Improving ferroptosis-mediated immunotherapy for colorectal cancer through lysosome-targeted photodynamic therapy by Zhian Chen, Yutong Wang, Zhenhao Li, Meijuan Chen, Yingshi Li, Chuyue Lu, Zhenyu Lin, Hua Zheng, Lujia Chen, Qianbing Zhang

“…Lysosomes is emerging as a promising therapeutic target for improving immunotherapy, which dysfunction would trigger lysosomal membrane permeabilization increase and subsequent leakage of reduced iron, which contributed to ferroptosis through cell-intrinsic Fenton chemistry. …”
Get full text

Inflammation and Inflammasomes: Pros and Cons in Tumorigenesis by Liliana R. Balahura, Aida Selaru, Sorina Dinescu, Marieta Costache

“…Additionally, microRNAs (miRNAs), evolutionary conserved noncoding molecules, have emerged as pivotal players during numerous biological events by regulating gene and protein expression. …”
Get full text

Involuntary intoxication caused by vaping the synthetic cannabinoid ADB-BUTINACA: A case report by Elise M.A. Slob, Maryam Lyousoufi, Sharif Pasha, Erik B. Wilms

“…We report a 27-year-old man who was admitted to the emergency room because of sudden headache, nausea, vertigo, red eyes and palpitations. …”
Get full text

Prevention of LPS-Induced Acute Lung Injury in Mice by Progranulin by Zhongliang Guo, Qinchuan Li, Yang Han, Yongjie Liang, Zengguang Xu, Tao Ren

“…Despite decades of research, few therapeutic strategies for clinical ARDS have emerged. Here we carefully evaluated the effect of progranulin (PGRN) in treatment of ARDS using the murine model of lipopolysaccharide (LPS)-induced ALI. …”
Get full text

Hyperspectral Image-Based Identification of Maritime Objects Using Convolutional Neural Networks and Classifier Models by Dongmin Seo, Daekyeom Lee, Sekil Park, Sangwoo Oh

“…Given its ability to provide detailed spectral information, hyperspectral imaging has emerged as a powerful tool for analyzing the physical and chemical properties of target objects. …”
Get full text

Challenges of Diabetes Self-Management in Adults Affected by Food Insecurity in a Large Urban Centre of Ontario, Canada by Justine Chan, Margaret DeMelo, Jacqui Gingras, Enza Gucciardi

“…Main Findings. Three themes emerged from our analysis of participants’ experiences of living with food insecurity and diabetes: (1) barriers to accessing and preparing food, (2) social isolation, and (3) enhancing agency and resilience. …”
Get full text

MESO-CMOS Hybrid Circuits With Time-Multiplexing Technique for Energy and Area-Efficient Computing in Memory by Tzuping Huang, Linran Zhao, Yiming Han, Hai Li, Ian A. Young, Yaoyao Jia

“…The magnetoelectric spin orbit (MESO), one of the emerging spin devices, represents a promising alternative to complementary metal-oxide–semiconductor (CMOS) technology. …”
Get full text

Impact of strategic orientation on sustainable competitive advantage: the mediating role of organizational capabilities by Mohammed Majeed, Ahmed Tijani, Kwame Simpe Ofori, Aidatu Abubakari, George Oppong Appiagyei Ampong

“…Emerging economies face numerous challenges; thus, gaining and sustaining competitive advantage has become imperative. …”
Get full text

Structural development of the HIV-1 apex-directed PGT145-PGDM1400 antibody lineage by Rosemarie D. Mason, Baoshan Zhang, Nicholas C. Morano, Chen-Hsiang Shen, Krisha McKee, Ashley Heimann, Renguang Du, Alexandra F. Nazzari, Shelby Hodges, Tapan Kanai, Bob C. Lin, Mark K. Louder, Nicole A. Doria-Rose, Tongqing Zhou, Lawrence Shapiro, Mario Roederer, Peter D. Kwong, Jason Gorman

“…Summary: Broadly neutralizing antibodies (bNAbs) targeting the apex of the HIV-1-envelope (Env) trimer comprise the most potent category of HIV-1 bNAbs and have emerged as promising therapeutics. Here, we investigate the development of the HIV-1 apex-directed PGT145-PGDM1400 antibody lineage and report cryo-EM structures at 3.4 Å resolution of PGDM1400 and of an improved PGT145 variant (PGT145-R100aS), each bound to the BG505 Env trimer. …”
Get full text

Tropical Medicine in China: Bibliometric Analysis Based on Web of Science (2010–2019) by Zhen Li, Jingbo Xue, Bin Zheng

“…Furthermore, Parasite & Vectors, which published 707 papers, emerged as the top journal according to the number of publications. …”
Get full text

Responsible Email Marketing in Higher Education by Lukas Vartiak, Martina Chrancokova, Miriam Garbarova, Juraj Fabus

“…In higher education, responsible email marketing emerges as a critical strategy for engaging students, alums, and potential students meaningfully and ethically. …”
Get full text

First Detection of <i>Alphacoronavirus</i> in Bats from the World’s Largest Wetland, the Pantanal, Brazil by Tayane B. S. Magalhães, Amanda de O. Viana, Thiago B. F. Semedo, Juliane S. Saldanha, Nicole A. dos Reis, Nathalia de A. Pereira, Rachel V. P. de Barros, Hannah R. Miranda, Gabriella C. Almeida, Desyrée Y. S. R. Ozaki, Giovana S. Caleiro, Gustavo O. Fenner, Fernanda P. Vizu, Theo Kraiser, Thais P. Carvalho, Luciano M. Thomazelli, Erick G. Dorlass, Clarice W. Arns, Helena L. Ferreira, Erika Hingst-Zaher, Rogério Vieira Rossi, Guilherme S. T. Garbino, Edison L. Durigon, Jansen de Araujo, Daniel M. de Aguiar

“…As they are natural reservoirs of CoVs, constant monitoring of bats is important to comprehend the epidemiology of emerging viruses, especially in the Pantanal biome.…”
Get full text

Psychosocial and mental health in cystic fibrosis in the modern era of care: time to evolve by Beth Smith, Tonia A Douglas, Alexandra L Quittner, Anna M Georgiopoulos, Maggie Harrigan

“…A symposium of international CF and psychosocial experts was convened in November 2022 to explore current and emerging issues in psychosocial health and identify opportunities and approaches to optimise psychosocial care. …”
Get full text

Ruptured Arteriovenous Malformation Presenting with Kernohan’s Notch by Christopher F. Dibble, Michael P. Wemhoff, Tarik Ibrahim, Deanna Sasaki-Adams, Sten Solander, Anand V. Germanwala

“…The patient underwent emergent hemicraniectomy and hematoma evacuation. …”
Get full text

Analysis of initiatives to promote education for sustainability and climate action in schools in Madrid and proposals for improvement by Susana Sastre Merino, Cristine Zanarotti Prestes Rosa, Marvin Josué Izaguirres Betancourth

“…As a powerful tool for social change, education is one of the key transversal areas for promoting sustainability and addressing the climate emergency. This is reflected in international guidelines, such as the 2030 Agenda and the European GreenComp framework, and national guidelines, such as the current Spanish education law (LOMLOE). …”
Get full text

Mediastinal Tracheostoma for Treatment of Tracheostenosis after Tracheostomy in a Patient with Mucopolysaccharidosis-Induced Tracheomalacia by Yasuhiro Chikaishi, Kenichi Kobayashi, Shuichi Shinohara, Akihiro Taira, Yusuke Nabe, Shinji Shinohara, Taiji Kuwata, Masaru Takenaka, Soichi Oka, Ayako Hirai, Kazue Yoneda, Koji Kuroda, Naoko Imanishi, Yoshinobu Ichiki, Fumihiro Tanaka

“…One week prior to presentation, he was admitted to another hospital on an emergency basis for major dyspnea. He was diagnosed with tracheostenosis caused by granulation. …”
Get full text

Supramolecular interactions-driven aggregation to prepare lipoic acid-bioadhesives for seawater-immersed wounds by Rui Lei, Wenjun Wang, Guan Li, Qian Yu, Haowei Fang, Jinghong Xu, Kunxi Zhang, Yinghai Ye

“…The present study develops an aggregation strategy for the rapid preparation of α-lipoic acid (LA)-based bioadhesives at room temperature with strong and underwater adhesion for emergency treatment of trauma in maritime activities. …”
Get full text

Improving the healthcare user experience: an optimization model grounded in patient-centredness by Elisa Peruzzo, Chiara Seghieri, Milena Vainieri, Sabina De Rosis

“…Results The results confirm that, among the significant determinants of satisfaction, some specific experiential aspects emerged as the potential primary focus to be prioritized in improvement actions. …”
Get full text

Assessment of Health-Related Quality of Life after TBI: Comparison of a Disease-Specific (QOLIBRI) with a Generic (SF-36) Instrument by Nicole von Steinbuechel, Amra Covic, Suzanne Polinder, Thomas Kohlmann, Ugne Cepulyte, Herbert Poinstingl, Joy Backhaus, Wilbert Bakx, Monika Bullinger, Anne-Lise Christensen, Rita Formisano, Henning Gibbons, Stefan Höfer, Sanna Koskinen, Andrew Maas, Edmund Neugebauer, Jane Powell, Jaana Sarajuuri, Nadine Sasse, Silke Schmidt, Holger Mühlan, Klaus von Wild, George Zitnay, Jean-Luc Truelle

“…Psychosocial, emotional, and physical problems can emerge after traumatic brain injury (TBI), potentially impacting health-related quality of life (HRQoL). …”
Get full text

Marked Rebound of Platelet Count in the Early Postpartum Period in a Patient with Essential Thrombocythemia by Yoshinori Hashimoto, Rina Hosoda, Hiromi Omura, Takayuki Tanaka

“…Her platelet count exceeded 1500 × 109/L by late pregnancy; interferon α was administered but failed to induce an adequate response. She underwent emergency cesarean delivery at 37 weeks of gestation. …”
Get full text