landscape drying reduces wetland function across the American West by J. Patrick Donnelly, Johnnie N. Moore, John S. Kimball, Kelsey Jencso, Mark Petrie, David E. Naugle

“…Water scarcity, in particular, is emerging as a new and powerful threat, forcing wetland ecosystems into altered functional states as the frequency and duration of their inundation diminish. …”
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A murine model of acute and prolonged abdominal sepsis, supported by intensive care, reveals time-dependent metabolic alterations in the heart by Bart Jacobs, Inge Derese, Sarah Derde, Sarah Vander Perre, Lies Pauwels, Greet Van den Berghe, Jan Gunst, Lies Langouche

“…Although SICM is considered reversible, emerging evidence suggests potential long-term sequelae. …”
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Sex and APOE genotype modulate neuropsychological profile and depression in temporal lobe epilepsy by Francesco Bruno, Francesco Bruno, Patrizia Spadafora, Ida Veltri, Mario L. Cuconati, Francesca Condino, Annamaria Cerantonio, Selene De Benedittis, Beatrice M. Greco, Beatrice M. Greco, Gemma Di Palma, Olivier Gallo, Luigi Citrigno, Antonio Qualtieri, Maurizio Cundari, Maurizio Cundari, Maurizio Cundari, Francesca Cavalcanti

“…For depression, only an effect of sex emerged. Females scored higher besides APOE genotype.ConclusionsThese findings underscore the importance of considering both sex and APOE genotype when assessing cognitive performance in patients with temporal lobe epilepsy. …”
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Question–Answer Methodology for Vulnerable Source Code Review via Prototype-Based Model-Agnostic Meta-Learning by Pablo Corona-Fraga, Aldo Hernandez-Suarez, Gabriel Sanchez-Perez, Linda Karina Toscano-Medina, Hector Perez-Meana, Jose Portillo-Portillo, Jesus Olivares-Mercado, Luis Javier García Villalba

“…The model outputs are interpretable, promoting greater transparency in code review processes and enabling efficient resolution of emerging vulnerabilities. Proto-MAML demonstrates strong performance across multiple programming languages, achieving an average precision of <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><mn>98.49</mn><mo>%</mo></mrow></semantics></math></inline-formula>, recall of <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><mn>98.54</mn><mo>%</mo></mrow></semantics></math></inline-formula>, F1-score of <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><mn>98.78</mn><mo>%</mo></mrow></semantics></math></inline-formula>, and exact match rate of <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><mn>98.78</mn><mo>%</mo></mrow></semantics></math></inline-formula> in PHP, Java, C, and C++.…”
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Advancements in Hyaluronic Acid Effect in Alveolar Ridge Preservation: A Narrative Review by Paul Andrei Nistor, Andreea Cândea, Iulia Cristina Micu, Andrada Soancă, Carmen Silvia Caloian, Alina Bârdea, Alexandra Roman

“…Hyaluronic acid (HYA) has emerged as a promising biological agent for ARP due to its osteoinductive, antimicrobial, and anti-inflammatory properties. …”
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Attention speed and anterior cingulate cortex volume in female and male veterans with suicide ideation and attempts by Erin C. McGlade, Erin C. McGlade, Erin C. McGlade, James R. Yancey, James R. Yancey, James R. Yancey, Keenan E. Roberts, Keenan E. Roberts, Keenan E. Roberts, Audrey Elias, Audrey Elias, Chelsea Carson, Chelsea Carson, Chelsea Carson, Jiyoung Ma, Jiyoung Ma, Margaret R. Legarreta, Margaret R. Legarreta, Deborah A. Yurgelun-Todd, Deborah A. Yurgelun-Todd, Deborah A. Yurgelun-Todd

“…Attentional processes have emerged as a possible predictor of suicide behaviors (SB), yet associated neural correlates remain understudied, particularly in the Veteran population.MethodsThe current study examines sustained and selective attention performance as indexed by the Ruff 2 &amp; 7 Selective Attention Test and anterior cingulate cortex (ACC) volume as they relate to SB in Veterans. …”
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Identification and validation of a prognostic signature of drug resistance and mitochondrial energy metabolism-related differentially expressed genes for breast cancer by Tiankai Xu, Chu Chu, Shuyu Xue, Tongchao Jiang, Ying Wang, Wen Xia, Huanxin Lin

“…Hence, drug resistance and mitochondrial energy metabolism-related differentially expressed genes (DMRDEGs) may emerge as candidates for novel cancer biomarkers. …”
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Therapeutic potential of Curcuma longa against monkeypox: antioxidant, anti-inflammatory, and computational insights by Farouk Boudou, Amal Belakredar, Ahcen Keziz, Linda Aissani, Huda Alsaeedi, David Cronu, Mikhael Bechelany, Mikhael Bechelany, Ahmed Barhoum

“…BackgroundMonkeypox (Mpox) is a re-emerging zoonotic disease with limited therapeutic options, necessitating the exploration of novel antiviral agents. …”
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Adjuvant-free, self−assembling ferritin nanoparticle vaccine coupled with influenza virus hemagglutinin protein carrying M1 and PADRE epitopes elicits cross-protective immune respo... by Yongqiang Zhao, Shuangshuang Guo, Jia Liu, Yating Wang, Bo Wang, Chun Peng, Enqi Du, Enqi Du, Enqi Du

“…Importantly, intranasal immunization with HMP-NPs, without any adjuvant, induced efficient mucosal IgA responses and conferred complete protection against the H3N2 virus, as well as partial protection against the H1N1 and H9N2 viruses and significantly reduced lung viral loads.DiscussionOverall, our results indicated that the self-assembled nanovaccines increased the potency and breadth of the immune response against various influenza viruses and are a promising delivery platform for developing vaccines with broader protection against emerging influenza viruses and other pathogens.…”
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“I believe it when there is an expert next to me:” a qualitative analysis on the perceptions and experiences of pregnant women to self-monitor blood pressure in Lombok, Indonesia... by Tigest Tamrat, Yuni Dwi Setiyawati, Maria Barreix, Nya’Jeumpa Madani, Antoine Geissbühler, Anuraj H. Shankar, Ozge Tuncalp

“…Results We enrolled a total of 71 pregnant women, across 11 FGDs and conducted 15 IDIs with participants who used the smartphone for SMBP. Themes emerged related to (i) understanding of and experiences related to BP; (ii) facilitators and motivations for SMBP; (iii) barriers and concerns with SMBP; and (iv) experiences of using a smartphone-based BP application. …”
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Depot-specific acetylation profiles of adipose tissues—therapeutic targets for metabolically unhealthy obesity by Haoyue Guo, Zhiyi Zhang, Juntao Yang, Jiangfeng Liu, Hongwei Lin, Ningbei Yin

“…The regulation of acetylated modifications in white adipose tissue (WAT), particularly for the differential Kac sites enriched in ECM remodeling and inflammation-related pathways, may serve as an effective intervention strategy for MUO, with NDST1 emerging as a promising therapeutic target. Trial registration Not applicable since this study did not involve clinical intervention.…”
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Prevalence and Molecular Characterization of Carbapenemase-Producing Multidrug-Resistant Bacteria in Diabetic Foot Ulcer Infections by Mohd Saleem, Soha Abdallah Moursi, Tahani Nasser Almofeed Altamimi, Mohammed Salem Alharbi, Alwaleed Mohammad Alaskar, Sahar Adly Hassan Hammam, Ehab Rakha, Ozair Ilyas Syed Muhammad, Hamoud Abdulmohsin Almalaq, Metab Nasser Alshammari, Azharuddin Sajid Syed Khaja

“…Among these pathogens, carbapenemase-producing pathogens have emerged as particularly concerning owing to their resistance to β-lactam antibiotics, including carbapenems. …”
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High-resolution 4D electrical resistivity tomography and below-ground point sensor monitoring of High Arctic deglaciated sediments capture zero-curtain effects, freeze–thaw transit... by M. O. Cimpoiasu, O. Kuras, H. Harrison, P. B. Wilkinson, P. Meldrum, J. E. Chambers, D. Liljestrand, C. Oroza, S. K. Schmidt, P. Sommers, L. Vimercati, T. P. Irons, Z. Lyu, A. Solon, J. A. Bradley, J. A. Bradley

“…Novel insights into soil moisture dynamics throughout the spring melt will help parameterize models of biological activity to build a more predictive understanding of newly emerging terrestrial landscapes and their impact on carbon and nutrient cycling.…”
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Crown structure indicates tree secondary growth, competition legacy, and growth potential of dominant species in Europe by Shamim Ahmed, Torben Hilmers, Enno Uhl, Frederico Tupinambá-Simões, Felipe Bravo, Miren del Río, Hans Pretzsch

“…However, stronger relationships emerged when considering the entire tree ring series, suggesting a long-term morphological legacy effect of crown structure.These results show the importance of understanding how specific traits related to different tree species and their functional roles impact tree structure and growth. …”
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Carbon cycle and climate feedbacks under CO₂ and non-CO₂ overshoot pathways by I. Melnikova, I. Melnikova, P. Ciais, K. Tanaka, K. Tanaka, H. Shiogama, K. Tachiiri, K. Tachiiri, T. Yokohata, O. Boucher

“…Next, we carry out a series of idealised ramp-up and ramp-down concentration-driven experiments and show that, while the impacts of increasing and decreasing <span class="inline-formula">CO₂</span> and non-<span class="inline-formula">CO₂</span> gases on the surface climate are nearly equivalent (when their radiative forcing magnitudes are set to be the same), regional differences emerge. We further explore the carbon cycle feedbacks and demonstrate that they differ under <span class="inline-formula">CO₂</span> and non-<span class="inline-formula">CO₂</span> forcing. …”
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Design and validation of a-SiC/SiN hybrid photonic platform for integrated quantum photonics by Naresh Sharma, Zizheng Li, Bruno Lopez-Rodriguez, Joey Vrugt, Stijn van der Waal, Luozhen Li, Roald van der Kolk, Philip J Poole, Dan Dalacu, Iman Esmaeil Zadeh

“…Amorphous silicon carbide (a-SiC) has emerged as an alternative with a high refractive index (higher than SiN), an extended transparency window compared to Silicon, and a thermo-optic coefficient three times higher than that of SiN, which is crucial for tuning photonic devices on a chip. …”
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Harmful newborn cord care practices and associated factors among mothers who gave birth in the last six months in Chencha town, Southern Ethiopia: a mixed-methods study by Misgana Seifu, Sultan Hassen, Mekdim Kassa, Yosef Haile, Zeleke Girma, Temesgen Mohammed Toma, Agune Ashole, Mintesinot Melka Gujo, Wondimagegn Taye Dema, Aleme Mekuriya, Endashaw Shibru

“…In the qualitative analysis, four themes emerged such as substance applied (butter, Vaseline, and ointment). …”
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Adaptive responses of large-seeded lentils across diverse Indian climates by Ashok Kumar Parihar, Kali Krishna Hazra, Amrit Lamichaney, Debjyoti Sen Gupta, Jitendra Kumar, Anil Kumar Singh, Sankar Prasad Das, Muniyandi Samuel Jeberson, Parvez Ahmad Sofi, Ajaz Ahmad Lone, Jai Dev, Ashok Kumar, Ravindra Kumar Panwar, Sarvjeet Singh, Harsh Kumar Dikshit, Murlidhar Aski, Bimal Singh Jamwal, Ved Prakash, Sumer Singh Punia, Khajan Singh, Sunil Kumar Nair, Mangala Parikh, Smita Tiwari, Ashok Kumar Saxena, Sudhakar Prasad Mishra, Kamaluddin, Hitesh Kumar, Umesh Kumar, Deepak Singh, Sanjeev Gupta, Shailesh Tripathi, Girish Prasad Dixit

“…The GGE biplot ''Which Won Where'' analysis identified two distinct mega-environments, with Durgapura (NWPZ), Sagar (CZ), Pantnagar (NWPZ), and Gurdaspur (NWPZ) emerged as ‘ideal’ testing sites with high representativeness and discriminatory scaling. …”
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Enhanced therapeutic effects of hypoxia-preconditioned mesenchymal stromal cell-derived extracellular vesicles in renal ischemic injury by Fei Yuan, Jie Liu, Liang Zhong, Pengtao Liu, Ting Li, Kexin Yang, Wei Gao, Guangyuan Zhang, Jie Sun, Xiangyu Zou

“…Abstract Background Extracellular vesicles (EVs) secreted by mesenchymal stromal cells (MSCs) have been shown to provide significant protection against renal ischemia–reperfusion injury (IRI). Hypoxia has emerged as a promising strategy to enhance the tissue repair capabilities of MSCs. …”
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