A relay race of ESCRT-III paralogs drives cell division in a hyperthermophilic archaeon by Junfeng Liu, Mickaël Lelek, Yunfeng Yang, Audrey Salles, Christophe Zimmer, Yulong Shen, Mart Krupovic

“…We propose the “relay race” model, whereby the cytokinesis is achieved through a sequential and concerted action of different ESCRT machinery components.IMPORTANCETwo major cytokinesis mechanisms, rooted in contractile FtsZ and endosomal sorting complexes required for transport (ESCRT) rings, respectively, have emerged in the course of evolution. Whereas bacteria rely on the FtsZ-based mechanism, different lineages of archaea use either of the two systems, and eukaryotes have inherited the ESCRT-based cell division machinery from their archaeal ancestors. …”
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Multiparametric cardiovascular magnetic resonance is associated with outcomes in pediatric heart transplant recipients by Andrew A. Lawson, Kae Watanabe, Lindsay Griffin, Christina Laternser, Michael Markl, Cynthia K. Rigsby, Joshua D. Robinson, Nazia Husain

“…ABSTRACT: Background: Multiparametric cardiovascular magnetic resonance (CMR) has an emerging role in non-invasive surveillance of pediatric heart transplant recipients (PHTR). …”
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Dynamic monitoring and drivers of ecological environmental quality in the Three-North region, China: Insights based on remote sensing ecological index by Leyi Zhang, Xia Li, Xiuhua Liu, Zhiyang Lian, Guozhuang Zhang, Zuyu Liu, Shuangxian An, Yuexiao Ren, Yile Li, Shangdong Liu

“…Future trends are likely to reflect those of the past 23 years, with improvement still predominant (37.5 % of the total), albeit with limited sustainability (including NWC). Precipitation (PRE) emerged as the dominant factor influencing the RSEI in the TNEP, North China (NC), and NWC (SHAP values of 0.1, 0.13, and 0.07, respectively). …”
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Anthropometric and metabolic parameters associated with visceral fat in non-obese type 2 diabetes individuals by Ming Jiao, Jiaoli Chen, Xiaoling Wang, Wenyu Tao, Yunhua Feng, Huijun Yang, Haiying Yang, Shanshan Zhao, Ying Yang, Yiping Li

“…The OR for VF gradually increased from the 1st to the 4th in LAP quartile (P < 0.05). LAP emerged as the root node, followed by NC in the decision tree model. …”
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Associations between age, red cell distribution width and 180-day and 1-year mortality in giant cell arteritis patients: mediation analyses and machine learning in a cohort study by Si Chen, Rui Nie, Xiaoran Shen, Yan Wang, Haixia Luan, Xiaoli Zeng, Yanhua Chen, Hui Yuan

“…In multivariate Cox regression analysis, both age and RDW (both with HR > 1, P < 0.05) also emerged as prognostic risk factors for 180-day and 1-year mortality in this patient population. …”
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Phase I study of efineptakin alfa (NT-I7) for the treatment of Kaposi sarcoma by Leonard D’Amico, Martin Cheever, Steven P Fling, Anna Wright, Kathryn Lurain, Ramya Ramaswami, Irene Ekwede, Thomas S Uldrick, Robert Yarchoan, Judith C Kaiser, Angela Shaulov Kask, Manoj P Menon, Paul Couey, Eli Burnham, Allysson Angeldekao, Byung Ha Lee, Li-Lian Kwok, Chia-Ching Jackie Wang

“…With regard to treatment-emergent adverse events (AEs), all participants had &lt;grade 2 AEs, which included injection site reaction and alanine aminotransferase increase. …”
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A randomized, placebo-controlled, cross-over trial of ketamine in Rett syndrome by Kathleen Campbell, Jeffrey L. Neul, David N. Lieberman, Elizabeth Berry-Kravis, Tim A. Benke, Cary Fu, Alan Percy, Bernhard Suter, David Morris, Randall L. Carpenter, Eric D. Marsh, Jana von Hehn

“…Ketamine was safe and tolerated in both cohorts, with 1 related treatment emergent adverse event of vomiting. No difference was observed in efficacy between ketamine and placebo. …”
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Characterizing populations prioritized for PrEP in 19 African countries: a review of national guidance by Lauren A. Graybill, Caroline N. McKay, Jiayu Wang, Nadia A. Sam‐Agudu, Marcel Yotebieng, Friday Saidi, Linda‐Gail Bekker, Bonnie E. Shook‐Sa, Benjamin H. Chi, Nora E. Rosenberg

“…Methods Between January and June 2023, we searched for current National HIV Treatment and Prevention Guidelines, National HIV Strategic Plans, and the United States President's Emergency Plan for AIDS Relief (PEPFAR) Country Operational Plans (COPs) for all African countries implementing PrEP programmes supported by PEPFAR in 2022. …”
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Long-term safety of dexamethasone sodium phosphate encapsulated in autologous erythrocytes in pediatric patients with ataxia telangiectasia by Mary Kay Koenig, Vincenzo Leuzzi, Riadh Gouider, Riadh Gouider, Eppie M. Yiu, Eppie M. Yiu, Barbara Pietrucha, Asbjørg Stray-Pedersen, Susan L. Perlman, Steve Wu, Trudy Burgers, Rupam Borgohain, Rukmini Mridula Kandadai, Isabelle Meyts, Giorgia Bucciol, Anaita Udwadia-Hegde, Ravi Yadav, Donna Roberts, Aaron Dane, Maureen Roden, Dirk Thye, Biljana Horn, Howard M. Lederman, William P. Whitehouse

“…Outcomes include adverse events, growth, hemoglobin and serum iron, glucose levels, HbA1c, CD4+ lymphocytes, and bone mineral density.ResultsSixty-eight patients completed a minimum of 2 years of treatment with EryDex (mean treatment length 39 ± 11 months). Treatment-emergent adverse events (TEAE), reported in 67 (99%) out of 68 patients, were typically mild and did not cause discontinuation of treatment or death. …”
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Utilization and quality of primary and specialized palliative homecare in nursing home residents vs. community dwellers: a claims data analysis by Juliane Poeck, Franziska Meissner, Bianka Ditscheid, Markus Krause, Ulrich Wedding, Cordula Gebel, Ursula Marschall, Gabriele Meyer, Werner Schneider, Antje Freytag

“…Second, we analyzed the (adjusted) relationship between PPC-only and SPHC (both: starting ≥ 30 days before death), and noPC with healthcare indicators (death in hospital, hospitalization, emergencies, intensive care treatment within the last 30 days of life), and compared these relationships between nursing home residents and community dwellers. …”
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Assessment of Chaves Low-Temperature CO2-Rich Geothermal System (N-Portugal) Using an Interdisciplinary Geosciences Approach by J. M. Marques, P. M. Carreira, L. A. Aires-Barros, F. A. Monteiro Santos, M. Antunes da Silva, P. Represas

“…This paper demonstrates the added value of an integrated and multi- and interdisciplinary approach for a given geothermal site characterization, which could be useful for other case studies linking the assessment of low-temperature CO2-rich geothermal waters and cold CO2-rich mineral waters emerging in a same region.…”
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Comparative abundance and diversity of populations of the Pseudomonas syringae and Soft Rot Pectobacteriaceae species complexes throughout the Durance River catchment from its Fren... by Morris, C.E., Lacroix, C., Chandeysson, C., Guilbaud, C., Monteil, C., Piry, S., Rochelle Newall, E., Fiorini, S., Van Gijsegem, F., Barny, M.A., Berge, O.

“…In parallel, there is an emerging awareness that crop pathogens might also be disseminated via surface waters especially when they are used for irrigation. …”
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<i>Bacillus cabrialesii</i> subsp. <i>cabrialesii</i> Strain TE5: A Promising Biological Control Bacterium Against the Causal Agent of Spot Blotch in Wheat by Ixchel Campos-Avelar, Michelle Fabiela García Jaime, Pamela Helué Morales Sandoval, Fannie Isela Parra-Cota, Sergio de los Santos Villalobos

“…Moreover, the antifungal activity of strain TE5 and its cell-free extract (CFE) was evaluated against <i>Bipolaris sorokiniana</i>, an emergent wheat pathogen. The results of in vitro dual confrontation showed fungal growth inhibition of 67% by strain TE5. …”
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Anesthesia for pregnant patients with symptomatic neurological disease: 13 years’ experience from a tertiary care center by Stefano Catarci, Bruno Antonio Zanfini, Marco Scorzoni, Salvatore De Martino, Pietro Paolo Giuri, Luciano Frassanito, Gian Luigi Gonnella, Emanuele Capone, Francesco Vitale Di Maio, Giovanni Maddaloni, Antonio Lanzone, Gaetano Draisci

“…A total of 234 (97.9%) pregnant women with neurological disorders and significant neurological symptoms underwent cesarean section: 192 (80.3% of the total cesarean sections) were elective, 39 (16.3%) were urgent type 2 and 3; 3 (1.2%) were emergency cesarean sections. General anesthesia was administered to 73 patients (30.5%), while 166 patients (69.5%) were managed with neuraxial techniques. 2 patients who had had neuraxial block reported worsening neurological symptoms that required a change in medical therapy. …”
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IL-2-armored peptide-major histocompatibility class I bispecific antibodies redirect antiviral effector memory CD8+ T cells to induce potent anti-cancer cytotoxic activity with lim... by John S. Schardt, Even Walseng, Kim Le, Chunning Yang, Pooja Shah, Ying Fu, Kausar Alam, Cathryn R. Kelton, Yu Gu, Fengying Huang, Jia Lin, Wenhai Liu, Andrew Dippel, Hanzhi Zhang, Kathy Mulgrew, Stacy Pryts, Vijaykumar Chennupati, Hung-Chang Chen, Jessica Denham, Xiaoru Chen, Pallab Pradhan, Yuling Wu, Colin Hardman, Chihao Zhao, Michael Kierny, Yang Song, Simon J. Dovedi, Saso Cemerski, Yariv Mazor

“…A promising strategy is the use of peptide-major histocompatibility class I bispecific antibodies (pMHC-IgGs), which have emerged as an intriguing modality of TCE, based on their ability to selectively redirect highly reactive viral-specific effector memory cytotoxic CD8+ T cells to eliminate cancer cells. …”
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A perinatal psychiatry access program to address rural and medically underserved populations using telemedicine by Courtney King, Marie Hayes, Lizmarie Maldonado, Elizabeth Monter, Rubin Aujla, Erin Phlegar, Claire Smith, Liz Parker, Kerry Blome, Amanda Sandford, Edie Douglas, Constance Guille

“…Perinatal Psychiatry Access Programs have emerged as a successful model to increase the capacity of front-line maternal health care providers to address perinatal mental health conditions through education, consultation, and increased resources and referrals. …”
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Systematic review and quantitative meta-analysis of age-dependent human T-lymphocyte homeostasis by Victoria Kulesh, Victoria Kulesh, Kirill Peskov, Kirill Peskov, Kirill Peskov, Gabriel Helmlinger, Gennady Bocharov, Gennady Bocharov, Gennady Bocharov

“…Notably, an increase in T-lymphocyte numbers is observed in neonates and infants (0 – 1 year of age) towards less differentiated T-lymphocyte subpopulations, while an increase into more differentiated subpopulations emerges later (1 – 5 years of age).ConclusionA comprehensive systematic review and meta-analysis of T-lymphocyte age-dependent homeostasis in healthy humans was performed, to evaluate immune T-cell profiles as a function of age and to characterize generalized estimates of T-lymphocyte counts across age groups. …”
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Comparative analysis of ocular biometrics using spectral domain optical coherence tomography with Purkinje image and optic nerve head alignments in mice by Ying Hon Sze, Bing Zuo, Da Qian Lu, King Kit Li, Dennis Yan Yin Tse, Qian Zhao, Thomas Chuen Lam

“…Abstract Background Mice are an emerging model for experimental myopia. Due to their small eye size, non-invasive optical coherence tomography is essential for evaluating ocular biometrics. …”
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Spatial deconvolution from bulk DNA methylation profiles determines intratumoral epigenetic heterogeneity by Binbin Liu, Yumo Xie, Yu Zhang, Guannan Tang, Jinxin Lin, Ze Yuan, Xiaoxia Liu, Xiaolin Wang, Meijin Huang, Yanxin Luo, Huichuan Yu

“…Abstract Background Intratumoral heterogeneity emerges from accumulating genetic and epigenetic changes during tumorigenesis, which may contribute to therapeutic failure and drug resistance. …”
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Impacts of environmental quality and employment resilience during the coronavirus disease 2019 recession and recovery by D.O. Ayuningsih, L. Hakim, A. Suryantoro, I. Mafruhah, S. Hassan, E. Gravitiani, N.Q. Fathoni, A.I. Hakim

“…Comparable findings indicate that the economic downturn resulted in diverse responses regarding employment resilience across different geographical areas. Numerous obstacles emerge in the pursuit of sustainable growth. The strategy involves fostering and bolstering support for the green economy, alongside promoting labor development in the renewable energy field, underpinned by heightened investment in green infrastructure.…”
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