The BET inhibitor JQ1 targets fat metabolism and counteracts obesity by Claudia Fornelli, Alessia Sofia Cento, Lorenzo Nevi, Raffaella Mastrocola, Gustavo Ferreira Alves, Giuseppina Caretti, Massimo Collino, Fabio Penna

“…Total fat mass frequently increases during aging, often coexisting with sarcopenia, thus resulting in an emerging condition defined sarcopenic obesity (SO). …”
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Inflammation and Immune Escape in Ovarian Cancer: Pathways and Therapeutic Opportunities by Liu C, Yin Q, Wu Z, Li W, Huang J, Chen B, Yang Y, Zheng X, Zeng L, Wang J

“…COX-2 inhibitors, Janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway blockers, and NF-kB inhibitors have shown potential in preclinical studies, while immune checkpoint inhibitors targeting PD-1/PD-L1 and CTLA-4 have been explored with mixed results in OC. Additionally, emerging research on the microbiome and inflammation-related biomarkers, such as microRNAs (miRNAs) and exosomes, points to new opportunities for early detection and precision medicine. …”
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Prognostic impact of tumor size on cancer-specific survival for postoperative WHO grade II oligodendroglioma: a SEER-based study by Qin Lu, Yongyan Wu, Yonglin Xie, Shuxu Yang, Hongchuan Jin

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Persistent cross-species transmission systems dominate Shiga toxin-producing Escherichia coli O157:H7 epidemiology in a high incidence region: A genomic epidemiology study by Gillian AM Tarr, Linda Chui, Kim Stanford, Emmanuel W Bumunang, Rahat Zaheer, Vincent Li, Stephen B Freedman, Chad R Laing, Tim A McAllister

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Spatial-temporal distribution and evolution of medical and health talents in China by Lei Zhang, Jie Tang, Qianqian Zhou, Yu Song, Dayong Zhang

“…Abstract Background In the context of public health emergencies, the presence of medical and health talents (MHT) is critically important for support in any country or region. …”
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The association of perirenal adipose tissue accumulation with left ventricular hypertrophy and the mediating role of insulin resistance: a cross-sectional study involving 1112 indi... by Wei Wang, Yang Chen, Xiu Ping Qiu, Xiu Li Guo

“…Adjusting for confounding factors, the LVMI demonstrated a positive correlation with PrFT (β=0.262, P<0.001) and TG/HDL-c (β=0.206, P<0.001). PrFT and TG/HDL-c emerged as independent variables for LVH, with odds ratios of 1.33 (95%CI:1.24-1.43, P<0.001) and 1.20 (95%CI:1.05-1.36, P=0.006), respectively. …”
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Access to support services for individuals who experience intimate partner violence during stressful life events (SLEs) in high-income countries: Protocol for a scoping review. by Dina Idriss-Wheeler, Ziad El-Khatib, Sanni Yaya

“…., pandemics and natural/environmental disasters/emergencies, economic recessions) where possible, highlighting key barriers, facilitators and lessons learned. …”
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Chronic Kidney Disease Preventive Attitude, Practice, and Associated Factors among Type 2 DM Patients in Ethiopia: A Cross-Sectional Study by Addisu Dabi Wake MSc, Sena Babsa Dinsa BSc

“…Introduction Globally, chronic kidney disease (CKD) has emerged as one of the leading causes of mortality and it is one of a small number of noncommunicable diseases that have shown an increase in associated deaths over the past two decades. …”
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A randomised trial comparing preoperative administration of single-dose kefazolin to kefazolin plus metronidazole as prophylactic antibiotics at caesarean section by R Lamfel, L Snyman, L Seopela, G Jahn, P Becker

“…All patients undergoing emergency or elective caesarean section were randomised and then sequentially numbered in opaque sealed envelopes, which were placed in the caesarean section operating theatre. …”
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Prevalence of COVID-19 Vaccine Hesitancy Among Healthcare Workers in Nigeria: A Systematic Review and Meta-Analysis by Taagbara Jolly Abaate, Dabota Yvonne Buowari, Utchay A. Agiri, Tamunodiepiriye Inimgba, Vivian Ifeoma Ogbonna, Chizaram Onyeaghala, Glory Ovunda Worgu, Abiye Somiari, Emmanuella I. Ezebuiro, Ibe Arthur Onuah

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Real-World Health Care Outcomes and Costs Among Patients With Juvenile Idiopathic Arthritis in Spain by Jordi Antón, Estefania Moreno Ruzafa, Mireia Lopez Corbeto, Rosa Bou, Judith Sánchez Manubens, Sonia Carriquí Arenas, Joan Calzada Hernández, Violetta Bittermann, Carolina Estepa Guillén, Juan Mosquera Angarita, Lucía Rodríguez Díez, Estíbaliz Iglesias, Miguel Marti Masanet, Berta Lopez Montesinos, Maria I. González Fernández, Alfonso de Lossada, Carmen Peral, Mónica Valderrama, Noelia Llevat, María Montoro Álvarez, Immaculada Calvo Penadés

“…Direct costs included medication, specialist and primary care visits, hospitalizations, emergency visits or consultations, surgeries, physiotherapy, and tests. …”
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Simultaneous Anti-Tuberculosis and Anti-Tumor Treatment with Immune Checkpoint Inhibitors for Co-Existent Pulmonary Tuberculosis and Advanced Lung Cancer by Wang H, Gao L, Cai X, Li J, Lang Y, Zheng R, Yang S

“…Huaichong Wang,1 Liujie Gao,2 Xinjun Cai,1 Jinmeng Li,1 Yuying Lang,1 Ren Zheng,1 Shengya Yang3 1Department of Pharmacy, Hangzhou Red Cross Hospital, Hangzhou, Zhejiang Province, People’s Republic of China; 2Department of Oncology, Hangzhou Red Cross Hospital, Hangzhou, Zhejiang Province, People’s Republic of China; 3Tuberculosis Diagnosis and Treatment Center, Hangzhou Red Cross Hospital, Hangzhou, Zhejiang Province, People’s Republic of ChinaCorrespondence: Shengya Yang, Tuberculosis Diagnosis and Treatment Center, Hangzhou Red Cross Hospital, East Huancheng Road No. 208, Hangzhou, Zhejiang Province, People’s Republic of China, Email 15967116949@163.comBackground: Immune checkpoint inhibitors (ICIs) have emerged as the first-line treatment for driver-negative advanced non-small cell lung cancer (NSCLC). …”
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Three effective cases of transcatheter arterial embolization after atezolizumab and bevacizumab treatment for hepatocellular carcinoma: a case report by Koji Rinka, Kiyohide Kioka, Yuga Amano, Takashi Nakai, Yasuko Kawasaki, Norifumi Kawada

“…However, the concepts of transcatheter-arterial-chemoembolization-unsuitable and transcatheter-arterial-chemoembolization-refractory tumors have emerged. The authors herein describe three Japanese patients with hepatocellular carcinoma who were treated with atezolizumab and bevacizumab followed by transcatheter arterial embolization or transcatheter arterial chemoembolization. …”
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Inequalities in colorectal cancer diagnosis by ethnic group: a population-level study in the English National Health Service by Amy Downing, Mo Thoufeeq, James Turvill, Eva J A Morris, Phil Quirke, John C Taylor, Rebecca J Birch, Nick E Burr

“…The Asian ethnic group had significantly lower odds of emergency diagnosis than the white ethnic group (OR 0.90, 95% CI 0.83 to 0.97). …”
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Elucidating the expression and role of cGAS in pan-cancer using integrated bioinformatics and experimental approaches by Zhen Lian, Xue Liu, Xue Li

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Exploring the association between statins use or HMG-CoA reductase inhibition and migraine: a systematic review and meta-analysis by Hamdy A. Makhlouf, Amr K. Hassan, Nereen A. Almosilhy, Ahmed S.A. Osman, Shrouk Ramadan, Moaz Elsayed Abouelmagd

“…Conclusions Statins, already well-established for cardiovascular benefits, emerge as a promising dual-purpose therapy for many neurological disorders. …”
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A New X-Ray and Radio Burst Activity from the Magnetar SGR 1935+2154 by Noor S. Rehan, Alaa I. Ibrahim

“…SGR 1935+2154 has emerged as the most active magnetar in recent years, exhibiting X-ray burst activity nearly annually and emitting a fast radio burst (FRB 200428 (FRB1)) in its 2020 April activity, for the first time from a Milky Way source, accompanied by an X-ray burst (X _FRB1 ). …”
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FedBFGCN: A Graph Federated Learning Framework Based on Balanced Channel Attention and Cross-Layer Feature Fusion Convolution by Hefei Wang, Ruichun Gu, Jingyu Wang, Xiaolin Zhang, Hui Wei

“…Graph Federated Learning (GFL) is an emerging distributed training paradigm that combines federated learning with graph data. …”
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Covid-19 Pandemisinde Genç Ergenlerin Uzaktan Eğitim ile İlgili Görüş ve Yaşadığı Durumların Belirlenmesi by Ulviye Günay, Abdullah Sarman

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PSYCHOLOGICAL FEATURES OF PROFESSIONAL IDENTITY CRISIS EXPERIENCE BY TEACHERS by N. O. Sadovnikova, F. Zannoni

“…At the same time, against the backdrop of the low social status of the profession as well as the increasing requirements for the level of performance of activities, many teachers and educators are not prepared to rethink own role in the modern educational process and to resolve emerging professional difficulties. The aim of the publication is to analyze the essence of the concept of “professional identity crisis” and to disclose the psychological features of the experience of this state by teachers. …”
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