Correlation of susceptibility to ortho-aminoazotolueneinduced hepatocarcinogenesis with Car and Ahr signaling pathway activation in mice by N. V. Baginskaya, E. V. Kashina, M. Yu. Shamanina, S. I. Ilnitskaya, V. I. Kaledin, V. A. Mordvinov

“…In resistant BR mice, OAT induced a pronounced and prolonged increase in Cyp1a1 mRNA, showing primarily Ahr activation, while the DD strain displayed a more pronounced elevation of Cyp2b10 expression, indicative of Car activation. …”
Get full text

Spatial-temporal evolution of habitat quality in tropical monsoon climate region based on “pattern–process–quality” – a case study of Cambodia by Kang Junmei, Yang Fengshuo, Wang Jun, Liu Yang, Fang Dengmao, Jiang Chengcheng

“…The results show that (1) during 2000–2022, forest in Cambodia covered a wide range, showing a landscape pattern mainly distributed in the east and west. (2) The degree of fragmentation of impervious landscape pattern increased gradually from 2000 to 2022, indicating that it was seriously affected by human activities and natural factors, and with the increase in elevation and slope, the area of various types converted to impervious decreased. (3) During 2000–2022, high habitat quality areas were concentrated in Tonle SAP Lake in the east, southwest, and central part of Cambodia, while low habitat quality areas were concentrated in the central part. (4) Natural factors, socio-economic factors, policies, and regulations all have an impact on the change in land use pattern and habitat quality in Cambodia.…”
Get full text

Relation Between Glycated Hemoglobin Level and Hearing Loss in Type 2 Diabetic Patients by Mayada ElSherif, Aya Fathey El Sayed Mahfouz, Noha Mohamed Gaber Amin, Hesham Saad Kozou

“…Conclusion: Poor glycemic control status [Hb A1c ≥ 7%] is significantly associated with elevated hearing thresholds.…”
Get full text

Impact of land use changes on waterlogging disasters in the small urban watershed of Hangzhou by Rikun Wen, Liu Yang, Hexian Jin, Hao Tao, Chingaipe N’tani

“…New hydrological insights for the region: 1) Using the GSSHA model to simulate waterlogging disasters at the small urban watershed scale was effective. 2) The waterlogging points in a small watershed were mainly distributed in areas with high building density, low forest area, low elevation, and low surface permeability. The most severely flooded points were often very close to the river system. 3) LULC has a significant impact on the spatial distribution of waterlogging points in small urban watersheds: When the forest area increases, the bare land area decreases, the area of land converted from construction land to forest land increases, the depth of waterlogging decreases, and the infiltration depth increases. 4) The responses of waterlogging and infiltration depth to forest cover exhibit spatial variations under the same rainfall intensity. …”
Get full text

Evaluation of Hepatoprotective Potential of Polyherbal Preparations in CCl4-Induced Hepatotoxicity in Mice by Rayhana Begum, Sonia Akther Papia, Mst Marium Begum, Hongbin Wang, Rubaba Karim, Rebeka Sultana, Priyanka Rani Das, Taslima Begum, Md. Ragibul Islam, Nargis Manwar, Md. Sohanur Rahman

“…CCl4 administration caused significant hepatotoxicity as evidenced by marked elevation in AST, ALT, ALP, and total bilirubin. Phenobarbitone-induced sleeping time and infiltration of inflammatory cells and centrizonal necrosis on histological examination of liver demonstrated hepatic injury after CCl4 administration. …”
Get full text

Hypnotics' association with mortality or cancer: a matched cohort study by Daniel F Kripke, Lawrence E Kline, Robert D Langer

“…Hypnotic use in the upper third was associated with a significant elevation of incident cancer; HR=1.35 (95% CI 1.18 to 1.55). …”
Get full text

Impact of strict IGF1 control on quality-of-life scores in patients with acromegaly by Chaitanya Gandhi, Marie-Claire Denis, Daniel Holmes, Juan Rivera, Stan van Uum, Shereen Ezzat, Constance Chik

“…ObjectiveExamine, in a real-world setting, whether strict normalization of modestly elevated insulin-like growth factor 1 (IGF1) results in clinical and health-related quality of life benefits in patients with acromegaly using an open-label, non-randomized, 6-month prospective interventional study.MethodsIn patients with acromegaly and modest IGF1 elevation, strict IGF1 control was achieved by addition or dose escalation of pegvisomant. …”
Get full text

The Role of Therapeutic Anticoagulation in COVID-19 by Ruth McGovern, Patrick Conway, Isabell Pekrul, Omar Tujjar

“…Her platelet count was normal and had an elevated fibrinogen during the first week of ICU stay. …”
Get full text

Focal Adhesion Kinase and ROCK Signaling Are Switch-Like Regulators of Human Adipose Stem Cell Differentiation towards Osteogenic and Adipogenic Lineages by Laura Hyväri, Miina Ojansivu, Miia Juntunen, Kimmo Kartasalo, Susanna Miettinen, Sari Vanhatupa

“…Inhibition of these kinases with specific small molecule inhibitors diminished osteogenesis, while inhibition of FAK and ROCK activity led to elevation of adipogenic marker genes AP2 and LEP and lipid accumulation implicating adipogenesis. …”
Get full text

Chronic Inflammatory Arthropathy Preceding Acute Systemic Manifestations of Sarcoidosis: A Possible Overlap of Idiopathic Juvenile Arthritis and Sarcoidosis by Matheus Campello Vieira, Priscilla Gomes Tosta, Fernanda Morello Nicole, Lucas Enock V. Roberto, Júlia Guasti P. Vianna, Paulo de Coelho Castro, Rafael Burgomeister Lourenço, Erica Vieira Serrano, Valéria Valim, Weverton Machado Luchi

“…The investigation revealed elevated serum calcium level, hepatosplenomegaly, retroperitoneal lymphadenopathy, anemia, thrombocytopenia, and nephrolithiasis. …”
Get full text

Effects of contralaterally controlled neuromuscular electrical stimulation on the connectivity pattern of poststroke patients with hemiplegia by ZHU Lan, SUI Youxin, WANG Qinglei, XU Sheng, SHEN Ying, GUO Chuan

“…The intensity of stimulation on the affected wrist was defined as the degree to which the affected wrist could be extended to the same extent （maximum elevation of the healthy wrist），but without causing pain. …”
Get full text

Effects of Dust Storms and Climatological Factors on Mortality and Morbidity of Cardiovascular Diseases Admitted to ED by Behcet Al, Mustafa Bogan, Suat Zengin, Mustafa Sabak, Seval Kul, M. Murat Oktay, Hasan Bayram, Ertan Vuruskan

“…Admission, hospitalization, and mortality due to chest pain both dependent and independent of ACS were increased by the presence of dust storms, PM10 elevation, and maximum temperature.…”
Get full text

Changes in movement patterns in relation to sun conditions and spatial scales in wild western gorillas by B. Robira, S. Benhamou, E. Obeki Bayanga, T. Breuer, S. Masi

“…By contrast, movement straightness was not markedly different when the sun elevation was low (the sun azimuth then being potentially usable as a compass) or high (so providing no directional information) and the sky was clear or overcast. …”
Get full text

Effects of Precipitation on the Air Quality Index, PM2.5 Levels and on the Dry Deposition of PCDD/Fs in the Ambient Air by Ruoxin Wang, Kangping Cui, Hwey-Lin Sheu, Lin-Chi Wang, Xueyan Liu

“…However, in some cases, the increase of source emissions and atmospheric vertical convection, the effect of precipitation or air humidity increased the AQI and elevated the concentration of PM2.5, and dry deposition flux of PCDD/Fs. …”
Get full text

Pre-injection of exosomes can significantly suppress ovarian cancer growth by activating the immune system in mice by Yuanyuan Wang, Changyi Zhang, Huimin Zeng, Liangliang Wang, Zanhong Wang, Zhiqiang Han

“…Additionally, there was a notable elevation in the concentration of interferon-gamma (IFN-γ) in peripheral blood. …”
Get full text

Efficacy and safety of avacopan in antineutrophil cytoplasmic autoantibody-associated vasculitis: a retrospective cohort study in Japan by Genri Tagami, Makoto Yamaguchi, Hirokazu Sugiyama, Hiroshi Kinashi, Kentaro Imai, Keisuke Kamiya, Takayuki Katsuno, Takahiro Imaizumi, Shogo Banno, Yasuhiko Ito, Takuji Ishimoto

“…Adverse events were reported in 10 patients (47.6%), with elevated liver enzyme levels observed in eight patients (38.1%) as the most frequent complication. …”
Get full text

Patient's head position-dependent safety analysis of birdcage coil, loop array, and dipole array for applications at 300 MHz in magnetic resonance imaging based on hydrogen nuclei:... by Eunwoo Lee, Taewoo Nam, Daniel Hernandez, Donghyuk Kim, Yeunchul Ryu, Yeji Han, Kyoung-Nam Kim

“…The specific absorption rate (SAR) substantially contributes to the elevation of patient temperatures during magnetic resonance imaging (MRI) scans, potentially leading to tissue degeneration and damage. …”
Get full text

Evaluation and driving force analysis of relative effectiveness in the giant panda national park in Sichuan, China by Bao Meng, Bao Meng, Mengchao Wang, Zhifeng Zhang, Hongyi Pan

“…The REI fell from 0.044 in 2000 to 0.031 in 2015 and although it then increased to 0.034 in 2020 to a small extent, the REI showed an overall decreasing trend, and the conservation effect has weakened. 2)The REI change patterns varied in different functional zones of the area, with a general fluctuation and decline, in which the Minshan and Baishuijiang Core Protection Area (MBJ-CPA) as a whole first rise and then fall, and it is the area with the best relative effectiveness of protection. 3) Natural factors such as temperature and elevation are the main factors affecting NDVI, while the influence of policy and economic factors such as the level of protected areas and distance to towns are increasing. …”
Get full text

Mapping forest-agroforest frontiers in the Peruvian Amazon with deep learning and PlanetScope satellite data by Wanting Yang, Daniel Ortiz-Gonzalo, Xiaoye Tong, Dimitri Gominski, Rasmus Fensholt

“…To achieve this, we combine deep learning and remote sensing data, including 3-m PlanetScope satellite imagery, a Digital Elevation Model (DEM), and temporal data from the Landtrendr change detection algorithm. …”
Get full text

Investigation of Herb-Drug Interactions between Xylopia aethiopica, Its Principal Constituent Xylopic Acid, and Antidepressants by Christian C. Ndu, Wonder K. M. Abotsi, Priscilla K. Mante

“…With interaction indices less than one, synergism of antidepressant effect was observed in the Xylopia aethiopica extract/fluoxetine (γXAE/FL = 0.502), Xylopia aethiopica extract/imipramine (γXAE/IP = 0.322), Xylopia aethiopica extract/venlafaxine (γXAE/VL = 0.601), xylopic acid/imipramine (γXA/IP = 0.556), xylopic acid/venlafaxine (γXA/VL = 0.451), and xylopic acid/fluoxetine (γXA/FL = 0.298) combinations, which may be potentially due to elevation of serotonergic neurotransmission via varying mechanisms. …”
Get full text