Trimetazidine: Activating AMPK Signal to Ameliorate Coronary Microcirculation Dysfunction after Myocardial Infarction by Xiaolong Qu, Pan Yang, Li Jiao, Yuehui Yin

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Predictors of treatment failure of tubal pregnancy with single-dose methotrexate regimen – a systematic review and meta-analysis by Lili Tang, Sipei Nie, Ling Ling, Qian Zhu

“…Background Ectopic pregnancies represent a potentially life-threatening medical emergency, with 95% being tubal. This meta-analysis aimed to identify early predictors for single-dose methotrexate (MTX) treatment failure in tubal pregnancies.Methods A literature search was conducted across several databases from their inception to December 2023, with references in the selected studies manually reviewed. 14 studies involving 2,804 patients were included in this meta-analysis.Results The results revealed that higher serum beta-human chorionic gonadotropin (β-hCG) levels on Day 1 (SMD = 1.25, 95% CI 0.73–1.77), foetal cardiac activity presence (OR = 12.64, 95% CI 3.15–50.75), adnexal mass presence (OR = 4.66, 95% CI 2.02–10.74), yolk sac presence (OR = 5.35, 95% CI 2.33–12.27), thicker endometrium (MD = 1.74, 95% CI 0.30–3.19), more number of previous ectopic pregnancies (MD = 0.21, 95% CI 0.13–0.30), history of pelvic inflammatory disease (PID) (OR = 3.97, 95% CI 2.02–7.79), higher progesterone levels on Day 1 (SMD = 0.22, 95% CI 0.07–0.36), a higher 48-hour pre-treatment increment in serum β-hCG percentage (MD = 11.46, 95% CI 2.95–19.98), and a higher percentage of serum β-hCG change from Day 4 to Day 0/1 (SMD = 2.58, 95% CI 1.02–4.14) were early predictive factors for treatment failure of tubal pregnancy with the MTX single-dose regimen.Conclusions This review clarifies early predictive factors for treatment failure with the MTX single-dose regimen in tubal pregnancies. …”
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Pre-injury frailty and clinical care trajectory of older adults with trauma injuries: A retrospective cohort analysis of A large level I US trauma center. by Oluwaseun Adeyemi, Corita Grudzen, Charles DiMaggio, Ian Wittman, Ana Velez-Rosborough, Mauricio Arcila-Mesa, Allison Cuthel, Helen Poracky, Polina Meyman, Joshua Chodosh

“…<h4>Objectives</h4>We sought to determine the relationship between frailty status and the care trajectories of older adult patients who underwent frailty screening in the emergency department (ED).<h4>Methods</h4>Using a retrospective cohort design, we pooled trauma data from a single institutional trauma database from August 2020 to June 2023. …”
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STUDY OF COMPATIBILITY OF METHODS AND TECHNOLOGIES OF HIGH-LEVEL PROTOCOLS AND ERROR-CORRECTING CODES by Vladyslav Sharov, Olena Nikulina

“…Simultaneously, VPNs remain critical for preserving user privacy, securing corporate networks, and protecting sensitive data in the face of sophisticated cyberattacks. Emerging technologies like quantum computing and artificial intelligence introduce both opportunities and threats, necessitating continuous innovation in these fields. …”
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Effects of a nurse-led peer support intervention for stroke survivors: protocol for a randomised controlled trial by Ying Wu, Janita Pak Chun Chau, Xiaojuan Wan, Limei Xu, Weijuan Gong

“…Introduction Many stroke survivors have unmet psychosocial needs during the recovery phase following a stroke. There is emerging evidence that peer support interventions may play a valuable role in managing stroke. …”
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Evaluating the Efficacy of Combined Intravaginal Estriol Therapy and Kegel Exercises in Managing Menopausal Atrophic Vulvovaginitis by Lucian Șerbănescu, Vadym Rotar, Dragoș Brezeanu, Sebastian Mirea, Elena-Valentina Ionescu, Paris Ionescu

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Value Cocreation and Codestruction in Digital Health Services: Protocol for a Systematic Review by Elina Laukka, Tuure Tuunanen, Miia Jansson, Minna Vanhanen, Nina Hirvonen, Jenni Palukka, Märt Vesinurm, Paulus Torkki

“…In the field of health care, the concepts of value cocreation and codestruction still need to be better established within emerging digital health services. Studying these concepts is essential for developing effective and sustainable patient-centered care. …”
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Beta-hydroxy-beta-methyl butyrate supplementation in critically ill patients: a systematic review and meta-analysis of randomized controlled trials by Yu Ren, Ya-Bei Gao, Da-Xing Yu, Hui-Bin Huang

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Correlations between caregiver competence, burden and health-related quality of life among Chinese family caregivers of elderly adults with disabilities: a cross-sectional study us... by Yan Shi, Shuzhen Niu, Silian Ding, Songqi Wu, Jiajia Ma

“…Objective To examine the relationship between caregiver competence and health-related quality of life (HRQoL) among family caregivers of disabled elderly adults, and to evaluate the role of caregiver burden as a potential mediator of that relationship.Design Cross-sectional study.Setting Two general hospitals in Shanghai, China.Participants Study participants were 135 family caregivers of disabled elderly adults listed on a roster for outpatient and emergency services utilisation from January to March 2022.Data analysis and outcome measures We used stratified linear regression and structural equation model analysis. …”
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Status of continuous glucose monitoring use and management in tertiary hospitals of China: a cross-sectional study by Xiaoqin Liu, Hongmei Dai, Liping Wu, Yong Zhao, Zumin Shi, Qin Lin, Liping Chen

“…Seventy-three (88.0%) hospitals had developed CGM standard operating procedures, but only 29 (34.9%) hospitals devised emergency plans to deal with adverse effects related to CGM. …”
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Effects of Video-based Gesture Gaming on Hand Functions in Autistic Population: A Quasi-experimental Study by J Sangeetha Priya, Kalidasan Varathan

“…Video gaming technology are emerging as valid tool in the intervention protocols for autism, by showing significant improvements in motor strength and executive functions. …”
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A scoping review on the impact of women’s global leadership: evidence to inform health leadership by Anna Kalbarczyk, Rosemary Morgan, Kelly E Perry, Katherine Banchoff, Charlotte Pram Nielsen, Anju Malhotra

“…Introduction The documented benefits of gender parity in leadership are emerging—women leaders have been shown to have a positive impact on maternal and health care policies, strengthen health facilities, and reduce health inequalities. …”
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Trait mindfulness in early pregnancy and adverse perinatal outcomes: a prospective cohort study by Audra C. Fain, Tess E. K. Cersonsky, Margaret H. Bublitz, Adam K. Lewkowitz, Erika F. Werner, Emily S. Miller, Nina K. Ayala

“…Abstract Background Mindfulness centered therapy has been shown to improve perinatal mental health outcomes. There is emerging evidence that mindfulness training (MT) can also be harnessed to improve somatic outcomes. …”
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Clinical Activity of Behcet&rsquo;s Disease Associated with SARS-CoV-2 and Herpes Simplex Virus: Insights from Three Case Reports by Bakti FU, Sufiawati I

“…In contrast, Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has recently emerged and may also initiate or worsen BD symptoms. …”
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Racial and gender disparities in patients undergoing mechanical thrombectomy for large vessel occlusion at a comprehensive stroke center by Olivia Duru, Ryan G. Eaton, Nathan Ritchey, Sharon Heaton, Ciarán J. Powers

“…These disparities may result from a multitude of other factors such as eligibility for MT, delayed presentation, and adequate diagnosis of LVO in the emergency department. This study highlights the importance of and potential causes of these disparities. …”
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Quality of Life Assessment in Diabetic Patients Using a Validated Tool in a Patient Population Visiting a Tertiary Care Center in Bhubaneswar, Odisha, India by Dayanidhi Meher, Sonali Kar, Mona Pathak, Snigdha Singh

“…Age over 50 years (OR = 1.81, CI 1.12–2.93; p=0.014), female gender (OR = 2.05, CI 1.26–3.35; p=0.004), having foot complications (OR = 2.81, CI 1.73–4.55; p<0.001), and having depression (OR = 1.88, CI 1.15–3.06, p=0.011) emerged as predictors of poor QOLID scores. The tool can be made a subtle part of chronic case management of diabetes to ensure patient’s participation in the treatment of the disease and to create a database that can redefine diabetic care in India to suit the diverse regional settings in the country.…”
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Multimodal low-opioid anesthesia as a factor in reducing the activation of the proinflammatory response in cardiac surgery by S.R. Maruniak, O.A. Loskutov, O.M. Druzhyna, I.R. Malysh, V.G. Kolesnikov, N.O. Korotchuk

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Detection of Alzheimer Disease in Neuroimages Using Vision Transformers: Systematic Review and Meta-Analysis by Vivens Mubonanyikuzo, Hongjie Yan, Temitope Emmanuel Komolafe, Liang Zhou, Tao Wu, Nizhuan Wang

“…Vision transformers (ViTs) are emerging as promising deep learning models in medical imaging, with potential applications in the detection and diagnosis of AD. …”
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Estimating the impact of school closures on the COVID-19 dynamics in 74 countries: A modelling analysis. by Romain Ragonnet, Angus E Hughes, David S Shipman, Michael T Meehan, Alec S Henderson, Guillaume Briffoteaux, Nouredine Melab, Daniel Tuyttens, Emma S McBryde, James M Trauer

“…We identified critical mechanisms for consideration in future policy decisions, highlighting the unpredictable nature of emerging variants and potential shifts in infection demographics associated with school closures.…”
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New Predictors of Early and Late Outcomes after Primary Percutaneous Coronary Intervention in Patients with ST-Segment Elevation Myocardial Infarction and Unprotected Left Main Cor... by Cãlin Homorodean, Adrian Corneliu Iancu, Daniel Leucuţa, Şerban Bãlãnescu, Ioana Mihaela Dregoesc, Mihai Spînu, Mihai Ober, Dan Tãtaru, Maria Olinic, Dan Bindea, Dan Olinic

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