An integrated approach to flood risk assessment using multi-criteria decision analysis and geographic information system. A case study from a flood-prone region of Pakistan by Muhammad Ibrahim, Aidi Huo, Aidi Huo, Aidi Huo, Waheed Ullah, Safi Ullah, Zhao Xuantao

“…However, the current research lacks strength in identifying high-risk areas, implementing flood early warning systems, prioritising risk reduction measures, and allocating resources for emergency response planning and management. This study aims to assess flood hazard in Mirzadhare, Charsadda a highly flood-prone area in Khyber Pakhtunkhwa province of Pakistan. …”
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Pooled safety analysis of two phase 3 studies investigating trifluridine/tipiracil plus bevacizumab in patients with metastatic colorectal cancer by Julien Taieb, Marwan Fakih, Gabor Liposits, Gerald W. Prager, Eric Van Cutsem, Fortunato Ciardiello, Nadia Amellal, Elizabeth Calleja, Mei Liu, Lucas Roby, Josep Tabernero, Thierry André

“…This pooled analysis was performed to further characterize the safety of FTD/TPI plus bevacizumab and to compare safety in untreated and previously treated patients with mCRC.MethodsPatients must have received at least one dose of FTD/TPI plus bevacizumab in SOLSTICE (NCT03869892) or SUNLIGHT (NCT04737187). Treatment-emergent adverse events (TEAEs) in SOLSTICE and SUNLIGHT were graded per Common Terminology Criteria for Adverse Events versions 4.03 and 5.0, respectively. …”
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Prediction of Soil Organic Carbon Content in <italic>Spartina alterniflora</italic> by Using UAV Multispectral and LiDAR Data by Jiannan He, Yongbin Zhang, Mingyue Liu, Lin Chen, Weidong Man, Hua Fang, Xiang Li, Xuan Yin, Jianping Liang, Wenke Bai, Fuping Li

“…The results show that the following. 1) The prediction accuracy is improved by classifying the data into three types: unlodging <italic>S. alterniflora</italic> (ULSA), lodging <italic>S. alterniflora</italic> (LSA), and mudflats. 2) XGBoost outperformed RF and SVM in accurately predicting SOC content, with <italic>R</italic>²; values of 0.743 for ULSA, 0.731 for LSA, and 0.705 for mudflats; 3) In the XGBoost models constructed for ULSA, LSA, and mudflats, spectral features contributed 75.7&#x0025;, 73.1&#x0025;, and 63.1&#x0025;, respectively, with the normalized difference vegetation index emerging as the most critical spectral feature. Slope aspect (AS) was identified as the most influential topographic feature. 4) The spatial distribution of SOC exhibited marked heterogeneity, with higher SOC content in ULSA and lower in mudflats, demonstrating a gradient of decreasing SOC content from land to sea. …”
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ROR1 CAR-T cells and ferroptosis inducers orchestrate tumor ferroptosis via PC-PUFA2 by Dan Li, Wenjie Zhang, Ruiheng Wang, Shufeng Xie, Yixin Wang, Wanxin Guo, Zixuan Huang, Chaoqun Lu, Liang Shan, Han Liu, Lifang Ma, Xumin Hou, Zhenshu Xu, Jiayi Wang

“…Abstract Background Lung cancer, particularly non-small cell lung cancer (NSCLC), has high recurrence rates and remains a leading cause of cancer-related death, despite recent advances in its treatment. Emerging therapies, such as chimeric antigen receptor (CAR)-T cell therapy, have shown promise but face significant challenges in targeting solid tumors. …”
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Preparation and Electrochemical Characterization of Y-Doped Li_1.3Al_0.3Ti_1.7(PO₄)₃ Solid Electrolytes for Lithium-Metal Batter... by Zhongran Yao, Fen Qi, Qiang Sun, Lin Ye, Xiaowei Yang, Guojie Chao, Pei Tang, Kongjun Zhu

“…Lithium-conducting NASICON materials have emerged as a promising alternative to organic liquid electrolytes for high-energy-density Li-metal batteries, owing to their superior ionic conductivity and excellent air stability. …”
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Reactogenicity and Immunogenicity Against MPXV of the Intradermal Administration of Modified Vaccinia Ankara Compared to the Standard Subcutaneous Route by Valentina Mazzotta, Pierluca Piselli, Alessandro Cozzi Lepri, Giulia Matusali, Eleonora Cimini, Rozenn Esvan, Francesca Colavita, Roberta Gagliardini, Stefania Notari, Alessandra Oliva, Silvia Meschi, Rita Casetti, Giulia Micheli, Licia Bordi, Alessandro Giacinta, Germana Grassi, Saba Gebremeskel Tekle, Claudia Cimaglia, Jessica Paulicelli, Alessandro Caioli, Paola Gallì, Giulia Del Duca, Miriam Lichtner, Loredana Sarmati, Enrica Tamburrini, Claudio Mastroianni, Alessandra Latini, Paolo Faccendini, Carla Fontana, Emanuele Nicastri, Andrea Siddu, Alessandra Barca, Francesco Vaia, Enrico Girardi, Fabrizio Maggi, Andrea Antinori

“…Background: The recent resurgence of mpox in central Africa has been declared a new public health emergency of international concern (PHEIC) requiring coordinated international responses. …”
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Short-term costs of alcohol-associated hepatitis care in different clinical settings by Chi Mai Nguyen, Jing Su, Yang Li, Ryan Healey, Shihui Jiang, Jiangqiong Li, Naga Chalasani, Samer Gawrieh, Suthat Liangpunsakul, Wanzhu Tu

“…This study quantifies medical costs within 30 days of an AH diagnosis across outpatient (OP), emergency department (ED), and inpatient (IP) settings. …”
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Potency of Bone Marrow-Derived Mesenchymal Stem Cells and Indomethacin in Complete Freund’s Adjuvant-Induced Arthritic Rats: Roles of TNF-α, IL-10, iNOS, MMP-9, and TGF-β1 by Eman A. Ahmed, Osama M. Ahmed, Hanaa I. Fahim, Tarek M. Ali, Basem H. Elesawy, Mohamed B. Ashour

“…Hence, the need for other treatment modalities has emerged in an attempt to develop a treating agent that is effective but without bad effects. …”
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Global disparities in cancer supportive care: An international survey by Alexandre Chan, Lawson Eng, Changchuan Jiang, Mary Dagsi, Yu Ke, Mary Tanay, Cristiane Bergerot, Niharika Dixit, Ana Cardeña Gutiérrez, Ana I. Velazquez, Farhad Islami, Enrique Soto‐Perez‐de‐Celis

“…Results A total of 218 active members participated, with one‐quarter (26.6%) from LMIC and 18.4% ethnic minorities, timely cancer care (43.7%) and timely supportive care (45.0%) emerged as the most pressing disparities globally. …”
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Evaluating Community Engagement Strategies to Manage Stigma in Two African Genomics Studies Involving People Living with Schizophrenia or Rheumatic Heart Disease by Megan M. Campbell, Olivia P. Matshabane, Sibonile Mqulwana, Michael Mndini, Mohamed Nagdee, Dan J. Stein, Jantina De Vries

“…Three important learnings emerged from these evaluations: firstly, integration of evaluation strategies at the research study planning phase is likely to promote more effective community engagement. …”
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Holistic health and social care outreach for people experiencing homelessness with recent non-fatal overdose in Glasgow, Scotland: the Pharmacist and third sector Homeless charity... by Vibhu Paudyal, Nicola Greenlaw, Frances S Mair, Kate Stock, Andrew McPherson, Andrea E Williamson, Richard Lowrie, Donogh Maguire, Steven Ross, James Roy Robertson, Alison Boyle, Clare Duncan, Rebecca Blair, Cian Lombard, Fiona Hughes, Jane Moir, Ailsa Scott, Frank Reilly, Laura Sills, Jennifer Hislop, Stephen Wishart, David Brannan, Rebekah Ramage

“…Objectives To examine randomised controlled trial (RCT) progression criteria including emergency department (ED) attendance and non-fatal overdose, from a holistic, integrated health and social care outreach intervention (PHOENIx), for people experiencing homelessness with recent non-fatal street drug overdose.Design Pilot RCT. 1:1 randomisation to PHOENIx plus usual care (UC) or UC.Setting Glasgow, Scotland.Participants 128 adults experiencing homelessness with at least one non-fatal street drug overdose in the preceding 6 months.Interventions Pharmacists from the National Health Service and third sector homelessness workers offered weekly outreach. …”
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Management of sleep apnoea syndrome (SAS) in patients with vasovagal syncope (VVS): a protocol for the VVS-SAS cohort study by Jean Louis Pepin, Nicolas Molinari, Frédéric Gagnadoux, Carey Meredith Suehs, Frédéric Roche, Vincent Puel, Isabelle Godard, Georgios Papaioannou, Philippe Gosse, Fabrice Thoin, Jean Claude Deharo, Naïma Zarqane

“…Introduction Recurrent vasovagal syncope (VVS) is associated with decreased quality-of-life and frequent use of emergency services. The evidence base for causality, diagnostic procedures and potential VVS treatments is poor. …”
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Water Management of Arabica Coffee Seedlings Cultivated with a Hydroretentive Polymer by Mateus Oliveira Silva, Vanessa Reniele Souza de Arruda, Francisco Raylan Sousa Barbosa, Michel Wakim Mendes Firmino, Adriene Woods Pedrosa, Fernando França da Cunha

“…In this context, the use of hydroretentive polymers, particularly biodegradable ones, emerges as a promising alternative to optimize water use, reduce the environmental impact associated with synthetic polymers, and improve the agronomic traits of seedlings. …”
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Cobalt oxide nanoparticles induce cytotoxicity and excessive ROS mediated mitochondrial dysfunction and p53-independent apoptosis in melanoma cells by Hanan R. H. Mohamed, Basma A. Mohamed, George M. Hakeem, Shahd H. Elnawasani, Maria Nagy, Rawan Essam, Ayman Diab, Gehan Safwat

“…Abstract Nanotherapy has emerged as a promising strategy for the targeted and efficient treatment of melanoma, the most aggressive and lethal form of skin cancer, with minimized systemic toxicity. …”
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Antifungal, Insecticidal, and Repellent Activities of Rosmarinus officinalis Essential Oil and Molecular Docking of Its Constituents against Acetylcholinesterase and β-Tubulin by Ghizlane Houzi, Youness El abdali, Ghada Beniaich, Mohamed Chebaibi, Mohamed Taibi, Amine Elbouzidi, Samiha Kaioua, Abdeslam Asehraou, Mohamed Addi, Khalid Chaabane, Rachid Flouchi, Aimad Allali, Soad Khal-Layoun

“…Concentration-dependent reductions were observed in the number of both laid eggs and emerged insects, reaching a 99.36% reduction. The EO also exhibited a moderate effectiveness in repelling insects, with an average repellency rate of 50.83%. …”
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Epidemiology and Ecology of Toscana Virus Infection and Its Global Risk Distribution by Xue-Geng Hong, Mei-Qi Zhang, Fang Tang, Si-Hui Song, Jia-Yi Wang, Zhen-Yu Hu, Li-Ming Liu, Xiao-Ai Zhang, Yi Sun, Li-Qun Fang, Wei Liu

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The Economic Implications of Psychosocial Peer Support for Health Workers in German Hospitals by Strametz R, Roesner H, Neusius T, Wiesenhuetter I, Bushuven S, Mira JJ, Hinzmann D, Heininger S

“…Reinhard Strametz,1,&ast; Hannah Roesner,1,2,&ast; Thomas Neusius,1,&ast; Isabell Wiesenhuetter,1 Stefan Bushuven,3,4 José Joaquín Mira,2,5 Dominik Hinzmann,6 Susanne Heininger7 1Wiesbaden Institute for Healthcare Economics and Patient Safety, RheinMain UAS, Wiesbaden, Germany; 2Miguel Hernández University of Elche, Elche, Spain; 3Training Center for Emergency Medicine (NOTIS e.V), Engen, 78234, Germany; 4Department of Anesthesiology and Critical Care, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, 79106, Germany; 5Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO), Alicante, Spain; 6Department Clinical Medicine, Department of Anesthesiology and Intensive Care, TUM School of Medicine and Health, Technical University of Munich, Munich, Germany; 7Faculty for Applied Healthcare Sciences, Deggendorf Institute of Technology, Deggendorf, Germany&ast;These authors contributed equally to this workCorrespondence: Reinhard Strametz, Wiesbaden Institute for Healthcare Economics and Patient Safety, RheinMain UAS, Bleichstr. 3, Wiesbaden, 65183, Germany, Email reinhard.strametz@hs-rm.dePurpose: The objective of this study is to evaluate whether the nationwide establishment and institutionalization of a peer-support program, is economically justified given the potential positive effects on the Second Victim Phenomenon (SVP) among healthcare professionals in Germany.Methods: A comprehensive methodological approach was employed, using data from the SeViD studies to assess the prevalence and duration of SVP among physicians and nurses in Germany. …”
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The phytoplasma SAP54 effector acts as a molecular matchmaker for leafhopper vectors by targeting plant MADS-box factor SVP by Zigmunds Orlovskis, Archana Singh, Adi Kliot, Weijie Huang, Saskia A Hogenhout

“…Critically, the host plant MADS-box transcription factor short vegetative phase (SVP) emerges as a key element in the female leafhopper preference for plants exposed to males, with SAP54 promoting the degradation of SVP. …”
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TGFβ-specific T cells induced by a TGFβ-derived immune modulatory vaccine both directly and indirectly modulate the phenotype of tumor-associated macrophages and fibroblasts by Mads Hald Andersen, Inés Lecoq, Evelina Martinenaite, Maria Perez-Penco, Lucia Lara de la Torre

“…Reducing immunosuppression and immune exclusion in pancreatic tumors by targeting TAMs and CAFs with the TGFβ-based immune modulatory vaccine emerges as an innovative strategy for the generation of a more favorable environment for immune-based therapies, such as immune checkpoint inhibitors.…”
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Analysis of the relationship between abdominal aortic calcification and frailty in the middle-aged and older US population by Rena Rehemuding, Kaisaierjiang Kadier, Xinliang Peng, Pengfei Liu, Diliyaer Dilixiati, Aikeliyaer Ainiwaer, Xiaozhu Liu, Xiangtao Liu, Xiang Ma

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