Sex-related association between smoke exposure and gallstones in a US population: a cross-sectional study by Xingyong Huang, Xuanyu Hao, Tingting Wang, Xiaoyue Zhang, Peng Wu, Lufan Shen, Yuanyuan Yang, Wanchuan Zhang, Kai Zhang

“…Conclusions This study indicates smoking and elevated serum cotinine levels may be risk factors associated with the development of gallstones. …”
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Pumpkin seed oil-loaded chitosan nanoparticles enhance growth, digestive enzymes, and immune response in whiteleg shrimp (Litopenaeus vannamei): Impacts on histopathology and survi... by El-Sayed Hemdan Eissa, Wesam Mohamed Salama, Samia Elbahnaswy, Mai A.M. El-Son, Zienab E. Eldin, Sara Amer, Layla A. Almutairi, Fatma Mohamed Ameen Khalil, Safia M.A. Bahshwan, Mada M. AL-Qurashi, Yasmin M. Abd El-Aziz, Moaheda E.H. Eissa, Aiman A. Alsaegh, Roshmon Thomas Mathew, El Sayed Taha Rizk

“…Furthermore, shrimp in these groups displayed significantly elevated total hemocyte counts, lysozyme activity, and bactericidal capacity (P < 0.05). …”
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Adaptation for Staphylococcus aureus to hosts via insertion mutation in the accessory gene regulator agrC gene: decreased virulence and enhanced persistence capacity by Jiawei Chen, Yun Wu, Ying Zhu, Li Zhang, Yingchun Xu, Yali Liu

“…ATP assay results indicated that 23B maintained elevated ATP levels during the exponential phase yet exhibited reduced levels in the stationary phase when compared with 23H. …”
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Exploring the alleviating effects of Bifidobacterium metabolite lactic acid on non-alcoholic steatohepatitis through the gut-liver axis by Hongmei Zhao, Hongmei Zhao, Juan Zhou, Lingzhi Yuan, Zhiyi Sun, Yi Liu, Xinyu Zhao, Feng Ye

“…In vitro, an NAFLD cell model was established using oleic acid, with cells treated with lactic acid and NLRP3 overexpression to assess lipid droplet accumulation and inflammation.ResultsIn vivo findings indicated that, in comparison to CBX group (Control group without antibiotic treatment), NAFLD/CBX group (NAFLD group without antibiotic administration) and NAFLD/ABX group (NAFLD group with antibiotic administration) exhibited increased liver-to-body weight ratio, higher lipid droplet accumulation, aggravated liver histopathological damage, and elevated levels of AST (Aspartate Aminotransferase), ALT (Alanine Aminotransferase), TC (Total Cholesterol), TG (Triglycerides), LDL-C (Low-Density Lipoprotein Cholesterol), IL-6 (Interleukin-6), TNF-α (Tumor Necrosis Factor-alpha), IL-1β (Interleukin-1 beta), and NLRP3-related molecules, while HDL-C (High-Density Lipoprotein Cholesterol) levels significantly decreased. …”
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Prognostic and diagnostic value of circRNA expression in cervical cancer: a meta analysis by Yi Xu, Yi Xu, Changxia Li, Changxia Li, Lifang Cheng, Shaoheng Wang, Yuqing Wu, Shiyang Li, Mingqiang Liu, Xiaohua Tao

“…The importance of circRNAs was further evaluated in terms of clinical relevance, pathological features, and prognostic value using pooled odds ratios (ORs) and hazard ratios (HRs).ResultsThe meta-analysis included 27 studies, which were categorised based on diagnostic applications (n=3), clinicopathological correlations (n=15), and prognostic evaluations (n=23). Elevated expression levels of oncogenic circRNAs were significantly associated with poor clinical indicators, including tumour size (odds ratio [OR] = 0.425, 95% confidence interval [CI]: 0.267–0.676), International Federation of Gynaecology and Obstetrics (FIGO) stage (OR = 0.315, 95% CI: 0.224–0.443), and lymph node metastasis (OR = 2.975, 95% CI: 1.816–4.872). …”
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Chinese herbal formula Tongxie Yaofang granules for diarrhoea-predominant irritable bowel syndrome: a randomised, double-blind, placebo-controlled, phase II trial by Nicola Robinson, Mei Han, Ling Yan, Vincent Chi Ho Chung, Jian-Ping Liu, Hui-Juan Cao, Shi-Bing Liang, Hong-Jie Cheng, Qiao-Yan Zhang, Yu-Fei Li, Ze-Yu Yu, Ling-Yao Kong, Yan-Mei Cai, Li-Bao An, Bao-Tuan Zhao, Shan-Shan Xu, Nai-Wei Zhang, Bo-Yi Jia, Wei-Fang Liu, Fang Niu, Ba-Teer Wu, Jin-Ming Song, Shu-Xin Jia, Meng-Meng Shi, Xiao-Na Zhang

“…Adverse events in the TXYF and placebo groups were one (sinus arrhythmia) and two (elevated transaminases, weakly positive faecal occult blood), respectively. …”
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New insights into the immunomodulatory potential of sialic acid on monocyte-derived dendritic cells by Zélia Silva, João Amorim Rabaça, Vanessa Luz, Rita Adubeiro Lourenço, Mariolina Salio, Alexandra Couto Oliveira, Pedro Bule, Sebastian Springer, Paula Alexandra Videira

“…Sialidase treatment induced rapid elevated surface expression of MHC-I, MHC-II and CD40 within an hour, a response not fully replicated by 48 h cytokine cocktail treatment. …”
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β-Catenin mediated TAM phenotype promotes pancreatic cancer metastasis via the OSM/STAT3/LOXL2 axis by Yijia Zhang, Xinya Zhu, Liyuan Chen, Tianyu Gao, Guang Chen, Jin Zhu, Guoyu Wang, Daiying Zuo

“…Additionally, mechanistic studies employed pharmacological inhibitors and genetic approaches targeting β-catenin, OSM, and STAT3 signaling.Notably, elevated expression of OSM and LOXL2 in PDAC specimens significantly correlated with poor patient survival. …”
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Anti-PD-1 amplifies costimulation in melanoma-infiltrating Th1-like Foxp3+ regulatory T cells to alleviate local immunosuppression by Fernando Alvarez, Fan Huang, Sonia V Del Rincon, Mikhaël Attias, Tho-Alfakar Al-Aubodah, Roman Istomine, Paige McCallum, Abrahim Sleiman, Tamiko Nishimura, Yasser Riazalhosseini, Ciriaco A Piccirillo

“…Using spatial proteomic and transcriptomic profiling, we demonstrate that Treg cells display an increased activity of PI3K/Akt signaling in regions of HR tumors with an elevated CD8:Treg cell ratio.Conclusions PD-1 blockade promotes the expansion of a subset of highly-activated Treg cells coexpressing PD-1 and Helios. …”
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Gαi1/3 signaling mediates IL-5-induced eosinophil activation and type 2 inflammation in eosinophilic chronic rhinosinusitis by Huanxia Xie, Jiang Ji, Zhichen Liu, Ning Lu, Yuqian Wei, Aina Zhou, Jisheng Liu, Qingqing Jiao, Qingqing Jiao

“…BackgroundUncontrolled severe eosinophilic chronic rhinosinusitis (eCRS) is associated with elevated levels of Th2 cells and raised immunoglobulin concentrations in nasal polyp tissue. eCRS is characterized by high eosinophilic infiltration and type 2 inflammation. …”
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Exome sequencing reveals a rare damaging variant in GRIN2C in familial late-onset Alzheimer's disease by Elisa Rubino, Maria Italia, Elisa Giorgio, Silvia Boschi, Paola Dimartino, Tommaso Pippucci, Fausto Roveta, Clara Maria Cambria, Gabriella Elia, Andrea Marcinnò, Salvatore Gallone, Ekaterina Rogaeva, Flavia Antonucci, Alfredo Brusco, Fabrizio Gardoni, Innocenzo Rainero

“…Surface expression assays demonstrated an elevated surface/total ratio of the mutant GluN2C, correlating with the increased NMDAR current. …”
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MiR-216a-3p inhibits the cytotoxicity of primary natural killer cells by Rowan Abdelbary, Rowan Abdelbary, Manon Ragheb, Manon Ragheb, Shereen A. El Sobky, Nagwa El-Badri, Nourhan Aboud, Ahmed Tawheed, Asmaa Gomaa, Mona Zidan, Ramy K. Aziz, Abd Elrahman Abouzid, Radwa Ayman Salah, Mohamed El-Kassas, Imam Waked, Ahmed Moustafa, Ahmed Moustafa, Injie Omar Fawzy, Nada El-Ekiaby, Ahmed Ihab Abdelaziz

“…After that, we performed an in silico analysis to understand the mechanistic regulation imposed by miR-216a-3p on NK cells to study its impact on one of its potential downstream targets.ResultsOur results have indicated that miR-216a-3p has higher expression in NK cells of patients with HCC, and simulating this elevated expression pattern via forcing miR-216a-3p expression in normal NK cells has negatively impacted the release of TNF- α, IFN- γ, GrB, and PRF. …”
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Limited Diagnostic Value of miRNAs in Early Trauma-Induced Liver Injury: Only miRNA-122 Emerges as a Late-Phase Marker by Jason-Alexander Hörauf, Amit Singh, Maika Voth, Hamed Moheimani, Cora Rebecca Schindler, Borna Relja, Liudmila Leppik, Ingo Marzi, Dirk Henrich

“…Conversely, L-FABP (<i>p</i> = 0.018) and ALT (<i>p</i> = 0.05) were significantly elevated in the LT group compared to the PT group at the time of ER admission. …”
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Low light reduces saffron corm yield by inhibiting starch synthesis by Weijing Yang, Weijing Yang, Xin Li, Xin Li, Fei Chang, Fei Chang, Xue Qiu, Xulong Huang, Xulong Huang, Zhan Feng, Zhan Feng, Jie Yan, Jie Yan, Qinghua Wu, Qinghua Wu, Feiyan Wen, Feiyan Wen, Jin Pei, Jin Pei, Tao Zhou, Tao Zhou

“…By the period of the daughter corms enlargement, elevated GA1 and IAA levels and reduced ABA concentration promote leaf growth while inhibiting carbohydrate metabolism in daughter corms, thereby reducing sucrose transport from leaves to daughter corms and suppressing corm yield formation.…”
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The prevalence of thromboembolic events among COVID-19 patients admitted to a single centre intensive care unit (ICU): an epidemiological study from a Malaysian population by Nur Farhani Mansor, Izzati Abdul Halim Zaki, Lee Chew Kiok, Eng Kar Seng, Tharmini Ravi, Mohan Pathmanathan, Khang Wen Goh, Long Chiau Ming, Pakhrur Razi, Hanis Hanum Zulkifly

“…Predictors of TE events were age [HR 1.01 (95% CI 1.00–1.02)], obesity [HR 1.98 (95% CI 1.51–2.6)], D-dimer [HR 1.01 (95% CI 1.00–1.01)], and duration of ICU stay [HR 0.98 (95% CI 0.97–0.99)].Conclusion In severely ill COVID-19 patients, TE complications were common, and patients with DVT, PE, stroke, or MI faced increased mortality, even with thromboprophylaxis. Age, obesity, elevated D-Dimer levels, and longer ICU stays were significant predictors of TE events. …”
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Chemotherapy-induced cellular senescence promotes stemness of aggressive B-cell non-Hodgkin’s lymphoma via CCR7/ARHGAP18/IKBα signaling activation by Yangyang Wang, Fan Wu, Yang Wan, Huiping Wang, Linhui Hu, Qianshan Tao, Zhimin Zhai, Jiyu Wang, Keke Huang, Anwen Ren, Jinlan Li, Liuying Yi, Yanjie Ruan, Zhixiang Wanyan, Chaohong Liu

“…Finally, inhibitors GS143 and Y27632 were used to examine the effect of IKBα and ARHGAP/RhoA inhibition on B-NHL-TIS.Results Here we identified a distinct group of TIS, composed of memory B-cell population characterized by strong positive expression of CCR7, which was significantly elevated in TIS population compared with normal proliferating and autonomously senescent lymphoma cell populations. …”
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Rat models of postintracerebral hemorrhage pneumonia induced by nasal inoculation with Klebsiella pneumoniae or intratracheal inoculation with LPS by Ruihua Wang, Changlian Gan, Rui Mao, Yang Chen, Ru Yan, Geng Li, Tianqin Xiong, Jianwen Guo

“…Kp challenge exacerbated the gut microbiota dysbiosis and fecal metabolic profile disorders, which were characterized by abnormal sphingolipid metabolism especially elevated ceramide levels; increased levels of neurotoxic quinolinic acid and an upregulation of tryptophan (Trp)–serotonin–melatonin pathway. …”
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Toxic effects and mechanisms of nanoplastics and sulfonamide antibiotics on Scenedesmus obliquus by Jianyuan Yang, Zhen Yang, Jing Wang, Yanpeng Liang, Honghu Zeng, Litang Qin, Xiaohong Song, Lingyun Mo

“…The exposure of two NPs and four SAs and their binary mixtures differently promoted or inhibited superoxide dismutase and catalase activities in algal cells to different degrees and resulted in elevated levels of malondialdehyde content, suggesting that oxidative stress led to significant inhibition of chlorophyll content, total protein content, and growth of algal cells. …”
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The Effect of “Carvacrol” on Ischemia-Reperfusion Injury in the Skeletal Muscles of Rats by Barış Mardin, Abdullah Özer, Başak Koçak, Ayşegül Küçük, Mustafa Hakan Zor, Şaban Cem Sezen, Mustafa Kavutçu, Mustafa Arslan, Gürsel Levent Oktar

“…Reperfusion injury refers to the detrimental effects of abrupt exposure of the ischemic tissue to elevated oxygen levels and subsequent generation of reactive oxygen derivatives inside the tissue. …”
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The effect of renal function on the clinical outcomes and management of patients hospitalized with hyperglycemic crises by Sumaya N. Almohareb, Sumaya N. Almohareb, Sumaya N. Almohareb, Norah Aljammaz, Nada Yousif, Mayar Sunbul, Raghad Alsemary, Lama Alkhathran, Mohammed Aldhaeefi, Omar A. Almohammed, Abdulrahman I. Alshaya, Abdulrahman I. Alshaya, Abdulrahman I. Alshaya

“…Patients with impaired renal function experience a delay in insulin clearance, complicating the adjustment of insulin dosing and elevating hypoglycemia risk. Accordingly, this study aims to evaluate the impact of renal function on the safety and efficacy of insulin use in patients with isolated DKA or combined DKA/HHS.MethodsA retrospective observational study was conducted at King Abdulaziz Medical City, Saudi Arabia, from January 2016 to December 2021. …”
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