Targeting cryptic allosteric sites of G protein-coupled receptors as a novel strategy for biased drug discovery by Xin Qiao, Xiaolong Li, Mingyang Zhang, Ning Liu, Yanmei Wu, Shaoyong Lu, Ting Chen

“…Targeting more variable allosteric sites, which are spatially different from the highly conserved orthosteric sites, represents a novel approach in biased GPCR drug discovery, leading to innovative strategies for targeting GPCRs. Notably, the emergence of cryptic allosteric sites on GPCRs has expanded the repertoire of available drug targets and improved receptor subtype selectivity. …”
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Premorbid and current intellectual performance reflects different backgrounds in patients with Parkinson's disease by Hidetomo Murakami, Machiko Kezuka, Junnosuke Ozawa, Kaoru Matsuoka, Tatsuya Nakanishi, Atsushi Ishida, Naohito Ito, Mizuki Kanemoto, Mitsuru Kawamura

“…Background: There is growing interest in targeting Parkinson's Disease (PD) at an earlier stage, especially before emergence of motor symptoms. Cognitive dysfunction is a non-motor symptom in PD, whereas the Japanese version of the National Adult Reading Test (JART) is a validated battery to estimate the premorbid intellectual quotient (IQ). …”
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Phylogenetic Analysis of Spike and Envelope Proteins for a Number of Bat Coronaviruses for Understanding the Hypothesis of Possible Origin for the Novel 2019- nCoV by Salar Ibrahim Ali

“…Coronavirus Disease 19 (COVID-19) emergence reveals  globally a great health issue and due to the limited information and knowledge on the origin of this novel coronavirus 2019 (2019-nCoV). …”
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Transmission of synthetic seed bacterial communities to radish seedlings: impact on microbiota assembly and plant phenotype by Simonin, Marie, Préveaux, Anne, Marais, Coralie, Garin, Tiffany, Arnault, Gontran, Sarniguet, Alain, Barret, Matthieu

“…Seed-borne microorganisms can be pioneer taxa during germination and seedling emergence. Still, the identity and phenotypic effects of these taxa that constitute a primary inoculum of plant microbiota is mostly unknown. …”
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Personal, environmental and behavioral predictors associated with online fraud victimization among adults. by Vimala Balakrishnan, Umayma Ahhmed, Faris Basheer

“…<h4>Implications</h4>The emergence of Overconfidence and Social Influence as significant predictors can guide the development of targeted online fraud awareness campaigns and/or tools emphasizing critical thinking and skepticism. …”
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Quantitative Performance Analysis of Respiratory Facemasks Using Atmospheric and Laboratory Generated Aerosols Following with Gamma Sterilization by Amit Kumar, D. N. Sangeetha, Ramani Yuvaraj, M. Menaka, Venkatesan Subramanian, Balasubramanian Venkatraman

“…Abstract The emergence of the recent COVID-19 pandemic has rendered mandatory wearing of respiratory masks by infected persons, frontline workers, security personnel and members of the public. …”
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Unlocking the genetic potential of Ethiopian fenugreek (Trigonella foenum-graecum L.) genotypes for future breeding by Zebib Berhe, Tesfaye Awas, Asmare Dejen, Metadel Adane, Baye Akele, Musa Adal, Faris Hailu

“…ANOVA revealed that there was highly significant (p < 0.001) difference among the thirty six genotypes for all studied traits except days to emergence. The present study revealed that high heritability with high genetic advance as percent of mean, respectively, showed for almost all the studied traits like, number of pods per plant (99.6 %, 97.7 %), number of seeds per pod (98.8 %, 84.2 %), number of primary branches per plant(98.5 %, 104.4 %), number of secondary branches per plant (98.3 %, 107.6), biomass yield (97.6 %, 59.9 %), plant height (94.6 %, 63 %), thousand seeds weight (92.6 %, 66.7 %), and pods length (91.5 %, 61.1 %). …”
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Business Development Strategy of Beverage Powder Company by M. Zaenal Mahasin, Hartoyo, Rokhani Hasbullah

“…This growth is due to the ease of starting a coffee business and the emergence of digital businesses. Coffee trends have triggered an increase in domestic consumption of coffee and other drinks like chocolate and tea. …”
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Prevalence of cardiovascular symptoms in post-acute COVID-19 syndrome: a meta-analysis by Li-wei Huang, Hua-min Li, Bei He, Xiao-bo Wang, Qi-zhi Zhang, Wen-xing Peng

“…Abstract Background Since its emergence in 2019, COVID-19 has continued to pose significant threats to both the physical and mental health of the global population, as well as to healthcare systems worldwide (Raman et al., Eur Heart J 43:1157–1172, 2022). …”
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Evolutionary determinants of reproductive seasonality: A theoretical approach by Burtschell, Lugdiwine, Dezeure, Jules, Huchard, Elise, Godelle, Bernard

“…Overall, this study contributes a powerful theoretical framework and modelling tool that may apply across the life-history space, as well as sheds new light on the emergence and maintenance of non-seasonal breeding in slow-living species, including humans. …”
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Synthetic peptides as valuable and versatile tools for research: our 20 year journey in Chile by Constanza Cárdenas, Paula Santana, Claudio Álvarez, Luis Mercado, Sergio Marshall, Fernando Albericio, Fanny Guzmán

“…Following nature’s example, peptides have emerged as alternatives in various fields. One particularly relevant area is in drug discovery, offering alternatives to face the emergence of antibiotic-resistant microorganisms. …”
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Distribution and Antifungal Susceptibility Profile of Oropharyngeal Candida Species Isolated from People Living with HIV in the Era of Universal Test and Treat Policy in Uganda. by Musinguzi, Benson, Turyamuhika, Laban, Mwesigwa, Alex, Nalumaga, Pauline Petra, Kabajulizi, Immaculate, Njovu, Israel Kiiza, Mwebesa, Edson, Luggya, Tonny, Ocheng, Francis, Kateete, David Patrick, Itabangi, Herbert, Mboowa, Gerald, Obondo, James Sande, Achan, Beatrice

“…Background: Despite the increased frequency of oropharyngeal candidiasis among people living with human immunodeficiency virus (HIV), its management is no longer effective due to empirical treatment and the emergence of antifungal resistance (AFR). This study sought to investigate the prevalence of oropharyngeal candidiasis and assess the antifungal susceptibility profile of oropharyngeal Candida species isolated from people living with human immunodeficiency virus. …”
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Revealing viral hepatitis epidemiology in the Democratic Republic of Congo: insights from yellow fever surveillance reanalysis by Patrick Mukadi-Kakoni, Yannick Munyeku-Bazitama, Gracia Kashitu-Mujinga, Marguerite Manwana-Pemba, Niclette Zenga-Bibi, Patient Okitale-Talunda, Christelle Mbelu-Kabongo, Fleurette Domai-Mbuyakala, Elisabeth Pukuta-Simbu, Pierre Mutantu-Nsele, Yoshinao Kubo, Sheila Makiala-Mandanda, Steve Ahuka-Mundeke, Koya Ariyoshi, Jean-Jacques Muyembe-Tamfum

“…Abstract Background Yellow fever surveillance systems are designed to identify cases of acute febrile jaundice, a clinical syndrome used to monitor the emergence of yellow fever outbreaks. However, this syndrome has diverse etiologies, particularly viral hepatitis. …”
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Immunologic and inflammatory consequences of SARS-CoV-2 infection and its implications in renal disease by Hiam Naiditch, Michael R. Betts, H. Benjamin Larman, Moshe Levi, Avi Z. Rosenberg

“…The emergence of the COVID-19 pandemic made it critical to understand the immune and inflammatory responses to the SARS-CoV-2 virus. …”
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Monitoring and evaluation in disaster management courses: a scoping review by George Teo Voicescu, Hamdi Lamine, Andra Elena Loșonți, Eugenia Maria Lupan-Mureșan, Sonia Luka, José García Ulerio, Luca Ragazzoni, Francesco Della Corte, Marta Caviglia

“…Abstract Background Owing to the infrequent emergence of disasters and the challenges associated with their management, responders need appropriate training beyond doubt. …”
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Investigating the formation and evolution of plant diversity patterns in the Qiangtang Plateau based on phylofloristics approach by Xiaoping Li, Yun Han, Lei Miao, Hao Xu, Jingya Yu, Shuang Han, Faqi Zhang

“…Furthermore, using fossil data, we deduced that the emergence of seed plant families in this region dates back to the Cretaceous period (145.00 Ma), with a significant acceleration in evolutionary rates observed since the onset of the Quaternary Ice Age (2.00 Ma). …”
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Identifying the Dimensions and Consequences of Digital Customer Experience: A Phenomenological Study by Fatemeh Eslahi, Seyed Mohammad Reza Mirahmadi, Mojtaba Aghajani

“…ObjectiveAchieving success, particularly in the realm of online and digital commerce, frequently hinges on customer experience, a multifaceted process influenced by numerous factors. Along with the emergence of new technologies, communication methods between organizations and customers have changed. …”
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The Consequences of Digital Storytelling-Based Customer Engagement in Social Media for the Tourism Industry by Meysam Ahmadnia, Taher Roshandel Arbatani, Abbas Nargesian, Seyed Mahdi Sharifi, Khabat Derafshi

“…Despite the creative and innovative nature of engagement activities, it is crucial to address the repercussions of customer engagement to gauge the effectiveness of these initiatives in light of the emergence of new technologies. Consequently, this research aims to investigate the implications of digital storytelling-based customer engagement on social media within the tourism sector in Iran. …”
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Creating a Digital Insurance Model: A Grounded Theory Approach by Mohammad Adabi, Nastaran Haji Heydari, Hamed Vares

“…Also, due to the presence of startups in the field of insurance services, we are witnessing the emergence of digital insurance features in this industry as a value proposition. …”
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Large-scale spatio-temporal variation in vital rates and population dynamics of an alpine bird by Nater, Chloé R., Frassinelli, Francesco, Martin, James A., Nilsen, Erlend B.

“…While the majority of participatory monitoring programs are limited by opportunistic sampling designs, we are starting to see the emergence of structured citizen science programs that employ trained volunteers to collect data according to standardized protocols. …”
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