Hurricanes, industrial animal operations, and acute gastrointestinal illness in North Carolina, USA by Arbor J L Quist, Mike Dolan Fliss, David B Richardson, Paul L Delamater, Lawrence S Engel

“…We used ZIP code-level disease surveillance data, 2016–2019, to calculate rates of AGI emergency department (ED) visits in NC. Using precipitation data, CAFO permit data, and interrupted time series methods, we assessed the change in AGI rate during the three weeks after Matthew and Florence in ZIP codes with heavy rain (>75th percentile of storm precipitation) and 0, 1–10, and >10 hog CAFOs. …”
Get full text

Modulation of local immunity by the vaginal microbiome is associated with triggering spontaneous preterm birth by Yijia Liang, Yijia Liang, Yijia Liang, Changying Zhao, Yan Wen, Dashuang Sheng, Tiantian Wei, Tianqi Hu, Junhui Dai, Guoping Zhao, Guoping Zhao, Guoping Zhao, Sijie Yang, Sijie Yang, Qinghua Wang, Lei Zhang, Lei Zhang

“…Mid-pregnancy immune status emerged as a key indicator of preterm birth risk, associated with the vaginal microbiome composition. …”
Get full text

Intramedullary Fixation for Metacarpal Fractures: A Multi-Institutional Prospective Outcomes Study by Michael B. Gehring, MD, Brandon Wolfe, BA, Riley Kahan, BS, Stephanie D. Malliaris, MD, Kia M. Washington, MD, Matthew D. Folchert, MD, Kyros Ipaktchi, MD, Mark A. Greyson, MD, Alexander Lauder, MD, Matthew L. Iorio, MD

“…Purpose: Intramedullary fixation (IMF) has emerged as an effective treatment for metacarpal fractures. …”
Get full text

Analysis of changes in the genome of the Omsk hemorrhagic fever virus (Flaviviridae: <i>Orthoflavivirus</i>) during laboratory practices for virus preservation by Zhanna S. Tyulko, Artem V. Fadeev, Aleksei G. Vasilenko, Ekaterina A. Gradoboeva, Valerii V. Yakimenko, Andrey B. Komissarov

“…Assessment of adaptive changes in the genome of the OHF virus was carried out using discriminant analysis methods, analyzing the composition and localization of emerging substitutions in viral RNA sequences obtained during the adaptation of viruses to the mouse organism as a result of passaging. …”
Get full text

DNA hypomethylation-mediated upregulation of GADD45B facilitates airway inflammation and epithelial cell senescence in COPD by Yuan Zhan, Qian Huang, Zhesong Deng, Shanshan Chen, Ruonan Yang, Jiaheng Zhang, Yating Zhang, Maocuo Peng, Jixing Wu, Yiya Gu, Zhilin Zeng, Jungang Xie

“…Introduction: Chronic obstructive pulmonary disease (COPD) is a heterogeneous disease typically characterized by chronic airway inflammation, with emerging evidence highlighting the driving role of cellular senescence-related lung aging. …”
Get full text

Bulk and single-cell transcriptome revealed the metabolic heterogeneity in human glioma by Yong Xiao, Mengjie Zhao, Ran Wang, Liang Liu, Chong Xiang, Taiping Li, Chunfa Qian, Hong Xiao, Hongyi Liu, Yuanjie Zou, Xianglong Tang, Kun Yang

“…Background: Emerging perspectives on tumor metabolism reveal its heterogeneity, a characteristic yet to be fully explored in gliomas. …”
Get full text

Study protocol of a pilot randomised controlled trial assessing the feasibility and acceptability of RecoverEsupport: a digital health intervention to enhance recovery in women und... by Christopher Oldmeadow, Mitch J Duncan, Penny Reeves, Priscilla Viana da Silva, Rebecca Wyse, Helen Moore, Alison Zucca, Sancha Robinson, Stephen Ridley Smith, Emma Sansalone, Owen Morris, Rebecca Chenery, Lara Riley, Anna Palazzi-Parsons

“…Data regarding patient behaviours related to patient-managed ERAS recommendations, Quality of Life, European Organization for the Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ-C30), Quality of Recovery (QOR-15), Anxiety (Hospital Anxiety and Depression Scale), hospital readmissions, emergency department presentations and health service utilisation postdischarge will also be collected.Ethics and dissemination This study has been approved by the Human Research Ethics Committees of the Hunter New England Local Health District (2022/ETH02010), the University of Newcastle (H-2023–0298) and the Calvary Mater Newcastle (2022/STE03757). …”
Get full text

Novel Prognostic Factors Associated with Cell Cycle Control in Sporadic Medullary Thyroid Cancer Patients by Raffaele Pezzani, Loris Bertazza, Elisabetta Cavedon, Simona Censi, Jacopo Manso, Sara Watutantrige-Fernando, Gianmaria Pennelli, Francesca Galuppini, Susi Barollo, Caterina Mian

“…The presence of an altered expression of PTTG1 and AURKA is a negative prognostic factor associated with a more aggressive course of disease, such as an advanced stage or disease persistence. It emerges as a cell cycle process mediated by the 2 factors, in addition to the RET pathway, which can be altered in MTC patients.…”
Get full text

Identification of standing dead trees in Robinia pseudoacacia plantations across China’s Loess Plateau using multiple deep learning models by Li Zhang, Xiaodong Gao, Shuyi Zhou, Zhibo Zhang, Tianjie Zhao, Yaohui Cai, Xining Zhao

“…Drought-induced tree mortality has increasingly expanded worldwide under the influence of climate warming, with China’s Loess Plateau (CLP) emerging as a critical hotspot for such impacts. As one of the most active tree-planting regions globally, the CLP primarily aims to achieve soil and water conservation despite facing challenges such as limited rainfall and frequent extreme drought events. …”
Get full text

Electrochemotherapy with bleomycin, oxaliplatin, or cisplatin in mouse tumor models, from tumor ablation to in situ vaccination by Katja Uršič Valentinuzzi, Katja Uršič Valentinuzzi, Urška Kamenšek, Urška Kamenšek, Simona Kranjc Brezar, Chloe Heranney, Chloe Heranney, Tilen Komel, Tilen Komel, Simon Buček, Simon Buček, Maja Čemažar, Maja Čemažar, Gregor Serša, Gregor Serša

“…By evaluating ECT’s potential for in situ vaccination, our goal was to pave the way for future advancements for its combination with emerging (immuno)therapies, leading to enhanced responses and outcomes.MethodsWe employed two mouse tumor models, the immunologically cold B16F10 melanoma and 4T1 mammary carcinoma, to explore both local and systemic (i.e., abscopal) antitumor effects following equieffective intratumoral ECT with BLM, OXA, and CDDP. …”
Get full text

Cardiovascular events observed among patients in the etrasimod clinical programme: an integrated safety analysis of patients with moderately to severely active ulcerative colitis by Xiang Guo, Peter M Irving, Laurent Peyrin-Biroulet, Séverine Vermeire, Joseph Wu, Irene Modesto, David T Rubin, Marla C Dubinsky, Andres J Yarur, Miguel Regueiro, Martina Goetsch, Krisztina Lazin, Guibao Gu, Aoibhinn McDonnell, Jesse Green, Alexis B Dalam

“…We report cardiovascular treatment-emergent adverse events (TEAEs) associated with S1P receptor modulators and other cardiovascular events in the etrasimod UC clinical programme.Methods Patients were analysed in the Placebo-controlled UC cohort and All UC cohort. …”
Get full text

A Comprehensive Analysis of <i>Echinococcus granulosus</i> Infections in Children and Adolescents: Results of a 7-Year Retrospective Study and Literature Review by Cristina Maria Mihai, Ancuta Lupu, Tatiana Chisnoiu, Adriana Luminita Balasa, Ginel Baciu, Vasile Valeriu Lupu, Violeta Popovici, Felicia Suciu, Florin-Daniel Enache, Simona Claudia Cambrea, Ramona Mihaela Stoicescu

“…They were hospitalized with cystic echinococcosis in the Pediatric Department and Pediatric Surgery Department of Constanta County Clinical Emergency Hospital “St. Apostle Andrew” between 1 January 2017 and 1 October 2024. …”
Get full text

A decade of treating traumatic sternal fractures in a single-center experience in Korea: a retrospective cohort study by Na Hyeon Lee, Seon Hee Kim, Jae Hun Kim, Ho Hyun Kim, Sang Bong Lee, Chan Ik Park, Gil Hwan Kim, Dong Yeon Ryu, Sun Hyun Kim

“…Surgical indications encompassed emergency cases involving intrathoracic injuries, unstable fractures, severe dislocations, flail chest, malunion, and persistent high-grade pain. …”
Get full text

Evaluation of musculoskeletal complaints, treatment approaches, and patient perceptions in family medicine clinics in a tertiary center in Jordan: a cross-sectional study by Moh’d S. Dawod, Mohammad N. Alswerki, Ahmad F. Alelaumi, Jehad Feras AlSamhori, Rana J. Rahhal, Lina Khraisat, Eman Mohammad Arabas, Hussein M. Bdair, Reem M. Alhyari, Mohammad Shahin, Mohammad Abu Hilal, Alaa Y. Akel, Aws Khanfar

“…Results In our study of 500 patients (mean age 46.1 years, 61.5% female), key gender differences emerged. Females had a higher prevalence of low back pain (61.9% vs. 38.1%, p = 0.024) and hip pain (100%, p = 0.008), as well as greater anxiety about disease progression (62.2% vs. 37.8%, p = 0.045) and fear of disability (64.2% vs. 35.8%, p = 0.048). …”
Get full text

European System for Cardiac Operative Risk Evaluation II and Liver Dysfunction by Andreea Ludusanu, Adelina Tanevski, Bogdan Mihnea Ciuntu, Razvan Lucian Bobeica, Dragos Andrei Chiran, Cristinel Ionel Stan, Viorel Dragos Radu, Vasile Lucian Boiculese, Grigore Tinica

“…<b>Methods:</b> This was a retrospective study, and it included 185 patients, with 93 survivors being randomly chosen from a total of 589 surviving patients using age, emergency and the weight of cardiac procedures as criteria to match the 92 deceased patients during hospitalization in the postoperative period who underwent coronary artery bypass grafting (CABG) alone or CABG and other concomitant cardiovascular interventions during a 10-year period of time. …”
Get full text

A randomized, double-blind, Phase 1, single- and multiple-dose placebo-controlled study of the safety and pharmacokinetics of IN-006, an inhaled antibody treatment for COVID-19 in... by Thomas R. Moench, Lakshmi Botta, Brian Farrer, Jason D. Lickliter, Hyunah Kang, Yoona Park, Cheolmin Kim, Marshall Hoke, Miles Brennan, Morgan D. McSweeney, Zachary Richardson, John B. Whelan, Jong Moon Cho, Soo Young Lee, Frances Faurot, Jeff Hutchins, Samuel K. Lai

“…All enrolled participants completed the study without treatment interruption or discontinuation. All treatment-emergent adverse events were transient, non-dose dependent, and graded mild to moderate in severity. …”
Get full text

Association between glyphosate exposure and cardiovascular health using “Life’s Essential 8” metrics in US adults by Yuankang Zhu, Zhenlin Yang, Yuhao Chen, Lingzi Qian, Changning Hao, Liangshi Hao, Boshen Yang, Junli Duan

“…A non-linear relationship between glyphosate and total CVH emerged (p for non-linear<0.001, p for overall = 0.003), and no safe threshold of glyphosate was observed. …”
Get full text

Addressing evidence needs during health crises in the province of Quebec (Canada): a proposed action plan for rapid evidence synthesis by Quan Nha Hong, Esther McSween-Cadieux, Maxime Guillette, Luiza Maria Manceau, Jingjing Li, Vera Granikov, Marie-Pascale Pomey, Marie-Pierre Gagnon, Saliha Ziam, Christian Dagenais, Pierre Dagenais, Alain Lesage, Thomas G. Poder, Martin Drapeau, Valéry Ridde, Julie Lane

“…Conclusions This project led to the development of a collective action plan aimed at preparing the Quebec ecosystem and other similar jurisdictions to meet knowledge needs more effectively in times of health emergency. The implementation of this plan and its evaluation will enable us to continue to fine-tune it.…”
Get full text

Association between different modalities of opioid use disorder-related care delivery and opioid use disorder-related patient outcomes: A retrospective cohort study by Nahiyan Bin Noor, George Pro, Mahip Acharya, Hari Eswaran, Corey J. Hayes

“…We examined the association between the most common modality of OUD-related care delivery (audio-only vs. audiovisual vs. in-person) and the number of emergency department (ED) visits for any overdose and opioid-specific overdose and receipt of medication treatment for OUD (MOUD; primary). …”
Get full text

Subsequent chemical and foraging ecology preferences of Theocolax elegans (Westwood) (Hymenoptera: Pteromalidae) reared on two alternate stored product host insects by Jacqueline M. Maille, Chloe E. Albin, Rachel R. Harman, Matthew C. Hetherington, Sabita Ranabhat, Jennifer Abshire, Jaye Montgomery, Ian M. Stoll, Madison Lillich, Samantha Gillette, Daniel Brabec, Kun Yan Zhu, Erin D. Scully, Alison R. Gerken, William R. Morrison, III

“…., the habitat in which a wasp emerges from a pupa) may influence the semiochemicals an organism utilizes when foraging for oviposition sites. …”
Get full text